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1. 发明申请

US20070109542A1 Optical resonance analysis unit 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：US20070109542A1
公开(公告)日：2007-05-17
申请号：US10566303
申请日：2004-08-02
申请人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
发明人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.
摘要翻译：特别适用于执行光栅耦合表面等离子体共振（SPR）成像的光学分析单元具有能够扫描投射到固定目标传感器（例如SPR传感器）上的入射光的角度范围的枢转光源。例如通过CCD照相机检测来自照明传感器的反射图像，并且例如通过拟合算法处理图像和角度扫描数据，以提供在传感器的表面上发生的反应的实时分析。

2. 发明申请

US20090213382A1 OPTICAL RESONANCE ANALYSIS UNIT 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：US20090213382A1
公开(公告)日：2009-08-27
申请号：US12330930
申请日：2008-12-09
申请人： David H. Tracy , Jennifer M. Brockman , Keith S. Ferrara , Martin Shenker , Robert Kersten , Steven E. Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
发明人： David H. Tracy , Jennifer M. Brockman , Keith S. Ferrara , Martin Shenker , Robert Kersten , Steven E. Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/253 , G01N21/7743 , Y10T137/86035
摘要： An array surface plasmon resonance (SPR) analysis instrument comprising a reflective SPR sensor array, a light source assembly arranged to project a collimated beam of light onto the reflective SPR sensor array to provide a reflected array image of the sensor array, and to scan the incident angle of the collimated beam of light over an angular range, and a detector assembly oriented to receive the reflected array image of the sensor array over the angular range, the detector assembly comprises a two-dimensional detector sensing element that is tilted with respect to the optical axis of the lens assembly in accordance with the Scheimpflug condition, and a lens assembly for focusing the reflected array image of said SPR sensor array onto said tilted detector sensing element. The lens assembly comprises an objective section which is arranged to produce a virtual image of the tilted reflected array at infinity, followed by an imaging section arranged to transform the virtual image of the tilted reflected array into a real tilted image on the tilted detector sensing element.
摘要翻译：阵列表面等离子体共振（SPR）分析仪器，其包括反射SPR传感器阵列，光源组件，被布置成将准直光束投射到反射SPR传感器阵列上，以提供传感器阵列的反射阵列图像，并扫描在角度范围内的准直光束的入射角以及定向成在角度范围内接收传感器阵列的反射阵列图像的检测器组件，检测器组件包括二维检测器感测元件，其相对于根据Scheimpflug条件的透镜组件的光轴，以及用于将所述SPR传感器阵列的反射阵列图像聚焦到所述倾斜检测器感测元件上的透镜组件。透镜组件包括物镜部分，该物镜部分布置成产生无限远的倾斜反射阵列的虚像，随后是成像部分，被配置为将倾斜的反射阵列的虚像转换成倾斜检测器感测元件上的实际倾斜图像。

3. 发明申请

US20050162657A1 Optical resonance analysis system 审中-公开
标题翻译：光学共振分析系统
公开(公告)号：US20050162657A1
公开(公告)日：2005-07-28
申请号：US11074604
申请日：2005-03-07
申请人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01N21/27 , G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

4. 发明授权

US5720923A Nucleic acid amplification reaction apparatus 失效
公开(公告)号：US5720923A
公开(公告)日：1998-02-24
申请号：US299033
申请日：1994-08-31
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , C12M1/40 , C12P19/34
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

5. 发明申请

US20060262313A1 Optical Resonance Analysis System 有权
标题翻译：光学共振分析系统
公开(公告)号：US20060262313A1
公开(公告)日：2006-11-23
申请号：US11460932
申请日：2006-07-28
申请人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

6. 发明授权

US6033880A Nucleic acid amplification reaction apparatus and method 失效
标题翻译：核酸扩增反应装置及方法
公开(公告)号：US6033880A
公开(公告)日：2000-03-07
申请号：US27989
申请日：1998-02-23
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg , Richard W. Noreiks
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg , Richard W. Noreiks
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , C12P19/34
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
摘要翻译：用于在至少一个毛细管中的反应混合物中进行核酸扩增反应和优选聚合酶链式反应（PCR）的装置和方法。公开了几个不同的实施例。一个实施例通过穿过两个恒温流体浴的毛细管回路循环样品。另一个实施例中，毛细管在两个热交换器之间交替布置，使得样品仅穿过管中一次。其他实施例保持热交换器平稳，并在它们之间平移样品。另外的实施例保持样品静止，并且自动地将热交换器平移或旋转通过毛细管内包含的样品，以进行扩增反应所需的热循环。

7. 发明授权

US5779977A Nucleic acid amplification reaction apparatus and method 失效
公开(公告)号：US5779977A
公开(公告)日：1998-07-14
申请号：US827353
申请日：1997-03-26
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Timothy M. Woudenberg
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Timothy M. Woudenberg
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , G01N15/06
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

8. 发明授权

US5282543A Cover for array of reaction tubes 失效
标题翻译：盖子用于反应管阵列
公开(公告)号：US5282543A
公开(公告)日：1994-02-01
申请号：US2559
申请日：1993-01-11
申请人： Enrico Picozza , Timothy M. Woudenberg , Robert Ragusa , Ralph Keese
发明人： Enrico Picozza , Timothy M. Woudenberg , Robert Ragusa , Ralph Keese
IPC分类号： G01N35/02 , B01L3/00 , B01L3/14 , B01L7/00 , G05D23/19 , B65D51/18
CPC分类号： B01L3/50853 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L7/00 , B01L7/52 , G05D23/1917 , G05D23/1919 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185
摘要： An array of reaction tube covers adapted to seal a plurality of reaction tubes comprises a unitary body of flexible material having a plurality of flexible plastic nodules. Each nodule is adapted to seal one of the reaction tubes. Each of the nodules is flexible held in a predetermined planar spaced relationship from each other in rows, preferably in rows and columns, by an integral web having a plurality of apertures therethrough. Each of the nodules has a downwardly convex, generally hemispherical lower portion extending from the web, an upwardly convex upper portion extending from the web over the lower portion, and a centrally domed nipple extending upwardly from the upper portion.
摘要翻译：适于密封多个反应管的反应管盖阵列包括具有多个柔性塑料结节的柔性材料的整体。每个结节适于密封反应管中的一个。每个结节通过具有穿过其中的多个孔的整体腹板而以行，优选地以行和列彼此以预定的平面间隔关系灵活地保持。每个结节具有从腹板延伸的向下凸出的，大致半球形的下部，从腹板延伸穿过下部的向上凸起的上部，以及从上部向上延伸的中心圆顶的乳头。

9. 发明授权

US5681741A In situ PCR amplification system 失效
标题翻译：原位PCR扩增系统
公开(公告)号：US5681741A
公开(公告)日：1997-10-28
申请号：US525321
申请日：1995-09-08
申请人： John G. Atwood , Enrico Picozza
发明人： John G. Atwood , Enrico Picozza
IPC分类号： B01J19/00 , B01L3/00 , B01L7/00 , B01L9/00 , C12Q1/68 , C40B40/06 , G01N1/31 , C12M1/40 , C12M1/34
CPC分类号： G01N1/312 , B01J19/0046 , B01L3/508 , B01L7/52 , C12Q1/686 , B01J2219/00722 , B01L2200/0684 , B01L2200/0689 , B01L2300/0822 , B01L2300/1827 , B01L2300/185 , B01L9/52 , C40B40/06
摘要： A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mounted on the slide, a flexible plastic cover over the sample, and a retaining assembly fastened to the slide and to the cover to retain and seal a reaction mixture against the sample during thermal cycling. The retaining assembly includes a rigid ring on a rim portion of the cover, a cross beam having spaced parallel rails joined by opposite flat ends, and a pair of clips which are pressed over the ends and opposite sides of the slide to fasten the cross beam and cover to the slide. In one form the retaining assembly includes a flexible compliant cover member, which is permeable to gas but non-permeable to liquid, for forming a closed liquid space adjacent a flat surface, a cross beam member enclosing the cover member to form a closed gas space therebetween, the periphery of the liquid space and of the gas space being sealed, and a pressure differential being established whereby the pressure in the liquid space is greater than the pressure in the gas space.
摘要翻译：用于扩增制备的细胞或组织样品中所含核酸的完整原位PCR系统。用于PCR样品的容纳系统包括玻璃显微镜载玻片，含有安装在载玻片上的靶核酸序列的样本样本，样品上的柔性塑料盖，以及固定到载玻片和保护盖的保持组件，在热循环期间将反应混合物密封在样品上。保持组件包括在盖的边缘部分上的刚性环，具有由相对的平坦端连接的间隔开的平行轨道的横梁和被压在滑块的端部和相对侧上的一对夹子，以将横梁并覆盖到幻灯片。在一种形式中，保持组件包括柔性顺应性盖构件，其可透气且不透液体，用于形成邻近平坦表面的封闭液体空间;横梁构件，其围绕盖构件以形成封闭气体空间在此之间，液体空间和气体空间的周边被密封，并且建立压力差，由此液体空间中的压力大于气体空间中的压力。

10. 发明授权

US5827480A Nucleic acid amplification reaction apparatus 失效
标题翻译：核酸扩增反应装置
公开(公告)号：US5827480A
公开(公告)日：1998-10-27
申请号：US823735
申请日：1997-03-25
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Timothy M. Woudenberg
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Timothy M. Woudenberg
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , G01N21/01 , C12M1/02 , G01N21/62 , G01N33/50
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
摘要翻译：用于在至少一个毛细管中的反应混合物中进行核酸扩增反应和优选聚合酶链式反应（PCR）的装置和方法。公开了几个不同的实施例。一个实施例通过穿过两个恒温流体浴的毛细管回路循环样品。另一个实施例中，毛细管在两个热交换器之间交替布置，使得样品仅穿过管中一次。其他实施例保持热交换器平稳，并在它们之间平移样品。另外的实施例保持样品静止，并且自动地将热交换器平移或旋转通过毛细管内包含的样品，以进行扩增反应所需的热循环。

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