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1. 发明申请

US20070113880A1 Thermal cycler for PCR 有权
公开(公告)号：US20070113880A1
公开(公告)日：2007-05-24
申请号：US11654239
申请日：2007-01-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： H01L35/28
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

2. 发明申请

US20070230535A1 Thermal cycler for PCR 有权
标题翻译：热循环仪用于PCR
公开(公告)号：US20070230535A1
公开(公告)日：2007-10-04
申请号：US11804298
申请日：2007-05-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： G01D18/00
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.
摘要翻译：提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。计算样品温度，而不是使用设计特定的模型和方程来测量。控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。块/散热器组件可以改变为相同或不同设计的另一个。该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。

3. 发明申请

US20070117200A1 Thermal cycler for PCR 有权
公开(公告)号：US20070117200A1
公开(公告)日：2007-05-24
申请号：US11654238
申请日：2007-01-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

4. 发明申请

US20050145273A1 Thermal cycler for PCR 有权
公开(公告)号：US20050145273A1
公开(公告)日：2005-07-07
申请号：US11057960
申请日：2005-02-15
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： B01L7/00 , G01R27/20 , G05D23/19 , H01L35/30 , H01L37/00 , G01K3/00 , H01L35/34
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

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