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    • 4. 发明授权
    • Method for preserving reduced coenzyme Q10
    • 保留还原型辅酶Q10的方法
    • US08067217B2
    • 2011-11-29
    • US11315161
    • 2005-12-23
    • Takahiro UedaTadao OnoShiro KitamuraYasuyoshi Ueda
    • Takahiro UedaTadao OnoShiro KitamuraYasuyoshi Ueda
    • C12N9/98
    • A61K9/4816
    • The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
    • 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法,所述还原型辅酶Q10可用作食品,功能营养食品,特定保健食品,营养补充剂,营养物质,动物药物,饮料,饲料,化妆品,药​​物, 补救剂,预防药物等。本发明涉及一种保存还原型辅酶Q10的方法,其包括制备或获得含有还原型辅酶Q10的胶囊,并且将胶囊周围的环境控制在相对湿度不小于0%但不超过 超过60%。 根据该方法,可以稳定地保持还原型辅酶Q10,而不需要巨大的成本和劳动力,或特殊设备。
    • 5. 发明授权
    • Method of stabilizing reduced coenzyme q10
    • 稳定还原型辅酶Q10的方法
    • US08703155B2
    • 2014-04-22
    • US10492122
    • 2002-10-10
    • Takahiro UedaTadao OnoMitsutoshi MoroShiro KitamuraYasuyoshi Ueda
    • Takahiro UedaTadao OnoMitsutoshi MoroShiro KitamuraYasuyoshi Ueda
    • A61K38/43A61K9/00
    • A61K31/122A61K9/4866A61K47/10A61K47/12A61K47/14A61K47/22B01D9/00C07C41/26C07C41/40C07C41/46C07C43/23
    • The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10, in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
    • 本发明提供还原型辅酶Q10的稳定化方法,保存方法等,其作为功能性营养食品,特定健康食品等有用。 此外,本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法,以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下,通过分子氧的氧化被抑制的条件下,可以处理和稳定地保持还原型辅酶Q10,从而得到稳定的组合物。 此外,将还原型辅酶Q10转化为结晶状态,使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化,使作为副产物的氧化型辅酶Q10的形成最小化, 生产高品质的还原型辅酶Q10晶体。 此外,通过使生成的还原型辅酶Q10连续结晶,在使用抗坏血酸或其相关化合物还原氧化型辅酶Q10至还原型辅酶Q10后,在抗坏血酸或其相关化合物的存在下,操作简化并最小化,从而减少了辅酶Q10 生产高品质。
    • 6. 发明申请
    • Solid preparation containing reduced coenzyme Q10 and method for producing the same
    • 含有还原型辅酶Q10的固体制剂及其制备方法
    • US20060147542A1
    • 2006-07-06
    • US11315159
    • 2005-12-23
    • Tadao OnoTakahiro UedaShiro KitamuraYasuyoshi Ueda
    • Tadao OnoTakahiro UedaShiro KitamuraYasuyoshi Ueda
    • A61K38/43A61K9/50A61K9/16
    • A61K9/2054A61K9/286A61K9/2866
    • The present invention has its object to provide a solid preparation containing reduced coenzyme Q10 with high stability by protecting reduced coenzyme Q10 against oxidization to oxidized coenzyme Q10 by molecular oxygen. The present invention provides a solid preparation containing reduced coenzyme Q10 which comprises a solid composition containing reduced coenzyme Q10 coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media. The present invention also provides a method for stabilizing a solid preparation containing reduced coenzyme Q10, wherein a solid composition containing reduced coenzyme Q10 is coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media to thereby stabilize the resulting solid preparation containing reduced coenzyme Q10.
    • 本发明的目的是提供一种含有还原型辅酶Q 10的固体制剂,其具有高度的稳定性,通过将还原型辅酶Q 10保护氧化成氧化型辅酶Q 10, / SUB>。 本发明提供了含有还原型辅酶Q 10固体制剂,其包含含有还原型辅酶Q 10的固体组合物,所述还原型辅酶包被至少一种选自油溶性涂层 介质和水溶性涂料介质。 本发明还提供了一种用于稳定含有还原型辅酶Q 10 N的固体制剂的方法,其中含有还原型辅酶Q 10的固体组合物涂覆有至少一种选择的涂层介质 从油溶性涂层介质和水溶性涂层介质中,由此使得到的含有还原型辅酶Q 10的固体制剂稳定。
    • 7. 发明申请
    • Method for preserving reduced coenzyme Q10
    • 保留还原型辅酶Q10的方法
    • US20060153911A1
    • 2006-07-13
    • US11315161
    • 2005-12-23
    • Takahiro UedaTadao OnoShiro KitamuraYasuyoshi Ueda
    • Takahiro UedaTadao OnoShiro KitamuraYasuyoshi Ueda
    • A61K9/48C07C29/94C12N9/00C07C37/88
    • A61K9/4816
    • The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
    • 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q 10的胶囊的方法,所述还原型辅酶Q 10可用作食品,功能营养食品,特定保健食品,营养补充剂,营养物质,动物药物, 饮料,饲料,化妆品,药​​物,补救剂,预防药物等。本发明涉及一种保存还原型辅酶Q 10的方法,其包括制备或获得含有还原型辅酶Q 10的胶囊 并且将胶囊周围的环境控制在不小于0%但不大于60%的相对湿度。 根据该方法,可以稳定地保持还原型辅酶Q 10,而不需要巨大的成本和劳动力或专用设备。
    • 8. 发明申请
    • Method of stabilizing reduced coenzyme q10
    • 稳定还原型辅酶Q10的方法
    • US20050008630A1
    • 2005-01-13
    • US10492122
    • 2002-10-10
    • Takahiro UedaTadao OnoMitsutoshi MoroShiro KitamuraYasuyoshi Ueda
    • Takahiro UedaTadao OnoMitsutoshi MoroShiro KitamuraYasuyoshi Ueda
    • A61K31/122A61K47/12A61K47/22A61K47/34A61P3/02A61K38/43C07C43/20
    • A61K31/122A61K9/4866A61K47/10A61K47/12A61K47/14A61K47/22B01D9/00C07C41/26C07C41/40C07C41/46C07C43/23
    • The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
    • 本发明提供还原型辅酶Q10的稳定化方法,保存方法等,其作为功能性营养食品,特定健康食品等有用。 此外,本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法,以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下,通过分子氧的氧化被抑制的条件下,可以处理和稳定地保持还原型辅酶Q10,从而得到稳定的组合物。 此外,将还原型辅酶Q10转化为结晶状态,使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化,使作为副产物的氧化型辅酶Q10的形成最小化, 生产高品质的还原型辅酶Q10晶体。 此外,通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后,在抗坏血酸或其相关化合物的存在下,依次结晶生成的还原型辅酶Q10,操作简化,最小化,从而减少了辅酶Q10 生产高品质。