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1. 发明授权

US07397166B1 Electroactive polymer-actuated peristaltic pump and medical lead incorporating such a pump 失效
标题翻译：电动聚合物致动的蠕动泵和包含这种泵的医用引线
公开(公告)号：US07397166B1
公开(公告)日：2008-07-08
申请号：US11404268
申请日：2006-04-12
申请人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
IPC分类号： H01L41/08
CPC分类号： F04B43/1223 , A61M5/14228 , A61M2205/0283 , F04B43/095 , F04B43/12 , Y10S310/80
摘要： A peristaltic pump for conveying a fluid comprises a flexible tube having an outer surface and a lumen for carrying the fluid such as a therapeutic agent. The tube has a length defined by opposed ends of the tube, the outer surface of the body carrying a plurality of longitudinally spaced-apart electroactive polymer actuators. The plurality of actuators are adapted to be responsive to electrical signals for energizing the actuators sequentially along the length of the tube to move a lumen pinch-off along the length of the tube to thereby convey the fluid from one end of the tube to the other end by means of a peristaltic pumping action. The peristaltic pump may be incorporated into a medical lead, such as an endocardial pacing lead, carrying at least one electrode.
摘要翻译：用于输送流体的蠕动泵包括具有用于承载诸如治疗剂的流体的外表面和内腔的柔性管。管具有由管的相对端限定的长度，本体的外表面承载多个纵向间隔开的电活性聚合物致动器。多个致动器适于响应于电信号，以沿着管的长度依次致动致动器，以沿着管的长度移动管腔夹紧，从而将流体从管的一端传送到另一端通过蠕动泵送动作结束。蠕动泵可以并入到携带至少一个电极的医疗引线（例如心内膜起搏引线）中。

2. 发明申请

US20120065532A1 Implantable Medical Devices Employing Electroactive Polymers For Sensing Cardiac Motion and/or Causing Cardiac Compression 审中-公开
标题翻译：使用电动聚合物的植入式医疗设备用于感测心脏运动和/或引起心脏压迫
公开(公告)号：US20120065532A1
公开(公告)日：2012-03-15
申请号：US12882095
申请日：2010-09-14
申请人： Kevin L. Morgan , Anne M. Shelchuk , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , John R. Helland
IPC分类号： A61B5/0245 , A61N1/362
CPC分类号： A61B5/1107 , A61B5/0245 , A61B5/6869 , A61B5/688 , A61B5/6882 , A61B5/6883 , A61B2562/0261 , A61B2562/222 , A61F2/2481 , A61N1/36578
摘要： Disclosed herein is a system for monitoring a motion of a cardiac tissue. The system includes a motion sensor configured to operably couple to the cardiac tissue. The motion sensor includes an electroactive polymer and is further configured to result in a deflection in the electroactive polymer when the cardiac tissue undergoes the motion. The deflection in the electroactive polymer generates an electrical event.
摘要翻译：本文公开了一种用于监测心脏组织的运动的系统。该系统包括配置成可操作地耦合到心脏组织的运动传感器。运动传感器包括电活性聚合物，并进一步构造成当心脏组织经历运动时导致电活性聚合物的偏转。电活性聚合物中的偏转产生电事件。

3. 发明授权

US06882887B1 Implantable lead and electrode portion 有权
标题翻译：可植入铅和电极部分
公开(公告)号：US06882887B1
公开(公告)日：2005-04-19
申请号：US10321307
申请日：2002-12-16
申请人： Anne M. Shelchuk , John R. Helland
发明人： Anne M. Shelchuk , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An exemplary electrode portion, capable of placement in a vessel of a patient's body, includes a double helix. Exemplary implantable stimulation devices, lead assemblies and methods are also disclosed.
摘要翻译：能够放置在患者身体的容器中的示例性电极部分包括双螺旋。还公开了示例性的可植入刺激装置，引线组件和方法。

4. 发明申请

US20120209345A1 SYSTEMS AND METHODS FOR REDUCING OCCURRENCES OF ATRIAL ARRHYTHMIAS 有权
标题翻译：降低急性心律失常的系统和方法
公开(公告)号：US20120209345A1
公开(公告)日：2012-08-16
申请号：US13027174
申请日：2011-02-14
申请人： Sergio Shkurovich , Anne M. Shelchuk
发明人： Sergio Shkurovich , Anne M. Shelchuk
IPC分类号： A61N1/365
CPC分类号： A61N1/3624 , A61B5/0031 , A61B5/0215 , A61B5/053 , A61B5/4836 , A61B5/6869 , A61B5/6876 , A61B5/7275 , A61B2562/0247 , A61N1/36564 , A61N1/3682 , A61N1/3684 , G06F19/00
摘要： A method for reducing occurrences of atrial arrhythmias includes obtaining measures indicative of atrial pressure of a patient, and monitoring for a change in the measures indicative of atrial pressure that is indicative of an increased vulnerability to an atrial arrhythmia. In response to detecting the change in the measures indicative of atrial pressure that is indicative of the increased vulnerability to an atrial arrhythmia, pacing therapy that is adapted to reduce atrial pressure and thereby reduce vulnerability to an atrial arrhythmia is selectively delivered. Additionally, or alternatively, pacing therapy is adjusted to reduce atrial pressure and thereby reduce vulnerability to an atrial arrhythmia.
摘要翻译：减少心房心律失常发生的方法包括获得指示患者心房压力的措施，以及监测指示心房压力改变的措施的变化，其指示心房心律失常易受伤害性增加。响应于检测指示心房压力的指标的变化，其指示心房心律失常增加的易感性，选择性地递送适于减少心房压力并因此降低心房心律失常的易失性的起搏治疗。此外，或者，调节起搏治疗以减少心房压力，从而降低心房心律失常的易感性。

5. 发明授权

US08209001B2 Monitoring for mitral valve regurgitation 有权
标题翻译：监测二尖瓣反流
公开(公告)号：US08209001B2
公开(公告)日：2012-06-26
申请号：US12915520
申请日：2010-10-29
申请人： Anne M. Shelchuk , Michael Paris
发明人： Anne M. Shelchuk , Michael Paris
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61B5/029 , A61N1/3627 , A61N1/3702
摘要： Implantable systems, and methods for use therein, for monitoring for mitral valve regurgitation (MR) are provided. An electrogram (EGM) signal and a corresponding pressure signal are obtained, where the EGM signal is representative of electrical functioning of the patient's heart during a plurality of cardiac cycles, and the corresponding pressure signal is representative of pressure within the left atrium the patient's heart during the cardiac cycles. Windows of the pressure signal are defined, based on events detected in the EGM signal, and measurements from the windows are used to monitor for MR.
摘要翻译：提供了可植入系统及其使用方法，用于监测二尖瓣关闭反流（MR）。获得电描记图（EGM）信号和对应的压力信号，其中EGM信号代表在多个心动周期期间患者心脏的电功能，并且相应的压力信号代表左心房内的患者心脏的压力在心脏周期。基于在EGM信号中检测到的事件来定义压力信号的窗口，并且使用来自窗口的测量来监测MR。

6. 发明授权

US07848793B1 Monitoring for mitral valve regurgitation 有权
标题翻译：监测二尖瓣反流
公开(公告)号：US07848793B1
公开(公告)日：2010-12-07
申请号：US11537322
申请日：2006-09-29
申请人： Anne M. Shelchuk , Michael Paris
发明人： Anne M. Shelchuk , Michael Paris
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61B5/029 , A61N1/3627 , A61N1/3702
摘要： Implantable systems, and methods for use therein, for monitoring for mitral valve regurgitation (MR) are provided. An electrogram (EGM) signal and a corresponding pressure signal are obtained, where the EGM signal is representative of electrical functioning of the patient's heart during a plurality of cardiac cycles, and the corresponding pressure signal is representative of pressure within the left atrium the patient's heart during the cardiac cycles. Windows of the pressure signal are defined, based on events detected in the EGM signal, and measurements from the windows are used to monitor for MR.
摘要翻译：提供了可植入系统及其使用方法，用于监测二尖瓣关闭反流（MR）。获得电描记图（EGM）信号和对应的压力信号，其中EGM信号代表在多个心动周期期间患者心脏的电功能，并且相应的压力信号代表左心房内的患者心脏的压力在心脏周期。基于在EGM信号中检测到的事件来定义压力信号的窗口，并且使用来自窗口的测量来监测MR。

7. 发明授权

US07277761B2 Vagal stimulation for improving cardiac function in heart failure or CHF patients 有权
标题翻译：用于改善心力衰竭或CHF患者心脏功能的迷走神经刺激
公开(公告)号：US07277761B2
公开(公告)日：2007-10-02
申请号：US10460013
申请日：2003-06-11
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627
摘要： Exemplary methods for decreasing workload, maintaining or increasing cardiac output and/or achieving a desirable autonomic balance by stimulating one or more parasympathetic nerves. Various exemplary methods include delivering one or more stimulation pulses postinspiration and/or based at least in part on detection of one or more cardiac event. Other methods and/or devices are also disclosed.
摘要翻译：通过刺激一个或多个副交感神经来降低工作负荷，维持或增加心输出量和/或实现期望的自主平衡的示例性方法。各种示例性方法包括至少部分地基于检测到一个或多个心脏事件递送吸入后和/或至少部分地输送一个或多个刺激脉冲。还公开了其它方法和/或装置。

8. 发明授权

US07223237B2 Implantable biosensor and methods for monitoring cardiac health 有权
标题翻译：植入式生物传感器和监测心脏健康的方法
公开(公告)号：US07223237B2
公开(公告)日：2007-05-29
申请号：US10830850
申请日：2004-04-22
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61B5/00
CPC分类号： A61N1/36528 , A61B5/00 , A61B5/0538 , A61B5/0809 , A61B5/145 , A61B5/14546 , A61B8/08 , A61N1/3622 , A61N1/3627
摘要： The ability to continuously monitor concentrations of any of a plurality of blood-borne substances, such as proteins, improves patient monitoring and overall care through early detection of cardiac threats. Ultrasound-based technology used in analytical chemistry to determine amounts of particles suspended in a colloidal composition can be employed in an implantable sensor to monitor levels of many different substances in the blood. A sensor system is implanted in or near a blood vessel in the body and generates an electric or acoustic field directed at that blood vessel. A receiver near the generator detects energy emitted once the assaulting field is turned off. Changes in the relative amounts of the substance(s) being monitored appear as changes in the amount of energy emitted once the assaulting field is removed. The sensor may be implemented in an implantable cardiac therapy device. A non-implantable or transcutaneous sensor may also be used to monitor cardiac health.
摘要翻译：连续监测多种血液中物质如蛋白质的浓度的能力通过早期检测心脏病威胁来改善患者的监测和整体护理。分析化学中用于确定悬浮在胶体组合物中的颗粒量的基于超声的技术可用于可植入传感器中以监测血液中许多不同物质的水平。将传感器系统植入体内的血管内或附近，并产生指向该血管的电场或声场。发生器附近的接收器检测到一旦突击场被关闭，发射的能量就会发出。被监测物质的相对量的变化表现为一旦罢工场被移除就能释放出的能量的变化。传感器可以在可植入心脏治疗装置中实现。非植入式或经皮传感器也可用于监测心脏健康。

9. 发明申请

US20110046492A1 MONITORING FOR MITRAL VALVE REGURGITATION 有权
标题翻译：监测麻药注册
公开(公告)号：US20110046492A1
公开(公告)日：2011-02-24
申请号：US12915520
申请日：2010-10-29
申请人： Anne M. Shelchuk , Michael Paris
发明人： Anne M. Shelchuk , Michael Paris
IPC分类号： A61B5/021 , A61B5/0402
CPC分类号： A61B5/0215 , A61B5/029 , A61N1/3627 , A61N1/3702
摘要： Implantable systems, and methods for use therein, for monitoring for mitral valve regurgitation (MR) are provided. An electrogram (EGM) signal and a corresponding pressure signal are obtained, where the EGM signal is representative of electrical functioning of the patient's heart during a plurality of cardiac cycles, and the corresponding pressure signal is representative of pressure within the left atrium the patient's heart during the cardiac cycles. Windows of the pressure signal are defined, based on events detected in the EGM signal, and measurements from the windows are used to monitor for MR.
摘要翻译：提供了可植入系统及其使用方法，用于监测二尖瓣关闭反流（MR）。获得电描记图（EGM）信号和对应的压力信号，其中EGM信号代表在多个心动周期期间患者心脏的电功能，并且相应的压力信号代表左心房内的患者心脏的压力在心脏周期。基于在EGM信号中检测到的事件来定义压力信号的窗口，并且使用来自窗口的测量来监视MR。

10. 发明授权

US07792585B1 Expedited set-up of multi-electrode lead (MEL) 有权
标题翻译：多电极引线（MEL）的快速设置
公开(公告)号：US07792585B1
公开(公告)日：2010-09-07
申请号：US11750153
申请日：2007-05-17
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N1/371 , A61N1/37247
摘要： Methods and systems are provided for expediting set-up of a multi-electrode lead (MEL). In accordance with specific embodiments, such an MEL includes N groups of electrodes, with each of the N groups including at least M electrodes, where N≧2 and M is ≧2. Electrodes in a same group are within 5 mm of one another. Electrodes in separate groups are at least 10 mm from one another. Specific embodiments relate to methods for identifying cathode-anode electrode configurations that can be used to not exceed a maximum acceptable capture threshold, and that provide a sensed intrinsic R-wave amplitude of at least a minimum acceptable sensing threshold. Such thresholds can be default values, or can be defined by a user (e.g., clinician, physician, nurse, or the like).
摘要翻译：提供了用于加速多电极引线（MEL）的设置的方法和系统。根据具体实施例，这样的MEL包括N组电极，N组中的每一个包括至少M个电极，其中N≥2且M为≥2。同一组中的电极彼此在5mm以内。分离组中的电极彼此至少10毫米。具体实施例涉及用于识别可被用于不超过最大可接受捕获阈值并且提供至少最小可接受感测阈值的感测本征R波振幅的阴极 - 阳极电极配置的方法。这样的阈值可以是默认值，或者可以由用户（例如，临床医师，医师，护士等）来定义。

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