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    • 4. 发明授权
    • Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
    • US06872405B2
    • 2005-03-29
    • US10142081
    • 2002-05-08
    • Yuuki TakaishiTakao MizumotoYoshinori Masuda
    • Yuuki TakaishiTakao MizumotoYoshinori Masuda
    • A61K9/00A61K9/20
    • A61K9/0056
    • The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.
    • 6. 发明授权
    • Motor control apparatus
    • 电机控制装置
    • US4518901A
    • 1985-05-21
    • US454028
    • 1982-12-28
    • Isao FukushimaYasunori KoboriHideo NishijimaYoshinori Masuda
    • Isao FukushimaYasunori KoboriHideo NishijimaYoshinori Masuda
    • H02P29/00H02P5/00H02P7/288G05B5/00
    • H02P7/2885H02P5/00Y10S388/915Y10S388/921
    • A motor control apparatus for driving and controlling a motor, in which a signal frequency proportional to a rotation number of the motor is converted into a d.c. voltage by a frequency/voltage converter so as to drive and control the motor by the d.c. voltage. The apparatus comprises a first, a second, and a third pulse generator for successively producing a first, a second, and a third repetitive pulse, respectively, in response to a signal period proportional to the rotation number of the motor; a constant current source; a first reset circuit driven by the third pulse to reset an output current of the constant current source; a first capacitor connected to the first reset circuit in parallel with the first reset circuit and charged by the output current of the constant current source; a sampling circuit driven by the second pulse to derive a saw tooth wave signal appearing across the first capacitor; a second reset circuit driven by the first pulse; a second capacitor connected to the second reset circuit in parallel therewith for charging the saw tooth wave signal through the sampling circuit; and a circuit for changing a pulse width of at least one of the first, second and third pulses substantially in accordance with the output current of the constant current source.
    • 用于驱动和控制电动机的电动机控制装置,其中与电动机的转数成正比的信号频率被转换成直流电动机。 电压由频率/电压转换器驱动和控制电机直流。 电压。 该装置包括第一,第二和第三脉冲发生器,用于响应于与电动机的转数成正比的信号周期分别连续产生第一,第二和第三重复脉冲; 恒流源; 由所述第三脉冲驱动的用于复位所述恒流源的输出电流的第一复位电路; 连接到与第一复位电路并联的第一复位电路并由恒流源的输出电流充电的第一电容器; 由第二脉冲驱动的采样电路,以导出出现在第一电容器两端的锯齿波信号; 由第一脉冲驱动的第二复位电路; 与第二复位电路并联连接的第二电容器,用于通过采样电路对锯齿波信号充电; 以及基本上根据恒流源的输出电流改变第一,第二和第三脉冲中的至少一个的脉冲宽度的电路。
    • 9. 发明申请
    • Quick disintegrating tablet in buccal cavity and production process thereof
    • 颊腔快速崩解片及其制作方法
    • US20050100598A1
    • 2005-05-12
    • US10961875
    • 2004-10-07
    • Takao MizumotoYoshinori MasudaAtsushi KajiyamaMasahiro YanagisawaJanaki Ram Nyshadham
    • Takao MizumotoYoshinori MasudaAtsushi KajiyamaMasahiro YanagisawaJanaki Ram Nyshadham
    • A61K9/00A61K9/20A61K47/26A61K47/36H04L12/44H04L29/06H04L29/08
    • H04L12/44A61K9/0056A61K9/2018A61K9/2095H04L29/06H04L67/12H04L67/26H04L69/08H04L69/329
    • The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
    • 本发明涉及颊腔中的快速崩解片,其包含:包含药物,糖(A)和无定形糖(B)的混合物,在形成片剂之后,将其加湿干燥。 特别地,本发明涉及颊腔中的快速崩解片剂,其包含:混合物; 包含药物,糖(A)和无定形糖(B),其中结晶状态的无定形形成糖溶解在药物允许溶剂中,通过除去溶剂从该溶液获得无定形糖,之后 正在形成片剂,并且被加湿和干燥。 本发明中的片剂是为了提供在保存的水分中的稳定性,因为无定形糖在制造​​过程中被加湿干燥后,在不可逆反应中变为结晶状态。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计,因为片剂由一种糖和无定形糖制造。 此外,本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。
    • 10. 发明授权
    • Tablets quickly disintegrating in the oral cavity and process for producing the same
    • 片剂在口腔中迅速崩解,并制备其
    • US06589554B1
    • 2003-07-08
    • US09646249
    • 2000-09-14
    • Takao MizumotoYoshinori MasudaAtsushi KajiyamaMasahiro YanagisawaJanaki Ram Nyshadham
    • Takao MizumotoYoshinori MasudaAtsushi KajiyamaMasahiro YanagisawaJanaki Ram Nyshadham
    • A61K920
    • H04L12/44A61K9/0056A61K9/2018A61K9/2095H04L29/06H04L67/12H04L67/26H04L69/08H04L69/329
    • The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
    • 本发明涉及颊腔中的快速崩解片,其包含:包含药物,糖(A)和无定形糖(B)的混合物,在形成片剂之后,将其加湿干燥。 特别地,本发明涉及颊腔中的快速崩解片剂,其包含:混合物; 包含药物,糖(A)和无定形糖(B),其中结晶状态的无定形形成糖溶解在药物允许溶剂中,通过除去溶剂从该溶液获得无定形糖,之后 是形成片剂,并且其被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性,因为无定形糖在制造​​过程中被加湿干燥后在非可逆反应中变为结晶状态 。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计,因为片剂由一种糖和无定形糖制造。 此外,本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。