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1. 发明授权

US09053913B2 Positioning guides and ion sources 有权
标题翻译：定位导轨和离子源
公开(公告)号：US09053913B2
公开(公告)日：2015-06-09
申请号：US13550732
申请日：2012-07-17
申请人： Keith Ferrara , Rosario Mannino , Timothy Neal , Gregory Hanlon
发明人： Keith Ferrara , Rosario Mannino , Timothy Neal , Gregory Hanlon
IPC分类号： G01N30/72 , H01J49/04 , G01N30/02
CPC分类号： G01N30/7206 , G01N30/02 , H01J49/04 , Y10T29/5313
摘要： Certain embodiments described herein are directed to inserts and ion sources. In some examples, an insert can comprise a positioning guide configured to provide for visual positioning of a chromatography column under the positioning guide. In other examples, an ion source configured with an aperture to couple to a carrier tube to render the ion source non-removable from an instrument housing when the carrier tube is coupled to the ion source is described.
摘要翻译：本文描述的某些实施例涉及插入物和离子源。在一些示例中，插入件可以包括定位引导件，该定位引导件被配置为提供在定位引导件下方的色谱柱的视觉定位。在其他示例中，描述了当载体管耦合到离子源时，配置有孔的耦合到载体管以使离子源不能从仪器外壳移除的离子源。

2. 发明授权

US09349580B2 Coupling devices and source assemblies including them 有权
标题翻译：耦合装置和源组件，包括它们
公开(公告)号：US09349580B2
公开(公告)日：2016-05-24
申请号：US12900574
申请日：2010-10-08
申请人： Keith Ferrara
发明人： Keith Ferrara
IPC分类号： H01J49/10 , F16B7/20
CPC分类号： H01J49/0495 , F16B7/20 , H01J49/10 , H01J2209/18 , Y10T403/7009
摘要： Certain embodiments described herein are directed to couplers that can be used to provide a seal between a source assembly and a vacuum chamber. In certain examples, the seal can be provided upon movement of a moveable component of the coupler. In some examples, rotation of the moveable component is operative to provide an axial force to a stationary component coupled to the moveable component such that the stationary component is biased to provide a suitable seal to the vacuum chamber.
摘要翻译：本文描述的某些实施例涉及可用于在源组件和真空室之间提供密封件的耦合器。在某些实例中，可以在联接器的可移动部件移动时提供密封。在一些示例中，可移动部件的旋转可操作以向耦合到可移动部件的固定部件提供轴向力，使得固定部件被偏置以提供对真空室的适当密封。

3. 发明申请

US20070109542A1 Optical resonance analysis unit 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：US20070109542A1
公开(公告)日：2007-05-17
申请号：US10566303
申请日：2004-08-02
申请人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
发明人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.
摘要翻译：特别适用于执行光栅耦合表面等离子体共振（SPR）成像的光学分析单元具有能够扫描投射到固定目标传感器（例如SPR传感器）上的入射光的角度范围的枢转光源。例如通过CCD照相机检测来自照明传感器的反射图像，并且例如通过拟合算法处理图像和角度扫描数据，以提供在传感器的表面上发生的反应的实时分析。

4. 发明申请

US20150028202A1 REFLECTRONS AND METHODS OF PRODUCING AND USING THEM 审中-公开
标题翻译：电子生产与使用方法
公开(公告)号：US20150028202A1
公开(公告)日：2015-01-29
申请号：US14289822
申请日：2014-05-29
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/06 , H01J49/40
CPC分类号： H01J49/067 , H01J49/405
摘要： Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.
摘要翻译：本文描述的某些实施例涉及反射器组件及其制造方法。在一些配置中，描述了包括多个透镜的反射器，每个透镜都包括平面主体，并且包括多个分离的和单独的导体，跨越从平面主体的第一表面的第一侧到第二侧的中心孔。在一些情况下，多个导体各自基本上彼此平行并且位于同一平面中。

5. 发明申请

US20150014524A1 TIME OF FLIGHT TUBES AND METHODS OF USING THEM 审中-公开
标题翻译：飞行时间及其使用方法
公开(公告)号：US20150014524A1
公开(公告)日：2015-01-15
申请号：US14291417
申请日：2014-05-30
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/02 , H01J49/24 , H01J49/40
CPC分类号： H01J49/405 , H01J49/02 , H01J49/24 , H01J49/40
摘要： Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.
摘要翻译：本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

6. 发明申请

US20050145273A1 Thermal cycler for PCR 有权
公开(公告)号：US20050145273A1
公开(公告)日：2005-07-07
申请号：US11057960
申请日：2005-02-15
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： B01L7/00 , G01R27/20 , G05D23/19 , H01L35/30 , H01L37/00 , G01K3/00 , H01L35/34
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

7. 发明授权

US09384954B2 Time of flight tubes and methods of using them 有权
标题翻译：飞行时间管和使用它们的方法
公开(公告)号：US09384954B2
公开(公告)日：2016-07-05
申请号：US14291417
申请日：2014-05-30
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/40 , H01J49/02 , H01J49/24
CPC分类号： H01J49/405 , H01J49/02 , H01J49/24 , H01J49/40
摘要： Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.
摘要翻译：本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

8. 发明申请

US20110089333A1 ASSEMBLIES FOR ION AND ELECTRON SOURCES AND METHODS OF USE 有权
标题翻译：用于离子和电子源的组件及其使用方法
公开(公告)号：US20110089333A1
公开(公告)日：2011-04-21
申请号：US12902391
申请日：2010-10-12
申请人： Keith Ferrara , David Barkus , Adam Patkin , Rosario Mannino , Daniel Pentek , Frank DeLorenzo , Barton Rasmussen
发明人： Keith Ferrara , David Barkus , Adam Patkin , Rosario Mannino , Daniel Pentek , Frank DeLorenzo , Barton Rasmussen
IPC分类号： H01J3/14
CPC分类号： H01J49/068 , H01J3/38 , H01J27/022 , H01J49/067 , H01J49/10 , H01J49/26 , H01J2237/061
摘要： Certain embodiments described herein are directed to devices that can be used to align the components of a source assembly in a source housing. In some examples, a terminal lens configured to couple to the housing through respective alignment features can be used to retain the source components in a source housing to provide a source assembly.
摘要翻译：本文描述的某些实施例涉及可用于对准源壳体中的源组件的部件的装置。在一些示例中，可以使用配置成通过相应对准特征耦合到壳体的终端镜头来将源组件保持在源壳体中以提供源组件。

9. 发明申请

US20070113880A1 Thermal cycler for PCR 有权
公开(公告)号：US20070113880A1
公开(公告)日：2007-05-24
申请号：US11654239
申请日：2007-01-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： H01L35/28
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

10. 发明授权

US09355832B2 Reflectrons and methods of producing and using them 有权
标题翻译：反射器及其制造和使用方法
公开(公告)号：US09355832B2
公开(公告)日：2016-05-31
申请号：US14289822
申请日：2014-05-29
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/06 , H01J49/40
CPC分类号： H01J49/067 , H01J49/405
摘要： Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.
摘要翻译：本文描述的某些实施例涉及反射器组件及其制造方法。在一些配置中，描述了包括多个透镜的反射器，每个透镜都包括平面主体，并且包括多个分离的和单独的导体，跨越从平面主体的第一表面的第一侧到第二侧的中心孔。在一些情况下，多个导体各自基本上彼此平行并且位于同一平面中。

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