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1. 发明申请

US20220148704A1 NUTRIMENT TRACK AND ALERT SYSTEM 有权
公开(公告)号：US20220148704A1
公开(公告)日：2022-05-12
申请号：US17523891
申请日：2021-11-10
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： G16H20/60 , G16H20/10
摘要： The present disclosure provides a nutriment track and alert system and method. The system includes at least one monitoring station configured to support a container; at least one weight-measuring device for detecting and measuring the container weight and/or weight differentials when a container is placed or lifted on the monitoring station. The monitoring station or weight-measuring device communicates with a computer executable protocol that can be executable on a mobile device, computer, web server, and/or coupled or housed in the system itself. The protocol can store medication data through user input or through communication with the monitoring station or weight-measuring device. When the weight-measuring device or the protocol detects a change in the weight differentials not aligned with the medication data, the system submits and alert.

2. 发明申请

US20210060545A1 CAPTURE, DISRUPTION, AND EXTRACTION APPARATUS AND METHOD 有权
公开(公告)号：US20210060545A1
公开(公告)日：2021-03-04
申请号：US16557137
申请日：2019-08-30
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： B01L3/00 , G01N1/40 , G01N1/28 , B01D24/10 , B01D24/00 , B01D15/34
摘要： A cell capture, disruption, and extraction method includes a introducing a plurality of abrasives in a disruption chamber, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The method includes agitating the abrasives by moving the disruption chamber and/or pestle, agitation of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives.

3. 发明授权

US10436680B2 Capture, disruption, and extraction apparatus and method 有权
公开(公告)号：US10436680B2
公开(公告)日：2019-10-08
申请号：US14512428
申请日：2014-10-11
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： G01N1/28
摘要： A cell capture, disruption, and extraction apparatus includes a disruption chamber configured to receive cell solution and having therein a plurality of abrasives, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The apparatus includes an actuation device configured to agitate the disruption chamber and/or pestle, movement of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. The pestle can rotate with respect to the disruption chamber. The pestle can include a nut-shaped core or axle, and/or include a plurality of extrusions. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content through the foregoing agitation process. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives.

4. 发明授权

US10240144B2 Sequential delivery device and method 有权
公开(公告)号：US10240144B2
公开(公告)日：2019-03-26
申请号：US15045247
申请日：2016-02-17
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： C12N15/10 , B01J4/02 , B01L3/00 , B01F15/02 , C12Q1/6806
摘要： A reagent delivery method includes placing a reagent delivery column including a plurality of reagent storage elements therein in a centrifugal device, coupling a breaching element to the housing, and rotating the centrifugal device to force the reagent storage elements toward the breaching element, breaching of the reagent storage elements releasing reagent therein and communicating the same to an external environment. A reagent delivery system includes a column having a housing, a plurality of reagent storage element sheets positioned in the housing or forming a stack, a plurality of breaching elements, and a microplate having a plurality of wells, the microplate coupled to the housing where each well corresponds or aligns with a breaching element and a reagent storage element. The system can be rotated in a centrifugal device to force the reagent storage element stacks toward the breaching elements.

5. 发明授权

US09308508B2 Sequential delivery device and method 有权
标题翻译：顺序递送装置和方法
公开(公告)号：US09308508B2
公开(公告)日：2016-04-12
申请号：US14335946
申请日：2014-07-21
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： B01J4/02 , B01L3/00 , B01F15/02 , C12N15/10
CPC分类号： C12N15/101 , B01F15/0206 , B01F15/0223 , B01F15/0224 , B01F15/0233 , B01F2015/0221 , B01J4/02 , B01J2219/00177 , B01L3/502 , B01L3/527 , B01L2200/0631 , B01L2300/0672 , B01L2300/0829 , B01L2300/087 , B01L2400/0409 , B01L2400/049 , B01L2400/0638 , C12N15/1003 , C12Q1/6806
摘要： A reagent delivery device includes a reagent delivery column with a housing receiving reagent storage elements that can move, and a breaching element coupled to the housing. The device includes an actuation member that during operation forces the reagent storage elements toward the breaching element. Breaching the storage elements releases the reagent. The breaching element and/or the housing are configured to communicate reagent between the reagent storage element and a target chamber coupled to the housing. The breaching element can be a needle, a blade, or a combination thereof. Multiple reagent delivery columns can be coupled to microplate wells for larger scale reagent delivery and processing. Biasing elements such as a spring and a counterweight can be directly or indirectly coupled to the housing and/or the reagent storage elements, resisting and/or moderating movement of the reagent elements.
摘要翻译：试剂递送装置包括具有容纳可移动的试剂存储元件的壳体的试剂输送塔和连接到壳体的破裂元件。该装置包括致动构件，其在操作期间迫使试剂储存元件朝向破坏元件。破坏存储元件释放试剂。破裂元件和/或壳体构造成在试剂储存元件和与壳体连接的目标腔室之间传递试剂。破裂元件可以是针，刀片或其组合。多个试剂递送柱可以耦合到微板孔，用于更大规模的试剂递送和处理。诸如弹簧和配重的偏压元件可以直接或间接地联接到壳体和/或试剂储存元件，抵抗和/或调节试剂元件的移动。

6. 发明申请

US20160160209A1 SEQUENTIAL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：顺序递送装置和方法
公开(公告)号：US20160160209A1
公开(公告)日：2016-06-09
申请号：US15045247
申请日：2016-02-17
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： C12N15/10 , C12Q1/68 , B01L3/00
CPC分类号： C12N15/101 , B01F15/0206 , B01F15/0223 , B01F15/0224 , B01F15/0233 , B01F2015/0221 , B01J4/02 , B01J2219/00177 , B01L3/502 , B01L3/527 , B01L2200/0631 , B01L2300/0672 , B01L2300/0829 , B01L2300/087 , B01L2400/0409 , B01L2400/049 , B01L2400/0638 , C12N15/1003 , C12Q1/6806
摘要： A reagent delivery method includes placing a reagent delivery column including a plurality of reagent storage elements therein in a centrifugal device, coupling a breaching element to the housing, and rotating the centrifugal device to force the reagent storage elements toward the breaching element, breaching of the reagent storage elements releasing reagent therein and communicating the same to an external environment. A reagent delivery system includes a column having a housing, a plurality of reagent storage element sheets positioned in the housing or forming a stack, a plurality of breaching elements, and a microplate having a plurality of wells, the microplate coupled to the housing where each well corresponds or aligns with a breaching element and a reagent storage element. The system can be rotated in a centrifugal device to force the reagent storage element stacks toward the breaching elements.
摘要翻译：试剂递送方法包括将包括多个试剂储存元件的试剂输送塔放置在离心装置中，将破裂元件连接到壳体，以及旋转离心装置以迫使试剂储存元件朝向破坏元件，破坏试剂储存元件在其中释放试剂并将其传送到外部环境。试剂递送系统包括具有壳体的柱，位于壳体中的多个试剂储存元件片或形成叠层，多个破裂元件和具有多个孔的微孔板，该微孔板联接到壳体，其中每个很好地对应于或与违反元件和试剂储存元件对准。该系统可以在离心装置中旋转以迫使试剂储存元件朝着破坏元件堆叠。

7. 发明申请

US20150104825A1 CAPTURE, DISRUPTION, AND EXTRACTION APPARATUS AND METHOD 审中-公开
标题翻译：捕获，破坏和提取装置和方法
公开(公告)号：US20150104825A1
公开(公告)日：2015-04-16
申请号：US14512428
申请日：2014-10-11
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： G01N1/31
CPC分类号： G01N1/286 , G01N2001/2866
摘要： A cell capture, disruption, and extraction apparatus includes a disruption chamber configured to receive cell solution and having therein a plurality of abrasives, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The apparatus includes an actuation device configured to agitate the disruption chamber and/or pestle, movement of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. The pestle can rotate with respect to the disruption chamber. The pestle can include a nut-shaped core or axle, and/or include a plurality of extrusions. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content through the foregoing agitation process. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives.
摘要翻译：细胞捕获，破碎和提取装置包括被配置为接收细胞溶液并且在其中具有多个研磨剂的破碎室，所述研磨剂可以包括可变和多维分布在其中的金刚石粉末和位于破碎室中的研杵。该装置包括被配置成搅动破碎室和/或杵的致动装置，研磨剂撕裂孔结构在溶液中的移动以便接近其内容物。结合柱或尺寸排阻柱可以位于破裂室的下游。杵可以相对于破碎室旋转。研杵可以包括螺母形的芯或轴，和/或包括多个挤压件。细胞溶液可以首先引入破碎室，研磨剂捕获细胞并允许其通过并清除废物，然后通过上述搅拌过程破坏细胞含量。裂解物然后可以结合到破碎室下游的提取基质，或者它可以与研磨剂混合。

8. 发明授权

US11504709B2 Capture, disruption, and extraction apparatus and method 有权
公开(公告)号：US11504709B2
公开(公告)日：2022-11-22
申请号：US16557137
申请日：2019-08-30
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： B01L3/00 , B01D15/34 , B01D24/00 , B01D24/10 , G01N1/28 , G01N1/40
摘要： A cell capture, disruption, and extraction method includes a introducing a plurality of abrasives in a disruption chamber, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The method includes agitating the abrasives by moving the disruption chamber and/or pestle, agitation of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives.

9. 发明申请

US20220023856A9 CAPTURE, DISRUPTION, AND EXTRACTION APPARATUS AND METHOD 有权
公开(公告)号：US20220023856A9
公开(公告)日：2022-01-27
申请号：US16557137
申请日：2019-08-30
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： B01L3/00 , G01N1/40 , G01N1/28 , B01D24/10 , B01D24/00 , B01D15/34
摘要： A cell capture, disruption, and extraction method includes a introducing a plurality of abrasives in a disruption chamber, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The method includes agitating the abrasives by moving the disruption chamber and/or pestle, agitation of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives.

10. 发明申请

US20150024384A1 SEQUENTIAL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：顺序递送装置和方法
公开(公告)号：US20150024384A1
公开(公告)日：2015-01-22
申请号：US14335946
申请日：2014-07-21
申请人： Kianoosh Peyvan
发明人： Kianoosh Peyvan
IPC分类号： C12Q1/68
CPC分类号： C12N15/101 , B01F15/0206 , B01F15/0223 , B01F15/0224 , B01F15/0233 , B01F2015/0221 , B01J4/02 , B01J2219/00177 , B01L3/502 , B01L3/527 , B01L2200/0631 , B01L2300/0672 , B01L2300/0829 , B01L2300/087 , B01L2400/0409 , B01L2400/049 , B01L2400/0638 , C12N15/1003 , C12Q1/6806
摘要： A reagent delivery device includes a reagent delivery column with a housing receiving reagent storage elements that can move, and a breaching element coupled to the housing. The device includes an actuation member that during operation forces the reagent storage elements toward the breaching element. Breaching the storage elements releases the reagent. The breaching element and/or the housing are configured to communicate reagent between the reagent storage element and a target chamber coupled to the housing. The breaching element can be a needle, a blade, or a combination thereof. Multiple reagent delivery columns can be coupled to microplate wells for larger scale reagent delivery and processing. Biasing elements such as a spring and a counterweight can be directly or indirectly coupled to the housing and/or the reagent storage elements, resisting and/or moderating movement of the reagent elements.
摘要翻译：试剂递送装置包括具有容纳可移动的试剂存储元件的壳体的试剂输送塔和连接到壳体的破裂元件。该装置包括致动构件，其在操作期间迫使试剂储存元件朝向破坏元件。破坏存储元件释放试剂。破裂元件和/或壳体构造成在试剂储存元件和与壳体连接的目标腔室之间传递试剂。破裂元件可以是针，刀片或其组合。多个试剂递送柱可以耦合到微板孔，用于更大规模的试剂递送和处理。诸如弹簧和配重的偏压元件可以直接或间接地联接到壳体和/或试剂储存元件，抵抗和/或调节试剂元件的移动。

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