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1. 发明申请

US20050085410A1 Artificial oxygen carrier and production method thereof 失效
标题翻译：人造氧载体及其制备方法
公开(公告)号：US20050085410A1
公开(公告)日：2005-04-21
申请号：US10927675
申请日：2004-08-27
申请人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
发明人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
IPC分类号： C07D487/22 , C07K14/76 , A61K38/40 , C07K14/765
CPC分类号： C07D487/22 , C07K14/76
摘要： The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
摘要翻译：本发明提供一种生产白蛋白和具有卟啉结构的脱氧形式金属络合物的复合物的方法，其包括在基本上不含一氧化碳和氧的气体气氛下混合白蛋白和具有卟啉结构的金属络合物作为方法在不使用一氧化碳的情况下，在脱氧（氮气，其他惰性气体）气氛下制造含有白蛋白和具有卟啉结构的金属络合物的人造氧载体。

2. 发明授权

US07285379B2 Artificial oxygen carrier and production method thereof 失效
标题翻译：人造氧载体及其制备方法
公开(公告)号：US07285379B2
公开(公告)日：2007-10-23
申请号：US10927675
申请日：2004-08-27
申请人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
发明人： Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
IPC分类号： A01N1/02 , C12P21/04 , C07K14/00
CPC分类号： C07D487/22 , C07K14/76
摘要： The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
摘要翻译：本发明提供一种生产白蛋白和具有卟啉结构的脱氧形式金属络合物的复合物的方法，其包括在基本上不含一氧化碳和氧的气体气氛下混合白蛋白和具有卟啉结构的金属络合物作为方法在不使用一氧化碳的情况下，在脱氧（氮气，其他惰性气体）气氛下制造含有白蛋白和具有卟啉结构的金属络合物的人造氧载体。

3. 发明授权

US07417118B2 Pharmaceutical composition containing artificial oxygen carrier 有权
标题翻译：含有人造氧载体的药物组合物
公开(公告)号：US07417118B2
公开(公告)日：2008-08-26
申请号：US10819352
申请日：2004-04-07
申请人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
发明人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
IPC分类号： C07K1/00
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/127 , A61K9/1271 , A61K38/42 , A61K47/6949 , B82Y5/00
摘要： A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
摘要翻译：一种含有人造氧载体的药物组合物，其具有高的氧气携带效率; 并具有所需的胶体渗透压，适当的晶体渗透压，pH和电解质平衡。通过将至少一种选自由能够提供胶体渗透压的化合物，电解质，糖类，氨基酸，抗氧化剂，pH调节剂和等渗剂组成的组中选择的物质适当添加至包括其中血红蛋白包封在脂质体中的脂质体包封的血红蛋白的制剂或包含卟啉 - 铁络合物和白蛋白的缀合物的制剂。

4. 发明申请

US20070190161A1 Solid formulation for dialysis and process for producing the same 审中-公开
标题翻译：用于透析的固体制剂及其制备方法
公开(公告)号：US20070190161A1
公开(公告)日：2007-08-16
申请号：US10588733
申请日：2005-02-02
申请人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
发明人： Toshiya Kai , Naohisa Katayama , Jun-Ichi Yokoe , Makoto Sato
IPC分类号： A61K9/14 , A61K31/215 , A61K31/7004
CPC分类号： A61K31/19 , A61K31/7004 , A61K33/14 , A61K2300/00
摘要： The present invention relates to a solid formulation for dialysis and a method for producing the same. The formulation is a mixture of: first particles having a coating layer containing magnesium chloride and sodium acetate on surfaces of sodium chloride particles; and second particles having a coating layer containing calcium chloride and sodium acetate on the surfaces of sodium chloride particles, at least one of the coating layers of the first and second particles further including potassium chloride. In the formulation of the present invention, aggregation or consolidation between particles due to moisture absorption thereof can be suppressed. Besides, the content of each component in the formulation becomes uniform, so as to quickly dissolve in water when used. In addition, the formulation of the present invention is an extremely stable solid formulation in which decomposition of glucose hardly occurs even when a formulation containing electrolyte components and acetic acid further contains glucose.
摘要翻译：本发明涉及透析用固体制剂及其制造方法。该制剂是以下混合物：在氯化钠颗粒表面上具有含有氯化镁和乙酸钠的涂层的第一颗粒; 和在氯化钠颗粒表面上具有含有氯化钙和乙酸钠的涂层的第二颗粒，第一和第二颗粒的至少一个涂层还包括氯化钾。在本发明的制剂中，可以抑制由于其吸湿而导致的颗粒之间的凝集或固结。此外，配方中的各成分的含量均匀，在使用时迅速溶解于水中。此外，本发明的制剂是极其稳定的固体制剂，即使含有电解质成分和乙酸的制剂还含有葡萄糖，几乎不发生葡萄糖分解。

5. 发明申请

US20070231395A1 Solid Pharmaceutical Preparation for Dialysis 审中-公开
标题翻译：固体制剂透析
公开(公告)号：US20070231395A1
公开(公告)日：2007-10-04
申请号：US10594613
申请日：2005-03-30
申请人： Toshiya Kai , Naohisa Katayama , Jun-ichi Yokoe , Makoto Sato
发明人： Toshiya Kai , Naohisa Katayama , Jun-ichi Yokoe , Makoto Sato
IPC分类号： A61K9/16 , A61K33/06 , A61K33/10 , A61P7/08 , A61K33/14
CPC分类号： A61K9/1611 , A61K9/0095 , A61K9/1682 , A61K31/191 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K45/06 , A61M1/1654 , A61M1/287 , A61K2300/00
摘要： A solid pharmaceutical preparation for dialysis which does not contain any acetic acid and a production process thereof. The solid pharmaceutical preparation for dialysis contains two pharmaceutical preparations: a solid pharmaceutical preparation (A) composed of particles having an average particle size of about 100 μm to 1,500 μm and containing one or more electrolytes selected from sodium chloride, calcium chloride, magnesium chloride, and potassium chloride, and an organic acid other than acetic acid and/or a salt of the organic acid; and a solid pharmaceutical preparation (B) containing sodium bicarbonate.
摘要翻译：不含任何乙酸的透析用固体药物制剂及其制造方法。用于透析的固体药物制剂包含两种药物制剂：由平均粒径为约100〜1,500μm的粒子构成的固体药物制剂（A），含有一种或多种选自氯化钠，氯化钙，氯化镁，和氯化钾，以及除乙酸以外的有机酸和/或有机酸的盐; 和含有碳酸氢钠的固体药物制剂（B）。

6. 发明申请

US20050119223A1 Injectable solution containing a shark-derived chondroitin sulfate iron colloid 审中-公开
标题翻译：含有鲨鱼衍生的硫酸软骨素铁胶体的注射液
公开(公告)号：US20050119223A1
公开(公告)日：2005-06-02
申请号：US11034259
申请日：2005-01-13
申请人： Seiji Nishida , Naohisa Katayama , Takashi Katsumata , Makoto Sato
发明人： Seiji Nishida , Naohisa Katayama , Takashi Katsumata , Makoto Sato
IPC分类号： A61K33/26 , A61K35/60 , A61K45/06 , A61K47/48 , A61P7/06 , A61K31/737
CPC分类号： A61K35/60 , A61K33/26 , A61K45/06 , A61K47/61 , A61K47/6905 , A61K2300/00
摘要： An injectable solution comprising a shark-derived chondroitin sulfate iron colloid, and a method for manufacturing an injectable solution comprising the step of adding an aqueous ferric salt solution and an aqueous alkali metal hydroxide solution to a shark-derived chondroitin sulfate solution, such that the resulting mixture has a pH value adjusted to any pH value within the range of from about 5.5 to about 7.5.
摘要翻译：包含鲨鱼衍生的硫酸软骨素铁胶体的可注射溶液以及用于制备注射溶液的方法，包括将水溶液和碱金属氢氧化物水溶液加入鲨鱼衍生的硫酸软骨素溶液中，所得混合物的pH值调节至约5.5至约7.5范围内的任何pH值。

7. 发明授权

US06923987B2 Solid preparation for dialysis and process for producing the same 失效
标题翻译：透析固体制剂及其制备方法
公开(公告)号：US06923987B2
公开(公告)日：2005-08-02
申请号：US09963570
申请日：2001-09-27
申请人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Makoto Sato
发明人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Makoto Sato
IPC分类号： A61M1/14 , A61K9/50 , A61K33/14 , A61M1/16 , A61K9/14 , A01N59/08 , A61K9/00 , A61K9/16
CPC分类号： A61M1/1654 , A61K9/5084 , A61K33/14 , A61K33/00 , A61K31/70 , A61K31/19 , A61K2300/00
摘要： A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar component is decomposed or colored, and which can maintain stability and is also excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride and a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that is covered with a coating layer comprising the same sugar or a different sugar, and an acid.
摘要翻译：一种用于制备用于透析的双重制备型碳酸氢钠固体制剂用于透析的固体制剂，其中不必担心糖组分分解或着色，并且其可以保持稳定性并且内容物均匀性优异，并且制备方法相同。用于透析的固体制剂是由包含氯化钠的核心颗粒和包含一种或多种电解质的涂层组成的第一组合物的混合物，由包含糖的核心颗粒组成的第二组合物，所述糖颗粒被包含相同糖的涂层或不同的糖和酸。

8. 发明授权

US06407070B1 Solid pharmaceutical composition for dialysate containing sodium bicarbonate and a process for producing the same 失效
标题翻译：含有碳酸氢钠的透析液的固体药物组合物及其制备方法
公开(公告)号：US06407070B1
公开(公告)日：2002-06-18
申请号：US09655450
申请日：2000-09-05
申请人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Hiroaki Kato , Makoto Sato
发明人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Hiroaki Kato , Makoto Sato
IPC分类号： A61K3300
CPC分类号： A61K33/00 , A61K9/167 , A61K9/5084 , A61K31/19 , A61K31/7004 , A61K33/06 , A61K33/14 , A61M1/1654 , A61K2300/00
摘要： A one-pack solid pharmaceutical composition for dialysate containing sodium bicarbonate which can prevent the reactions between sodium bicarbonate and acetic acid and between sodium bicarbonate and electrolytes, and is excellent in long term storage stability is provided. The solid pharmaceutical composition for dialysate containing sodium bicarbonate is a mixture of an agent A containing sodium chloride, calcium chloride, magnesium chloride, potassium chloride, sodium acetate and acetic acid and an agent B containing sodium bicarbonate coated with sodium acetate.
摘要翻译：提供含有碳酸氢钠的透析液的单组分固体药物组合物，其可以防止碳酸氢钠和乙酸之间以及碳酸氢钠和电解质之间的反应，并且具有优异的长期保存稳定性。含有碳酸氢钠的透析液的固体药物组合物是含有氯化钠，氯化钙，氯化镁，氯化钾，乙酸钠和乙酸的试剂A和含有用乙酸钠包被的碳酸氢钠的试剂B的混合物。

9. 发明申请

US20050222024A1 Stabilized albumin preparations 有权
标题翻译：稳定的白蛋白制剂
公开(公告)号：US20050222024A1
公开(公告)日：2005-10-06
申请号：US10505783
申请日：2003-02-28
申请人： Masaki Otagiri , Toshiya Kai , Makoto Sato
发明人： Masaki Otagiri , Toshiya Kai , Makoto Sato
IPC分类号： A61K38/38 , A61K47/12 , A61K47/18 , A61P1/16 , A61P7/00 , A61P7/10 , A61P13/12 , C07K14/765
CPC分类号： A61K38/38 , A61K9/0019 , A61K47/12 , A61K47/183
摘要： This invention provides albumin preparations with safety and without any risk of side effects, which are free from viruses or contaminating proteins and can be stably stored over a long time while showing neither changes in appearance nor decrease in content. There are provided a stabilized albumin preparation produced by uniformly mixing a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof with an aqueous albumin solution (e.g., a buffer such as phosphate buffer which can be administered as pharmaceutical preparations, injection water, or a physiological saline) and dissolving them therein, and then processing the mixture solution into a formulation suitable for parenteral administration such as an intravenous fluid preparation or an injectable solution, and a stabilization method for an albumin preparation.
摘要翻译：本发明提供具有安全性且没有任何副作用的白蛋白制剂，其不含病毒或污染蛋白质，并且可长期稳定地储存，同时既不显示外观变化，也不显示内容物的减少。提供了通过将中链脂肪酸或其盐和含硫氨基酸或其衍生物与白蛋白水溶液（例如，可以施用的磷酸盐缓冲液的缓冲液）均匀混合而制备的稳定的白蛋白制剂作为药物制剂，注射用水或生理盐水）并将其溶解在其中，然后将该混合溶液加工成适用于肠胃外给药的制剂如静脉内液体制剂或注射溶液，以及白蛋白制备的稳定化方法。

10. 发明授权

US06464977B2 Solid preparation for dialysis and process for producing the same 失效
标题翻译：透析固体制剂及其制备方法
公开(公告)号：US06464977B2
公开(公告)日：2002-10-15
申请号：US09963550
申请日：2001-09-27
申请人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Makoto Sato
发明人： Toshiya Kai , Kazuyuki Yamamoto , Kazutaka Fujiki , Makoto Sato
IPC分类号： A61K39395
CPC分类号： A61K9/209
摘要： A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.
摘要翻译：一种用于制备用于透析的双重制备型碳酸氢钠固体制剂用于透析的固体制剂，其中不必担心糖分解或着色，并且其可以保持稳定性并且还具有优异的含量均匀性及其制备方法。透析固体制剂是由包含氯化钠的核心颗粒组成的第一组合物，涂覆有包含一种或多种电解质的涂层的第二组合物，由包含糖的核心颗粒组成的第二组合物，该第二组合物被覆盖有包含一种或多种电解质和酸。

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