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1. 发明授权

US08318684B2 Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics 有权
标题翻译：抗生素，双酚A，A2和A3以及双酚B1，B2a，B2b和B3以及生产所述抗生素的方法
公开(公告)号：US08318684B2
公开(公告)日：2012-11-27
申请号：US12300468
申请日：2007-05-15
申请人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
发明人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
IPC分类号： A61K31/70 , C07H17/08 , C12P19/62
CPC分类号： C07H17/04 , A61K31/04 , A61K31/7048 , C12P17/08 , A61K2300/00
摘要： Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.
摘要翻译：可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株来生产七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。这些双吡啶衍生物是具有如以下通式（III）统称为化学结构的新型化合物：这些双酚化物对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高抗菌活性，因此这些双吡哆醇各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。

2. 发明申请

US20100144658A1 NOVEL ANTIBIOTICS, BISPOLIDES A1, A2, AND A3 AS WELL AS BISPOLIDES B1, B2A, B2B AND B3 AND PROCESSES FOR PRODUCING SAID ANTIBIOTICS 有权
标题翻译：新型抗生素，BISPOLIDES A1，A2和A3作为双酚A B1，B2A，B2B和B3以及生产抗生素的方法
公开(公告)号：US20100144658A1
公开(公告)日：2010-06-10
申请号：US12300468
申请日：2007-05-15
申请人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
发明人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08 , C12P19/60 , C12N1/20
CPC分类号： C07H17/04 , A61K31/04 , A61K31/7048 , C12P17/08 , A61K2300/00
摘要： Seven novel antibiotic substances could be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below. These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in human and animals.The general formula (III):
摘要翻译：可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株产生七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。这些双吡啶衍生物是具有如以下通式（III）统称的化学结构的新化合物。这些双糖苷酸各自对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高的抗菌活性，因此这些双吡啶苷各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。通式（III）：

3. 发明授权

US07915946B2 Switch circuit for high frequency signals wherein distortion of the signals are suppressed 有权
标题翻译：用于高频信号的开关电路，其中信号的失真被抑制
公开(公告)号：US07915946B2
公开(公告)日：2011-03-29
申请号：US12301488
申请日：2007-05-22
申请人： Yuji Takahashi , Keiichi Numata
发明人： Yuji Takahashi , Keiichi Numata
IPC分类号： H03K17/60
CPC分类号： H03K17/693 , H03K17/165
摘要： A high-frequency switch circuit includes: a switch section comprised of a field effect transistor having a plurality of bias circuits and a potential generating circuit for generating bias voltages from a control signal and supplying them to the bias circuits. The field effect transistor forms the passage route of a high-frequency signal by turning on and off in accordance with the control signal. The bias circuits are provided to produce a potential difference between the drain terminal and the source terminal of the field effect transistor and to apply bias voltages lower than the voltage of the control signal to the drain terminal, and the source terminal.
摘要翻译：高频开关电路包括：开关部分，包括具有多个偏置电路的场效应晶体管和用于从控制信号产生偏置电压并将其提供给偏置电路的电位产生电路。场效应晶体管根据控制信号通过导通和截止形成高频信号的通路。提供偏置电路以产生场效应晶体管的漏极端子和源极端子之间的电位差，并将低于控制信号的电压的偏置电压施加到漏极端子和源极端子。

4. 发明申请

US20060033573A1 Amplifying circuit 有权
标题翻译：放大电路
公开(公告)号：US20060033573A1
公开(公告)日：2006-02-16
申请号：US10537470
申请日：2003-12-03
申请人： Hitoshi Yano , Tomoyuki Yamase , Keiichi Numata , Tadashi Maeda
发明人： Hitoshi Yano , Tomoyuki Yamase , Keiichi Numata , Tadashi Maeda
IPC分类号： H03G3/30
CPC分类号： H03F1/56 , H03F1/02
摘要： The present invention provides an amplifying circuit capable of accomplishing high-impedance input/output, and providing a high gain and low power consumption. The amplifier amplifies a signal received through an input terminal, and outputs the signal through an output terminal. A control circuit comprised of the inductors, and the switches turns input/output impedances of the amplifier into a high impedance.
摘要翻译：本发明提供一种能够实现高阻抗输入/输出并提供高增益和低功耗的放大电路。放大器放大通过输入端接收的信号，并通过输出端输出信号。由电感器组成的控制电路，并且开关将放大器的输入/输出阻抗转换成高阻抗。

5. 发明申请

US20050179506A1 High frequency switch circuit 有权
标题翻译：高频开关电路
公开(公告)号：US20050179506A1
公开(公告)日：2005-08-18
申请号：US10514394
申请日：2003-05-19
申请人： Yuji Takahashi , Keiichi Numata
发明人： Yuji Takahashi , Keiichi Numata
IPC分类号： H03K17/693 , H03K17/06 , H04B1/48 , H01P1/10
CPC分类号： H04B1/48 , H03K17/063 , H03K17/693
摘要： A high-frequency switch circuit has a plurality of high-frequency switches for passing and blocking a high-frequency signal between an input terminal and an output terminal depending on a control potential applied as a control signal, a high-frequency detecting terminal for detecting high-frequency signal passing through the high-frequency switch which is in ON-state, and a voltage boosting circuit for generating a potential for increasing the control potential applied to the high-frequency switch which is in ON-state in order to increase difference between the control potential applied to the high-frequency switch which is in an ON-state and the control potential applied to the high-frequency switch which is in an OFF-state, depending on an intensity or amplitude of the detected high-frequency signal.
摘要翻译：高频开关电路具有多个高频开关，用于根据作为控制信号施加的控制电位，在输入端子和输出端子之间传递和阻断高频信号，高频检测端子用于检测高频信号通过处于导通状态的高频开关，以及升压电路，用于产生用于增加施加到处于导通状态的高频开关的控制电位的电位，以增加差分根据检测到的高频信号的强度或幅度，施加在处于导通状态的高频开关的控制电位与施加到处于断开状态的高频开关的控制电位之间。

6. 发明授权

US06201416B1 Field effect transistor logic circuit with reduced power consumption 失效
标题翻译：场效应晶体管逻辑电路具有降低的功耗
公开(公告)号：US06201416B1
公开(公告)日：2001-03-13
申请号：US09276327
申请日：1999-03-25
申请人： Keiichi Numata
发明人： Keiichi Numata
IPC分类号： H03K19084
CPC分类号： H03K19/0952 , H03K19/0013 , H03K19/018535
摘要： There is disclosed a field effect transistor logic circuit having an output terminal to be connected to a gate of an input field effect transistor in a next stage field effect transistor logic circuit. The field effect transistor logic circuit includes a depletion transistor having a drain connected to a first power supply voltage, an enhancement transistor having a drain connected at a node in common to a gate and a source of the depletion transistor. A gate of the enhancement transistor is connected to an input terminal, and a source of the enhancement transistor is connected to a second power supply voltage which is lower than the first power supply voltage. A high level potential limiting circuit is connected between the node and the output terminal, to lower a potential of the output terminal to a level which turns on a drain-source channel of the input field effect transistor of the next stage field effect transistor logic circuit but which never turns on a gate-source of the input field effect transistor of the next stage field effect transistor logic circuit, when the potential of the node is at a high level. A lower level lowering circuit having an input connected to the input terminal, is also connected between the output terminal and the second power supply voltage, for pulling down the potential of the output terminal to the potential of the second power supply voltage when the potential on the node is at a low level.
摘要翻译：公开了一种场效应晶体管逻辑电路，其具有在下一级场效应晶体管逻辑电路中连接到输入场效应晶体管的栅极的输出端。场效应晶体管逻辑电路包括具有连接到第一电源电压的漏极的耗尽型晶体管，具有与栅极共同的节点和耗尽型晶体管的源极连接的漏极的增强型晶体管。增强晶体管的栅极连接到输入端子，并且增强型晶体管的源极连接到低于第一电源电压的第二电源电压。在节点和输出端子之间连接一个高电位限制电路，将输出端子的电位降低到接通下一级场效应晶体管逻辑电路的输入场效应晶体管的漏极 - 源极通道的电平但是当节点的电位处于高电平时，它不会打开下一级场效应晶体管逻辑电路的输入场效应晶体管的栅极源。具有连接到输入端子的输入的下降电路也连接在输出端子和第二电源电压之间，用于当电位开启时将输出端子的电位降低到第二电源电压的电位节点处于低电平。

7. 发明授权

US5639735A Antitumor antibiotic compounds: hayumicins and analogs thereof 失效
标题翻译：抗肿瘤抗生素化合物：海马素及其类似物
公开(公告)号：US5639735A
公开(公告)日：1997-06-17
申请号：US308232
申请日：1994-09-19
申请人： Rolf Menzel , Scott T. Taylor , Mitsuaki Tsunakawa , Keiichi Numata , Tamotsu Furumai
发明人： Rolf Menzel , Scott T. Taylor , Mitsuaki Tsunakawa , Keiichi Numata , Tamotsu Furumai
IPC分类号： C12P19/60 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12N1/20 , C12R1/03 , A61K31/71
CPC分类号： C07H17/04
摘要： Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic, particularly antibacterial, activity.
摘要翻译：海马素化合物，可通过培养Actinomadura sp。命名为ATCC 55432，以及这些化合物的类似物。新型化合物具有抗肿瘤和抗生素，特别是抗菌活性。

8. 发明授权

US5619146A Switching speed fluctuation detecting apparatus for logic circuit arrangement 失效
标题翻译：用于逻辑电路布置的开关速度波动检测装置
公开(公告)号：US5619146A
公开(公告)日：1997-04-08
申请号：US604621
申请日：1996-02-21
申请人： Masahiro Fujii , Yasuo Ohno , Tadashi Maeda , Takao Atsumo , Noriaki Matsuno , Keiichi Numata , Nobuhide Yoshida
发明人： Masahiro Fujii , Yasuo Ohno , Tadashi Maeda , Takao Atsumo , Noriaki Matsuno , Keiichi Numata , Nobuhide Yoshida
IPC分类号： G01R31/319 , H03K17/14 , H03K19/00 , H03K19/003
CPC分类号： H03K19/00369 , H03K17/14
摘要： In a switching speed fluctuation detecting apparatus, an input terminal for receiving a signal having a definite time period, a series arrangement of at least one first logic circuit connected to the input terminal, a second logic circuit having a first input connected to the input terminal and a second input connected to an output of the series arrangement and an integrator connected to an output of the second logic circuit are provided.
摘要翻译：在切换速度波动检测装置中，接收具有确定时间段的信号的输入端子，连接到输入端子的至少一个第一逻辑电路的串联布置，具有连接到输入端子的第一输入端的第二逻辑电路并且提供连接到串联装置的输出的第二输入和连接到第二逻辑电路的输出的积分器。

9. 发明授权

US4789731A Semi-synthetic peptide antibiotics 失效
标题翻译：半合成肽抗生素
公开(公告)号：US4789731A
公开(公告)日：1988-12-06
申请号：US115072
申请日：1987-10-30
申请人： Masahisa Oka , Keiichi Numata , Masataka Konishi
发明人： Masahisa Oka , Keiichi Numata , Masataka Konishi
IPC分类号： C07K5/02 , C07K5/12
CPC分类号： C07K5/0215
摘要： Semi-synthetic derivatives of the BU-2867T antibiotics are disclosed. These derivatives are active against experimental mammalian tumors, and may be prepared from enzymatic degradation product(s) of BU-2867T A.
摘要翻译：公布了BU-2867T抗生素的半合成衍生物。这些衍生物对实验性哺乳动物肿瘤是有效的，并且可以由BU-2867T A的酶促降解产物制备。

10. 发明授权

US4742047A Semi-synthetic peptide antibiotics 失效
标题翻译：半合成肽抗生素
公开(公告)号：US4742047A
公开(公告)日：1988-05-03
申请号：US917575
申请日：1986-10-10
申请人： Masahisa Oka , Keiichi Numata , Masataka Konishi
发明人： Masahisa Oka , Keiichi Numata , Masataka Konishi
IPC分类号： C07K5/02 , C07K5/12
CPC分类号： C07K5/0215
摘要： Semi-synthetic derivatives of the BU-2867T antibotics are disclosed. These derivatives are active against experimental mammalian tumors, and may be prepared from enzymatic degradation product(s) of BU-2867T A.
摘要翻译：公布了BU-2867T抗菌剂的半合成衍生物。这些衍生物对实验性哺乳动物肿瘤是有效的，并且可以由BU-2867T A的酶促降解产物制备。

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