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1. 发明授权

US5791345A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5791345A
公开(公告)日：1998-08-11
申请号：US565046
申请日：1995-11-30
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
IPC分类号： A61B5/00 , A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B1/04
CPC分类号： A61B5/1455 , A61B5/0261 , A61B5/14535 , G01N21/53 , A61B5/14532 , A61B5/14546 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.
摘要翻译：非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置，通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。图像捕获装置包括用于会聚来自检测区域的反射光的物镜。光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。

2. 发明授权

US5598842A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5598842A
公开(公告)日：1997-02-04
申请号：US296897
申请日：1994-08-29
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
IPC分类号： A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B5/00 , A61B1/04
CPC分类号： G01N21/53 , A61B5/0261 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer includes a light application device for applying light to a detection region of vessels contained in part of the living body, an imaging device for imaging the detection region to which light is applied, a fixing device for relatively fixing the imaging device and the part of the living body; a stabilizing device for stabilizing a focus of the imaging device with respect to the detection region; and an analyzer for analyzing the morphology and/or number of blood cells contained in the detection region by processing images captured with the imaging device, the light application device and the imaging device forming one image with a light application and capturing process during an interval of one ten thousandth to one billionth of a second.
摘要翻译：非侵入性血液分析仪包括：用于将光照射到生物体的一部分容纳的血管的检测区域的光施加装置，对被施加光的检测区域成像的成像装置，用于相对固定成像的定影装置装置和活体的一部分; 稳定装置，用于相对于所述检测区域稳定所述成像装置的焦点; 以及分析器，用于通过处理由成像装置拍摄的图像，所述光施加装置和所述成像装置在所述检测区域中包含的血细胞的形态和/或数量分析，万分之一到十分之一秒。

3. 发明授权

US5741213A Apparatus for analyzing blood 失效
标题翻译：用于分析血液的装置
公开(公告)号：US5741213A
公开(公告)日：1998-04-21
申请号：US736822
申请日：1996-10-25
申请人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
发明人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
IPC分类号： A61B5/00 , G06K9/00
CPC分类号： G06K9/00127 , A61B5/0059
摘要： An apparatus for analyzing blood includes an image capturing device for capturing an image including at least one object blood cell and an analyzer for analyzing the captured image as an image F(x, y) in an x-y coordinate system. The analyzer includes an edge calculator for calculating an edge intensity distribution E(x, y) representing an outline of the image F(x, y); a weight memory for storing in advance a weight distribution W(i, j) corresponding to an average outline of the object cell; an assessment value calculator for obtaining an assessment value C (x, y) at each point (x, y) by calculating a degree of correspondence between the edge intensity distribution E (x, y) and the weight distribution W(i, j) for each point (x, y); and an extractor for extracting a point (x, y) at which the assessment value C(x, y) is larger than a predetermined value, thereby determining that the object blood cell is present at the point (x, y). The apparatus is useful as a device for identifying the object blood cell.
摘要翻译：用于分析血液的装置包括用于捕获包括至少一个对象血细胞的图像的图像捕获装置和用于在x-y坐标系统中分析捕获图像作为图像F（x，y）的分析器。分析器包括用于计算表示图像F（x，y）的轮廓的边缘强度分布E（x，y）的边缘计算器。权重存储器，用于预先存储与所述对象单元的平均轮廓对应的权重分布W（i，j）; 评估值计算器，用于通过计算边缘强度分布E（x，y）和权重分布W（i，j）之间的对应度来获得每个点（x，y）处的评估值C（x，y）对于每个点（x，y）; 以及提取器，用于提取评估值C（x，y）大于预定值的点（x，y），从而确定所述对象血细胞存在于所述点（x，y）处。该装置可用作识别对象血细胞的装置。

4. 发明授权

US6061583A Noninvasive blood analyzer 失效
标题翻译：无创血液分析仪
公开(公告)号：US6061583A
公开(公告)日：2000-05-09
申请号：US77743
申请日：1998-06-11
申请人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
发明人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
IPC分类号： A61B5/145 , A61B5/00 , G01N21/47
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14552 , A61B5/6826 , A61B5/6838 , G01N21/4795
摘要： A noninvasive blood analyzer is provided which comprises: a light source for illuminating a part of tissues of a living body including a blood vessel; an image pickup section for picking up an image of the illuminated blood vessel and tissues; and an analyzing section for analyzing the picked image; the analyzing section including an extracting section for extracting image density distribution across the blood vessel in the image as an image density profile, a quantifying section for quantifying configurational characteristics of the image density profile, a computing section for computing the concentration of a blood constituent on the basis of the quantified characteristics, and an outputting section for outputting a computation result. The blood analyzer can measure the concentration of blood hemoglobin and the hematocrit in real time with an improved repeatability without blood sampling.
摘要翻译： PCT No.PCT / JP96 / 03894 Sec。 371日期：1998年6月11日 102（e）1998年6月11日PCT PCT 1996年12月27日PCT公布。出版物WO97 / 24066 日期1997年7月10日提供了一种无创血液分析仪，其包括：用于照射包括血管的生物体的一部分组织的光源; 用于拾取照明的血管和组织的图像的图像拾取部分; 以及分析部分，用于分析所拾取的图像; 所述分析部分包括提取部分，用于提取图像中的血管中的图像浓度分布作为图像浓度分布;量化部分，用于量化图像浓度分布的结构特征;计算部分，用于计算血液成分的浓度量化特性的基础，以及用于输出计算结果的输出部分。血液分析仪可以实时测量血红蛋白浓度和血细胞比容，改善重复性，无需采血。

5. 发明授权

US5934278A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5934278A
公开(公告)日：1999-08-10
申请号：US442654
申请日：1995-05-16
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： A61B5/145 , A61B5/00 , A61B5/026 , A61B5/1455 , G01N15/14 , G01N33/48 , A61B6/00
CPC分类号： G01N15/147 , A61B5/0261 , A61B5/1455
摘要： A non-invasive blood analyzer includes a light applying device for applying light to a detection region including a blood vessel in a living body and a capturing device for capturing an image of the detection region to which the light is applied. Finally, an analyzing device is included for further processing the captured image to analyze blood cells in the blood vessel included in the detection region. Preferably, the analyzing device includes a reference image forming device for forming a reference image by using at least one of a plurality of images which the capturing device repeatedly captures with respect to the same detection region. In addition, it includes a differential image forming device for calculating a difference in pixel information between the reference image and one of the plurality of images to form a differential image by using the calculated difference as pixel information. Finally, a blood cell image detecting device is included for detecting a blood cell image from the differential image.
摘要翻译：非侵入式血液分析仪包括：用于对包括生物体中的血管的检测区域进行光照射的光施加装置和用于拍摄被施加光的检测区域的图像的拍摄装置。最后，包括分析装置，用于进一步处理所捕获的图像，以分析检测区域中包括的血管中的血细胞。优选地，分析装置包括用于通过使用捕获装置相对于相同检测区域重复捕获的多个图像中的至少一个来形成参考图像的参考图像形成装置。此外，它包括差分图像形成装置，用于通过使用所计算的差分作为像素信息来计算参考图像和多个图像中的一个图像之间的像素信息的差异，以形成差分图像。最后，包括用于从差分图像检测血细胞图像的血细胞图像检测装置。

6. 发明授权

US5769076A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5769076A
公开(公告)日：1998-06-23
申请号：US641828
申请日：1996-05-02
申请人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
发明人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/1455
摘要： A non-invasive blood analyzer contains a light applicator for illuminating a detection region under the skin of a living body including a blood vessel; a camera for capturing an image of the illuminated detection region; an analyzer for processing the captured image and analyzing at least a component of blood in the blood vessel; a transparent plate; and a support for supporting the transparent plate and contacting the transparent plate closely with the skin over the detection region. The light applicator and the camera are constructed to illuminate the detection region and capture the image of the detection region through the transparent plate. Further, a drive controller is included for driving the support to move the transparent plate contacted closely with the skin in order to adjust the detection region to thereby compensate for any change in position of the blood vessel.
摘要翻译：非侵入性血液分析仪包括用于照射包括血管的生物体的皮肤下的检测区域的光施加器; 用于捕获所述被照亮检测区域的图像的照相机; 用于处理所捕获的图像并分析血管中的血液的至少一部分的分析器; 透明板以及用于支撑透明板并使透明板与检测区域上的皮肤紧密接触的支撑件。光照射器和相机被构造为照亮检测区域并通过透明板捕获检测区域的图像。此外，包括用于驱动支撑件的驱动控制器以移动与皮肤紧密接触的透明板，以便调整检测区域，从而补偿血管位置的任何改变。

7. 发明授权

US5722398A Apparatus for measuring concentration of hemoglobin and method for the same 失效
标题翻译：用于测量血红蛋白浓度的装置及其方法
公开(公告)号：US5722398A
公开(公告)日：1998-03-03
申请号：US557573
申请日：1995-11-14
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： G01B11/08 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/31 , G01N33/49
CPC分类号： A61B5/1455
摘要： An apparatus for measuring a concentration of hemoglobin includes a light application device for applying light to a detection region containing a blood vessel present in a living body; an image capturing device for capturing an image of the detection region to which the light is applied; and an analyzer for analyzing the concentration of hemoglobin in blood flowing through the blood vessel by processing the captured image. The analyzer includes a light intensity detector for detecting a light intensity of a body tissue and a light intensity of blood using the captured image. It further includes a calculator for calculating the concentration of hemoglobin from a ratio of the light intensity of the body tissue relative to the light intensity of blood thus detected.
摘要翻译：用于测量血红蛋白浓度的装置包括：用于将光照射到存在于生物体内的血管的检测区域的光施加装置; 用于捕获被施加光的检测区域的图像的图像捕获装置; 以及分析器，用于通过处理所捕获的图像分析血液中血红蛋白的浓度。该分析器包括用于使用捕获的图像检测身体组织的光强度和血液的光强度的光强度检测器。其还包括计算器，用于根据身体组织的光强度相对于这样检测的血液的光强度的比率计算血红蛋白的浓度。

8. 发明授权

US5974338A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5974338A
公开(公告)日：1999-10-26
申请号：US60080
申请日：1998-04-15
申请人： Kaoru Asano , Yasuhiro Kouchi
发明人： Kaoru Asano , Yasuhiro Kouchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14551
摘要： A non-invasive blood analyzer includes a light source unit for irradiating a portion of a living body, the portion including a blood vessel, and includes an image capturing unit for capturing an image of the irradiated portion. An analyzing unit is included for setting an analysis region in the captured image and analyzing a blood vessel portion in the set analysis region. The image capturing unit captures images of the irradiated portion of the living body a plurality of times and the analyzing unit specifies analysis regions including the same blood vessel portions with respect to the captured images. The analyzing unit determines these regions based upon a position of a feature in sequential images and calculates at least one of blood vessel width, blood component concentration and blood component concentration ratio with respect to the blood vessel portion in each specified analysis region.
摘要翻译：非侵入性血液分析仪包括用于照射生物体的一部分的光源单元，该部分包括血管，并且包括用于捕获照射部分的图像的图像捕获单元。包括分析单元，用于设置拍摄图像中的分析区域并分析设定分析区域中的血管部分。图像拍摄单元多次拍摄生物体的照射部分的图像，并且分析单元针对捕获的图像指定包括相同血管部分的分析区域。分析单元基于连续图像中的特征的位置来确定这些区域，并且计算每个指定分析区域中的血管部分的血管宽度，血液成分浓度和血液成分浓度比中的至少一个。

9. 发明授权

US06353750B1 Living body inspecting apparatus and noninvasive blood analyzer using the same 有权
标题翻译：生物体检查装置及无创血液分析仪
公开(公告)号：US06353750B1
公开(公告)日：2002-03-05
申请号：US09403551
申请日：1999-10-25
申请人： Rokusaburo Kimura , Kaoru Asano , Hideo Kusuzawa , Yasuhiro Kouchi , Toshiyuki Ozawa
发明人： Rokusaburo Kimura , Kaoru Asano , Hideo Kusuzawa , Yasuhiro Kouchi , Toshiyuki Ozawa
IPC分类号： A61B500
CPC分类号： A61B5/0031 , A61B5/0261 , G06F19/00 , H04B10/532
摘要： The purpose is to fix a portion of a living body, which is an object of measurement, stably without strain and to acquire accurate inspection results with good reproducibility. An apparatus for capturing an image of a living body includes: a base for mounting a portion of a living body to be inspected; two sidewall members capable of holding the mounted portion of the living body therebetween from both sides; a light source section for supplying a light to the portion of the living body held on the base and between the sidewall members; and a light receiving section for detecting optical information from the portion of the living body supplied with the light, and a non-invasive apparatus for living body inspection including the above apparatus for capturing an image of a living body in which the light receiving section includes an image capturing element, and an analyzing section for calculating information on blood flowing through a blood vessel by analyzing an image of a tissue including the blood vessel obtained by the image capturing element.
摘要翻译：目的是将作为测量对象的生物体的一部分稳定地固定而不变形，并以良好的再现性获得精确的检查结果。一种用于捕获生物体图像的装置，包括：用于安装待检查的生物体的一部分的基座; 两侧壁构件能够从两侧保持活体的安装部分; 光源部，用于向保持在基部上的活体和侧壁部件之间的部分供给光; 以及用于从提供有光的生物体的部分检测光学信息的光接收部分，以及用于生物体检查的非侵入性装置，包括用于捕获其中光接收部分包括的生物体的图像的上述装置图像捕获元件和分析部分，用于通过分析包括由图像捕获元件获得的血管的组织的图像来计算关于血管流动的血液的信息。

10. 发明申请

US20050170353A1 Gene examination method for judging the onset risk of glaucoma 审中-公开
标题翻译：用于判断青光眼发病风险的基因检查方法
公开(公告)号：US20050170353A1
公开(公告)日：2005-08-04
申请号：US10509595
申请日：2003-03-19
申请人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
发明人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N33/6887 , G01N2800/168
摘要： To provide a gene examination method for predicting the onset risk of glaucoma based on the relation between a glaucoma-associated gene and the onset of glaucoma, the onset of glaucoma in future is predicted by using as an indication mutations in the gene region involving the code region and/or the upstream region of a glaucoma-associated gene. In the base sequence represented by SEQ ID NO:1, mutation(s) in at least one of the following positions are detected, i.e., the 194-, 199-, 324-, 1051-, 1084-, 1627-, 1685-, 1756-, 1853-, 2830-, 3371-, 4037- and 4364-positions.
摘要翻译：为了提供基于青光眼相关基因与青光眼发生之间的关系来预测青光眼的发病风险的基因检查方法，通过使用涉及代码的基因区域中的指示突变来预测未来的青光眼发作区域和/或青光眼相关基因的上游区域。在由SEQ ID NO：1表示的碱基序列中，检测至少一个以下位置的突变，即194-，199-，324-，1051-，1084-，1627-，1685- ，1756-，1853-，2830-，3371-4037-和4364-位。

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