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1. 发明授权

US06518556B2 Large dynamic range light detection 失效
公开(公告)号：US06518556B2
公开(公告)日：2003-02-11
申请号：US10068419
申请日：2002-02-04
申请人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
发明人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
IPC分类号： H01J4014
CPC分类号： G01J1/44 , G01N2021/6463 , H01J43/30
摘要： System for large dynamic range light detection. In one aspect, the system includes a hybrid counting/integrating system for processing a signal from a photomultiplier tube. In another aspect, large dynamic range is achieved in a cascaded detector system utilizing at least one asymmetric beam splitter for delivering a larger fraction of incident light to one photomultiplier tube and for delivering a smaller fraction of the incident light to another photomultiplier tube.

2. 发明授权

US06355921B1 Large dynamic range light detection 失效
标题翻译：大动态范围光检测
公开(公告)号：US06355921B1
公开(公告)日：2002-03-12
申请号：US09313102
申请日：1999-05-17
申请人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
发明人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
IPC分类号： H01J4014
CPC分类号： G01J1/44 , G01N2021/6463 , H01J43/30
摘要： System for large dynamic range light detection. In one aspect, the system includes a hybrid counting/integrating system for processing a signal from a photomultiplier tube. In another aspect, large dynamic range is achieved in a cascaded detector system utilizing at least one asymmetric beam splitter for delivering a larger fraction of incident light to one photomultiplier tube and for delivering a smaller fraction of the incident light to another photomultiplier tube.
摘要翻译：大动态范围光检测系统。一方面，该系统包括用于处理来自光电倍增管的信号的混合计数/积分系统。在另一方面，在级联检测器系统中实现了大的动态范围，该系统利用至少一个非对称分束器将较大部分的入射光传送到一个光电倍增管，并将较小部分的入射光传送到另一个光电倍增管。

3. 发明授权

US09182325B2 Method and apparatus for changing relative concentrations of gases present within a gaseous sample for mass spectrometry 有权
标题翻译：用于改变气相样品中存在的气体相对浓度的方法和装置用于质谱
公开(公告)号：US09182325B2
公开(公告)日：2015-11-10
申请号：US11489150
申请日：2006-07-18
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： G01N33/00 , B01L5/00 , G01N1/40 , B01L3/00
CPC分类号： G01N1/4005 , B01L3/5027
摘要： An apparatus for changing relative concentrations of first and second analyte substances in an analyte sample comprises a sample cell defining a sample chamber therewithin, and a semipermeable boundary member disposed in the sample chamber to define first and second sides of the sample chamber. Sample flow input and sample flow output ducts direct an analyte sample containing respective initial concentrations of the first and second analyte substances into the first side of the sample chamber. The semipermeable boundary member permits diffusion therethrough of the first and second analyte substances to the second side of the sample chamber at different rates. An analyte sample in the second side of the sample chamber, and an analyte sample exiting the first side via the sample flow output duct, have respective concentrations of the first and second analyte substances that are different from the initial concentrations.
摘要翻译：用于改变分析物样品中第一和第二分析物质的相对浓度的装置包括在其中限定样品室的样品池和设置在样品室中以限定样品室的第一和第二侧的半透性边界部件。样品流入口和样品流输出管道将含有相应初始浓度的第一和第二分析物质的分析物样品引导到样品室的第一侧。半透性边界构件允许第一和第二分析物质以不同的速率扩散到样品室的第二侧。样品室第二侧中的分析物样品和经由样品流量输出管道离开第一侧的分析物样品具有不同于初始浓度的第一和第二分析物质的相应浓度。

4. 发明授权

US07365852B2 Methods and systems for selecting pathlength in absorbance measurements 失效
标题翻译：用于在吸光度测量中选择光程的方法和系统
公开(公告)号：US07365852B2
公开(公告)日：2008-04-29
申请号：US10996913
申请日：2004-11-24
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： G01N21/00
CPC分类号： G01N21/0303 , G01N21/31 , G01N2021/035 , G01N2021/036
摘要： Methods and sub-systems for substantially optimizing the absorbance measurement in optical instruments are provided. A method comprises forming a liquid sample into a droplet extending between two opposing surfaces, passing a light beam through the sample, and varying the distance between the two opposing surfaces until a distance substantially corresponding to a optimum absorbance is obtained.
摘要翻译：提供了用于基本上优化光学仪器中的吸光度测量的方法和子系统。一种方法包括将液体样品形成为在两个相对表面之间延伸的液滴，使光束通过样品，并改变两个相对表面之间的距离，直到获得基本上对应于最佳吸光度的距离。

5. 发明申请

US20070170995A1 Plasma generating devices and methods for using the same 审中-公开
标题翻译：等离子体发生装置及其使用方法
公开(公告)号：US20070170995A1
公开(公告)日：2007-07-26
申请号：US11485222
申请日：2006-07-11
申请人： David Dutton , Arthur Schleifer , Robert Taber , Karen Seward
发明人： David Dutton , Arthur Schleifer , Robert Taber , Karen Seward
IPC分类号： H03B7/14
CPC分类号： H05H1/46 , H05H2001/4622
摘要： Aspects of the invention include plasma generating devices and systems thereof, as well as methods of using the same in plasma generation. Embodiments of the plasma generating devices include a resonator having a discharge gap and a ground plane disposed on opposing sides of a substrate; and a gas flow element configured to flow gas through the discharge gap. In using the plasma generating devices, a gas is flowed through the discharge gap and sufficient power is applied to the resonator to produce a plasma, e.g., in the form of a plasma jet, at the discharge gap. The subject devices and methods find use in a variety of different applications.
摘要翻译：本发明的方面包括等离子体生成装置及其系统，以及在等离子体生成中使用该装置的方法。等离子体产生装置的实施例包括具有放电间隙的谐振器和设置在基板的相对侧上的接地平面; 以及气体流动元件，其构造成使气体流过所述放电间隙。在使用等离子体产生装置时，气体流过放电间隙，并且向谐振器施加足够的功率以在放电间隙处产生例如等离子体射流形式的等离子体。主题设备和方法可用于各种不同的应用。

6. 发明申请

US20060105461A1 Nanopore analysis system 审中-公开
标题翻译：纳米分析系统
公开(公告)号：US20060105461A1
公开(公告)日：2006-05-18
申请号：US10971966
申请日：2004-10-22
申请人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
发明人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
IPC分类号： G01N35/00
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , Y10T436/11 , C12Q2565/631
摘要： Nanopore analysis systems, methods of preparing nanopore analysis systems, and methods of automating the analysis of samples using nanopore analysis systems, are provided.
摘要翻译：提供纳米孔分析系统，制备纳米孔分析系统的方法以及使用纳米孔分析系统自动分析样品的方法。

7. 发明申请

US20110146380A1 Capsule Injection System for Gas Chromatography 有权
标题翻译：胶囊注射系统用于气相色谱
公开(公告)号：US20110146380A1
公开(公告)日：2011-06-23
申请号：US12642843
申请日：2009-12-20
申请人： Arthur Schleifer , Carl A. Myerholtz
发明人： Arthur Schleifer , Carl A. Myerholtz
IPC分类号： G01N30/16 , B01L3/00
CPC分类号： G01N30/16 , G01N2030/025
摘要： The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.
摘要翻译：本发明包括适用于诸如GC之类的分析装置的可热封胶囊，以及使用该胶囊在这些装置中进行分析的方法。胶囊包括具有热封端以容纳在注射温度下待分析的样品的管。管包括具有封闭端部的热封的热封介质，管具有内表面和外表面，两个表面相对于样品基本上是化学惰性的。该管基本上不含任何在注射温度下会出现的物质。管可打开而不会碎片，并且在注射温度下保持完好。胶囊可以包括可编程标签，其存储与其中包含的样品有关的信息。

8. 发明授权

US07537936B2 Method of testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品的方法
公开(公告)号：US07537936B2
公开(公告)日：2009-05-26
申请号：US11136227
申请日：2005-05-23
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/502 , B01L3/5025 , B01L7/00 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0803 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

9. 发明申请

US20090035187A1 Microarray assay devices and methods of making and using the same 审中-公开
标题翻译：微阵列测定装置及其制造和使用方法
公开(公告)号：US20090035187A1
公开(公告)日：2009-02-05
申请号：US11888932
申请日：2007-08-02
申请人： Arthur Schleifer , Richard Paul Tella , William D. Fisher
发明人： Arthur Schleifer , Richard Paul Tella , William D. Fisher
IPC分类号： B01L3/00 , B23P17/00
CPC分类号： B01L3/50855 , B01L3/50853 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0829 , Y10T29/49
摘要： Aspects of the invention include systems for producing microarray assay devices. Further aspects of the invention include assembled microarray assay devices, as well as methods of assembling the devices and methods of using the assembled devices.
摘要翻译：本发明的方面包括用于生产微阵列测定装置的系统。本发明的其它方面包括组装的微阵列测定装置，以及组装装置的方法和使用组装的装置的方法。

10. 发明授权

US07247497B2 Testing multiple fluid samples with multiple biopolymer arrays 有权
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US07247497B2
公开(公告)日：2007-07-24
申请号：US10160620
申请日：2002-05-31
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L9/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

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