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1. 发明申请

US20120294947A1 Oral Preparation Having Improved Quality 审中-公开
标题翻译：提高质量的口腔准备
公开(公告)号：US20120294947A1
公开(公告)日：2012-11-22
申请号：US13519193
申请日：2010-12-28
申请人： Kennichiro Kuninobu , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
发明人： Kennichiro Kuninobu , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
IPC分类号： A61K9/14 , A61K31/437 , A61J3/10 , A61K31/4422 , A61P25/28 , A61K31/445 , A61K31/519
CPC分类号： A61K31/445 , A61K9/2077 , A61K9/2846 , A61K31/437 , A61K31/4422 , A61K31/519
摘要： Provided is an oral preparation that contains a medicinal component having an unpleasant taste and that has better qualities, for example, generation of an analogue can be reduced, better than oral preparations that are produced by conventional techniques and that contain a medicinal component having an unpleasant taste. This objective is achieved by adding a coating agent on the medicinal component and a disintegrator that has a carboxymethyl group.
摘要翻译：本发明提供含有具有令人不快的味道并且具有更好质量的药物成分的口服制剂，例如可以减少类似物的产生，优于常规技术制备的含有不愉快的药物成分的口服制剂味道。该目的通过在药物成分上添加涂布剂和具有羧甲基的崩解剂来实现。

2. 发明申请

US20080166769A1 High-Copy-Number, High-Expression Vector Having Methionine Aminopeptidase Gene 审中-公开
标题翻译：具有甲硫氨酸氨基肽酶基因的高拷贝数，高表达载体
公开(公告)号：US20080166769A1
公开(公告)日：2008-07-10
申请号：US11921329
申请日：2006-06-01
申请人： Tadayuki Uno , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
发明人： Tadayuki Uno , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
IPC分类号： C12N15/63 , C12N1/21
CPC分类号： C12N15/70 , C07K14/805 , C12N15/69 , C12P21/02
摘要： Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a cloning site of the target gene, (B) a sequence element necessary for the high copying of the target gene, (C) a sequence element necessary for the expression of the target gene and a methionine aminopeptidase gene; a method of producing the vector; a transformant having the vector introduced therein; and a process for producing a protein using the transformant.
摘要翻译：提供了能够以大量和简单的方式产生具有与天然形式的蛋白质相同水平的令人满意的功能和活性的蛋白质的高拷贝数高表达载体。还提供了载体，其包括：（A）靶基因的靶基因或克隆位点，（B）靶基因的高拷贝所必需的序列元件，（C）表达所需靶序列所需的序列元件靶基因和甲硫氨酸氨基肽酶基因; 生成载体的方法; 其中引入载体的转化体; 以及使用该转化体生产蛋白质的方法。

3. 发明申请

US20080311195A1 BASIS PARTICLES, METHOD FOR MANUFACTURING THE SAME, AND ORALLY-DISINTEGRATING TABLET 审中-公开
标题翻译：基础颗粒，其制造方法和异位消毒片
公开(公告)号：US20080311195A1
公开(公告)日：2008-12-18
申请号：US12099688
申请日：2008-04-08
申请人： Shiho SAKURAGI , Naomi Ohmichi , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
发明人： Shiho SAKURAGI , Naomi Ohmichi , Yohei Hoashi , Naohisa Katayama , Toshiya Kai
IPC分类号： A61K9/20 , A61K9/14
CPC分类号： A61K9/0056 , A61K9/2081
摘要： A basis particle comprises a basic or acidic basis particle coated by a water-insoluble coating film, wherein the water-insoluble coating film contains a substance that is acidic with respect to the basic basis or basic with respect to the acidic basis. According to the basis particles (i.e., a main ingredient or an active drug)of the present invention, it is possible to temporarily adjust pH occurring in the immediate proximity of the basis particles by using a coating film, elution of the basis particles is suppressed and superior elution is exhibited without dependence on bodily pH. It is also possible to mask tastes such as the bitterness of the basis and it is possible to ingest drugs without sensing any bitterness.
摘要翻译：基础颗粒包含由水不溶性涂膜包衣的碱性或酸性基质颗粒，其中所述水不溶性涂膜含有相对于碱性基础为酸性的物质或相对于酸性基质为碱性的物质。根据本发明的基础颗粒（即主要成分或活性药物），可以通过使用涂膜临时调节在基础颗粒附近发生的pH，抑制基础颗粒的洗脱并且在不依赖于身体pH的情况下表现出优异的洗脱。也可以掩盖基础的苦味，并且可以摄取药物而不感觉到任何苦味。

4. 发明申请

US20140093567A1 Method for Producing Orodispersible Tablets 审中-公开
标题翻译：生产分散性片剂的方法
公开(公告)号：US20140093567A1
公开(公告)日：2014-04-03
申请号：US14125240
申请日：2012-06-08
申请人： Yohei Hoashi , Naohisa Katayama , Shunsuke Daidouji
发明人： Yohei Hoashi , Naohisa Katayama , Shunsuke Daidouji
IPC分类号： A61K9/28 , A61K9/20
CPC分类号： A61K9/2893 , A61K9/0056 , A61K9/2004 , A61K9/2018 , A61K9/2081 , A61K9/5026 , A61K31/00 , A61K31/196 , A61K31/4178
摘要： A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.
摘要翻译：提供了一种容易地生产可分散片剂的方法，其确保了消化道中主剂的洗脱行为并掩盖了口腔中的不愉快味道。本发明提供一种生产可分散片剂的方法，其包括将添加剂与主剂混合以形成主剂颗粒作为造粒方法，用涂布剂涂覆主剂颗粒以形成涂布颗粒作为涂布方法，并将涂布的颗粒形成片剂作为压片方法，其中在造粒方法中使用的添加剂含有pH调节剂，并且在涂布方法中使用的涂布剂含有溶于pH5以上的pH依赖性聚合物。

5. 发明授权

US10195154B2 Method for producing orodispersible tablets 有权
公开(公告)号：US10195154B2
公开(公告)日：2019-02-05
申请号：US14125240
申请日：2012-06-08
申请人： Yohei Hoashi , Naohisa Katayama , Shunsuke Daidouji
发明人： Yohei Hoashi , Naohisa Katayama , Shunsuke Daidouji
IPC分类号： A61K9/28 , A61K9/00 , A61K9/20 , A61K9/50 , A61K31/00 , A61K31/196 , A61K31/4178
摘要： A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.

6. 发明授权

US07417118B2 Pharmaceutical composition containing artificial oxygen carrier 有权
标题翻译：含有人造氧载体的药物组合物
公开(公告)号：US07417118B2
公开(公告)日：2008-08-26
申请号：US10819352
申请日：2004-04-07
申请人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
发明人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
IPC分类号： C07K1/00
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/127 , A61K9/1271 , A61K38/42 , A61K47/6949 , B82Y5/00
摘要： A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
摘要翻译：一种含有人造氧载体的药物组合物，其具有高的氧气携带效率; 并具有所需的胶体渗透压，适当的晶体渗透压，pH和电解质平衡。通过将至少一种选自由能够提供胶体渗透压的化合物，电解质，糖类，氨基酸，抗氧化剂，pH调节剂和等渗剂组成的组中选择的物质适当添加至包括其中血红蛋白包封在脂质体中的脂质体包封的血红蛋白的制剂或包含卟啉 - 铁络合物和白蛋白的缀合物的制剂。

7. 发明授权

US08426451B2 Oral solid preparation and method of manufacturing the same 有权
标题翻译：口服固体制剂及其制造方法
公开(公告)号：US08426451B2
公开(公告)日：2013-04-23
申请号：US12149039
申请日：2008-04-25
申请人： Junichi Yokoe , Keisuke Nakajo , Naohisa Katayama , Toshiya Kai
发明人： Junichi Yokoe , Keisuke Nakajo , Naohisa Katayama , Toshiya Kai
IPC分类号： A61K31/44 , A61K31/4422
CPC分类号： A61K9/2013 , A61K9/0056 , A61K9/2095 , A61K47/20
摘要： An oral solid preparation including a base compound and a powdery or granular additive colored with a colorant and a method of manufacturing an oral solid preparation including the steps of: coloring an additive with a colorant, mixing the resultant additive with a base compound, and tableting the mixture.
摘要翻译：一种口服固体制剂，包括碱性化合物和用着色剂着色的粉状或颗粒状添加剂和制备口腔固体制剂的方法，包括以下步骤：用着色剂着色添加剂，将所得添加剂与碱性化合物混合，混合物。

8. 发明申请

US20100145298A1 OXYGEN-CARRYING BLOOD SUBSTITUTE PREPARATIONS 审中-公开
标题翻译：氧气替代血液制剂
公开(公告)号：US20100145298A1
公开(公告)日：2010-06-10
申请号：US12704700
申请日：2010-02-12
申请人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
发明人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
IPC分类号： A61J1/10
CPC分类号： A61K47/183 , A61K9/1271 , A61K9/1272 , A61K38/41 , A61K38/42 , A61K47/12 , A61K47/24
摘要： An oxygen-carrying blood substitute preparation stable upon storage is provided. The preparation comprises an oxygen-carrying substance capable of reversibly binding and releasing oxygen in vivo and an amount of a physiologically tolerable reducing agent effective for preventing at least partially irreversible oxidation of said oxygen-carrying substance. Preferably the oxygen-carrying substance is a hemoglobin-based substance in the form of a liposome encapsulating hemoglobin.
摘要翻译：提供了一种在储存时稳定的载氧血液替代物制剂。该制剂包含能够在体内可逆地结合和释放氧的携氧物质以及有效预防所述携氧物质的至少部分不可逆氧化的生理上可耐受的还原剂的量。优选地，携氧物质是包封血红蛋白的脂质体形式的基于血红蛋白的物质。

9. 发明申请

US20070190161A1 Solid formulation for dialysis and process for producing the same 审中-公开
标题翻译：用于透析的固体制剂及其制备方法
公开(公告)号：US20070190161A1
公开(公告)日：2007-08-16
申请号：US10588733
申请日：2005-02-02
申请人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
发明人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
IPC分类号： A61K9/14 , A61K31/215 , A61K31/7004
CPC分类号： A61K31/19 , A61K31/7004 , A61K33/14 , A61K2300/00
摘要： The present invention relates to a solid formulation for dialysis and a method for producing the same. The formulation is a mixture of: first particles having a coating layer containing magnesium chloride and sodium acetate on surfaces of sodium chloride particles; and second particles having a coating layer containing calcium chloride and sodium acetate on the surfaces of sodium chloride particles, at least one of the coating layers of the first and second particles further including potassium chloride. In the formulation of the present invention, aggregation or consolidation between particles due to moisture absorption thereof can be suppressed. Besides, the content of each component in the formulation becomes uniform, so as to quickly dissolve in water when used. In addition, the formulation of the present invention is an extremely stable solid formulation in which decomposition of glucose hardly occurs even when a formulation containing electrolyte components and acetic acid further contains glucose.
摘要翻译：本发明涉及透析用固体制剂及其制造方法。该制剂是以下混合物：在氯化钠颗粒表面上具有含有氯化镁和乙酸钠的涂层的第一颗粒; 和在氯化钠颗粒表面上具有含有氯化钙和乙酸钠的涂层的第二颗粒，第一和第二颗粒的至少一个涂层还包括氯化钾。在本发明的制剂中，可以抑制由于其吸湿而导致的颗粒之间的凝集或固结。此外，配方中的各成分的含量均匀，在使用时迅速溶解于水中。此外，本发明的制剂是极其稳定的固体制剂，即使含有电解质成分和乙酸的制剂还含有葡萄糖，几乎不发生葡萄糖分解。

10. 发明申请

US20050085410A1 Artificial oxygen carrier and production method thereof 失效
标题翻译：人造氧载体及其制备方法
公开(公告)号：US20050085410A1
公开(公告)日：2005-04-21
申请号：US10927675
申请日：2004-08-27
申请人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
发明人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
IPC分类号： C07D487/22 , C07K14/76 , A61K38/40 , C07K14/765
CPC分类号： C07D487/22 , C07K14/76
摘要： The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
摘要翻译：本发明提供一种生产白蛋白和具有卟啉结构的脱氧形式金属络合物的复合物的方法，其包括在基本上不含一氧化碳和氧的气体气氛下混合白蛋白和具有卟啉结构的金属络合物作为方法在不使用一氧化碳的情况下，在脱氧（氮气，其他惰性气体）气氛下制造含有白蛋白和具有卟啉结构的金属络合物的人造氧载体。

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