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1. 发明申请

US20050170353A1 Gene examination method for judging the onset risk of glaucoma 审中-公开
标题翻译：用于判断青光眼发病风险的基因检查方法
公开(公告)号：US20050170353A1
公开(公告)日：2005-08-04
申请号：US10509595
申请日：2003-03-19
申请人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
发明人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N33/6887 , G01N2800/168
摘要： To provide a gene examination method for predicting the onset risk of glaucoma based on the relation between a glaucoma-associated gene and the onset of glaucoma, the onset of glaucoma in future is predicted by using as an indication mutations in the gene region involving the code region and/or the upstream region of a glaucoma-associated gene. In the base sequence represented by SEQ ID NO:1, mutation(s) in at least one of the following positions are detected, i.e., the 194-, 199-, 324-, 1051-, 1084-, 1627-, 1685-, 1756-, 1853-, 2830-, 3371-, 4037- and 4364-positions.
摘要翻译：为了提供基于青光眼相关基因与青光眼发生之间的关系来预测青光眼的发病风险的基因检查方法，通过使用涉及代码的基因区域中的指示突变来预测未来的青光眼发作区域和/或青光眼相关基因的上游区域。在由SEQ ID NO：1表示的碱基序列中，检测至少一个以下位置的突变，即194-，199-，324-，1051-，1084-，1627-，1685- ，1756-，1853-，2830-，3371-4037-和4364-位。

2. 发明申请

US20070015980A1 Non-invasive living body measuring device 失效
标题翻译：无创生物测量装置
公开(公告)号：US20070015980A1
公开(公告)日：2007-01-18
申请号：US11485564
申请日：2006-07-12
申请人： Shigehiro Numada , Toshiyuki Ozawa
发明人： Shigehiro Numada , Toshiyuki Ozawa
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/489
摘要： A non-invasive living body measuring device is described, a representative one of which includes: a non-invasive living body measuring device for measuring the components contained in blood, comprising: an imaging part for imaging a living body; a display part; and a display control part for generating a blood vessel image showing blood vessels within a living body image obtained by the imaging part, and displaying the blood vessel image on the display part, wherein an index representing a suitable region for imaging by the imaging part is displayed on the display part.
摘要翻译：一种非侵入式生物体测量装置，其代表性的方法包括：用于测量血液中所含的成分的无创生物体测量装置，包括：用于使生物体成像的成像部件; 显示部分; 以及显示控制部，其生成由所述摄像部获取的生物体图像内的血管的血管图像，并且在所述显示部上显示所述血管图像，其中，所述成像部成像的合适区域的指标为显示在显示部分上。

3. 发明申请

US20090005661A1 Non-invasive blood component measuring device and non-invasive blood component measuring method 审中-公开
标题翻译：非侵入性血液成分测量装置和非侵入性血液成分测量方法
公开(公告)号：US20090005661A1
公开(公告)日：2009-01-01
申请号：US12215520
申请日：2008-06-27
申请人： Toshiyuki Ozawa , Shigehiro Numada
发明人： Toshiyuki Ozawa , Shigehiro Numada
IPC分类号： A61B5/1455
CPC分类号： A61B5/681 , A61B5/1455
摘要： A non-invasive blood component measuring device comprising: a light source section for irradiating a light to a blood vessel through a skin; an imaging section for imaging the irradiated blood vessel through the skin; and a controller, including a memory under control of a processor, the memory storing instructions enabling the processor to carry out operations, comprising: creating a concentration profile based on an image obtained by imaging the blood vessel with the imaging section; calculating a blood component concentration based on the concentration profile; acquiring a shape feature of the concentration profile; and correcting the blood component concentration based on the shape feature of the concentration profile is disclosed. A non-invasive blood component measuring method is also disclosed.
摘要翻译：一种非侵入性血液成分测量装置，包括：光源部，用于通过皮肤将光照射到血管; 成像部，用于使照射的血管通过皮肤成像; 以及控制器，其包括处理器控制下的存储器，所述存储器存储使所述处理器执行操作的指令，包括：基于通过所述成像部分对所述血管成像而获得的图像来创建浓度分布; 基于浓度分布计算血液成分浓度; 获取浓度分布的形状特征; 并且基于浓度分布的形状特征来校正血液成分浓度。还公开了非侵入性血液成分测量方法。

4. 发明授权

US08185177B2 Noninvasive living body measuring device and noninvasive living body measuring method 有权
标题翻译：无创生物测量装置和无创生物测量方法
公开(公告)号：US08185177B2
公开(公告)日：2012-05-22
申请号：US11904983
申请日：2007-09-28
申请人： Shigehiro Numada , Toshiyuki Ozawa
发明人： Shigehiro Numada , Toshiyuki Ozawa
IPC分类号： A61B5/00
CPC分类号： A61B5/02007 , A61B5/1455 , A61B5/489
摘要： The present invention is to present a noninvasive living body measuring device that is capable of simplifying the structure and performing the analysis with accuracy in a short time. The noninvasive living body measuring device comprises: a light source for illuminating a living body which includes a blood vessel; an imaging part for imaging the illuminated living body to obtain a living body image; and an analyzing part for obtaining a density of a component contained in blood of the living body based on an image of the blood vessel in the living body image, and correcting the density of the component based on an image of a peripheral tissue of the blood vessel in the living body image.
摘要翻译：本发明是提供能够在短时间内精确地简化结构并进行分析的非侵入式生物体测量装置。无创生物体测量装置包括：用于照射包括血管的生物体的光源; 用于对被照明的生物进行成像以获得生物体图像的成像部件; 以及分析部，其基于生物体图像中的血管的图像获得生物体的血液中成分的密度，并且基于血液的周边组织的图像来校正成分的浓度血管在活体图像。

5. 发明申请

US20090248316A1 METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS 失效
标题翻译：通过使用蒽环类抗生素药物来治疗治疗效果的诊断方法和用于支持通过使用安非他酮类抗生素治疗药物治疗效果的装置的方法
公开(公告)号：US20090248316A1
公开(公告)日：2009-10-01
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

6. 发明授权

US06349227B1 Non-invasive living body measuring apparatus and method 有权
标题翻译：无创生物测量仪器及方法
公开(公告)号：US06349227B1
公开(公告)日：2002-02-19
申请号：US09422798
申请日：1999-10-22
申请人： Shigehiro Numada
发明人： Shigehiro Numada
IPC分类号： A61B500
CPC分类号： G06T7/0012 , A61B5/0059 , A61B5/061 , A61B5/1455 , A61B5/6826 , A61B5/6838 , G06T7/30 , G06T2207/30101
摘要： A non-invasive living body measuring apparatus includes an image capturing section for capturing an image of the irradiated portion of the living body. When the image capturing section captures first and subsequent images of a portion of a living body at different times and the data processing section extracts characteristic patterns from the images, and sets an analysis region in the first image, the data processing section sets an analysis region in subsequent images based on a relative shift amount between the characteristic patterns of the first and subsequent image requisite for matching the characteristic patterns to each other.
摘要翻译：非侵入式生物体测量装置包括用于捕获生物体照射部分的图像的图像捕获部分。当图像拍摄部分在不同时间拍摄生物体的一部分的第一和后续图像，并且数据处理部分从图像中提取特征图案，并且设置第一图像中的分析区域时，数据处理部分设置分析区域在随后的图像中，基于用于将特征图案彼此匹配的第一和后续图像的特征图案之间的相对偏移量。

7. 发明授权

US08437823B2 Noninvasive living body measurement apparatus and noninvasive living body measurement method 失效
标题翻译：无创生物测量仪器和无创生物测量方法
公开(公告)号：US08437823B2
公开(公告)日：2013-05-07
申请号：US12696882
申请日：2010-01-29
申请人： Toshiyuki Ozawa , Shigehiro Numada , Toshihiko Kodera
发明人： Toshiyuki Ozawa , Shigehiro Numada , Toshihiko Kodera
IPC分类号： A61B5/1455
CPC分类号： A61B5/14546 , A61B5/026 , A61B5/1455 , A61B5/489 , A61B5/681
摘要： An easily wearable noninvasive living body measurement apparatus is provided. The noninvasive living body measurement apparatus (1) is composed of an apparatus body (3) and a wristband (40). The apparatus body (3) is composed of a body section (31) and a body section retention member (4). The body section (31) is retained by the wristband (40) via the body section retention member (4). By allowing the wristband (40) to be attached to a position in the vicinity of a wrist of a forearm of a human, the apparatus body (3) is attached to a human body. An imaging section (5) is retained at a position protruding outside from a width D of the wristband (40). This allows, when the wristband (40) is worn around the arm, the imaging section (5) to be located at a position at which the imaging by the imaging section (5) can be performed.
摘要翻译：提供了一种易穿戴式无创生物测量装置。非侵入式生物体测量装置（1）由装置主体（3）和腕带（40）构成。装置主体（3）由主体部（31）和主体部保持部件（4）构成。身体部分（31）经由身体部分保持构件（4）被腕带（40）保持。通过使腕带（40）安装在人的前臂附近的位置，将装置主体（3）安装在人体上。成像部（5）保持在从腕带（40）的宽度D向外突出的位置。这样当腕带（40）围绕臂被佩戴时，成像部分（5）能够位于可由成像部分（5）进行成像的位置。

8. 发明授权

US08160821B2 Method for supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs and a device for supporting a diagnosis for an effect of a treatment by using anthracycline anticancer drugs 失效
标题翻译：支持通过使用蒽环类抗癌药物治疗效果的诊断的方法和通过使用蒽环类抗癌药物进行治疗效果的支持诊断的装置
公开(公告)号：US08160821B2
公开(公告)日：2012-04-17
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

9. 发明授权

US08014960B2 Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US08014960B2
公开(公告)日：2011-09-06
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G01N33/50
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

10. 发明授权

US07962189B2 Non-invasive living body measuring device 失效
标题翻译：无创生物测量装置
公开(公告)号：US07962189B2
公开(公告)日：2011-06-14
申请号：US11485564
申请日：2006-07-12
申请人： Shigehiro Numada , Toshiyuki Ozawa
发明人： Shigehiro Numada , Toshiyuki Ozawa
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/14552 , A61B5/489
摘要： A non-invasive living body measuring device is described, a representative one of which includes: a non-invasive living body measuring device for measuring the components contained in blood, comprising: an imaging part for imaging a living body; a display part; and a display control part for generating a blood vessel image showing blood vessels within a living body image obtained by the imaging part, and displaying the blood vessel image on the display part, wherein an index representing a suitable region for imaging by the imaging part is displayed on the display part.
摘要翻译：一种非侵入式生物体测量装置，其代表性的方法包括：用于测量血液中所含的成分的无创生物体测量装置，包括：用于使生物体成像的成像部件; 显示部分; 以及显示控制部，其生成由所述摄像部获取的生物体图像内的血管的血管图像，并且在所述显示部上显示所述血管图像，其中，所述成像部成像的合适区域的指标为显示在显示部分上。

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