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1. 发明授权

US5791345A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5791345A
公开(公告)日：1998-08-11
申请号：US565046
申请日：1995-11-30
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
IPC分类号： A61B5/00 , A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B1/04
CPC分类号： A61B5/1455 , A61B5/0261 , A61B5/14535 , G01N21/53 , A61B5/14532 , A61B5/14546 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.
摘要翻译：非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置，通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。图像捕获装置包括用于会聚来自检测区域的反射光的物镜。光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。

2. 发明授权

US5598842A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5598842A
公开(公告)日：1997-02-04
申请号：US296897
申请日：1994-08-29
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
IPC分类号： A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B5/00 , A61B1/04
CPC分类号： G01N21/53 , A61B5/0261 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer includes a light application device for applying light to a detection region of vessels contained in part of the living body, an imaging device for imaging the detection region to which light is applied, a fixing device for relatively fixing the imaging device and the part of the living body; a stabilizing device for stabilizing a focus of the imaging device with respect to the detection region; and an analyzer for analyzing the morphology and/or number of blood cells contained in the detection region by processing images captured with the imaging device, the light application device and the imaging device forming one image with a light application and capturing process during an interval of one ten thousandth to one billionth of a second.
摘要翻译：非侵入性血液分析仪包括：用于将光照射到生物体的一部分容纳的血管的检测区域的光施加装置，对被施加光的检测区域成像的成像装置，用于相对固定成像的定影装置装置和活体的一部分; 稳定装置，用于相对于所述检测区域稳定所述成像装置的焦点; 以及分析器，用于通过处理由成像装置拍摄的图像，所述光施加装置和所述成像装置在所述检测区域中包含的血细胞的形态和/或数量分析，万分之一到十分之一秒。

3. 发明授权

US5934278A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5934278A
公开(公告)日：1999-08-10
申请号：US442654
申请日：1995-05-16
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： A61B5/145 , A61B5/00 , A61B5/026 , A61B5/1455 , G01N15/14 , G01N33/48 , A61B6/00
CPC分类号： G01N15/147 , A61B5/0261 , A61B5/1455
摘要： A non-invasive blood analyzer includes a light applying device for applying light to a detection region including a blood vessel in a living body and a capturing device for capturing an image of the detection region to which the light is applied. Finally, an analyzing device is included for further processing the captured image to analyze blood cells in the blood vessel included in the detection region. Preferably, the analyzing device includes a reference image forming device for forming a reference image by using at least one of a plurality of images which the capturing device repeatedly captures with respect to the same detection region. In addition, it includes a differential image forming device for calculating a difference in pixel information between the reference image and one of the plurality of images to form a differential image by using the calculated difference as pixel information. Finally, a blood cell image detecting device is included for detecting a blood cell image from the differential image.
摘要翻译：非侵入式血液分析仪包括：用于对包括生物体中的血管的检测区域进行光照射的光施加装置和用于拍摄被施加光的检测区域的图像的拍摄装置。最后，包括分析装置，用于进一步处理所捕获的图像，以分析检测区域中包括的血管中的血细胞。优选地，分析装置包括用于通过使用捕获装置相对于相同检测区域重复捕获的多个图像中的至少一个来形成参考图像的参考图像形成装置。此外，它包括差分图像形成装置，用于通过使用所计算的差分作为像素信息来计算参考图像和多个图像中的一个图像之间的像素信息的差异，以形成差分图像。最后，包括用于从差分图像检测血细胞图像的血细胞图像检测装置。

4. 发明授权

US5769076A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5769076A
公开(公告)日：1998-06-23
申请号：US641828
申请日：1996-05-02
申请人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
发明人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/1455
摘要： A non-invasive blood analyzer contains a light applicator for illuminating a detection region under the skin of a living body including a blood vessel; a camera for capturing an image of the illuminated detection region; an analyzer for processing the captured image and analyzing at least a component of blood in the blood vessel; a transparent plate; and a support for supporting the transparent plate and contacting the transparent plate closely with the skin over the detection region. The light applicator and the camera are constructed to illuminate the detection region and capture the image of the detection region through the transparent plate. Further, a drive controller is included for driving the support to move the transparent plate contacted closely with the skin in order to adjust the detection region to thereby compensate for any change in position of the blood vessel.
摘要翻译：非侵入性血液分析仪包括用于照射包括血管的生物体的皮肤下的检测区域的光施加器; 用于捕获所述被照亮检测区域的图像的照相机; 用于处理所捕获的图像并分析血管中的血液的至少一部分的分析器; 透明板以及用于支撑透明板并使透明板与检测区域上的皮肤紧密接触的支撑件。光照射器和相机被构造为照亮检测区域并通过透明板捕获检测区域的图像。此外，包括用于驱动支撑件的驱动控制器以移动与皮肤紧密接触的透明板，以便调整检测区域，从而补偿血管位置的任何改变。

5. 发明授权

US5722398A Apparatus for measuring concentration of hemoglobin and method for the same 失效
标题翻译：用于测量血红蛋白浓度的装置及其方法
公开(公告)号：US5722398A
公开(公告)日：1998-03-03
申请号：US557573
申请日：1995-11-14
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： G01B11/08 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/31 , G01N33/49
CPC分类号： A61B5/1455
摘要： An apparatus for measuring a concentration of hemoglobin includes a light application device for applying light to a detection region containing a blood vessel present in a living body; an image capturing device for capturing an image of the detection region to which the light is applied; and an analyzer for analyzing the concentration of hemoglobin in blood flowing through the blood vessel by processing the captured image. The analyzer includes a light intensity detector for detecting a light intensity of a body tissue and a light intensity of blood using the captured image. It further includes a calculator for calculating the concentration of hemoglobin from a ratio of the light intensity of the body tissue relative to the light intensity of blood thus detected.
摘要翻译：用于测量血红蛋白浓度的装置包括：用于将光照射到存在于生物体内的血管的检测区域的光施加装置; 用于捕获被施加光的检测区域的图像的图像捕获装置; 以及分析器，用于通过处理所捕获的图像分析血液中血红蛋白的浓度。该分析器包括用于使用捕获的图像检测身体组织的光强度和血液的光强度的光强度检测器。其还包括计算器，用于根据身体组织的光强度相对于这样检测的血液的光强度的比率计算血红蛋白的浓度。

6. 发明授权

US07857759B2 Extraction device, analyzer, extraction method, and analysis method 有权
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US07857759B2
公开(公告)日：2010-12-28
申请号：US10810412
申请日：2004-03-25
申请人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532 , A61N1/30 , A61N1/325
摘要： Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm2; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.
摘要翻译：描述了通过皮肤从活组织提取分析物的提取装置，其包括：（a）具有小于约50mm 2的与皮肤接触面积的第一电极部分; （b）直通电极部分; 以及（c）用于向第一电极部分和贯通电极部分提供电能并用于提取第一电极部分中的分析物的电源部分。还描述了分析仪，提取方法和分析方法。

7. 发明申请

US20060129035A1 Devices, methods, and systems for measuring analytes extracted through skin 审中-公开
标题翻译：用于测量通过皮肤提取的分析物的装置，方法和系统
公开(公告)号：US20060129035A1
公开(公告)日：2006-06-15
申请号：US10745443
申请日：2003-12-23
申请人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
发明人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/1495 , A61B10/0045 , A61B2010/008
摘要： Measuring devices for measuring an analyte extracted through skin of a living body are described that include: a noninvasive sampling unit for extracting the analyte from the living body through analyte transmission paths formed in an extracting region of the skin; an analyte detection unit for detecting a quantity of extracted analyte; and a control unit for obtaining a corrected analyte quantity based on the quantity of the extracted analyte and number of analyte transmission paths in the extracting region. Methods and systems for measuring analytes extracted through skin are also described.
摘要翻译：描述了用于测量通过生物体的皮肤提取的分析物的测量装置，其包括：非侵入式取样单元，用于通过形成在皮肤提取区域中的分析物传播路径从活体提取分析物; 用于检测提取的分析物的量的分析物检测单元; 以及控制单元，用于基于所提取的分析物的量和提取区域中的分析物传播路径的数量来获得校正的分析物量。还描述了通过皮肤提取的测量分析物的方法和系统。

8. 发明申请

US20060116563A1 Extraction device, analyzer, extraction method, and analysis method 失效
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US20060116563A1
公开(公告)日：2006-06-01
申请号：US11280100
申请日：2005-11-16
申请人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61N1/30
摘要： An extraction device for extracting an analyte from living tissue is disclosed that comprises a power source; a first electrode and second electrode connected to the power source; and a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously. An analyzer comprising the extraction device, method for extracting an analyte, and method for extracting and analyzing an analyte are also described.
摘要翻译：公开了一种用于从活体组织提取分析物的提取装置，其包括电源; 连接到电源的第一电极和第二电极; 以及保持单元，用于保持用于收集从活体组织中提取的分析物的收集介质，其中所述收集介质与所述第一电极和所述第二电极连续地接触。还描述了包括提取装置，用于提取分析物的方法的分析器以及用于提取和分析分析物的方法。

9. 发明授权

US08046043B2 Extraction device, analyzer, extraction method, and analysis method 失效
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US08046043B2
公开(公告)日：2011-10-25
申请号：US11280100
申请日：2005-11-16
申请人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61N1/30
摘要： An extraction device for extracting an analyte from living tissue is disclosed that comprises a power source; a first electrode and second electrode connected to the power source; and a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously. An analyzer comprising the extraction device, method for extracting an analyte, and method for extracting and analyzing an analyte are also described.
摘要翻译：公开了一种用于从活体组织提取分析物的提取装置，其包括电源; 连接到电源的第一电极和第二电极; 以及保持单元，用于保持用于收集从活体组织中提取的分析物的收集介质，其中所述收集介质与所述第一电极和所述第二电极连续地接触。还描述了包括提取装置，用于提取分析物的方法的分析器以及用于提取和分析分析物的方法。

10. 发明申请

US20080208024A1 Method of measuring skin conductance, method of analyzing component concentration, skin conductance measuring apparatus, and component concentration analyzer 审中-公开
标题翻译：皮肤电导率测定方法，成分浓度分析方法，皮肤电导率测定装置，成分浓度分析仪等
公开(公告)号：US20080208024A1
公开(公告)日：2008-08-28
申请号：US12074198
申请日：2008-02-28
申请人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
发明人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
IPC分类号： A61B5/053 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0531 , A61B5/14514 , A61B5/1486 , A61N1/30
摘要： The present invention provides a method of measuring skin conductance which can obtain an accuracy measurement result, comprising the steps of: supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part; disposing the medium containing part on an extraction region of a skin of the subject; extracting tissue fluid through the extraction region into the low conductivity medium within the medium containing part; supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode. A method of analyzing a component concentration, a skin conductance measuring apparatus, and a component concentration analyzer are also disclosed.
摘要翻译：本发明提供一种测量皮肤电导率的方法，其可以获得精确度测量结果，该方法包括以下步骤：将含有预定组分的组织液的低电导率介质作为包含受试者的介质的培养基供应到介质容纳部分; 将所述培养基包含部分放置在所述对象的皮肤的提取区域上; 将组织液通过提取区域提取到介质容纳部分内的低电导率介质中; 在用于向提取区域提供电力的第一电极和用于向提取区域外部的皮肤供电的第二电极之间提供电力; 以及基于在第一电极和第二电极之间提供的电力来测量提取区域的电导。还公开了分析组分浓度的方法，皮肤电导率测量装置和组分浓度分析仪。

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