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1. 发明授权

US07198939B2 Apparatus for interrogating an addressable array 失效
标题翻译：用于询问可寻址阵列的装置
公开(公告)号：US07198939B2
公开(公告)日：2007-04-03
申请号：US10080641
申请日：2002-02-21
申请人： Andreas N. Dorsel , David A. King , Nicholas M. Sampas
发明人： Andreas N. Dorsel , David A. King , Nicholas M. Sampas
IPC分类号： C12M1/36 , G01N15/06 , B32B5/02
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , G01N21/6428 , G01N2021/6421 , G01N2021/6441
摘要： A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously with reflected and non-reflected interrogating light. A light emitted from respective features is detected. Either or both, constructive interference of interrogating light at the features, or constructive interference of light emitted from the features, can be obtained to allow lowering of light power from the source, enhanced signal, or reduced noise, or combinations of the foregoing. High depth discrimination may also be obtained without the need for a confocal detection system with conventional pinhole.
摘要翻译：一种询问可寻址阵列单元的方法和装置，其包括基板，在基板的前侧上的光反射层，以及阵列的前侧上的多个特征。对于多个特征中的每一个，该方法可以包括与反射和未反射的询问光同时照亮特征。检测从各个特征发射的光。可以获得在特征中询问光的建构性干扰或从特征发射的光的建构性干扰，以允许降低源的光功率，增强的信号或降低的噪声或前述的组合。也可以获得高深度鉴别，而不需要具有常规针孔的共焦检测系统。

2. 发明授权

US06902112B2 Apparatus and method for scanning a surface 失效
标题翻译：用于扫描表面的装置和方法
公开(公告)号：US06902112B2
公开(公告)日：2005-06-07
申请号：US10620918
申请日：2003-07-15
申请人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
发明人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
IPC分类号： G01N21/64 , G06K7/14
CPC分类号： G01N21/6452 , G01N2021/6463
摘要： Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.
摘要翻译：用于扫描表面的装置和方法。光学系统产生光束照射表面。载体支撑表面相对于光束往复运动以形成光栅的一个轴。推进系统以基本恒定的速度移动载体，并且位置传感器提供表示相对于光束的表面位置的输出信号。响应于输出信号的控制系统将采样周期相互调制为载波速度，以实现每个采样的基本上恒定的扫描长度并且控制数据采集定时。

3. 发明授权

US06592036B2 Apparatus and method for scanning a surface 失效
公开(公告)号：US06592036B2
公开(公告)日：2003-07-15
申请号：US10124138
申请日：2002-04-16
申请人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
发明人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
IPC分类号： G06K714
CPC分类号： G01N21/6452 , G01N2021/6463
摘要： Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

4. 发明授权

US06371370B1 Apparatus and method for scanning a surface 有权
公开(公告)号：US06371370B1
公开(公告)日：2002-04-16
申请号：US09317654
申请日：1999-05-24
申请人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
发明人： John W. Sadler , Andreas N. Dorsel , Kenneth L. Staton
IPC分类号： G06K714
摘要： Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

5. 发明授权

US07089123B2 Array scanner control system 失效
标题翻译：阵列扫描仪控制系统
公开(公告)号：US07089123B2
公开(公告)日：2006-08-08
申请号：US10261563
申请日：2002-09-30
申请人： John F. Corson , Andreas N. Dorsel
发明人： John F. Corson , Andreas N. Dorsel
IPC分类号： G01N33/48
CPC分类号： G01N21/6452 , B01J2219/00659 , B01J2219/00693 , B01J2219/00702 , H04N1/60
摘要： An optical scanning system adapted to physically adjust scanner settings in response to control feature readings is disclosed. The scanner and methodology finds particular use in reading of biopolymer arrays. The system may operate in any of a number of ways such that optimal data from scans is obtained. It may also be possible to use the system as a tool to aid in manufacture of arrays by providing feedback to a manufacturer regarding the signal produce for a given batch of samples tested.
摘要翻译：公开了一种适于物理地调整扫描器设置以响应于控制特征读数的光学扫描系统。扫描仪和方法在读取生物聚合物阵列时特别有用。系统可以以多种方式中的任一种操作，从而获得来自扫描的最佳数据。也可以使用该系统作为工具来帮助制造阵列，通过向制造商提供关于给定批次样品的信号产生的反馈。

6. 发明授权

US07013220B2 Biopolymer array scanner with real-time saturation detection 失效
标题翻译：生物聚合物阵列扫描仪，具有实时饱和度检测
公开(公告)号：US07013220B2
公开(公告)日：2006-03-14
申请号：US10262124
申请日：2002-09-30
申请人： Andreas N. Dorsel , Jeffrey M. McMillan
发明人： Andreas N. Dorsel , Jeffrey M. McMillan
IPC分类号： G01N33/50 , G01N33/48 , G06G7/00 , C12Q1/68
CPC分类号： G01N21/6456 , C12Q1/6837 , G01N21/6452 , G01N2021/6419 , G01N2021/6421
摘要： Optical scanner system approaches are described in which signal saturation data is produced in real-time. The data generated may be used for tuning a subsequent scan, in protection of optical detector components from damage or otherwise. Approaches for obtaining and storing or expressing the data are also disclosed. Also provided are methods of using the subject system is biopolymer array based application, including genomic and proteomic applications.
摘要翻译：描述了实时地产生信号饱和数据的光学扫描器系统方法。生成的数据可用于调整后续扫描，保护光学检测器部件免受损坏或以其他方式。还公开了获取和存储或表达数据的方法。还提供了使用主题系统的方法是基于生物聚合物阵列的应用，包括基因组和蛋白质组学应用。

7. 发明授权

US06956203B2 Scanning system with calibrated detection and method 失效
标题翻译：具有校准检测和方法的扫描系统
公开(公告)号：US06956203B2
公开(公告)日：2005-10-18
申请号：US10852904
申请日：2004-05-24
申请人： Kenneth L. Staton , Andreas N. Dorsel
发明人： Kenneth L. Staton , Andreas N. Dorsel
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/274 , G01N21/6428 , G01N21/6458
摘要： A self-calibrating scanning system and method are used in the analysis of biomolecules on a microarray. The self-calibrating scanning system comprises an excitation light source, an optical portion, a detection portion and a calibration portion that includes a calibration apparatus and compensation portion. The calibration apparatus comprises a light source having a highly reproducible or calibrated light based on a preselected or reference light level. The calibration apparatus emits the calibrated light that is measured by the detection portion of the scanning equipment. If the detection components are stable, the components will measure a constant output value for the calibrated light over time. As a detection component changes with time, the output value will change for the same calibrated light. The method comprises the steps of initially calibrating the detection portion of the scanning system and subsequently calibrating the detection portion to compensate for sensitivity changes.
摘要翻译：自动校准扫描系统和方法用于分析微阵列上的生物分子。自校准扫描系统包括激发光源，光学部分，检测部分和包括校准装置和补偿部分的校准部分。校准装置包括基于预选或参考光级别具有高度可再现或校准的光的光源。校准装置发射由扫描设备的检测部分测量的校准光。如果检测组件稳定，则组件将随着时间的推移测量校准光的恒定输出值。当检测组件随时间变化时，相同的校准光的输出值将发生变化。该方法包括以下步骤：首先校准扫描系统的检测部分，随后校准检测部分以补偿灵敏度变化。

8. 发明授权

US06930301B2 High quantum efficiency point light detector 有权
标题翻译：高量子效率点光检测器
公开(公告)号：US06930301B2
公开(公告)日：2005-08-16
申请号：US10843249
申请日：2004-05-10
申请人： Kenneth L. Staton , Andreas N. Dorsel
发明人： Kenneth L. Staton , Andreas N. Dorsel
IPC分类号： G01J1/46 , H01J40/14
CPC分类号： G01J1/4228 , G01J1/46
摘要： High quantum efficiency point detector system. The system includes a light source generating a light beam having an area and includes a CCD detector with a cell size comparable to the light beam area. The CCD cell may include a single pixel or at least two pixels.
摘要翻译：高量子效率点检测系统。该系统包括产生具有区域的光束的光源，并且包括具有与光束区域相当的单元尺寸的CCD检测器。 CCD单元可以包括单个像素或至少两个像素。

9. 发明授权

US06791690B2 Reading dry chemical arrays 失效
标题翻译：阅读干化学阵列
公开(公告)号：US06791690B2
公开(公告)日：2004-09-14
申请号：US10137658
申请日：2002-04-30
申请人： John F. Corson , Andreas N. Dorsel
发明人： John F. Corson , Andreas N. Dorsel
IPC分类号： G01N2155
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00547 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , Y10S435/808
摘要： Array units and methods are provided which have constructions to reduce or take advantage of Fresnel reflection. The array units may have a subtantially unreflective substrate. In one arrangement a transparent spacer layer is provided while in another an anti-reflective layer is present.
摘要翻译：提供了阵列单元和方法，其具有减少或利用菲涅耳反射的结构。阵列单元可以具有非对称基板。在一种布置中，提供透明间隔层，而在另一个中存在抗反射层。

10. 发明授权

US06583424B2 Scanning system with calibrated detection and method 失效
公开(公告)号：US06583424B2
公开(公告)日：2003-06-24
申请号：US09892209
申请日：2001-06-25
申请人： Kenneth L. Staton , Andreas N. Dorsel
发明人： Kenneth L. Staton , Andreas N. Dorsel
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , G01N21/274 , G01N21/6428 , G01N21/6458
摘要： A self-calibrating scanning system and method are used in the analysis of biomolecules on a microarray. The self-calibrating scanning system comprises an excitation light source, an optical portion, a detection portion and a calibration portion that includes a calibration apparatus and compensation portion. The calibration apparatus comprises a light source having a highly reproducible or calibrated light based on a preselected or reference light level. The calibration apparatus emits the calibrated light that is measured by the detection portion of the scanning equipment. If the detection components are stable, the components will measure a constant output value for the calibrated light over time. As a detection component changes with time, the output value will change for the same calibrated light. The method comprises the steps of initially calibrating the detection portion of the scanning system and subsequently calibrating the detection portion to compensate for sensitivity changes.

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