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    • 1. 发明授权
    • Locking cap for replaceable needle assembly
    • 可更换针组件的锁盖
    • US06364859B1
    • 2002-04-02
    • US09586246
    • 2000-05-31
    • Kenny J. St. RomainPaul B. RobbinsDavid J. Wright
    • Kenny J. St. RomainPaul B. RobbinsDavid J. Wright
    • A61M5315
    • B01L3/0275
    • A syringe with replaceable needle assembly (10), having a syringe barrel (18) with a proximal end (14), a distal end (16), and an outer surface (87). The syringe barrel (18) surrounds an internal bore (20). A plunger assembly (60) is inserted into the syringe barrel internal bore (20). A needle assembly (80) has a sealing portion (72), which is configured to be removably insertable into the internal bore (20). The sealing portion (72) forms a fluid-tight seal with the internal bore (20). The needle assembly (80) further includes a releasable locking mechanism (79), which includes a collar (76) having a locking flange (86). Also disclosed is a replaceable needle assembly (80), which releasably locks onto the outer surface (87) of the proximal end (14) of a syringe barrel (18). The replaceable needle assembly (80) includes a collar (76), having a locking flange (86), which engages the outer surface (87) of the syringe barrel (18), and releasably locks the replaceable needle assembly (80) onto the syringe barrel (18).
    • 一种具有可更换针组件(10)的注射器,其具有具有近端(14),远端(16)和外表面(87)的注射器筒(18)。 注射器筒(18)围绕内孔(20)。 柱塞组件(60)插入到注射器筒内孔(20)中。 针组件(80)具有密封部分(72),其被构造成可移除地插入内孔(20)中。 密封部分(72)与内孔(20)形成流体密封。 针组件(80)还包括可释放的锁定机构(79),其包括具有锁定凸缘(86)的凸缘(76)。 还公开了一种可更换的针组件(80),其可释放地锁定在注射器筒(18)的近端(14)的外表面(87)上。 可替换针组件(80)包括具有与注射器筒(18)的外表面(87)接合的锁定凸缘(86)的套环(76),并且可释放地将可更换针组件(80) 注射器筒(18)。
    • 2. 发明授权
    • Multi-well array with adjustable plenum
    • 具有可调节气室的多孔阵列
    • US06436350B1
    • 2002-08-20
    • US09499068
    • 2000-02-04
    • James E. StanchfieldDavid J. WrightChris N. BaileyPaul B. Robbins
    • James E. StanchfieldDavid J. WrightChris N. BaileyPaul B. Robbins
    • B01L100
    • B01L3/5025B01J19/0046B01J2219/00283B01J2219/00308B01J2219/0031B01J2219/00335B01J2219/00351B01J2219/00585C40B60/14
    • An apparatus for multiple simultaneous synthesis (110), having a number of vials (28), each vial (28) having an upper end (31), a lower end (30), and a barrel (29), the upper end (31) opening into a mouth (32). It also includes a lower frame assembly (180) having a number of holes (101, 103, 105) for receiving the vials (28), and an upper frame assembly (180), which includes inner side-walls (195) and a ceiling portion (190). A gas-tight seal (197) surrounds a plenum (85), the plenum (85) being formed between the ceiling portion (190) of the upper frame assembly (180) and the lower frame assembly (181). The plenum (85) is adjustable in volume by the positioning of the upper frame assembly (180) in variable relation to the lower frame assembly (181), while maintaining the gas-tight seal (197). The volume of the plenum (85) is adjustable to a minimum whereby the mouths (32) of the vials (28) are sealed by the ceiling (190) of the gas-tight seal (197), which is optionally an upper gasket (90). Also disclosed is a plenum enclosure (182) for multiple simultaneous synthesis used in conjunction with vials (28), which includes the upper frame assembly (180) and lower frame assembly (181) and the gastight seal (197), as well as a gasket vial holder (185) to be used in the plenum enclosure (182).
    • 一种用于多个同时合成(110)的装置,具有多个小瓶(28),每个小瓶(28)具有上端(31),下端(30)和筒(29),所述上端 31)开口(32)。 它还包括具有用于接纳小瓶(28)的多个孔(101,103,105)的下框架组件(180),以及包括内侧壁(195)和 顶棚部分(190)。 气密封(197)围绕增压室(85),所述增压室(85)形成在上框架组件(180)的顶部(190)和下框架组件(181)之间。 在保持气密密封(197)的同时,通过上框架组件(180)与下框架组件(181)的可变关系的定位,气室(85)可以体积调节。 增压室(85)的容积可调节至最小,由此小瓶(28)的口部(32)由气密密封件(197)的顶部(190)密封,气密密封件(197)的顶部可选地是上垫圈 90)。 还公开了一种用于与包括上框架组件(180)和下框架组件(181)和气密密封件(197))的小瓶(28)结合使用的多个同时合成的增压室(182),以及一 密封小瓶架(185),用于增压室外壳(182)。
    • 3. 发明授权
    • Syringe array with adjustable needle spacing
    • 注射器阵列,可调节针距
    • US6146594A
    • 2000-11-14
    • US344750
    • 1999-06-25
    • David De GraaffKevin HeyesDavid J. WrightPaul B. Robbins
    • David De GraaffKevin HeyesDavid J. WrightPaul B. Robbins
    • B01L3/02B01L9/00G01N35/10G01N1/16
    • B01L9/54B01L3/0217G01N35/1067G01N2035/1069
    • A syringe array (10) for holding a plurality of syringes (12), each syringe having a barrel (14), a plunger (18) and a needle (16), the syringe array (10) including a distal assembly (50) which holds the plungers (18) of the plurality of syringes (12) and by which all of the plurality of plungers (18) are urged to move in unison, a pivot assembly (52) wherein a portion of each the barrels (14) of the plurality of syringes (12) is pivotally attached to a pivot (92, 94) and a proximal assembly (48) wherein each needle (16) of the plurality of syringes (12) is positioned with a controlled center-to-center spacing (100, 102) from each other. An adjusting portion (62, 64, 70) of the syringe array (10) is adjustable to controllably change the needle center-to-center spacing from a first spacing (100) to at least a second spacing (102) as the barrel portions (14) are allowed to rotate about the pivots (92, 94).
    • 一种用于保持多个注射器(12)的注射器阵列(10),每个注射器具有枪管(14),柱塞(18)和针(16),所述注射器阵列(10)包括远端组件(50) 其保持多个注射器(12)的柱塞(18)并且所有多个柱塞(18)被促使其一致地移动;枢轴组件(52),其中每个筒体(14)的一部分 所述多个注射器(12)的枢轴(92,94)和近侧组件(48)枢转地连接到所述多个注射器(12)中,其中所述多个注射器(12)中的每个针(16)被定位成受控的中心到中心 间距(100,102)彼此。 注射器阵列(10)的调节部分(62,60,70)是可调节的,以将针头的中心到中心间隔从第一间隔(100)可控地改变为至少第二间隔(102),因为镜筒部分 (14)允许围绕枢轴(92,94)旋转。
    • 4. 发明授权
    • Multi-well apparatus with independently detachable upper and lower covers
    • 具有独立可拆卸的上盖和下盖的多孔设备
    • US06479020B1
    • 2002-11-12
    • US09498942
    • 2000-02-04
    • James E. StanchfieldPaul B. RobbinsChris N. BaileyDavid J. Wright
    • James E. StanchfieldPaul B. RobbinsChris N. BaileyDavid J. Wright
    • B01L300
    • B01L3/50255B01J19/0046B01J2219/00286B01J2219/00313B01J2219/00319B01J2219/00335B01J2219/00416B01J2219/00423B01J2219/00585B01J2219/00596B01L3/5025C40B60/14
    • An improved multi-well synthesis and filtration apparatus (10) includes a deep-well synthesis block (12) having a plurality of flowthrough wells (24) optionally fitted with filter disks (48) each of the wells (24) being integrally formed in the synthesis block (12), such that any material placed in the wells (24) is in immediate contact with the material of the synthesis block (12), an upper cover (14), a lower cover (16), and a pair of first and second sheet gaskets (18, 20). The first and second sheet gaskets (18, 20) are interposed between the upper and lower covers (14, 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). The upper and lower covers (14, 16) are independently releasable, and, with the gaskets (18, 20) form a gas tight seal, so that material is retained in the wells (24) when the lower cover (16) is removed, but the upper seal maintained. Apertures (70) in the upper cover (14) provide that the first sheet gasket (18) may be punctured for introduction of materials and/or maintenance of an inert atmosphere. An alternative synthesis block (412) having half the number of wells (424) but configured to be able to use a collection plate (123) of the same array as the first embodiment is also described.
    • 改进的多孔合成和过滤装置(10)包括深井合成块(12),其具有可选地装配有过滤盘(48)的多个通孔(24),每个孔(24)整体形成在 合成块(12),使得放置在孔(24)中的任何材料与合成块(12)的材料,上盖(14),下盖(16)和一对 的第一和第二片状垫片(18,20)。 第一和第二片状垫片(18,20)介于上盖和下盖(14,16)之间,以密封孔(24)的入口部分(38)和出口(40)。 上盖和下盖独立地可拆卸,并且垫圈(18,20)形成气密密封,使得当下盖(16)被移除时材料保留在井(24)中 ,但保持上密封。 上盖(14)中的孔(70)提供了第一片垫片(18)可被穿孔以引入材料和/或维持惰性气氛。具有一半孔数的备选合成块(412) 424)但是被配置为能够使用与第一实施例相同的阵列的收集板(123)。
    • 8. 发明授权
    • System and method for creating pattern-recognizing computer structures
from example text
    • 从示例文本创建模式识别计算机结构的系统和方法
    • US5864789A
    • 1999-01-26
    • US669642
    • 1996-06-24
    • Henry A. LiebermanBonnie A. NardiDavid J. Wright
    • Henry A. LiebermanBonnie A. NardiDavid J. Wright
    • G06F17/24G06F17/27G06F17/28G06F17/30
    • G06F17/27G06F17/24G06F17/2775Y10S707/99936
    • A system comprises a structure editor, a structure library, an extractor and a user interface, which are stored in computer memory and create structures for recognizing patterns in computer text. The structure editor via the user interface enables a user to input a text string called a model pattern, and uses previously-created structures such as lexical category structures for parsing the model pattern into default definition items. Each default definition item includes attributes specifying the patterns recognizable by the definition item and relationships with other definition items. The structure editor enables and facilitates user modification of the default definition items by generating attribute choices for user selection and allowing a user to generate a new structure if none of the choices is adequate. The resulting definition items form a new definition of a new structure, which is stored in the structure library. The extractor locates a pattern in computer text by satisfying the conditions of a definition of a new structure.
    • 系统包括存储在计算机存储器中的结构编辑器,结构库,提取器和用户界面,并且创建用于识别计算机文本中的模式的结构。 通过用户界面的结构编辑器使用户能够输入一个称为模型模式的文本字符串,并使用先前创建的结构,例如词法类别结构,将模型模式解析为默认定义项。 每个默认定义项包括指定定义项可识别的模式和与其他定义项的关系的属性。 结构编辑器通过为用户选择生成属性选择,并且允许用户在没有选择足够的情况下生成新的结构来启用和促进用户对默认定义项的修改。 结果定义项形成新结构的新定义,存储在结构库中。 提取器通过满足新结构的定义的条件来定位计算机文本中的模式。