发明申请
US20050100598A1 Quick disintegrating tablet in buccal cavity and production process thereof
审中-公开
![Quick disintegrating tablet in buccal cavity and production process thereof](/abs-image/US/2005/05/12/US20050100598A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: Quick disintegrating tablet in buccal cavity and production process thereof
- 专利标题(中):颊腔快速崩解片及其制作方法
- 申请号:US10961875 申请日:2004-10-07
- 公开(公告)号:US20050100598A1 公开(公告)日:2005-05-12
- 发明人: Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
- 申请人: Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
- 申请人地址: US OK Norman
- 专利权人: Yamanouchi Pharmaceutical Co., Ltd.,Yamanouchi Pharma Technologies, Inc.
- 当前专利权人: Yamanouchi Pharmaceutical Co., Ltd.,Yamanouchi Pharma Technologies, Inc.
- 当前专利权人地址: US OK Norman
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K9/20 ; A61K47/26 ; A61K47/36 ; H04L12/44 ; H04L29/06 ; H04L29/08
摘要:
The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要(中):
本发明涉及颊腔中的快速崩解片,其包含:包含药物,糖(A)和无定形糖(B)的混合物,在形成片剂之后,将其加湿干燥。 特别地,本发明涉及颊腔中的快速崩解片剂,其包含:混合物; 包含药物,糖(A)和无定形糖(B),其中结晶状态的无定形形成糖溶解在药物允许溶剂中,通过除去溶剂从该溶液获得无定形糖,之后 正在形成片剂,并且被加湿和干燥。 本发明中的片剂是为了提供在保存的水分中的稳定性,因为无定形糖在制造过程中被加湿干燥后,在不可逆反应中变为结晶状态。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计,因为片剂由一种糖和无定形糖制造。 此外,本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K9/00 | 以特殊物理形状为特征的医药配制品 |