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1. 发明授权

US07122633B2 Natural killer stimulatory factor 失效
标题翻译：自然杀伤刺激因子
公开(公告)号：US07122633B2
公开(公告)日：2006-10-17
申请号：US10358395
申请日：2003-02-05
申请人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K14/64
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

2. 发明授权

US5811523A Antibodies to natural killer stimulatory factor 失效
公开(公告)号：US5811523A
公开(公告)日：1998-09-22
申请号：US956240
申请日：1997-10-22
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24
CPC分类号： C07K14/5434 , C07K14/52 , A61K38/00
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.

3. 发明申请

US20070104680A1 Antibodies to natural killer stimulatory factor 审中-公开
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US20070104680A1
公开(公告)日：2007-05-10
申请号：US11504768
申请日：2006-08-16
申请人： Giorgio Trinchieri , Bice Perussia , Stanley Wolf , Steven Clark , Gordon Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Stanley Wolf , Steven Clark , Gordon Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： A61K38/19 , A61K38/20 , A61K38/18 , C07K14/52 , C07H21/04 , C12P21/02
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamia interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及具有在人外周血淋巴细胞中诱导体外产生血浆干扰素的能力的新型均质人细胞因子（Natural Killer Stimulator Factor，NKSF）的抗体的抗体和含有该抗体的药物制剂。

4. 发明授权

US5569454A Methods of treating infection using natural killer stimulatory factor 失效
标题翻译：使用自然杀伤刺激因子治疗感染的方法
公开(公告)号：US5569454A
公开(公告)日：1996-10-29
申请号：US403086
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K38/20
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.
摘要翻译：公开了使用天然杀伤刺激因子（NKSF）治疗感染的方法。

5. 发明授权

US06555658B2 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06555658B2
公开(公告)日：2003-04-29
申请号：US09924703
申请日：2001-08-09
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

6. 发明授权

US06300478B1 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06300478B1
公开(公告)日：2001-10-09
申请号：US09325958
申请日：1999-06-04
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子，天然杀伤刺激因子（NKSF），NKSF反应的抗体以及含有该抗体的药物制剂。

7. 发明授权

US5648467A Natural killer cell stimulatory factor 失效
标题翻译：自然杀伤细胞刺激因子
公开(公告)号：US5648467A
公开(公告)日：1997-07-15
申请号：US403013
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K38/20
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
摘要翻译：具有诱导在人外周血淋巴细胞体外产生γ干扰素的能力的新型均质人细胞因子，天然杀伤刺激因子，以及含有它的药物制剂。

8. 发明申请

US20060025570A1 Megakaryocyte stimulating factors 失效
标题翻译：巨核细胞刺激因子
公开(公告)号：US20060025570A1
公开(公告)日：2006-02-02
申请号：US11169232
申请日：2005-06-28
申请人： Katherine Turner , Steven Clark , Kenneth Jacobs , Rodney Hewick , Thomas Gesner
发明人： Katherine Turner , Steven Clark , Kenneth Jacobs , Rodney Hewick , Thomas Gesner
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译：人类巨核细胞刺激因子（MSF）的新型多肽。提供含有它们的药物组合物及其制备和使用方法。

9. 发明申请

US20050014278A1 Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures 失效
标题翻译：酸不稳定同位素编码提取物（ALICE）及其在蛋白质混合物的定量质谱分析中的应用
公开(公告)号：US20050014278A1
公开(公告)日：2005-01-20
申请号：US10919365
申请日：2004-08-17
申请人： Yongchang Qiu , Jack Wang , Rodney Hewick
发明人： Yongchang Qiu , Jack Wang , Rodney Hewick
IPC分类号： G01N27/62 , C07D405/12 , G01N1/28 , G01N30/46 , G01N30/72 , G01N30/88 , G01N33/532 , G01N33/58 , G01N33/68 , G01N33/00
CPC分类号： G01N33/6848 , C07D405/12 , G01N30/461 , G01N30/463 , G01N30/468 , G01N30/7233 , G01N33/532 , G01N33/58 , G01N33/6803 , Y10T436/10 , Y10T436/105831 , Y10T436/13 , Y10T436/24 , Y10T436/25125 , B01D15/362 , B01D15/325
摘要： The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a thiol-reactive group that is used to capture cysteine-containing peptides from all peptide mixtures, an acid-labile linker, and a non-biological polymer. One of the two acid-labile linkers is isotopically labeled and therefore enables the direct quantitation of peptides/proteins through mass spectrometric analysis. Because no functional proteins are required to capture peptides, a higher percentage of organic solvent can be used to solubilize the peptides, particularly hydrophobic peptides, through the binding, washing and eluting steps, thus permitting much better recover of peptides. Moreover, since the peptides are covalently linked to the non-biological polymer (ALICE), more stringent washing is allowed in order to completely remove non-specifically bound species. Finally, peptides captured by ALICE are readily eluted from the polymer support under mild acidic condition with high yield and permit the direct down stream mass spectrometric analysis without any further sample manipulation. In combination with our novel dual column two dimensional liquid chromatography- mass spectrometry (2D-LC-MS/MS) design, the ALICE procedure proves to a general approach for quantitative mass spectrometric analysis of protein mixtures with better dynamic range and sensitivity.
摘要翻译：本发明的方法提供了新的化合物，称为酸不稳定同位素编码的提取物（ALICE），用于蛋白质混合物的定量质谱分析。该化合物含有硫醇反应性基团，其用于从所有肽混合物，酸不稳定接头和非生物聚合物捕获含半胱氨酸的肽。两个酸不稳定接头之一是同位素标记的，因此能够通过质谱分析直接定量肽/蛋白质。由于不需要功能蛋白来捕获肽，所以可以使用较高百分比的有机溶剂来通过结合，洗涤和洗脱步骤来增溶肽，特别是疏水性肽，因此可以更好地恢复肽。此外，由于肽与非生物聚合物（ALICE）共价连接，所以允许更严格的洗涤以完全除去非特异性结合的物质。最后，ALICE捕获的肽在温和的酸性条件下以高产率容易地从聚合物载体上洗脱，并允许直接的下游质谱分析，无需进一步的样品操作。结合我们的双柱二维液相色谱 - 质谱（2D-LC-MS / MS）设计，ALICE方法证明了具有更好的动态范围和灵敏度的蛋白质混合物的定量质谱分析的一般方法。

10. 发明授权

US5648072A Methods of inducing gamma interferon and stimulating blood cell populations using natural killer stimulatory factor 失效
标题翻译：使用自然杀伤刺激因子诱导γ干扰素和刺激血细胞群的方法
公开(公告)号：US5648072A
公开(公告)日：1997-07-15
申请号：US402667
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Michiko Kobayashi , Gordon G. Wong , Rodney Hewick , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Michiko Kobayashi , Gordon G. Wong , Rodney Hewick , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K45/05 , A61K39/00 , C07K1/00
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
摘要翻译：公开了使用自然杀伤刺激因子（NKSF）诱导γ干扰素产生和刺激淋巴细胞群体的方法。

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