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1. 发明申请

US20150306183A1 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE 审中-公开
标题翻译：作为血液替代品使用五种协调的神经营养因子及其使用
公开(公告)号：US20150306183A1
公开(公告)日：2015-10-29
申请号：US14795115
申请日：2015-07-09
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , Wake Forest University
发明人： Mark T. Gladwin , Daniel B. Kim-Shapiro , Mauro Tiso
IPC分类号： A61K38/41 , A61K45/06 , A61K9/00
CPC分类号： A61K38/41 , A61K9/0019 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/42 , A61K45/06 , Y02A50/387
摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.
摘要翻译：这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。五配位神经球蛋白也能够结合和释放氧气。基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或血浆）或全血。

2. 发明授权

US09114109B2 Five-coordinate neuroglobin and use thereof as a blood substitute 有权
标题翻译：五配位神经球蛋白及其作为血液代用品
公开(公告)号：US09114109B2
公开(公告)日：2015-08-25
申请号：US12817085
申请日：2010-06-16
申请人： Mark T. Gladwin , Daniel B. Kim-Shapiro , Mauro Tiso
发明人： Mark T. Gladwin , Daniel B. Kim-Shapiro , Mauro Tiso
IPC分类号： A61K35/16 , A61K35/18 , A61K35/42 , A61K35/14 , A61K38/42
CPC分类号： A61K38/41 , A61K9/0019 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/42 , A61K45/06 , Y02A50/387
摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.
摘要翻译：这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。五配位神经球蛋白也能够结合和释放氧气。基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或血浆）或全血。

3. 发明授权

US09572816B2 Method of treatment of disease 有权
标题翻译：疾病治疗方法
公开(公告)号：US09572816B2
公开(公告)日：2017-02-21
申请号：US14438413
申请日：2013-10-24
申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
发明人： Zeev Gross , Adi Haber , Itzchak Angel
IPC分类号： A61K31/555 , A61K31/409 , A61K38/41 , C07D487/22
CPC分类号： A61K31/555 , A61K31/409 , A61K38/41 , C07D487/22
摘要： An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.
摘要翻译：本发明的一个实施方案提供了有效量的角role的过渡金属络合物，其旋光异构体或其药学上可接受的盐在治疗患有眼睛和/或肾脏的受试者的眼睛和/或肾脏疾病中的用途糖尿病。本发明的一个实施方案进一步提供了用于降低患有糖尿病的受试者的血清葡萄糖和血清甘油三酯水平的糠醛，其旋光异构体或其药学上可接受的盐的过渡金属络合物的用途。

4. 发明申请

US20150273024A1 BIOMARKERS FOR H-NOX DELIVERY OF OXYGEN 审中-公开
标题翻译：氧气输送的生物标志物
公开(公告)号：US20150273024A1
公开(公告)日：2015-10-01
申请号：US14530569
申请日：2014-10-31
申请人： OMNIOX, INC.
发明人： STEPHEN P. L. CARY , ANA KRTOLICA , NATACHA LE MOAN , LAURA SERWER , JENNIFER A. GETZ
IPC分类号： A61K38/41 , A61N5/10 , G01N33/574
CPC分类号： A61K38/41 , A61N5/10 , A61N2005/1098 , G01N33/53 , G01N33/57407 , G01N2800/52 , Y02A50/478
摘要： The invention provides methods to monitor tumor oxygenation by H-NOX proteins. H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. For example, the invention provides methods to monitor brain tumor oxygenation by H-NOX proteins for enhanced treatment of brain cancers.
摘要翻译：本发明提供了通过H-NOX蛋白监测肿瘤氧合作用的方法。 H-NOX蛋白质外渗到肿瘤组织中并优先积累以持续传递氧气。例如，本发明提供了通过H-NOX蛋白监测脑肿瘤氧合作用以增强脑癌的治疗方法。

5. 发明授权

US08680182B2 Methods for promoting the revascularization and reenervation of CNS lesions 失效
标题翻译：促进CNS病变血运重建和再神经的方法
公开(公告)号：US08680182B2
公开(公告)日：2014-03-25
申请号：US13447041
申请日：2012-04-13
申请人： Xing Jin , Xuejun Wen , Vibhor Krishna , Ning Zhang
发明人： Xing Jin , Xuejun Wen , Vibhor Krishna , Ning Zhang
IPC分类号： A01N25/08 , A61F2/44 , A61L27/52 , A61L27/54 , A61L27/58 , A61L15/32
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/185 , A61K38/41 , A61K45/06 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/412 , A61L2430/38 , B82Y5/00 , A61K2300/00 , C08L89/06 , C08L5/08
摘要： The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering to the spinal cord injury site a vehicle comprising a neurotrophic factor and/or anti-inflammatory agent. Also provided are methods of treating a spinal cord injury by topically administering or delivering a hydrogel to the injury site.
摘要翻译：本发明提供了使用原位可交联水凝胶促进中枢神经系统损伤的血运重建和/或再神经化的方法。本发明还提供了通过向脊髓损伤部位局部递送包含神经营养因子和/或抗炎剂的载体来治疗脊髓损伤的方法。还提供了通过向受伤部位局部施用或递送水凝胶来治疗脊髓损伤的方法。

6. 发明授权

US06365619B1 Treatment of arteriosclerosis 失效
标题翻译：治疗动脉硬化
公开(公告)号：US06365619B1
公开(公告)日：2002-04-02
申请号：US09358526
申请日：1999-07-22
申请人： Victor Chengwei Shi
发明人： Victor Chengwei Shi
IPC分类号： A61K31405
CPC分类号： A61K45/06 , A61K31/17 , A61K31/403 , A61K38/41 , A61K2300/00
摘要： A method is disclosed of treating transplant-associated arteriosclerosis in a mammal which comprises administering to a mammal, preferably man, in need of such treatment an effective amount of a VLA-4 antagonist of formula I and a VCAM-1 inhibitor of formula II.
摘要翻译：公开了一种在哺乳动物中治疗移植相关动脉硬化的方法，其包括向需要这种治疗的哺乳动物，优选男性施用有效量的式I的VLA-4拮抗剂和式II的VCAM-1抑制剂。

7. 发明申请

US20150290214A1 METHOD OF TREATMENT OF DISEASE 有权
标题翻译：治疗疾病的方法
公开(公告)号：US20150290214A1
公开(公告)日：2015-10-15
申请号：US14438413
申请日：2013-10-24
申请人： Zeev GROSS , Adi HABER , Itzchak ANGEL , TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
发明人： Zeev Gross , Adi Haber , Itzchak Angel
IPC分类号： A61K31/555
CPC分类号： A61K31/555 , A61K31/409 , A61K38/41 , C07D487/22
摘要： An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.
摘要翻译：本发明的一个实施方案提供了有效量的角role的过渡金属络合物，其旋光异构体或其药学上可接受的盐在治疗患有眼睛和/或肾脏的受试者的眼睛和/或肾脏疾病中的用途糖尿病。本发明的一个实施方案进一步提供了用于降低患有糖尿病的受试者的血清葡萄糖和血清甘油三酯水平的糠醛，其旋光异构体或其药学上可接受的盐的过渡金属络合物的用途。

8. 发明授权

US08252281B2 Methods for the treatment of sepsis and sepsis-associated cardiac dysfunction 有权
标题翻译：治疗败血症和败血症相关心脏功能障碍的方法
公开(公告)号：US08252281B2
公开(公告)日：2012-08-28
申请号：US11816230
申请日：2006-02-14
申请人： Richard J. Levy , Clifford S. Deutschman
发明人： Richard J. Levy , Clifford S. Deutschman
IPC分类号： A61K38/43 , C12P21/06 , C07K1/00
CPC分类号： A61K38/41
摘要： Methods for the treatment of sepsis related cardiac dysfunction are disclosed.
摘要翻译：公开了治疗败血症相关心脏功能障碍的方法。

9. 发明申请

US20100323029A1 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE 有权
标题翻译：作为血液替代品使用五种协调的神经营养因子及其使用
公开(公告)号：US20100323029A1
公开(公告)日：2010-12-23
申请号：US12817085
申请日：2010-06-16
申请人： Mark T. Gladwin , Daniel B. Kim-Shapiro , Mauro Tiso
发明人： Mark T. Gladwin , Daniel B. Kim-Shapiro , Mauro Tiso
IPC分类号： A61K38/41 , A61K35/14 , A61K35/16 , A61K35/18 , A61P7/06 , A61P7/08 , A61P7/00 , A61P9/10 , A61P17/02 , A61P9/12
CPC分类号： A61K38/41 , A61K9/0019 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/42 , A61K45/06 , Y02A50/387
摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.
摘要翻译：这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。五配位神经球蛋白也能够结合和释放氧气。基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或血浆）或全血。

10. 发明申请

US20050208151A1 Treatment of rheumatoid arthritis with FLIP antagonists 审中-公开
标题翻译：用FLIP拮抗剂治疗类风湿关节炎
公开(公告)号：US20050208151A1
公开(公告)日：2005-09-22
申请号：US10980145
申请日：2004-11-01
申请人： Vincent Hurez , Saroja Ramanujan , Lisl Shoda , Leif Wennerberg , Seth Michelson , Nadine Defranoux
发明人： Vincent Hurez , Saroja Ramanujan , Lisl Shoda , Leif Wennerberg , Seth Michelson , Nadine Defranoux
IPC分类号： A61K31/16 , A61K31/19 , A61K31/277 , A61K31/407 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K33/24 , A61K38/16 , A61K38/17 , A61K38/21 , A61K38/41 , A61K45/00 , A61K48/00 , C12Q1/00 , G01N33/50 , G01N33/564
CPC分类号： G01N33/564 , A61K31/52 , A61K38/162 , A61K38/1709 , A61K38/215 , A61K38/41 , G01N2800/102
摘要： The invention encompasses novel methods of treating rheumatoid arthritis and its symptoms and novel methods of identifying and screening for drugs useful in the treatment of rheumatoid arthritis and its clinical symptoms. Targeted manipulation of a computer model of a human rheumatic joint provided the surprising result that decreasing the activity of FLIP, an inhibitor of apoptosis, by at least 25% has a significant impact on the pathophysiology of rheumatoid arthritis. Inhibition of the activity of FLIP by at least 25% is predicted to alleviate the symptoms of rheumatoid arthritis.
摘要翻译：本发明包括治疗类风湿性关节炎及其症状的新方法及其鉴定和筛选用于治疗类风湿性关节炎及其临床症状的药物的新方法。人类风湿关节的计算机模型的目标操纵提供令人惊奇的结果，即将凋亡抑制剂FLIP的活性降低至少25％，对类风湿性关节炎的病理生理学具有显着影响。 FLIP活性抑制至少25％被预测为减轻类风湿性关节炎的症状。

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