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1. 发明授权

US07397166B1 Electroactive polymer-actuated peristaltic pump and medical lead incorporating such a pump 失效
标题翻译：电动聚合物致动的蠕动泵和包含这种泵的医用引线
公开(公告)号：US07397166B1
公开(公告)日：2008-07-08
申请号：US11404268
申请日：2006-04-12
申请人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
IPC分类号： H01L41/08
CPC分类号： F04B43/1223 , A61M5/14228 , A61M2205/0283 , F04B43/095 , F04B43/12 , Y10S310/80
摘要： A peristaltic pump for conveying a fluid comprises a flexible tube having an outer surface and a lumen for carrying the fluid such as a therapeutic agent. The tube has a length defined by opposed ends of the tube, the outer surface of the body carrying a plurality of longitudinally spaced-apart electroactive polymer actuators. The plurality of actuators are adapted to be responsive to electrical signals for energizing the actuators sequentially along the length of the tube to move a lumen pinch-off along the length of the tube to thereby convey the fluid from one end of the tube to the other end by means of a peristaltic pumping action. The peristaltic pump may be incorporated into a medical lead, such as an endocardial pacing lead, carrying at least one electrode.
摘要翻译：用于输送流体的蠕动泵包括具有用于承载诸如治疗剂的流体的外表面和内腔的柔性管。管具有由管的相对端限定的长度，本体的外表面承载多个纵向间隔开的电活性聚合物致动器。多个致动器适于响应于电信号，以沿着管的长度依次致动致动器，以沿着管的长度移动管腔夹紧，从而将流体从管的一端传送到另一端通过蠕动泵送动作结束。蠕动泵可以并入到携带至少一个电极的医疗引线（例如心内膜起搏引线）中。

2. 发明申请

US20120065532A1 Implantable Medical Devices Employing Electroactive Polymers For Sensing Cardiac Motion and/or Causing Cardiac Compression 审中-公开
标题翻译：使用电动聚合物的植入式医疗设备用于感测心脏运动和/或引起心脏压迫
公开(公告)号：US20120065532A1
公开(公告)日：2012-03-15
申请号：US12882095
申请日：2010-09-14
申请人： Kevin L. Morgan , Anne M. Shelchuk , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , John R. Helland
IPC分类号： A61B5/0245 , A61N1/362
CPC分类号： A61B5/1107 , A61B5/0245 , A61B5/6869 , A61B5/688 , A61B5/6882 , A61B5/6883 , A61B2562/0261 , A61B2562/222 , A61F2/2481 , A61N1/36578
摘要： Disclosed herein is a system for monitoring a motion of a cardiac tissue. The system includes a motion sensor configured to operably couple to the cardiac tissue. The motion sensor includes an electroactive polymer and is further configured to result in a deflection in the electroactive polymer when the cardiac tissue undergoes the motion. The deflection in the electroactive polymer generates an electrical event.
摘要翻译：本文公开了一种用于监测心脏组织的运动的系统。该系统包括配置成可操作地耦合到心脏组织的运动传感器。运动传感器包括电活性聚合物，并进一步构造成当心脏组织经历运动时导致电活性聚合物的偏转。电活性聚合物中的偏转产生电事件。

3. 发明授权

US06882887B1 Implantable lead and electrode portion 有权
标题翻译：可植入铅和电极部分
公开(公告)号：US06882887B1
公开(公告)日：2005-04-19
申请号：US10321307
申请日：2002-12-16
申请人： Anne M. Shelchuk , John R. Helland
发明人： Anne M. Shelchuk , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An exemplary electrode portion, capable of placement in a vessel of a patient's body, includes a double helix. Exemplary implantable stimulation devices, lead assemblies and methods are also disclosed.
摘要翻译：能够放置在患者身体的容器中的示例性电极部分包括双螺旋。还公开了示例性的可植入刺激装置，引线组件和方法。

4. 发明授权

US06968237B2 Implantable coronary sinus lead and lead system 失效
标题翻译：植入性冠状动脉窦引导系统
公开(公告)号：US06968237B2
公开(公告)日：2005-11-22
申请号：US10154893
申请日：2002-05-22
申请人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
发明人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.
摘要翻译：公开了一种植入式刺激引线，用于放置在冠状窦区及其相关联的冠状动脉血管，其覆盖在患者心脏的左侧。引线包括至少一个近端连接器; 至少一个组织刺激电极; 耦合在所述至少一个近端连接器和所述至少一个刺激电极之间的至少一个导体; 以及引线体，其包括围绕所述至少一个导体的绝缘材料的外壳，所述引线主体具有例如硅橡胶的相对柔性的远端部分，其长度对应于心脏的冠状窦区域，并且较硬例如聚氨酯的近端部分。包括引导体的远侧和近端部分的伸缩部分的鲁棒的过渡接头将引线体的两个部分相互连接。还提供了一种多功能引线输送系统，其包括设置在引线主体的远端部分内的探针止动器。探针止动器限定了通过导丝而不是通孔的扩大的远端的尺寸的孔。引线包括具有纵向延伸的孔的尖端电极，其尺寸允许引导线通过尖端电极。

5. 发明授权

US07229450B1 Kink resistant introducer with mapping capabilities 失效
标题翻译：具有映射功能的抗扭结导引器
公开(公告)号：US07229450B1
公开(公告)日：2007-06-12
申请号：US10365270
申请日：2003-02-11
申请人： Yougandh Chitre , Kevin L. Morgan , John R. Helland
发明人： Yougandh Chitre , Kevin L. Morgan , John R. Helland
IPC分类号： A61B5/042
CPC分类号： A61B5/0422
摘要： An introducer system for use with a pacemaker lead includes a plastic sheath compatible for insertion within a body, a first end configured for insertion into the body with a second end extending out of the body. A central lumen of the sheath is configured to permit introduction of the lead and includes a flexible, kink-resistant section smooth on its outer surface with a helical pleat defining a helical groove enabling a conductor extending from the mapping probe to the pacing system analyzer to be received in the helical groove of the sheath. A mapping probe at the first end of the sheath is connectable to a pacing system analyzer for seeking a location on the myocardial surface of the heart or an endocardial location at which optimal pacing parameters can be achieved prior to implantation of the lead.
摘要翻译：用于与起搏器引线一起使用的导引器系统包括与插入体内相容的塑料护套，第一端被构造成用延伸出身体的第二端插入身体。护套的中心管被构造成允许引入引线并且在其外表面上包括柔性的抗扭结部分，其中螺旋形褶皱限定了使得能够从映射探针延伸到起搏系统分析器的导体，被容纳在护套的螺旋槽中。在鞘的第一端的映射探针可连接到起搏系统分析器，用于寻找心脏心肌表面上的位置或在植入引线之前可以实现最佳起搏参数的心内膜位置。

6. 发明授权

US07369901B1 Myocardial lead and lead system 有权
标题翻译：心肌铅和铅系统
公开(公告)号：US07369901B1
公开(公告)日：2008-05-06
申请号：US11056666
申请日：2005-02-10
申请人： Kevin L. Morgan , John R. Helland , Sheldon Williams , Yougandh Chitre , Andrew W. McGarvey , Christopher Fleck , Jnyan Patel , Scott Salys , Kerwyn Schimke
发明人： Kevin L. Morgan , John R. Helland , Sheldon Williams , Yougandh Chitre , Andrew W. McGarvey , Christopher Fleck , Jnyan Patel , Scott Salys , Kerwyn Schimke
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/059
摘要： An implantable myocardial stimulation lead comprises a lead body having a distal end and a proximal end, and an electrical connector carried by the proximal end of the lead body. An electrode header carried by the distal end of the lead body has an axis and includes a helical fixation element extending along the axis, the electrode header having a surface configured to receive a driver for rotating the electrode header to screw the helical fixation element into the tissue of the heart. The lead body carries along its length a strain relief member resisting excessive bending of the lead body.
摘要翻译：植入式心肌刺激引线包括具有远端和近端的引线主体和由引线主体的近端承载的电连接器。由引线主体的远端承载的电极头具有轴线并且包括沿着轴线延伸的螺旋固定元件，电极头具有被配置为接收驱动器的表面，该驱动器用于旋转电极头以将螺旋固定元件拧入心脏的组织引线体沿其长度方向承载抵抗引线体的过度弯曲的应变消除部件。

7. 发明授权

US06988007B1 Single pass telescoping cardiac lead for the left heart 失效
标题翻译：单通伸缩心脏线为左心
公开(公告)号：US06988007B1
公开(公告)日：2006-01-17
申请号：US10218353
申请日：2002-08-13
申请人： Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , John R. Helland
发明人： Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： An implantable single-pass cardiac stimulation lead provides for placement of electrodes into electrical contact with two chambers of a patient's heart. The lead includes an inner lead body having at least one electrode at its distal end and an outer lead body having at least one electrode at its distal end. The outer lead body has an internal lumen that slidingly receives the inner lead body. The inner lead body is extendable from the outer lead body at a point proximal to the distal end of the outer lead body. The sliding of the inner lead body relative to the outer lead body enables the inner lead body distal electrode to have a varying distance from the outer lead body distal electrode and enables the inner lead body to extend into the coronary sinus region of the heart to place the inner lead body electrode into electrical contact with the left ventricle.
摘要翻译：可植入的单程心脏刺激引线提供将电极放置在与患者心脏的两个腔室电接触的位置。引线包括在其远端具有至少一个电极的内引线体和在其远端具有至少一个电极的外引线体。外引线体具有滑动地接收内引线体的内腔。内引线体可以在外引线体的远离外引线体的远端的位置处延伸。内引线体相对于外引线体的滑动能够使内引线体远端电极与外引线体远端电极间距离变化，能够使内引线体延伸到心脏的冠状窦区域内部引线体电极与左心室电接触。

8. 发明授权

US06490489B2 Implantable cardiac single pass coronary sinus lead for providing pacing and defibrillation and method of manufacture 有权
标题翻译：可植入心脏单程冠状动脉窦导管用于提供起搏和除颤及其制造方法
公开(公告)号：US06490489B2
公开(公告)日：2002-12-03
申请号：US09771505
申请日：2001-01-26
申请人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
发明人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： A single chronic implantable cardiac lead for use in the coronary sinus region of the heart provides both atrial and ventricular pacing and defibrillation therapy. The lead includes an elongated lead body having a distal end and a proximal end, a first electrode assembly including a ventricular pacing electrode and a ventricular defibrillation at the distal end, a second electrode assembly proximal to the first electrode assembly including at least one atrial pacing electrode and an atrial defibrillation electrode, and a further defibrillation electrode proximal to the second electrode assembly. The electrode assemblies and further defibrillation electrode are spaced apart so that when the lead is implanted within the coronary sinus region of the heart with the first electrode assembly adjacent the left ventricle, the second electrode assembly is adjacent the left atrium and the further defibrillation electrode is within the right atrium and/or the superior vena cava.
摘要翻译：用于心脏冠状静脉窦区域的单一慢性可植入心脏线可提供心房起搏和除颤治疗。引线包括具有远端和近端的细长引线主体，包括心室起搏电极和在远端处的心室除颤的第一电极组件，靠近第一电极组件的第二电极组件，包括至少一个心房起搏电极和心房除颤电极，以及靠近第二电极组件的另外的除颤电极。电极组件和另外的除颤电极间隔开，使得当铅被植入心脏的冠状窦区域内时，第一电极组件邻近左心室，第二电极组件邻近左心房，另外的除颤电极在右心房和/或上腔静脉内。

9. 发明授权

US08538555B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08538555B1
公开(公告)日：2013-09-17
申请号：US12973810
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/00
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

10. 发明授权

US08311648B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08311648B1
公开(公告)日：2012-11-13
申请号：US12973800
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.
摘要翻译：一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

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