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1. 发明授权

US08232079B2 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US08232079B2
公开(公告)日：2012-07-31
申请号：US11197335
申请日：2005-08-05
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/00 , C12P19/18
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

2. 发明授权

US07070988B2 Oligosaccharide synthesizer 失效
公开(公告)号：US07070988B2
公开(公告)日：2006-07-04
申请号：US10715385
申请日：2003-11-19
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/34
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.

3. 发明申请

US20060024817A1 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US20060024817A1
公开(公告)日：2006-02-02
申请号：US11197335
申请日：2005-08-05
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/34 , C40B60/14
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

4. 发明授权

US06962809B1 Sugar chain synthesizer 失效
标题翻译：糖链合成器
公开(公告)号：US06962809B1
公开(公告)日：2005-11-08
申请号：US10482626
申请日：2002-07-01
申请人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
发明人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
IPC分类号： C12P19/14 , C12P19/18 , C12M1/34
CPC分类号： C12P19/18 , C12P19/14
摘要： A sugar chain synthesizer comprising one or more reaction columns packed with immobilized glycosyltransferase and/or glycosidase; one or more separation means, arranged downstream from the reaction columns, for separating reaction products, unreaction products and byproducts contained in the solution eluted from the reaction columns; a first pump for feeding a primer of water soluble polymer and buffer solution to the reaction columns through a first selector valve; a second pump for feeding a buffer solution and sugar nucleotide solution to any one of the reaction columns through a second selector valve; one or more circulation flow paths connecting between a flow path downstream from the separation means and a flow path upstream from each of the reaction columns; and a third selector valve, arranged between the separation means and one or more circulation flow paths, for selective connection between the separation means and a desired circulation flow path. This synthesizer ensures continuous and automatic synthesis of sugar chains even if complicated.
摘要翻译：一种糖链合成仪，其包含一个或多个填充有固定的糖基转移酶和/或糖苷酶的反应柱; 一个或多个分离装置，布置在反应塔的下游，用于分离从反应塔洗脱的溶液中所含的反应产物，未反应产物和副产物; 第一泵，用于通过第一选择阀向反应塔供给水溶性聚合物和缓冲溶液的底漆; 第二泵，其通过第二选择阀将缓冲溶液和糖核苷酸溶液供给到任一反应塔; 连接在分离装置下游的流动路径和每个反应塔上游的流动路径之间的一个或多个循环流动路径; 以及第三选择阀，布置在所述分离装置和一个或多个循环流动路径之间，用于分离装置和期望的循环流动路径之间的选择性连接。这种合成器即使复杂，也能确保糖链的连续和自动合成。

5. 发明申请

US20100057379A1 METHOD AND APPARATUS FOR CHROMATOGRAPHIC DATA PROCESSING 失效
标题翻译：用于色谱数据处理的方法和装置
公开(公告)号：US20100057379A1
公开(公告)日：2010-03-04
申请号：US12611181
申请日：2009-11-03
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G06F19/00 , G01N31/00 , G06F17/18
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8637 , G01N30/8641
摘要： A chromatographic analyzer is provided for facilitating curve fitting by means of the linear least-square method for a chromatogram that contains a plurality of overlapping peaks. The present invention is characterized by a chromatographic data processor for executing data processing of a chromatogram obtained by separating a sample to be measured using a column and detecting the separated sample, wherein fitting processing is executed to each peak in an arbitrary time region having the plurality of peaks of the chromatogram starting from the front side of the time region or from the back side of the time region, and the processed peaks are subtracted from the chromatogram in the time region so that the plurality of peaks in the chromatogram can be separated from one another. Thus, the plurality of overlapping peaks, particularly three or more overlapping peaks in the chromatogram can be easily separated from one another only by defining some setting conditions.
摘要翻译：提供了一种色谱分析仪，用于利用包含多个重叠峰的色谱图的线性最小二乘法促进曲线拟合。本发明的特征在于一种色谱数据处理器，用于执行通过使用色谱柱分离待测样品并检测分离的样品而获得的色谱图的数据处理，其中对具有多个样品的任意时间区域中的每个峰值执行拟合处理从时间区域的前侧或时间区域的背面开始的色谱图的峰值，并且在时间区域中从色谱图中减去处理的峰，使得色谱图中的多个峰可以从另一个。因此，仅通过限定一些设定条件，可以容易地将色谱图中的多个重叠峰，特别是三个或更多个重叠峰相互分离。

6. 发明申请

US20050143948A1 Method and apparatus for chromatographic data processing 失效
标题翻译：色谱数据处理方法和装置
公开(公告)号：US20050143948A1
公开(公告)日：2005-06-30
申请号：US11061610
申请日：2005-02-22
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N30/86 , G01F23/00
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8637 , G01N30/8641
摘要： A chromatographic analyzer is provided for facilitating curve fitting by means of the linear least-square method for a chromatogram that contains a plurality of overlapping peaks. A chromatographic data processor executes fitting processing to each peak in an arbitrary time region having the plurality of peaks of the chromatogram starting from the front or back side of the time region, and the processed peaks are subtracted from the chromatogram in the time region so that the plurality of peaks in the chromatogram can be separated from one another.
摘要翻译：提供了一种色谱分析仪，用于利用包含多个重叠峰的色谱图的线性最小二乘法促进曲线拟合。色谱数据处理器对从时区的正面或背面开始的具有多个色谱图的峰的任意时间区域中的每个峰值进行拟合处理，并且在时间区域中从色谱图中减去处理的峰，使得色谱图中的多个峰可以彼此分离。

7. 发明授权

US06314374B1 Data processing apparatus for chromatograph 有权
标题翻译：色谱数据处理装置
公开(公告)号：US06314374B1
公开(公告)日：2001-11-06
申请号：US09562026
申请日：2000-05-01
申请人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
发明人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
IPC分类号： G06F1900
CPC分类号： G06F17/10 , G01N30/8641
摘要： A method of properly correcting a base line. A concept of flexibility of a base line is introduced as an input index and a gravitation is presumed between the base line and signal data which is measured, thereby constructing a method of correcting the base line which changes gentler than a change in signal with respect to time in a peak area and which is sensitive to an area where a value of the signal data is small. A base line like a natural and smooth curve which isn't easily influenced by a local change in signal such as noise or the like can be set by an input of the flexibility.
摘要翻译：一种正确校正基线的方法。引入基线的灵活性的概念作为输入索引，并且在基线和被测量的信号数据之间推测引力，由此构建校正基线相对于信号变化更温和的方法，相对于在峰值区域中的时间，并且其对信号数据的值较小的区域敏感。可以通过输入灵活性来设定像自然平滑曲线的基线，其不容易受诸如噪声等信号的局部变化的影响。

8. 发明授权

US08496819B2 Separation column for liquid chromatograph apparatus and liquid chromatograph apparatus using thereof 失效
标题翻译：液相色谱仪分离柱及其使用的液相色谱仪
公开(公告)号：US08496819B2
公开(公告)日：2013-07-30
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08 , G01N30/02 , C02F1/28
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using the column are provided. A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供了具有高耐压性并且即使以小流量进行高速分离和分析的柱和使用该柱的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成使其围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

9. 发明申请

US20110303599A1 LIQUID CHROMATOGRAPH, LIQUID CHROMATOGRAPH COLUMN AND FILTER FOR LIQUID CHROMATOGRAPH COLUMN 有权
标题翻译：液相色谱，液相色谱柱和液相色谱柱过滤器
公开(公告)号：US20110303599A1
公开(公告)日：2011-12-15
申请号：US13202722
申请日：2010-03-10
申请人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
发明人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
IPC分类号： B01D15/08 , B01D39/10
CPC分类号： G01N30/603
摘要： In a liquid chromatograph, the disulfide adsorption of iron atoms in a filter for a column is avoided and thus peak tailing in a chromatogram is prevented to thereby prevent a lowering in the sample recovery rate. A liquid chromatograph column comprising a hollow tubular column body, a bead-shaped packing material which is packed in the hollow part of the column body, a filter provided with a mesh which has a mesh size smaller than the particle diameter of the packing material, and a cap which presses the filter against the packing material to thereby enclose the packing material within the column body, characterized in that the main component of the filter is nickel or hastelloy.
摘要翻译：在液相色谱仪中，避免了用于柱的过滤器中的铁原子的二硫键吸附，因此防止了色谱图中的峰值拖尾，从而防止了样品回收率的降低。一种液相色谱柱，包括中空管状柱体，填充在柱体中空部分中的珠状包装材料，具有筛网尺寸小于包装材料粒径的筛网的过滤器，以及将过滤器压靠在包装材料上的盖子，从而将包装材料包围在柱体内，其特征在于，过滤器的主要部件是镍或哈氏合金。

10. 发明申请

US20070199874A1 Three-dimensional liquid chromatography 审中-公开
标题翻译：三维液相色谱
公开(公告)号：US20070199874A1
公开(公告)日：2007-08-30
申请号：US11700844
申请日：2007-02-01
申请人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
发明人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
IPC分类号： B01D15/08
CPC分类号： G01N30/463 , G01N30/461 , G01N30/7233 , G01N30/96 , B01D15/322 , B01D15/362 , B01D15/325 , B01D15/363
摘要： In a liquid chromatography apparatus, a separation column of intermediate stage is additionally connected between a separation column of first stage and a separation column of second stage. Preferably, a switching unit and a liquid feed unit for mixing and feeding a plurality of solutions are added to improve a separation capability. A three-dimensional liquid chromatography apparatus capable of avoiding the “solution interference” can be realized. Even a complex sample containing a hydrophilic component and a hydrophobic component in a mixed state can be separated and analyzed satisfactorily on-line.
摘要翻译：在液相色谱装置中，中间级分离塔另外连接在第一级分离塔和第二级分离塔之间。优选地，添加用于混合和供给多个溶液的切换单元和液体进料单元以提高分离能力。可以实现能够避免“溶液干扰”的三维液相色谱仪。即使是含有亲水性成分和混合状态的疏水性成分的复合物，也可以在线进行分离和分析。

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