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1. 发明授权

US08680483B2 Fluorescence detector 失效
标题翻译：荧光检测器
公开(公告)号：US08680483B2
公开(公告)日：2014-03-25
申请号：US13141127
申请日：2009-12-22
申请人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
发明人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译：一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。

2. 发明申请

US20110272596A1 FLUORESCENCE DETECTOR 失效
标题翻译：荧光检测器
公开(公告)号：US20110272596A1
公开(公告)日：2011-11-10
申请号：US13141127
申请日：2009-12-22
申请人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
发明人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译：一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。

3. 发明授权

US08389959B2 Fluorescence analyzing device and fluorescence analyzing method 有权
标题翻译：荧光分析装置及荧光分析方法
公开(公告)号：US08389959B2
公开(公告)日：2013-03-05
申请号：US13147147
申请日：2009-11-30
申请人： Satoshi Takahashi , Tsuyoshi Sonehara , Tomoyuki Sakai , Takanobu Haga , Hirokazu Kato , Nobutaka Kumazaki , Takuya Matsui
发明人： Satoshi Takahashi , Tsuyoshi Sonehara , Tomoyuki Sakai , Takanobu Haga , Hirokazu Kato , Nobutaka Kumazaki , Takuya Matsui
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01J3/10 , G01J3/14 , G01J3/36 , G01J3/4406 , G01N21/6452
摘要： The present invention has an object to provide a method for efficiently detecting an image with a smaller number of pixels.The invention relates to fluorescence analysis which uses a substrate having a plurality of regions for being capable of immobilizing biologically-related molecules in positions of lattice points of a lattice structure, and which causes the fluorescence from a certain lattice point to be wavelength-dispersed in a direction other than the direction toward the adjacent closest lattice point. According to an embodiment, for example, the number of pixels of a two-dimensional sensor required for fluorescence analysis of the regions with the biologically-related molecules immobilized can be set to several hundred times to fifty times smaller than that in the conventional case without degrading the measurement accuracy. This can achieve the improvement of throughput, reduction in price, and/or improvement of the operability of an analyzing device.
摘要翻译：本发明的目的是提供一种用于有效检测具有较少像素数的图像的方法。本发明涉及使用具有多个区域的基板的荧光分析，其能够将生物相关分子固定在格子结构的格点的位置，并且使得来自特定格子点的荧光波长分散在除了朝向相邻最近格子点的方向之外的方向。根据一个实施例，例如，具有生物相关分子固定的区域的荧光分析所需的二维传感器的像素数量可以设定为比常规情况下少几百次到五十次，而没有降低测量精度。这可以实现分析装置的吞吐量的提高，价格的降低和/或改善可操作性。

4. 发明申请

US20110284768A1 FLUORESCENCE ANALYZING DEVICE AND FLUORESCENCE ANALYZING METHOD 有权
标题翻译：荧光分析装置和荧光分析方法
公开(公告)号：US20110284768A1
公开(公告)日：2011-11-24
申请号：US13147147
申请日：2009-11-30
申请人： Satoshi Takahashi , Tsuyoshi Sonehara , Tomoyuki Sakai , Takanobu Haga , Hirokazu Kato , Nobutaka Kumazaki , Takuya Matsui
发明人： Satoshi Takahashi , Tsuyoshi Sonehara , Tomoyuki Sakai , Takanobu Haga , Hirokazu Kato , Nobutaka Kumazaki , Takuya Matsui
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01J3/10 , G01J3/14 , G01J3/36 , G01J3/4406 , G01N21/6452
摘要： The present invention has an object to provide a method for efficiently detecting an image with a smaller number of pixels.The invention relates to fluorescence analysis which uses a substrate having a plurality of regions for being capable of immobilizing biologically-related molecules in positions of lattice points of a lattice structure, and which causes the fluorescence from a certain lattice point to be wavelength-dispersed in a direction other than the direction toward the adjacent closest lattice point. According to an embodiment, for example, the number of pixels of a two-dimensional sensor required for fluorescence analysis of the regions with the biologically-related molecules immobilized can be set to several hundred times to fifty times smaller than that in the conventional case without degrading the measurement accuracy. This can achieve the improvement of throughput, reduction in price, and/or improvement of the operability of an analyzing device.
摘要翻译：本发明的目的是提供一种用于有效检测具有较少像素数的图像的方法。本发明涉及使用具有多个区域的基板的荧光分析，其能够将生物相关分子固定在格子结构的格点的位置，并且使得来自特定格子点的荧光波长分散在除了朝向相邻最近格子点的方向之外的方向。根据一个实施例，例如，具有生物相关分子固定的区域的荧光分析所需的二维传感器的像素数量可以设定为比常规情况下少几百次到五十次，而没有降低测量精度。这可以实现分析装置的吞吐量的提高，价格的降低和/或改善可操作性。

5. 发明授权

US08040515B2 Fluorescence detection apparatus and method, and prism used therein 有权
标题翻译：荧光检测装置和方法以及其中使用的棱镜
公开(公告)号：US08040515B2
公开(公告)日：2011-10-18
申请号：US12051245
申请日：2008-03-19
申请人： Tsuyoshi Sonehara , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
发明人： Tsuyoshi Sonehara , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
IPC分类号： G01N21/25
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译：为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由样品排列表面上的光可能为1±0.1。照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。

6. 发明申请

US20080239311A1 FLUORESCENCE DETECTION APPARATUS AND METHOD, AND PRISM USED THEREIN 有权
标题翻译：荧光检测装置及其使用方法
公开(公告)号：US20080239311A1
公开(公告)日：2008-10-02
申请号：US12051245
申请日：2008-03-19
申请人： Tsuyoshi SONEHARA , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
发明人： Tsuyoshi SONEHARA , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
IPC分类号： G01J3/30 , G02B5/08
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译：为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由样品排列表面上的光可能为1±0.1。照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。

7. 发明申请

US20120064527A1 NUCLEIC ACID ANALYSIS DEVICE, NUCLEIC ACID ANALYSIS APPARATUS, AND NUCLEIC ACID ANALYSIS METHOD 审中-公开
标题翻译：核酸分析装置，核酸分析装置和核酸分析方法
公开(公告)号：US20120064527A1
公开(公告)日：2012-03-15
申请号：US13322203
申请日：2010-05-24
申请人： Akira Maekawa , Tomoyuki Sakai , Tsuyoshi Sonehara , Satoshi Takahashi
发明人： Akira Maekawa , Tomoyuki Sakai , Tsuyoshi Sonehara , Satoshi Takahashi
IPC分类号： C12Q1/68 , G01N33/50 , C12M1/34 , G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6837 , G01N21/6452 , Y10T436/143333 , C12Q2565/513
摘要： The present invention relates to a nucleic acid analysis device in a nucleic acid analysis apparatus, whereby waste of reaction spots on the nucleic acid analysis device is eliminated and leakage of fluorescence excitation light to unobserved nucleic acid measurement regions is minimized. Specifically, the nucleic acid analysis device has a plurality of nucleic acid measurement regions, which are characterized in that one nucleic acid measurement region is disposed at a sufficient distance from the other nucleic acid measurement regions such that the other nucleic acid measurement regions do not enter an irradiation region.
摘要翻译：本发明涉及核酸分析装置中的核酸分析装置，其中消除了核酸分析装置上的反应点的浪费，使荧光激发光向未观察到的核酸测量区域的泄漏最小化。具体而言，核酸分析装置具有多个核酸测定区域，其特征在于，将一个核酸测定区域配置在距离其他核酸测定区域足够的距离，使得其他核酸测定区域不进入照射区域。

8. 发明申请

US20090128807A1 Photometric instrument 有权
标题翻译：光度仪
公开(公告)号：US20090128807A1
公开(公告)日：2009-05-21
申请号：US12292444
申请日：2008-11-19
申请人： Tsuyoshi Sonehara , Satoshi Takahashi , Tomoyuki Sakai
发明人： Tsuyoshi Sonehara , Satoshi Takahashi , Tomoyuki Sakai
IPC分类号： G01N21/31
CPC分类号： G01N21/648 , G01N21/6456 , G01N2021/6423
摘要： A metallic structure is provided on a surface of a substrate. A component having a longer wavelength than excitation light is detected from luminescence from fixation positions of biomolecules and emitted from a material other than the biomolecules, and is used for photometrical analysis. As the structure, usable is a particulate (a metallic structure of a size not larger than a wavelength of the excitation light), a minute protrusion, or a thin film with minute apertures, which are made of a metal such as gold, chrome, silver or aluminum. In the case of the particulate or the minute protrusion, photoluminescence of the structure is detected with a biomolecule being fixed thereon. In the case of the thin film with minute apertures, Raman scattered light of specimen solution around the biomolecules, and photoluminescence of the metallic structure near the biomolecules are detected with biomolecules being fixed in the apertures.
摘要翻译：金属结构设置在基板的表面上。从生物分子的固定位置的发光和从生物分子以外的材料发射的发光中检测到具有比激发光更长波长的成分，并用于光度分析。作为结构，可以使用由金，铬等金属制成的颗粒（不大于激发光的波长的金属结构），微小突起或微小孔的薄膜，银或铝。在颗粒或微小突起的情况下，通过固定有生物分子来检测结构的光致发光。在具有微小孔的薄膜的情况下，拉曼散射生物分子周围的样品溶液的光，并且用生物分子固定在孔中来检测生物分子附近的金属结构的光致发光。

9. 发明授权

US08004673B2 Photometric instrument 有权
标题翻译：光度仪
公开(公告)号：US08004673B2
公开(公告)日：2011-08-23
申请号：US12292444
申请日：2008-11-19
申请人： Tsuyoshi Sonehara , Satoshi Takahashi , Tomoyuki Sakai
发明人： Tsuyoshi Sonehara , Satoshi Takahashi , Tomoyuki Sakai
IPC分类号： G01J3/30
CPC分类号： G01N21/648 , G01N21/6456 , G01N2021/6423
摘要： A metallic structure is provided on a surface of a substrate. A component having a longer wavelength than excitation light is detected from luminescence from fixation positions of biomolecules and emitted from a material other than the biomolecules, and is used for photometrical analysis. As the structure, usable is a particulate (a metallic structure of a size not larger than a wavelength of the excitation light), a minute protrusion, or a thin film with minute apertures, which are made of a metal such as gold, chrome, silver or aluminum. In the case of the particulate or the minute protrusion, photoluminescence of the structure is detected with a biomolecule being fixed thereon. In the case of the thin film with minute apertures, Raman scattered light of specimen solution around the biomolecules, and photoluminescence of the metallic structure near the biomolecules are detected with biomolecules being fixed in the apertures.
摘要翻译：金属结构设置在基板的表面上。从生物分子的固定位置的发光和从生物分子以外的材料发射的发光中检测到具有比激发光更长波长的成分，并用于光度分析。作为结构，可以使用由金，铬等金属制成的颗粒（不大于激发光的波长的金属结构），微小突起或微小孔的薄膜，银或铝。在颗粒或微小突起的情况下，通过固定有生物分子来检测结构的光致发光。在具有微小孔径的薄膜的情况下，拉曼散射生物分子周围的样品溶液的光，并且用生物分子固定在孔中来检测生物分子附近的金属结构的光致发光。

10. 发明授权

US08293191B2 Method for transferring droplet 有权
标题翻译：液滴转移方法
公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
申请人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
发明人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译：本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。为了合并两个液滴，它们被接触。为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。设置通过液滴的光路以进行光学测量。本发明可实现廉价的简单的液滴转印。根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。

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