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1. 发明申请

US20110065202A1 Method for Examination of Alzheimer's Disease 审中-公开
标题翻译：阿尔茨海默病检查方法
公开(公告)号：US20110065202A1
公开(公告)日：2011-03-17
申请号：US12992309
申请日：2009-06-11
申请人： Khin Than Myint , Yoshiya Oda , Naoki Asai
发明人： Khin Than Myint , Yoshiya Oda , Naoki Asai
IPC分类号： G01N33/53 , G01N27/26 , G01N30/02 , H01J49/26
CPC分类号： G01N33/9453 , G01N30/72 , G01N33/9486 , G01N2800/2821 , Y10T436/174614
摘要： A method for examining Alzheimer's disease comprising (1) the measurement step of measuring an amount of lidocaine or a metabolite thereof in a cerebrospinal fluid derived from a lidocaine-administered test subject, and (2) the determination step of determining whether the test subject has Alzheimer's disease or not on the basis of the measured amount.
摘要翻译：一种检查阿尔茨海默氏病的方法，其特征在于，包括：（1）测定利多卡因或其代谢物在来自利多卡因的测试对象的脑脊液中的量的测定步骤，以及（2）阿尔茨海默氏病或不是基于测量量。

2. 发明授权

US5789727A Integrated method and apparatus for reading mier code and printing 失效
标题翻译：用于读取微码和打印的集成方法和装置
公开(公告)号：US5789727A
公开(公告)日：1998-08-04
申请号：US544528
申请日：1995-10-18
申请人： Mitsuaki Teradaira , Tsutomu Momose , Kenji Komatsu , Eizo Takahashi , Akira Koyabu , Naoki Asai
发明人： Mitsuaki Teradaira , Tsutomu Momose , Kenji Komatsu , Eizo Takahashi , Akira Koyabu , Naoki Asai
IPC分类号： B41J3/44 , B41J3/60 , B41J11/48 , B41J11/50 , B41J13/10 , G06K1/12 , G06K7/08 , G06K17/00
CPC分类号： G06Q20/042 , B41J11/48 , B41J11/50 , B41J13/10 , B41J3/44 , B41J3/60 , G06K1/125 , G06K17/00 , G06K7/084 , Y10S271/902
摘要： Printing to aNd MICR code reading from a cut-sheet form imprinted with an MICR code, such as personal checks, are continuously accomplished by a single apparatus, thereby simplifying processing and reducing the required installation space. A magnetic head and a magnet for reading the MICR code are disposed on the slope of a paper path provided in a printer housing. A personal check in paper path is held by cut-sheet form loading rollers and/or transportation rollers which operate at a synchronized speed, and is passed over the magnetic head for MICR code reading. Thereafter, the personal check is held by the loading rollers and/or the transportation rollers for endorsement printing by the print head.
摘要翻译：通过单个设备连续地进行打印到由打印有MICR码（例如个人检查）的单张纸形式读取的MICR代码，从而简化处理并减少所需的安装空间。用于读取MICR码的磁头和磁铁设置在设置在打印机壳体中的纸路的斜面上。纸张通行的个人检查由以同步速度操作的片状加载辊和/或输送辊保持，并且通过用于MICR代码读取的磁头。此后，个人支票由装载辊和/或输送辊保持，用于由打印头进行背书印刷。

3. 发明授权

US07667052B2 Bioactive substance 有权
标题翻译：生物活性物质
公开(公告)号：US07667052B2
公开(公告)日：2010-02-23
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： C07D313/00 , C07D407/06 , A61K31/365
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

4. 发明授权

US06328490B1 Winding shaft and a printer using the same 有权
标题翻译：绕线轴和使用其的打印机
公开(公告)号：US06328490B1
公开(公告)日：2001-12-11
申请号：US09583190
申请日：2000-05-30
申请人： Hiroshi Narita , Masahiko Yamada , Naoki Asai , Kenichiro Arai
发明人： Hiroshi Narita , Masahiko Yamada , Naoki Asai , Kenichiro Arai
IPC分类号： B41J1126
CPC分类号： B65H75/24 , B65H18/04 , B65H75/242
摘要： A winding shaft, for use in a printer allows a wound recording paper to be easily removed therefrom. The winding shaft includes a shaft main body, a winding portion and a support-removing member. The winding portion, which sandwiches the shaft main body, winds the recording paper therearound. The shaft main body includes a pair of support-removing members, which respectively project from the shaft main body. The two support-removing members are respectively supported on the two side portions of the shaft main body in such a manner that they can be freely rotated about their respective support shafts. A tension-coiled spring is bridgingly disposed between the two support-removing members, so that the two support-removing members remain in standing positions when no external force is applied to them. If the recording paper is lightly rotated in a direction opposite to the winding direction of the recording paper, then the two support-removing members are brought down in the same direction due to an external force applied thereto from the innermost peripheral recording paper. As a result, the innermost peripheral recording paper is loosened, that is, is caused to float loosely from the outer peripheral surface of the shaft main body, thereby enabling the removal of the recording paper from the winding shaft.
摘要翻译：用于打印机中的卷绕轴允许容易地从其上移除卷绕的记录纸。卷绕轴包括轴主体，卷绕部分和支撑件移除部件。卷绕轴主体的卷绕部分绕着记录纸卷绕。轴主体包括分别从轴主体突出的一对支撑移除构件。两个支撑移除部件分别支撑在轴主体的两个侧部上，使得它们能够绕其各自的支撑轴自由旋转。张紧螺旋弹簧桥接地布置在两个支撑移除构件之间，使得当没有施加外力时，两个支撑件移除构件保持在竖立位置。如果记录纸在与记录纸的卷绕方向相反的方向上轻微旋转，则两个支撑件移除部件由于从最内侧的周边记录纸施加到其上的外力而沿同一方向下降。结果，最内侧的周边记录纸被松动，从而从轴主体的外周表面松动地浮动，从而能够从卷轴移除记录纸。

5. 发明授权

US5902059A Printer 失效
标题翻译：打印机
公开(公告)号：US5902059A
公开(公告)日：1999-05-11
申请号：US7017
申请日：1998-01-14
申请人： Naoki Asai , Masahiko Yamada , Kenichi Hirabayashi
发明人： Naoki Asai , Masahiko Yamada , Kenichi Hirabayashi
IPC分类号： B41J11/14 , B41J11/20 , B41J11/48 , B41J15/20
CPC分类号： B41J11/20 , B41J11/48
摘要： A print head 6 is disposed next to a transportation path for transporting a cut-sheet form V. A guide frame 17 with a guide member 17a projecting into the transportation path away from the print head 6 is disposed on the cut-sheet form V insertion opening side of the print head 6. A platen unit 16 with a platen 33 is mounted to rotate freely, and a frame member 30 is disposed on the platen unit 16. When the platen unit 16 is closed, the guide member 17a of the guide frame 17 and the guide member 30b of the frame member 30 touch, thus forming an ejection path guiding the roll paper S away from the junction with the cut-sheet form V transportation path. When the platen unit 16 is opened, the guide member 17a of guide frame 17 and the guide member 30b of frame member 30 separate, thereby enabling cut-sheet form V insertion.
摘要翻译：打印头6靠近用于传送片材形式V的传送路径旁边。具有从打印头6突出到传送路径中的引导构件17a的引导框架17设置在片材形式V插入件打印头6的打开侧。具有压板33的压板单元16被安装成自由旋转，框架构件30设置在压板单元16上。当压板单元16关闭时，导向件的引导构件17a 框架构件30的引导构件30b与框架构件30的引导构件30b接触，从而形成将卷纸S引导离开与片材V形输送路径的连接处的排出路径。当压板单元16打开时，引导框架17的引导构件17a和框架构件30的引导构件30b分离，从而使得片材形式V插入。

6. 发明授权

US5664895A Printing apparatus and a control method therefor 失效
标题翻译：印刷装置及其控制方法
公开(公告)号：US5664895A
公开(公告)日：1997-09-09
申请号：US415966
申请日：1995-04-03
申请人： Naoki Asai , Hideki Kawakami , Choji Morozumi
发明人： Naoki Asai , Hideki Kawakami , Choji Morozumi
IPC分类号： B41J2/22 , B41J11/20 , B41J31/12 , B41J35/26 , B41J35/28 , B41J35/04
CPC分类号： B41J11/20 , B41J2/22 , B41J31/12 , B41J35/26 , B41J35/28
摘要： A printing apparatus comprises a platen, a dot impact print head (23) opposite to the platen, a mask plate (40) between the platen and the print head with a paper passage between the platen and the mask plate (40), and an ink ribbon (31) between the print head and the mask plate. Transport mechanisms are provided to move the mask plate (40) in a direction substantially perpendicular to said paper passage between a first position on the print head side and a second position on the platen side, the transport mechanisms being responsive to the position of the print head along the platen. In the first position of the mask plate a relatively wide gap between the platen and the mask plate enables easy paper insertion, while in the second position a relatively wide gap between the mask plate and the print head facilitates replacement of the ink ribbon without problems.
摘要翻译：打印装置包括压板，与压板相对的点冲击打印头（23），在压板和打印头之间的掩模板（40），在压板和掩模板（40）之间具有纸通道，并且墨带（31）在打印头和掩模板之间。提供传送机构以在打印头侧的第一位置和压纸卷一侧的第二位置之间沿着基本上垂直于所述纸通道的方向移动掩模板（40），所述传送机构响应于打印位置头沿着压板。在掩模板的第一位置中，压板和掩模板之间的相对较宽的间隙能够容易地进行纸的插入，而在第二位置，掩模板和打印头之间的相对宽的间隙有利于更换墨带。

7. 发明授权

US07816401B2 Process for total synthesis of pladienolide B and pladienolide D 失效
标题翻译：丙二烯内酯B和普拉二烯内酯D的全合成方法
公开(公告)号：US07816401B2
公开(公告)日：2010-10-19
申请号：US11580047
申请日：2006-10-13
申请人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
发明人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
IPC分类号： A61K31/335 , A61K31/16
CPC分类号： C07D493/04 , C07D303/12 , C07D303/14 , C07D313/00 , C07D315/00 , C07D405/12 , C07D407/06 , Y02P20/55
摘要： A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined herein, characterized by including reacting a compound represented by Formula (12): with a compound represented by Formula (13): in the presence of a catalyst.
摘要翻译：一种制备由式（11）表示的化合物的方法：其中P1，P7，P8，P9和R1与本文所定义的相同，其特征在于包括使由式（12）表示的化合物与式（12）表示的化合物 13）：在催化剂存在下。

8. 发明申请

US20060079572A1 Novel bioactive substance 有权
标题翻译：新型生物活性物质
公开(公告)号：US20060079572A1
公开(公告)日：2006-04-13
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： A61K31/365 , C07D313/00
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

9. 发明授权

US06523927B2 Method and apparatus for processing recording media having embedded information 有权
公开(公告)号：US06523927B2
公开(公告)日：2003-02-25
申请号：US09987435
申请日：2001-11-14
申请人： Naoki Asai , Kunio Omura
发明人： Naoki Asai , Kunio Omura
IPC分类号： B41J29393
CPC分类号： B41J3/44 , B41J3/60 , B41J11/46 , B41J11/48
摘要： An apparatus includes a passage along which a recording medium with magnetic information recorded thereon can travel and an information read head disposed along the passage for reading the magnetic information. The apparatus also includes a first print head disposed on the first side of the passage and a second print head disposed on the second side of the passage. The first print head prints information on a first surface of the recording media based on data obtained by the information read head and the second print head prints information on a second surface of the recording media based on the data obtained by the information read head. Methods of processing a recording medium with magnetic information recorded thereon also are disclosed.

10. 再颁专利

USRE35319E Printer accommodating two types of printing sheets 失效
标题翻译：打印机可容纳两种类型的打印纸
公开(公告)号：USRE35319E
公开(公告)日：1996-08-27
申请号：US316469
申请日：1994-10-03
申请人： Masahiko Yamada , Yoshikazu Ito , Naoki Asai
发明人： Masahiko Yamada , Yoshikazu Ito , Naoki Asai
IPC分类号： B41J11/48 , B41J29/13 , B41J15/20
CPC分类号： B41J11/48
摘要： A printer which can accommodate both continuous sheets and cut sheets includes both a continuous sheet path and a cut sheet path. A printing section is provided in common for the continuous and cut sheets. A manually .[.slidable.]. .Iadd.movable .Iaddend.continuous sheet guide plate is provided in the upper portion of the printing section. A detector detects .[.operatin.]. .Iadd.operation .Iaddend.of the continuous sheet guide plate. When the guide plate is .[.slid.]. .Iadd.moved .Iaddend.so that the cut sheet path is closed and the continuous sheet path is selected, in response to the output of the detector the continuous sheet is fed to the exit of the continuous sheet path.
摘要翻译：可以容纳连续片材和切割片材的打印机包括连续片材路径和切割片材路径。为连续和切割的片材共同提供印刷部分。在打印部分的上部设置有可移动的可移动的连续片材引导板。检测器检测连续片材导板的[操作]操作。当引导板被滑动移动以使得切割的纸张路径被关闭并且连续的纸张路径被选择时，响应于检测器的输出，连续纸张被供给到连续纸张路径的出口。

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