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1. 发明授权

US07026352B1 Physiologically active substances 有权
标题翻译：生理活性物质
公开(公告)号：US07026352B1
公开(公告)日：2006-04-11
申请号：US10470806
申请日：2002-02-01
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： A61K31/365 , C07D313/00
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法

2. 发明授权

US07667052B2 Bioactive substance 有权
标题翻译：生物活性物质
公开(公告)号：US07667052B2
公开(公告)日：2010-02-23
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： C07D313/00 , C07D407/06 , A61K31/365
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

3. 发明申请

US20060079572A1 Novel bioactive substance 有权
标题翻译：新型生物活性物质
公开(公告)号：US20060079572A1
公开(公告)日：2006-04-13
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： A61K31/365 , C07D313/00
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

4. 发明授权

US07745198B2 Method of producing macrolide compound 失效
标题翻译：大环内酯类化合物的制备方法
公开(公告)号：US07745198B2
公开(公告)日：2010-06-29
申请号：US10532412
申请日：2003-11-27
申请人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
发明人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
IPC分类号： C12N1/20 , A01N43/02
CPC分类号： C07D407/06 , A61K31/336 , C12P17/162
摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution.
摘要翻译：本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的肌肉和氧的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

5. 发明申请

US20060141589A1 Method of producing macrolide compound 失效
标题翻译：大环内酯类化合物的制备方法
公开(公告)号：US20060141589A1
公开(公告)日：2006-06-29
申请号：US10532412
申请日：2003-11-27
申请人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
发明人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
IPC分类号： C12P17/02 , C12N1/21
CPC分类号： C07D407/06 , A61K31/336 , C12P17/162
摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured mycelia and oxygen, and then 11107D substance which is a target material is collected from the treating solution.
摘要翻译：本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的菌丝体和氧气的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

6. 发明授权

US07816401B2 Process for total synthesis of pladienolide B and pladienolide D 失效
标题翻译：丙二烯内酯B和普拉二烯内酯D的全合成方法
公开(公告)号：US07816401B2
公开(公告)日：2010-10-19
申请号：US11580047
申请日：2006-10-13
申请人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
发明人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
IPC分类号： A61K31/335 , A61K31/16
CPC分类号： C07D493/04 , C07D303/12 , C07D303/14 , C07D313/00 , C07D315/00 , C07D405/12 , C07D407/06 , Y02P20/55
摘要： A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined herein, characterized by including reacting a compound represented by Formula (12): with a compound represented by Formula (13): in the presence of a catalyst.
摘要翻译：一种制备由式（11）表示的化合物的方法：其中P1，P7，P8，P9和R1与本文所定义的相同，其特征在于包括使由式（12）表示的化合物与式（12）表示的化合物 13）：在催化剂存在下。

7. 发明申请

US20080021226A1 Process for total synthesis of pladienolide B and pladienolide D 失效
标题翻译：丙二烯内酯B和普拉二烯内酯D的全合成方法
公开(公告)号：US20080021226A1
公开(公告)日：2008-01-24
申请号：US11580047
申请日：2006-10-13
申请人： Regina Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
发明人： Regina Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
IPC分类号： C07D313/00 , C07D303/02
CPC分类号： C07D493/04 , C07D303/12 , C07D303/14 , C07D313/00 , C07D315/00 , C07D405/12 , C07D407/06 , Y02P20/55
摘要： [Problems to be Solved]To provide an effective process for total synthesis of pladienolide B and pladienolide D having excellent anti-tumor activity and to provide useful intermediates in the above-described process. [Measure for Solving the Problem]A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined below, characterized by including reacting a compound represented by Formula (12): wherein P7 means a hydrogen atom or a protecting group for hydroxy group; R1 means a hydrogen atom or a hydroxy group, with a compound represented by Formula (13): wherein P1 means a hydrogen atom or a protecting group for hydroxy group; P8 means a hydrogen atom, an acetyl group or a protecting group for hydroxy group; P9 means a hydrogen atom or a protecting group for hydroxy group; or P8 and P9 may form together a group represented by a formula: wherein R5 means a phenyl group which may have a substituent, in the presence of a catalyst.
摘要翻译： [待解决的问题]为了提供具有优异的抗肿瘤活性的普拉二烯内酯B和普拉二烯内酯D的全合成的有效方法，并且在上述方法中提供有用的中间体。 [解决问题的措施]制备由式（11）表示的化合物的方法：其中P 1，P 2，P 3，，其中P 9和R 12与下述定义相同，其特征在于包括使由式（12）表示的化合物：其中P 是指氢原子或羟基的保护基; R 1表示氢原子或羟基，与式（13）表示的化合物：其中P 1是氢原子或羟基的保护基; “8”表示氢原子，乙酰基或羟基保护基; “9”表示氢原子或羟基的保护基; 或者P 9和P 9可以一起形成由下式表示的基团：其中R 5表示可以具有取代基的苯基，在催化剂存在下。

8. 发明授权

US07884128B2 Process for total synthesis of pladienolide B and pladienolide D 失效
标题翻译：丙二烯内酯B和普拉二烯内酯D的全合成方法
公开(公告)号：US07884128B2
公开(公告)日：2011-02-08
申请号：US12764336
申请日：2010-04-21
申请人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
发明人： Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
IPC分类号： A61K31/36
CPC分类号： C07D493/04 , C07D303/12 , C07D303/14 , C07D313/00 , C07D315/00 , C07D405/12 , C07D407/06 , Y02P20/55
摘要： Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.
摘要翻译：制备式的化合物的方法：其中P2，P3和R2与下文定义相同，其特征在于包括使由式（7）表示的化合物反应：其中P3表示羟基的保护基; 和Het表示1-苯基-1H-四唑-5-基与式（8）表示的化合物：其中P2表示羟基的保护基; 并且R 2表示在碱的存在下可被取代的苯基。

9. 发明申请

US20100204490A1 PROCESS FOR TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D 失效
标题翻译： PLADIENOLIDE B和PLADENENOL D的合成方法D
公开(公告)号：US20100204490A1
公开(公告)日：2010-08-12
申请号：US12764336
申请日：2010-04-21
申请人： Regina Mikie KANADA , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
发明人： Regina Mikie KANADA , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
IPC分类号： C07D493/04
CPC分类号： C07D493/04 , C07D303/12 , C07D303/14 , C07D313/00 , C07D315/00 , C07D405/12 , C07D407/06 , Y02P20/55
摘要： Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.
摘要翻译：制备式的化合物的方法：其中P2，P3和R2与下文定义相同，其特征在于包括使由式（7）表示的化合物反应：其中P3表示羟基的保护基; 和Het表示1-苯基-1H-四唑-5-基与式（8）表示的化合物：其中P2表示羟基的保护基; 并且R 2表示在碱的存在下可被取代的苯基。

10. 发明授权

US08870292B2 Vehicle seat 有权
标题翻译：车座
公开(公告)号：US08870292B2
公开(公告)日：2014-10-28
申请号：US13285258
申请日：2011-10-31
申请人： Takashi Sakai , Kazuhiro Tawada
发明人： Takashi Sakai , Kazuhiro Tawada
IPC分类号： B60N2/66 , B60N2/64 , B60N2/72 , B60N2/70
CPC分类号： B60N2/72 , B60N2/7017 , B60N2/7094
摘要： Provided is a vehicle seat, including: a frame; a rod of which ends are held by the frame; and a pad of which back side is supported by the rod. The rod has: a the metal core; and a resin member that is injection molded under a state where the core is set in a forming mold and the core is positioned with respect to the forming mold by projections of the forming mold and covers the ends of the core. The resin member is locked on hooks that are formed on the frame, and recesses of the resin member, which are formed by the projections of the forming mold, are disposed in a position that is spaced from the hooks.
摘要翻译：提供一种车座，包括：一框架; 其端部的杆由框架保持; 并且其后侧的垫被杆支撑。杆具有：金属芯; 以及树脂构件，其在芯设置在成形模具中并且芯通过成形模具的突起相对于成形模具定位并覆盖芯的端部的状态下注塑成型。树脂构件被锁定在形成在框架上的钩上，并且由成形模的突起形成的树脂构件的凹部设置在与钩间隔开的位置。

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