专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5639735A Antitumor antibiotic compounds: hayumicins and analogs thereof 失效
标题翻译：抗肿瘤抗生素化合物：海马素及其类似物
公开(公告)号：US5639735A
公开(公告)日：1997-06-17
申请号：US308232
申请日：1994-09-19
申请人： Rolf Menzel , Scott T. Taylor , Mitsuaki Tsunakawa , Keiichi Numata , Tamotsu Furumai
发明人： Rolf Menzel , Scott T. Taylor , Mitsuaki Tsunakawa , Keiichi Numata , Tamotsu Furumai
IPC分类号： C12P19/60 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12N1/20 , C12R1/03 , A61K31/71
CPC分类号： C07H17/04
摘要： Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic, particularly antibacterial, activity.
摘要翻译：海马素化合物，可通过培养Actinomadura sp。命名为ATCC 55432，以及这些化合物的类似物。新型化合物具有抗肿瘤和抗生素，特别是抗菌活性。

2. 发明授权

US5744314A Periplasmic membrane-bound system for detecting protein-protein interactions 失效
标题翻译：用于检测蛋白质 - 蛋白质相互作用的周质膜结合系统
公开(公告)号：US5744314A
公开(公告)日：1998-04-28
申请号：US642552
申请日：1996-05-03
申请人： Rolf Menzel , Scott T. Taylor
发明人： Rolf Menzel , Scott T. Taylor
IPC分类号： G01N33/566 , C07K14/035 , C07K14/16 , C07K14/28 , C07K14/71 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/63 , C12N15/12
CPC分类号： C12Q1/6897 , C07K14/005 , C07K14/28 , C07K14/71 , C12N15/62 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/61 , C07K2319/715 , C07K2319/73 , C12N2710/16622 , C12N2740/16222
摘要： The present invention relates to: (1) a fusion protein having a dimerizing domain with or without a ligand-binding region and toxR DNA-binding and hydrophobic transmembrane regions; (2) host cells comprising the fusion protein and a nucleic acid molecule having a reporter gene operatively linked to the ctx operon, wherein dimerization (ligand-dependent or -independent) is signaled by expression of the reporter gene; (3) a nucleic acid molecule coding for the fusion protein; (4) an expression vector comprising a coding region for the fusion protein;(5) a process for detecting dimer formation (ligand dependent or ligand independent) of the fusion protein, which comprises treating a culture of the host cells with a ligand, ligand mimetic, or dimerization inhibitor, and screening for expression of the reporter gene. The present invention can be used to generate a signal from a variety of ligand-binding domains, allowing ligand binding to be indicated by a simple colorimeteric test or antibiotic resistance. The fusion proteins could include therapeutically relevant domains, so that biologically pertinent interactions can be indicated by a readily measurable signal.
摘要翻译：本发明涉及：（1）具有具有或不具有配体结合区和toxR DNA结合和疏水跨膜区的二聚结构域的融合蛋白; （2）包含融合蛋白的宿主细胞和具有可操作地连接到ctx操纵子的报告基因的核酸分子，其中通过报告基因的表达来发出二聚（配体依赖或不依赖）信号通路; （3）编码融合蛋白的核酸分子; （4）包含融合蛋白的编码区的表达载体; （5）检测融合蛋白的二聚体形成（配体依赖性或配体相关性）的方法，其包括用配体，配体模拟物或二聚抑制剂处理宿主细胞的培养物，以及筛选报道基因的表达。本发明可用于产生来自各种配体结合结构域的信号，允许通过简单的色度计测试或抗生素抗性来指示配体结合。融合蛋白可以包括治疗相关的结构域，使得生物相关的相互作用可以通过容易测量的信号来指示。

3. 发明授权

US07027668B2 Optical modulators with coplanar-waveguide-to-coplanar-strip electrode transitions 有权
公开(公告)号：US07027668B2
公开(公告)日：2006-04-11
申请号：US10427982
申请日：2003-05-02
申请人： Robert F. Tavlykaev , Ganesh K. Gopalakrishnan , Scott T. Taylor
发明人： Robert F. Tavlykaev , Ganesh K. Gopalakrishnan , Scott T. Taylor
IPC分类号： G02B6/26 , G02B6/10 , G02F1/035 , G02F1/295
CPC分类号： G02F1/0316 , G02F1/0356 , G02F2201/126 , G02F2201/127
摘要： The present invention relates to an optical modulator including an optical waveguide, and at least one CPW-to-CPS transition. The CPW segments include a hot electrode; and a ground plane disposed on each side of the hot electrode, and they share a ground plane. The CPS segment extends along an interaction length of the modulator. In one embodiment, two driving signals are applied so that the modulator operates as a dual-drive modulator. In another embodiment, a domain-inverted region is formed in a substrate of the dual-drive modulator to overlap with one arm of the optical waveguide (MZI) and invert a sign of a phase shift induced in that arm. Finally, a fixed chirp can be introduced into the dual-drive modulator by asymmetrically positioning the interferometer arms into gaps of the CPW segments with respect to the hot electrode, and by employing unequal width gaps in the CPW segments.

4. 发明授权

US5656495A Expression vector for human topoisomerase I 失效
标题翻译：人拓扑异构酶I的表达载体
公开(公告)号：US5656495A
公开(公告)日：1997-08-12
申请号：US376164
申请日：1995-01-20
申请人： Rolf Menzel , Scott T. Taylor
发明人： Rolf Menzel , Scott T. Taylor
IPC分类号： C12N15/09 , C12N1/21 , C12N9/90 , C12N15/61 , C12Q1/02 , C12Q1/34 , C12Q1/533 , C12R1/19 , C12N15/70 , C07H21/04
CPC分类号： C12N9/90
摘要： Expression vectors for human topoisomerase I and a method for detecting poisons of human topoisomerase I. The vector preferably contains a promoter, DNA coding for human topoisomerase I, DNA coding for a selectable marker, an origin of replication, and lac I.sup.q DNA which encodes a repressor for the promoter.
摘要翻译：用于人拓扑异构酶I的表达载体和用于检测人拓扑异构酶I的毒物的方法。载体优选含有启动子，编码人拓扑异构酶I的DNA，编码选择性标记的DNA，复制起点和编码阻遏剂为启动子。

5. 发明授权

US5521066A Periplasmic membrane-bound system for detecting protein-protein interactions 失效
标题翻译：用于检测蛋白质 - 蛋白质相互作用的周质膜结合系统
公开(公告)号：US5521066A
公开(公告)日：1996-05-28
申请号：US121201
申请日：1993-09-13
申请人： Rolf Menzel , Scott T. Taylor
发明人： Rolf Menzel , Scott T. Taylor
IPC分类号： G01N33/566 , C07K14/035 , C07K14/16 , C07K14/28 , C07K14/71 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/63 , C12N15/12
CPC分类号： C12Q1/6897 , C07K14/005 , C07K14/28 , C07K14/71 , C12N15/62 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/61 , C07K2319/715 , C07K2319/73 , C12N2710/16622 , C12N2740/16222
摘要： The present invention relates to:(1) a fusion protein having a dimerizing domain with or without a ligand-binding region and toxR DNA-binding and hydrophobic transmembrane regions;(2) host cells comprising the fusion protein and a nucleic acid molecule having a reporter gene operatively linked to the ctx operon, wherein dimerization (ligand-dependent or -independent) is signaled by expression of the reporter gene;(3) a nucleic acid molecule coding for the fusion protein;(4) an expression vector comprising a coding region for the fusion protein;(5) a process for detecting dimer formation (ligand dependent or ligand independent) of the fusion protein, which comprises treating a culture of the host cells with a ligand, ligand mimetic, or dimerization inhibitor, and screening for expression of the reporter gene.The present invention can be used to generate a signal from a variety of ligand-binding domains, allowing ligand binding to be indicated by a simple colorimetric test or antibiotic resistance. The fusion proteins could include therapeutically relevant domains, so that biologically pertinent interactions can be indicated by a readily measurable signal.
摘要翻译：本发明涉及：（1）具有具有或不具有配体结合区和toxR DNA结合和疏水跨膜区的二聚结构域的融合蛋白; （2）包含融合蛋白的宿主细胞和具有可操作地连接到ctx操纵子的报告基因的核酸分子，其中通过报告基因的表达来发出二聚（配体依赖或不依赖）信号通路; （3）编码融合蛋白的核酸分子; （4）包含融合蛋白的编码区的表达载体; （5）检测融合蛋白的二聚体形成（配体依赖性或配体相关性）的方法，其包括用配体，配体模拟物或二聚抑制剂处理宿主细胞的培养物，以及筛选报道基因的表达。本发明可用于产生来自各种配体结合结构域的信号，允许通过简单的比色测试或抗生素抗性来指示配体结合。融合蛋白可以包括治疗相关的结构域，使得生物相关的相互作用可以通过容易测量的信号来指示。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式