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1. 发明授权

US06433142B1 Megakaryocyte stimulating factors 失效
标题翻译：巨核细胞刺激因子
公开(公告)号：US06433142B1
公开(公告)日：2002-08-13
申请号：US07757022
申请日：1991-09-10
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K1452
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译：提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞刺激因子（MSFS），含有其的药物组合物及其制备和使用方法。

2. 发明授权

US07361738B2 Megakaryocyte stimulating factors 失效
标题翻译：巨核细胞刺激因子
公开(公告)号：US07361738B2
公开(公告)日：2008-04-22
申请号：US11169232
申请日：2005-06-28
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K14/47 , C12N15/10 , C12P21/02
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译：人类巨核细胞刺激因子（MSF）的新型多肽。提供含有其的药物组合物及其制备和使用方法。

3. 发明授权

US5326558A Megakaryocytopoietic factor 失效
标题翻译：巨核细胞生成因子
公开(公告)号：US5326558A
公开(公告)日：1994-07-05
申请号：US546114
申请日：1990-06-29
申请人： Katherine Turner , Steven C. Clark , Thomas G. Gesner , Rodney M. Hewick
发明人： Katherine Turner , Steven C. Clark , Thomas G. Gesner , Rodney M. Hewick
IPC分类号： A61K38/00 , A61P7/04 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/53 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/19 , C07K15/00 , A61K37/02
CPC分类号： C07K14/53 , A61K38/00 , Y10S530/82 , Y10S530/827 , Y10S930/14 , Y10S930/145
摘要： A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
摘要翻译：提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞生成因子，包括其纯化和用作药剂的方法。

4. 发明授权

US07030223B2 Megakaryocyte stimulating factors 失效
公开(公告)号：US07030223B2
公开(公告)日：2006-04-18
申请号：US10124557
申请日：2002-04-16
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K14/475 , C07K14/47 , C12N15/12 , C12P21/02
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.

5. 发明授权

US06555658B2 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06555658B2
公开(公告)日：2003-04-29
申请号：US09924703
申请日：2001-08-09
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

6. 发明授权

US06300478B1 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06300478B1
公开(公告)日：2001-10-09
申请号：US09325958
申请日：1999-06-04
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子，天然杀伤刺激因子（NKSF），NKSF反应的抗体以及含有该抗体的药物制剂。

7. 发明授权

US5460810A Method for maintaining gut epithelial cells by treatment with a cytokine such as interleukin 11 失效
标题翻译：用细胞因子如白细胞介素11处理维持肠上皮细胞的方法
公开(公告)号：US5460810A
公开(公告)日：1995-10-24
申请号：US941372
申请日：1992-09-02
申请人： David A. Williams , Steven C. Clark
发明人： David A. Williams , Steven C. Clark
IPC分类号： A61K38/00 , A61K38/18 , A61K38/20 , A61P1/00 , A61P43/00 , C07K14/54 , C12N9/02 , A61K38/19
CPC分类号： C07K14/5431 , A61K38/204 , C12N9/0036 , C12Y108/01008 , A61K38/00 , Y10S514/867 , Y10S514/908
摘要： A method for reducing damage or depletion of gut epithelial cells (e.g., as a result of radiation therapy or chemotherapy) by administration of one or more of the following cytokines: interleukin 11 (IL-11), interleukin 6 (IL-6), leukemia inhibitory factor/cholinergic differentiation factor (LIF/CDF), oncostatin M (OSM), or ciliary neurotrophic factor (CNTF).
摘要翻译：通过施用以下一种或多种细胞因子来减少肠上皮细胞损伤或消耗的方法（例如，作为放射治疗或化疗的结果）：白细胞介素11（IL-11），白介素6（IL-6），白血病抑制因子/胆碱能分化因子（LIF / CDF），制瘤素M（OSM）或睫状神经营养因子（CNTF）。

8. 发明授权

US4675285A Method for identification and isolation of DNA encoding a desired protein 失效
标题翻译：用于鉴定和分离编码所需蛋白质的DNA的方法
公开(公告)号：US4675285A
公开(公告)日：1987-06-23
申请号：US652316
申请日：1984-09-19
申请人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
发明人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
IPC分类号： C07K14/53 , C12N15/10 , C12N15/85 , C12Q1/68 , C12N5/00 , C12N15/00 , C12P21/00
CPC分类号： C12N15/1086 , C07K14/53 , C12N15/85
摘要： A method for identifying and isolating clones containing DNA coding for a desired protein is described. DNA prepared from a cell that expresses the desired protein is inserted into an isolation expression vector having means for replication (as a means of producing DNA) and a suitable promoter for expression of said DNA in a predetermined mammalian host cell as well as means for replication in a bacterial cell. The transient expression vector is then inserted into a bacterial cell for replication of the DNA. Pools of DNA, prepared from a predetermined number of bacterial clones so that the nucleic acids (DNA and RNA) is substantially free of other bacterial contaminants are transfected or microinjected into mammalian host cells and conditioned medium from growing such cells is tested for the presence of the desired protein. Positive pools are selected and the clones used to make the pool are screened to identify and isolate the clone containing the desired DNA.
摘要翻译：描述了鉴定和分离含有编码所需蛋白质的DNA的克隆的方法。将从表达所需蛋白质的细胞制备的DNA插入具有复制方式的分离表达载体（作为生产DNA的手段）和用于在预定哺乳动物宿主细胞中表达所述DNA的合适启动子以及复制手段在细菌细胞中。然后将瞬时表达载体插入用于DNA复制的细菌细胞中。从预定数量的细菌克隆制备DNA，使得核酸（DNA和RNA）基本上不含其它细菌污染物的DNA转染或显微注射到哺乳动物宿主细胞中，并测试来自培养这样的细胞的条件培养基的存在所需蛋白质。选择阳性池，筛选用于制备池的克隆以鉴定并分离含有所需DNA的克隆。

9. 发明授权

US06284237B1 Methods of treatment using IL-6 失效
标题翻译：使用IL-6治疗方法
公开(公告)号：US06284237B1
公开(公告)日：2001-09-04
申请号：US08224985
申请日：1994-04-06
申请人： Steven C. Clark , Gordon G. Wong , Paul Schendel , John McCoy
发明人： Steven C. Clark , Gordon G. Wong , Paul Schendel , John McCoy
IPC分类号： A61K3820
CPC分类号： C07K14/5412 , A61K38/2013 , A61K38/204 , A61K38/217 , A61K39/395 , Y10S514/885 , A61K2300/00
摘要： IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.
摘要翻译：通过重组DNA技术产生IL-6。该肽可用于治疗以造血细胞缺陷为特征的疾病，并与癌症治疗中的其它造血素组合。

10. 发明授权

US5569454A Methods of treating infection using natural killer stimulatory factor 失效
标题翻译：使用自然杀伤刺激因子治疗感染的方法
公开(公告)号：US5569454A
公开(公告)日：1996-10-29
申请号：US403086
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K38/20
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.
摘要翻译：公开了使用天然杀伤刺激因子（NKSF）治疗感染的方法。

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