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1. 发明申请

US20070190161A1 Solid formulation for dialysis and process for producing the same 审中-公开
标题翻译：用于透析的固体制剂及其制备方法
公开(公告)号：US20070190161A1
公开(公告)日：2007-08-16
申请号：US10588733
申请日：2005-02-02
申请人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
发明人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
IPC分类号： A61K9/14 , A61K31/215 , A61K31/7004
CPC分类号： A61K31/19 , A61K31/7004 , A61K33/14 , A61K2300/00
摘要： The present invention relates to a solid formulation for dialysis and a method for producing the same. The formulation is a mixture of: first particles having a coating layer containing magnesium chloride and sodium acetate on surfaces of sodium chloride particles; and second particles having a coating layer containing calcium chloride and sodium acetate on the surfaces of sodium chloride particles, at least one of the coating layers of the first and second particles further including potassium chloride. In the formulation of the present invention, aggregation or consolidation between particles due to moisture absorption thereof can be suppressed. Besides, the content of each component in the formulation becomes uniform, so as to quickly dissolve in water when used. In addition, the formulation of the present invention is an extremely stable solid formulation in which decomposition of glucose hardly occurs even when a formulation containing electrolyte components and acetic acid further contains glucose.
摘要翻译：本发明涉及透析用固体制剂及其制造方法。该制剂是以下混合物：在氯化钠颗粒表面上具有含有氯化镁和乙酸钠的涂层的第一颗粒; 和在氯化钠颗粒表面上具有含有氯化钙和乙酸钠的涂层的第二颗粒，第一和第二颗粒的至少一个涂层还包括氯化钾。在本发明的制剂中，可以抑制由于其吸湿而导致的颗粒之间的凝集或固结。此外，配方中的各成分的含量均匀，在使用时迅速溶解于水中。此外，本发明的制剂是极其稳定的固体制剂，即使含有电解质成分和乙酸的制剂还含有葡萄糖，几乎不发生葡萄糖分解。

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