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1. 发明授权

US07101915B1 P-terphenyl compounds 失效
标题翻译：对三联苯化合物
公开(公告)号：US07101915B1
公开(公告)日：2006-09-05
申请号：US09214277
申请日：1997-07-30
申请人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
发明人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
IPC分类号： C07C43/205 , C07C43/225 , C07C43/23 , A61K31/075 , A61K31/09
CPC分类号： C07D213/30 , C07C15/14 , C07C43/225 , C07C43/23 , C07C43/253 , C07C43/315 , C07C45/68 , C07C47/57 , C07C47/575 , C07C59/64 , C07C59/70 , C07C65/24 , C07C65/28 , C07C69/712 , C07C69/734 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/20 , C07C217/76 , C07C217/80 , C07C229/52 , C07C233/25 , C07C233/27 , C07C233/80 , C07C235/60 , C07C251/38 , C07C251/60 , C07C255/54 , C07C271/28 , C07C275/32 , C07C281/04 , C07C281/10 , C07C307/10 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/22 , C07C327/42 , C07D215/14 , C07D239/54 , C07D295/30 , C07D307/42 , C07D309/22 , C07D317/54 , C07D319/20 , C07D333/28 , C07D333/38 , C07D333/54 , C09K2019/123
摘要： The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R1–R13 are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, CH2—, —NR14— or —S(O)p— and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供了IgE生产的选择性抑制剂，其包含抑制从成熟B细胞分化成抗体产生细胞至产生抗体并且不抑制或弱抑制的过程中的IgE产生的化合物同时产生的IgG，IgM和/或IgA的制备，式（I）的化合物：其中R 1 -R 13是氢，卤素，低级烷基，低级烷氧基等，X是-O-，CH 2 - ， - NR 14 - 或-S（O）其中Y为低级烷基，低级链烯基等，其制备方法和含有该化合物的药物组合物。

2. 发明授权

US07220783B2 Para-terphenyl compounds 失效
标题翻译：对三联苯化合物
公开(公告)号：US07220783B2
公开(公告)日：2007-05-22
申请号：US10704876
申请日：2003-11-12
申请人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
发明人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
IPC分类号： A61K31/075 , A61K31/09 , C07C43/205 , C07C43/225 , C07C43/23
CPC分类号： C07D213/30 , C07C15/14 , C07C43/225 , C07C43/23 , C07C43/253 , C07C43/315 , C07C45/68 , C07C47/57 , C07C47/575 , C07C59/64 , C07C59/70 , C07C65/24 , C07C65/28 , C07C69/712 , C07C69/734 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/20 , C07C217/76 , C07C217/80 , C07C229/52 , C07C233/25 , C07C233/27 , C07C233/80 , C07C235/60 , C07C251/38 , C07C251/60 , C07C255/54 , C07C271/28 , C07C275/32 , C07C281/04 , C07C281/10 , C07C307/10 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/22 , C07C327/42 , C07D215/14 , C07D239/54 , C07D295/30 , C07D307/42 , C07D309/22 , C07D317/54 , C07D319/20 , C07D333/28 , C07D333/38 , C07D333/54 , C09K2019/123
摘要： The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R1–R13 are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, —CH2—, —NR14— or —S(O)p- and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供了IgE生产的选择性抑制剂，其包含抑制从成熟B细胞分化成抗体产生细胞至产生抗体并且不抑制或弱抑制的过程中的IgE产生的化合物同时产生的IgG，IgM和/或IgA的制备，式（I）的化合物：其中R 1 -R 13是氢，卤素，低级烷基，低级烷氧基等，X是-O-，-CH 2 - ， - NR 14 - 或-S（O）p-和Y 低级烷基，低级烯基等，其制备方法和含有该方法的药物组合物。

3. 发明授权

US07074836B1 Para-terphenyl compounds 失效
标题翻译：对三联苯化合物
公开(公告)号：US07074836B1
公开(公告)日：2006-07-11
申请号：US10705505
申请日：2003-11-12
申请人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
发明人： Kenji Kawada , Mitsuaki Ohtani , Ryuji Suzuki , Akinori Arimura
IPC分类号： A61K31/075 , A61K31/09 , C07C43/205 , C07C43/225 , C07C43/23
CPC分类号： C07D213/30 , C07C15/14 , C07C43/225 , C07C43/23 , C07C43/253 , C07C43/315 , C07C45/68 , C07C47/57 , C07C47/575 , C07C59/64 , C07C59/70 , C07C65/24 , C07C65/28 , C07C69/712 , C07C69/734 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/20 , C07C217/76 , C07C217/80 , C07C229/52 , C07C233/25 , C07C233/27 , C07C233/80 , C07C235/60 , C07C251/38 , C07C251/60 , C07C255/54 , C07C271/28 , C07C275/32 , C07C281/04 , C07C281/10 , C07C307/10 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/22 , C07C327/42 , C07D215/14 , C07D239/54 , C07D295/30 , C07D307/42 , C07D309/22 , C07D317/54 , C07D319/20 , C07D333/28 , C07D333/38 , C07D333/54 , C09K2019/123
摘要： The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R1–R13 are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, —CH2—, NR14— or —S(O)p— and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供了IgE生产的选择性抑制剂，其包含抑制从成熟B细胞分化成抗体产生细胞至产生抗体并且不抑制或弱抑制的过程中的IgE产生的化合物同时产生的IgG，IgM和/或IgA的制备，式（I）的化合物：其中R 1 -R 13是氢，卤素，低级烷基，低级烷氧基等，X是-O-，-CH 2 - ，NR 14 - 或-S（O）p-和Y是低级烷基，低级烯基等，其制备方法和含有该方法的药物组合物。

4. 发明授权

US07008954B1 Th2 differentiation inhibitors 失效
标题翻译： Th2分化抑制剂
公开(公告)号：US07008954B1
公开(公告)日：2006-03-07
申请号：US09980475
申请日：2000-07-14
申请人： Akinori Arimura , Kenji Kawada
发明人： Akinori Arimura , Kenji Kawada
IPC分类号： A61K31/09 , A61K31/136 , A61K31/15
CPC分类号： C07C251/58 , A61K31/05 , A61K31/075 , A61K31/095 , A61K31/135 , A61K31/136 , A61K31/15 , A61K31/235 , A61K31/44 , A61K31/4418 , A61K31/495 , A61K31/50 , A61K31/505 , C07C211/50 , C07C217/80
摘要： The present invention provides a pharmaceutical composition for use as a Th2 differentiation inhibitor comprising a compound represented by Formula (I): wherein each of ring A, ring B and ring C is an aromatic carbocyclic ring, a heterocyclic ring and the like, X is a single bond, —O—, —CH2—, —NH—, —SO— and the like, Y is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl and the like, each of V1 and V2 is a single bond, —O—, —NH—, —OCH2— and the like, a prodrug, pharmaceutically acceptable salt or solvate thereof.
摘要翻译：本发明提供一种用作Th2分化抑制剂的药物组合物，其包含由式（I）表示的化合物：其中环A，环B和环C各自为芳族碳环，杂环等，X为单键，-O-，-CH 2 - ， - NH - ， - SO-等，Y是氢，任选取代的低级烷基，任选取代的低级烯基等， V 1和V 2是单键，-O - ， - NH - ， - OCH 2 - 等，前药，其药学上可接受的盐或溶剂合物。

5. 发明授权

US5043456A 6-oxa and thiabicyclo [3.1.0.] compounds 失效
标题翻译： 6-氧杂和硫杂双环[3.1.0。]化合物
公开(公告)号：US5043456A
公开(公告)日：1991-08-27
申请号：US516141
申请日：1990-04-27
申请人： Mitsuaki Ohtani , Fumihiko Watanabe , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
发明人： Mitsuaki Ohtani , Fumihiko Watanabe , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： There are provided compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 is an C.sub.1 -C.sub.10 alkyl, aryl, aralkyl, or pyridyl, where the aryl, aralkyl, or pyridyl are unsubstituted or are substituted by C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, nitro, hydroxy, carboxy, amino, C.sub.1 -C.sub.5 alkylamino, C.sub.1 -C.sub.5 dialkyamino whose two alkyl groups may be different from each other, C.sub.2 -C.sub.3 alkanoylamino, or halogen and X is an C.sub.1 -C.sub.7 alkylene, C.sub.2 -C.sub.7 alkenylene, --CH(F)CH.dbd.CH(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 --S--(CH.sub.2).sub.2 --, --(CH.sub.2).sub.2 --S--(CH.sub.2).sub.3 --, --C.sub.6 H.sub.4 -O--CH.sub.2 -- or --CH.sub.2 CH.dbd.CH--m--C.sub.6 H.sub.4 --, or their pharmaceutically accepatble salts. The compounds are useful as antithrombotic, anti-vasconstricting and anti-bronchoconstricting drugs.

6. 发明授权

US4861913A Bicyclic sulfonamide derivatives 失效
标题翻译：双环磺酰胺衍生物
公开(公告)号：US4861913A
公开(公告)日：1989-08-29
申请号：US927823
申请日：1986-11-05
申请人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
发明人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： Bicyclic sulfonamido derivatives represented by the formula: ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is an alkyl, substituted or unsubstituted aryl, aralkyl or heterocycle; R.sub.3 is a hydrogen or methyl; X is an alkylene or alkenylene which may be substituted by a fluorine atom or atoms an may contain an oxygen, sulfur and/or phenylene in the chain; Y is straight or branched alkylene or alkenylene, oxygen, or sulfur; m is 0 or 1; and n is 0, 1 or 2, or their salt, said derivatives being useful as antithrombotic, anti-vasoconstricting, and anti-bronchoconstricting drugs.
摘要翻译：由下式表示的双环磺酰氨基衍生物：其中R1是氢或低级烷基; R2是烷基，取代或未取代的芳基，芳烷基或杂环基; R3是氢或甲基; X是可以被氟原子或原子取代的亚烷基或亚烯基，链中可以含有氧，硫和/或亚苯基; Y是直链或支链亚烷基或亚烯基，氧或硫; m为0或1; 并且n为0,1或2或其盐，所述衍生物可用作抗血栓形成，抗血管收缩和抗支气管收缩药物。

7. 发明授权

US5043451A Bicyclo (2.2.1.) hept-exo-2-yl and bicyclo (2.2.2.) oct-endo-2-yl compounds 失效
标题翻译：双环（2.2.1。）庚 - 外-2-基和双环（2.2.2。）辛 - 内-2-基化合物
公开(公告)号：US5043451A
公开(公告)日：1991-08-27
申请号：US516140
申请日：1990-04-27
申请人： Mitsuaki Ohtani , Fumihiko Watanabe , Tadadiko Tsushima , Kenji Kawada , Susumu Kamata
发明人： Mitsuaki Ohtani , Fumihiko Watanabe , Tadadiko Tsushima , Kenji Kawada , Susumu Kamata
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： There are provided compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 is an C.sub.1 -C.sub.10 alkyl, aryl, aralkyl, or pyridyl, where the aryl, aralkyl, or pyridyl are unsubstituted or are substituted by C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, nitro, hydroxy, carboxy, amino, C.sub.1 -C.sub.5 alkylamino, C.sub.1 -C.sub.5 dialkylamino whose two alkyl groups may be different from each other, C.sub.2 -C.sub.3 alkanoylamino, or halogen and X is an C.sub.1 -C.sub.7 alkylene, C.sub.2 -C.sub.7 alkenylene, --CH(F)CH.dbd.CH(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 --S--(CH.sub.2).sub.2 --, --CH.sub.2).sub.2 --S--(CH.sub.2).sub.3 --, --C.sub.6 H.sub.4 --O--CH.sub.2 --or --CH.sub.2 CH.dbd.CH--m--C.sub.6 H.sub.4 --, or their pharmaceutically acceptable salts. The compounds are useful as antithrombotic, anti-vasoconstricting and anti-bronchoconstricting drugs.

8. 发明授权

US4960909A 7-oxabicyclo[2.2.1] heptane sulfonamide derivatives 失效
标题翻译： 7-氧杂二环[2.2.1]庚烷磺酰胺衍生物
公开(公告)号：US4960909A
公开(公告)日：1990-10-02
申请号：US327772
申请日：1989-03-23
申请人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
发明人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： Bicyclic sulfonamido derivatives represented by the formula: ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is an alkyl, substituted or unsubstituted aryl, aralkyl or hetelocycle; R.sub.3 is a hydrogen or methyl; X is an alkylene or alkenylene which may be substituted by a fluorine atom or atoms and may contain an oxygen, sulfur and/or phenylene in the chain; Y is straight or branched alkylene or alkenylene oxygen, or sulfur; m is 0 or 1; and n is 0, 1 or 2, or their salt, said derivatives being useful as antithrombotic, anti-vasoconstricting, and anti-bronchoconstricting drugs.

9. 发明授权

US07957195B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US07957195B2
公开(公告)日：2011-06-07
申请号：US12630295
申请日：2009-12-03
申请人： Masamichi Fujito , Makoto Mizuno , Takahiro Yokoyama , Kenji Kawada , Takashi Iwase , Yasunobu Aoki , Takashi Kurafuji , Tomohiro Uchiyama , Shuichi Sato , Yuji Uji
发明人： Masamichi Fujito , Makoto Mizuno , Takahiro Yokoyama , Kenji Kawada , Takashi Iwase , Yasunobu Aoki , Takashi Kurafuji , Tomohiro Uchiyama , Shuichi Sato , Yuji Uji
IPC分类号： G11C16/00
CPC分类号： G11C7/04 , G11C16/0441 , G11C16/10 , G11C16/28
摘要： The semiconductor device includes a nonvolatile memory, having a memory array containing 1-bit twin cells, each composed of electrically rewritable first and second storage devices, the first and second storage devices holding binary data according to difference of their threshold voltages, and having different retention characteristics depending on difference of the binary data thereof; a read circuit for differentially amplifying complementary data output from the first and second storage devices of the twin cell selected for read, and judging information stored in the twin cell; and a control circuit. Two memory cells constituting a twin cell are arranged to hold different data. Therefore, even when the retention performance of one memory cell deteriorates, the difference between data held by the two memory cells can be maintained. Hence, differential amplification of such difference enables acquisition of proper stored information. Thus, retention performance of an electrically rewritable nonvolatile memory cell is improved.
摘要翻译：半导体器件包括非易失性存储器，具有包含1比特双胞胞的存储器阵列，每个存储器阵列由电可重写的第一和第二存储器件组成，第一和第二存储器件根据其阈值电压的差异保持二进制数据，并具有不同的保留特性取决于其二进制数据的差异; 用于差分放大从被选择读取的双胞胎的第一和第二存储装置输出的互补数据的读取电路，以及判断存储在双胞胎中的信息; 和控制电路。布置构成双胞胎的两个存储单元以保存不同的数据。因此，即使一个存储单元的保持性能劣化，也能够维持由两个存储单元保持的数据之间的差异。因此，这种差异的差分放大使得能够获得正确的存储信息。因此，提高了电可重写非易失性存储单元的保持性能。

10. 发明授权

US4420377A Method for continuously electroplating wire or the like and apparatus therefor 失效
标题翻译：连续电镀线等的方法及其装置
公开(公告)号：US4420377A
公开(公告)日：1983-12-13
申请号：US260779
申请日：1981-05-05
申请人： Shoji Shiga , Akitoshi Suzuki , Yasuo Goma , Kenji Kawada
发明人： Shoji Shiga , Akitoshi Suzuki , Yasuo Goma , Kenji Kawada
IPC分类号： C25D7/06 , C25D17/06
CPC分类号： C25D7/0607
摘要： Method and apparatus for continuously electroplating wire or the like wherein two or more drums combine a power supply with a wire turn direction, each drum having a vertical and rotatable shaft, are provided; a wire or the like to be electroplated is wound on the drums in multiple stages so as to be run; an electroplating cell is positioned between the drums so that the wire to be electroplated is arranged to pass in and out of the electroplating cell in multiple stages and repeatedly; and, particularly, an end of the electroplating cell is provided with a slit for passage of the wire to be electroplated, the slit being provided with weir plates placed one on top of another such that the weir plates put each of wires in multiple stages running through the electroplating cell between upper and lower weir plates and passage holes for running the wires at multiple stages are formed at joints between individual weir plates.
摘要翻译：提供用于连续电镀线等的方法和装置，其中两个或更多个鼓组合电源与线转方向，每个鼓具有垂直和可旋转的轴; 要电镀的线等以多个阶段缠绕在鼓上以便运行; 电镀槽位于鼓之间，使得要电镀的电线被布置成多次并重复地进出电镀电池; 特别地，电镀单元的端部设置有用于电镀线的通道的狭缝，该狭缝设置有一个放置在另一个之上的堰板，使得堰板将每根导线放置在多个级中通过上堰板和下堰板之间的电镀槽，在各个堰板之间的接头处形成用于在多个阶段运行导线的通孔。

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