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1. 发明授权

US08562975B2 Method for stabilizing reduced coenzyme Q10 and composition therefor 有权
标题翻译：稳定还原型辅酶Q10及其组成的方法
公开(公告)号：US08562975B2
公开(公告)日：2013-10-22
申请号：US10501698
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Takahiro Ueda , Tadao Ono , Shiro Kitamura , Kenji Fujii , Kazunori Hosoe
发明人： Yasuyoshi Ueda , Takahiro Ueda , Tadao Ono , Shiro Kitamura , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K38/43
CPC分类号： A61K8/347 , A23D9/007 , A23K20/105 , A23L33/10 , A23V2002/00 , A61K8/345 , A61K8/355 , A61K8/375 , A61K8/39 , A61K8/92 , A61K8/922 , A61K8/925 , A61K31/122 , A61K47/10 , A61K47/14 , A61K2800/52 , A61Q19/00 , C07C41/46 , C07C43/23 , A23V2250/314 , A23V2250/1842 , A23V2250/18 , A23V2250/192 , A23V2250/1944
摘要： The present invention relates to a method for stabilizing reduced coenzyme Q10, which is useful as an ingredient in good foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc., and to a composition therefor. The composition comprises reduced coenzyme Q10, a fat and oil (excluding olive oil) and/or a polyol, and doesn't substantially inhibit the stabilization of reduced coenzyme Q10. Additionally, the composition is a reduced coenzyme Q10-containing composition which comprises reduced coenzyme Q10, a polyglycerol fatty acid ester, and a fat and oil and/or a polyol.
摘要翻译：本发明涉及一种用于稳定还原型辅酶Q10的方法，其可用作良好食品中的成分，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物，补救剂，预防剂药物等，以及其组合物。组合物包含还原型辅酶Q10，脂肪和油（不包括橄榄油）和/或多元醇，并且基本上不抑制还原型辅酶Q10的稳定化。此外，该组合物是还原型辅酶Q 10组合物，其包含还原型辅酶Q10，聚甘油脂肪酸酯和脂肪和油和/或多元醇。

2. 发明申请

US20070196349A1 Whitening composition containing reduced coenzyme Q 审中-公开
标题翻译：含有还原型辅酶Q的美白组合物
公开(公告)号：US20070196349A1
公开(公告)日：2007-08-23
申请号：US11653974
申请日：2007-01-17
申请人： Shiro Kitamura , Takahiro Ueda , Yasuyoshi Ueda , Hideyuki Kishida , Kenji Fujii , Kazunori Hosoe
发明人： Shiro Kitamura , Takahiro Ueda , Yasuyoshi Ueda , Hideyuki Kishida , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K8/18
CPC分类号： A61Q19/02 , A23L33/10 , A23V2002/00 , A61K8/355 , A23V2200/318 , A23V2250/314
摘要： The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.
摘要翻译：本发明提供一种护肤效果优异的化妆品或食品组合物，特别是由于紫外线照射或老化而使皮肤变白而变白的效果，可以安全地用于许多哺乳动物。本发明提供一种美白组合物，其包含由式（1）表示的还原型辅酶Q作为有效成分：其中n表示1〜12的整数。本发明还提供了还含有由式（2）表示的氧化型辅酶Q ）作为有效成分：其中n表示1至12的整数。本发明还提供了一种使哺乳动物的皮肤变白的方法，所述方法包括给哺乳动物施用该组合物。

3. 发明申请

US20050226858A1 Compositions containing reduced coenzyme Q10 and carotenoid 审中-公开
标题翻译：含有还原型辅酶Q10和类胡萝卜素的组合物
公开(公告)号：US20050226858A1
公开(公告)日：2005-10-13
申请号：US11101437
申请日：2005-04-08
申请人： Shiro Kitamura , Takahiro Ueda , Kenji Fujii , Yasuyoshi Ueda
发明人： Shiro Kitamura , Takahiro Ueda , Kenji Fujii , Yasuyoshi Ueda
IPC分类号： A61K31/015 , A61K31/07 , A61K38/43
CPC分类号： A61K31/015 , A61K31/07 , A61K2300/00
摘要： A composition having an antioxidative activity, especially, having a sufficient activity for removing active oxygen and/or free radicals is provided. The composition includes both reduced coenzyme Q10 and a carotenoid, and the activity for removing active oxygen and/or free radicals is synergistically enhanced. A method for removing active oxygen and/or free radicals by using the composition containing both reduced coenzyme Q10 and a carotenoid is also provided.
摘要翻译：提供具有抗氧化活性的组合物，特别是具有足够的活性氧和/或自由基活性的活性。该组合物包括还原型辅酶Q 10和类胡萝卜素，并且促进除去活性氧和/或自由基的活性协同增强。还提供了通过使用含有还原型辅酶Q 10和类胡萝卜素的组合物除去活性氧和/或自由基的方法。

4. 发明申请

US20090246185A1 CARDIAC DYSFUNCTION-AMELIORATING AGENT OR CARDIAC FUNCTION-MAINTAINING AGENT 审中-公开
标题翻译：心脏功能改善剂或心脏功能维持剂
公开(公告)号：US20090246185A1
公开(公告)日：2009-10-01
申请号：US12282448
申请日：2007-03-09
申请人： Hideyuki Kishida , Kenji Fujii , Hiroshi Kubo , Kazunori Hosoe
发明人： Hideyuki Kishida , Kenji Fujii , Hiroshi Kubo , Kazunori Hosoe
IPC分类号： A61K31/122 , C07C43/23 , A61P9/00
CPC分类号： A61K31/122 , A23K20/111 , A23K20/174 , A23L33/10 , A23L33/15 , A23V2002/00 , A61K45/06 , A23V2200/326 , A23V2250/314
摘要： An object of the present invention is to provide a highly safe oral composition superior in a cardiac dysfunction-ameliorating or cardiac function-maintaining action. The present inventors have conducted intensive studies in an attempt to solve the aforementioned problems and found that use of, particularly, reduced coenzyme Q10 from among highly safe coenzyme Q affords a composition useful for amelioration of cardiac dysfunction and maintenance of cardiac function. Accordingly, the present invention provides a cardiac dysfunction-ameliorating agent or cardiac function-maintaining agent containing reduced coenzyme Q as an active ingredient, and a pharmaceutical product, a food, an animal drug, a feed and the like, which contain the agent.
摘要翻译：本发明的目的是提供在心脏功能障碍改善或心脏功能保持作用方面优异的高度安全的口服组合物。本发明人为了解决上述问题进行了深入研究，发现特别是来自高度安全性的辅酶Q中的还原型辅酶Q10的使用提供了用于改善心脏功能障碍和维持心脏功能的组合物。因此，本发明提供含有还原型辅酶Q作为活性成分的心脏功能障碍改善剂或心脏功能维持剂，以及含有该药剂的药物，食品，动物药物，饲料等。

5. 发明授权

US06939897B2 Method and composition for inhibiting arteriosclerosis 有权
标题翻译：抑制动脉硬化的方法和组合物
公开(公告)号：US06939897B2
公开(公告)日：2005-09-06
申请号：US10892164
申请日：2004-07-16
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/05 , A61K45/00 , A61K45/06 , A61P9/10 , A61P43/00 , A61K31/12 , A61K31/35 , A61K31/405
CPC分类号： A61K45/06 , A61K31/09 , A61K31/22 , A61K2300/00
摘要： The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.
摘要翻译：本发明的目的是提供一种方法和组合物，其通过使用抗高脂血症或降胆固醇药物抑制血浆LDL的抗氧化活性或甚至增加，从而更有效地回收确保增强的抗动脉硬化功效。一种抑制动脉硬化的方法，其包括使用降胆固醇剂和由下式（1）表示的还原型辅酶Q 10的组合，以及抑制动脉硬化的组合物，其含有胆固醇 - 降低剂和所述还原型辅酶Q 10。

6. 发明申请

US20050070481A1 Stabilized compositions of aqueous reduced coenzyme q solution 有权
标题翻译：水性还原型辅酶Q溶液的稳定组合物
公开(公告)号：US20050070481A1
公开(公告)日：2005-03-31
申请号：US10492167
申请日：2002-10-10
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K9/08 , A61K9/127 , A61K31/05 , A61K31/085 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/46 , A61P3/02 , A61P9/00 , A61P43/00 , C07C43/23 , A61K38/05 , A61K31/075 , A61K31/198 , A61K31/375
CPC分类号： A61K47/18 , A61K9/127 , A61K31/085 , A61K47/183 , A61K47/22 , C07C43/23
摘要： The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
摘要翻译：本发明提供一种还原型辅酶Q溶液，其能够通过使用疏水性并易受氧化并因此不稳定的还原型辅酶Q而更加稳定地保持抗氧化。含有本发明得到的还原型辅酶Q的水溶液是含有还原型辅酶Q和抗氧化剂如维生素C和/或螯合剂如乙二胺四乙酸的溶液。

7. 发明授权

US06362169B1 Antibacterial compositions with synergistic effect, drugs and remedies for digestive diseases containing the same, process for the production thereof and preparations associated therewith 失效
标题翻译：具有协同效应的抗菌组合物，含有其的消化疾病的药物和补救剂，其生产方法和与其相关的制剂
公开(公告)号：US06362169B1
公开(公告)日：2002-03-26
申请号：US09622712
申请日：2000-08-22
申请人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K3170
CPC分类号： A61K45/00 , A61K31/395 , A61K31/415 , A61K31/44 , A61K31/60 , A61K33/245 , A61K2300/00
摘要： Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.
摘要翻译：抗菌组合物，其包含（1）由式（I）表示的利福霉素衍生物或其生理学上可接受的盐，和（2）质子泵抑制剂（a）或铋制剂（b），其中组分（1）和（2）用于产生对幽门螺杆菌的协同效应，含有抗菌组合物的消化器官疾病的药物和补救剂，其制备方法和与抗菌组合物相关的药物制剂。与常规治疗相比，组合物可以以较小的剂量和较低的施用频率施用于由幽门螺杆菌感染引起的消化系统疾病的患者。

8. 发明授权

US08946303B2 Fatigue reducing agent 有权
标题翻译：减疲劳剂
公开(公告)号：US08946303B2
公开(公告)日：2015-02-03
申请号：US10541020
申请日：2004-01-19
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/122 , A61K38/43 , A61K38/44 , A61K31/09
CPC分类号： A61K31/09 , A61K31/122
摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.
摘要翻译：为了保持生活在老龄化社会门槛的中老年人的身体健康和健康，本发明提供了一种对预防和减轻疲劳高度有效的疲劳减轻剂，其中药剂由物质组成这是非常安全的，以便长期管理是可能的。发现含有还原型辅酶Q的组合物可有效预防和减少疲劳，包括肌肉疲劳。由于本发明的组合物的疲劳降低效果不仅在年轻大鼠中被观察到，而且在老年大鼠中也更加显着，本发明可以提供非常有用的疲劳减轻剂，特别是对于中老年人以及年轻人。

9. 发明申请

US20080254016A1 Composition For Increasing Anti-Oxidation Activity In Blood 审中-公开
标题翻译：用于增加血液中抗氧化活性的组合物
公开(公告)号：US20080254016A1
公开(公告)日：2008-10-16
申请号：US11909966
申请日：2006-03-28
申请人： Hiroshi Kubo , Kenji Fujii , Kazunori Hosoe
发明人： Hiroshi Kubo , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K31/122 , A61P7/00
CPC分类号： A61K31/09 , A61K31/122
摘要： The present invention provides a composition capable of maintaining antioxidative activity in blood high by keeping the reduced coenzyme Q10 ratio in blood high after taking coenzyme Q10 even in aged mammals.The present invention relates to a composition which comprises reduced coenzyme Q10 as an active component and enhances the antioxidative activity in blood of aged mammals.
摘要翻译：本发明提供了即使在老化的哺乳动物中，在服用辅酶Q 10之后，通过将血液中的还原型辅酶Q 10比例保持在较低水平，能够维持血液中的抗氧化活性。本发明涉及一种组合物，其包含还原型辅酶Q 10作为活性组分并增强老年哺乳动物血液中的抗氧化活性。

10. 发明授权

US07364751B2 Stabilized compositions of aqueous reduced coenzyme Q solution 有权
标题翻译：水性还原型辅酶Q溶液的稳定组合物
公开(公告)号：US07364751B2
公开(公告)日：2008-04-29
申请号：US10492167
申请日：2002-10-10
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K9/127 , A61K31/19 , A61K31/13 , A61K31/05 , A01N37/00 , A01N33/08 , A01N31/08
CPC分类号： A61K47/18 , A61K9/127 , A61K31/085 , A61K47/183 , A61K47/22 , C07C43/23
摘要： The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable.The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
摘要翻译：本发明提供一种还原型辅酶Q溶液，其能够通过使用疏水性并易受氧化并因此不稳定的还原型辅酶Q而更加稳定地保持抗氧化。含有本发明得到的还原型辅酶Q的水溶液是含有还原型辅酶Q和抗氧化剂如维生素C和/或螯合剂如乙二胺四乙酸的溶液。

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