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1. 发明授权

US06433142B1 Megakaryocyte stimulating factors 失效
标题翻译：巨核细胞刺激因子
公开(公告)号：US06433142B1
公开(公告)日：2002-08-13
申请号：US07757022
申请日：1991-09-10
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K1452
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译：提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞刺激因子（MSFS），含有其的药物组合物及其制备和使用方法。

2. 发明授权

US07361738B2 Megakaryocyte stimulating factors 失效
标题翻译：巨核细胞刺激因子
公开(公告)号：US07361738B2
公开(公告)日：2008-04-22
申请号：US11169232
申请日：2005-06-28
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K14/47 , C12N15/10 , C12P21/02
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
摘要翻译：人类巨核细胞刺激因子（MSF）的新型多肽。提供含有其的药物组合物及其制备和使用方法。

3. 发明授权

US5326558A Megakaryocytopoietic factor 失效
标题翻译：巨核细胞生成因子
公开(公告)号：US5326558A
公开(公告)日：1994-07-05
申请号：US546114
申请日：1990-06-29
申请人： Katherine Turner , Steven C. Clark , Thomas G. Gesner , Rodney M. Hewick
发明人： Katherine Turner , Steven C. Clark , Thomas G. Gesner , Rodney M. Hewick
IPC分类号： A61K38/00 , A61P7/04 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/53 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/19 , C07K15/00 , A61K37/02
CPC分类号： C07K14/53 , A61K38/00 , Y10S530/82 , Y10S530/827 , Y10S930/14 , Y10S930/145
摘要： A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
摘要翻译：提供能够刺激巨核细胞集落生长发育的新型人类巨核细胞生成因子，包括其纯化和用作药剂的方法。

4. 发明授权

US07030223B2 Megakaryocyte stimulating factors 失效
公开(公告)号：US07030223B2
公开(公告)日：2006-04-18
申请号：US10124557
申请日：2002-04-16
申请人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
发明人： Katherine Turner , Steven C. Clark , Kenneth Jacobs , Rodney M. Hewick , Thomas G. Gesner
IPC分类号： C07K14/475 , C07K14/47 , C12N15/12 , C12P21/02
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.

5. 发明授权

US4610847A Conversion flask for sequential performance apparatus 失效
标题翻译：转炉用于顺序性能设备
公开(公告)号：US4610847A
公开(公告)日：1986-09-09
申请号：US602699
申请日：1984-04-23
申请人： Leroy E. Hood , Michael W. Hunkapiller , William J. Dreyer , Rodney M. Hewick , Anton W. Stark
发明人： Leroy E. Hood , Michael W. Hunkapiller , William J. Dreyer , Rodney M. Hewick , Anton W. Stark
IPC分类号： B01J4/02 , B01J19/00 , C40B40/10 , C40B60/14 , G01N33/483 , G01N35/00 , G01N35/10 , B01J19/26 , G01N33/68
CPC分类号： G01N35/00 , B01J19/0046 , B01J4/02 , B01J2219/00283 , B01J2219/00286 , B01J2219/00398 , B01J2219/00418 , B01J2219/00423 , B01J2219/00495 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00725 , C40B40/10 , C40B60/14 , G01N35/1079
摘要： Conversion flask for use is an apparatus for the sequential performance of chemical processes on a sample of chemical material. The flask includes at least three capillary tubes and a large bore tube extending into the interior thereof for the introduction and withdrawal of various fluids. The capillary tubes are constructed to introduce a plurality of fine bubbles into a liquid within the flask to agitate the liquid and accelerate drying, to impinge chemicals on the walls of the flask, and to produce a spray onto the interior walls of the flask in proximity to its upper end to wash down the interior walls of the flask.
摘要翻译：用于使用的转炉是用于在化学材料样品上顺序执行化学过程的装置。烧瓶包括至少三个毛细管和延伸到其内部的用于引入和取出各种流体的大孔管。毛细管被构造成将多个细小气泡引入烧瓶内的液体中以搅拌液体并加速干燥，将化学物质撞击在烧瓶的壁上，并在接近的温度下在烧瓶的内壁上产生喷雾到其上端以冲洗烧瓶的内壁。

6. 发明授权

US4603114A Method for the sequential performance of chemical processes 失效
标题翻译：化学过程顺序性能的方法
公开(公告)号：US4603114A
公开(公告)日：1986-07-29
申请号：US602516
申请日：1984-04-20
申请人： Leroy E. Hood , Michael W. Hunkapiller , William J. Dreyer , Rodney M. Hewick , Anton W. Stark
发明人： Leroy E. Hood , Michael W. Hunkapiller , William J. Dreyer , Rodney M. Hewick , Anton W. Stark
IPC分类号： B01J4/02 , B01J19/00 , C40B40/10 , C40B60/14 , G01N33/483 , G01N33/68 , G01N35/00 , G01N35/10 , G01N1/18 , G01N33/48
CPC分类号： G01N33/6818 , B01J19/0046 , B01J4/02 , G01N35/00 , B01J2219/00283 , B01J2219/00286 , B01J2219/00398 , B01J2219/00418 , B01J2219/00423 , B01J2219/00495 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00725 , C40B40/10 , C40B60/14 , G01N35/1079 , Y10T436/25
摘要： An improved method for the sequential performance of chemical processes on a sample of chemical material wherein the sample is embedded in a solid matrix of fluid permeable material located within a reaction chamber and is sequentially subjected to a plurality of fluids passed through the chamber in a pressurized stream, causing chemical interaction between the sample and the fluids.
摘要翻译：一种用于在化学材料样品上顺序执行化学过程的改进方法，其中样品被嵌入在位于反应室内的流体可渗透材料的固体基质中，并且依次经受多个流体通过加压室流，导致样品和流体之间的化学相互作用。

7. 发明授权

US06905879B2 Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry 失效
标题翻译：使用基质辅助激光解吸电离质谱法进行高通量蛋白质鉴定和定量的同位素编码电离增强试剂（ICIER）
公开(公告)号：US06905879B2
公开(公告)日：2005-06-14
申请号：US10044708
申请日：2001-10-22
申请人： Yongchang Qiu , Jack H. Wang , Rodney M. Hewick
发明人： Yongchang Qiu , Jack H. Wang , Rodney M. Hewick
IPC分类号： G01N27/62 , G01N27/447 , G01N27/64 , G01N33/483 , G01N33/68 , G01N33/00
CPC分类号： G01N33/6848 , G01N33/6851 , G01N2458/15 , Y10T436/13 , Y10T436/24 , Y10T436/25125
摘要： Arginine-containing cysteine-modifying compounds useful for MALDI-MS analysis of proteins are provided. These compounds termed isotope-coded ionization enhancement reagents (ICIER) can provide ionization enhancement in MALDI-MS, relative quantitation, and additional database searching constraints at the same time without any extra sample manipulation. More specifically, ICIER increase the ionization efficiency of cysteine-containing peptides by attachment of a guanidino functional group. ICIER also increase the overall hydrophilicity of these peptides due to the hydrophilic nature of ICIER and thus increase the percentage of recovery of these peptides during sample handling and processing such as in-gel digestion or liquid chromatography. Finally, a combination of both light and heavy ICIER provides an accurate way to obtain relative quantitation of proteins by MALDI-MS and additional database searching constraints (number of cysteine residues in every single peptide peak) to increase the confidence of protein identification by peptide mass mapping.
摘要翻译：提供了可用于蛋白质MALDI-MS分析的含精氨酸的半胱氨酸修饰化合物。这些称为同位素编码电离增强试剂（ICIER）的化合物可以在MALDI-MS中提供电离增强，相对定量和额外的数据库搜索约束，同时没有任何额外的样品操作。更具体地，ICIER通过连接胍基官能团来增加含半胱氨酸的肽的电离效率。由于ICIER的亲水性，ICIER还增加了这些肽的整体亲水性，因此在样品处理和加工（如凝胶内消化或液相色谱）期间增加了这些肽的回收百分比。最后，轻和重的ICIER的组合提供了通过MALDI-MS和附加的数据库搜索约束（每个肽峰中的半胱氨酸残基数）获得蛋白质的相对定量的精确方式，以增加肽质量的蛋白质鉴定的置信度映射。

8. 发明授权

US07378392B1 Bone and cartilage inductive proteins 失效
标题翻译：骨和软骨诱导蛋白
公开(公告)号：US07378392B1
公开(公告)日：2008-05-27
申请号：US08319831
申请日：1994-10-06
申请人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
发明人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
IPC分类号： A61K38/18 , C07K14/435 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的软骨和/或骨诱导蛋白及其制备方法。蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。

9. 发明授权

US07122377B2 Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures 失效
标题翻译：酸不稳定同位素编码提取物（ALICE）及其在蛋白质混合物的定量质谱分析中的应用
公开(公告)号：US07122377B2
公开(公告)日：2006-10-17
申请号：US10919365
申请日：2004-08-17
申请人： Yongchang Qiu , Jack H. Wang , Rodney M. Hewick
发明人： Yongchang Qiu , Jack H. Wang , Rodney M. Hewick
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , C07D405/12 , G01N30/461 , G01N30/463 , G01N30/468 , G01N30/7233 , G01N33/532 , G01N33/58 , G01N33/6803 , Y10T436/10 , Y10T436/105831 , Y10T436/13 , Y10T436/24 , Y10T436/25125 , B01D15/362 , B01D15/325
摘要： The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a thiol-reactive group that is used to capture cysteine-containing peptides from all peptide mixtures, an acid-labile linker, and a non-biological polymer. One of the two acid-labile linkers is isotopically labeled and therefore enables the direct quantitation of peptides/proteins through mass spectrometric analysis. Because no functional proteins are required to capture peptides, a higher percentage of organic solvent can be used to solubilize the peptides, particularly hydrophobic peptides, through the binding, washing and eluting steps, thus permitting much better recover of peptides. Moreover, since the peptides are covalently linked to the non-biological polymer (ALICE), more stringent washing is allowed in order to completely remove non-specifically bound species. Finally, peptides captured by ALICE are readily eluted from the polymer support under mild acidic condition with high yield and permit the direct down stream mass spectrometric analysis without any further sample manipulation. In combination with our novel dual column two dimensional liquid chromatography-mass spectrometry (2D-LC-MS/MS) design, the ALICE procedure proves to a general approach for quantitative mass spectrometric analysis of protein mixtures with better dynamic range and sensitivity.
摘要翻译：本发明的方法提供了新的化合物，称为酸不稳定同位素编码的提取物（ALICE），用于蛋白质混合物的定量质谱分析。该化合物含有硫醇反应性基团，其用于从所有肽混合物，酸不稳定接头和非生物聚合物捕获含半胱氨酸的肽。两个酸不稳定接头之一是同位素标记的，因此能够通过质谱分析直接定量肽/蛋白质。由于不需要功能蛋白来捕获肽，所以可以使用较高百分比的有机溶剂来通过结合，洗涤和洗脱步骤来增溶肽，特别是疏水性肽，从而可以更好地恢复肽。此外，由于肽与非生物聚合物（ALICE）共价连接，所以允许更严格的洗涤以完全除去非特异性结合的物质。最后，ALICE捕获的肽在温和的酸性条件下以高产率容易地从聚合物载体上洗脱，并允许直接的下游质谱分析，无需进一步的样品操作。结合我们的双柱二维液相色谱 - 质谱（2D-LC-MS / MS）设计，ALICE方法证明了具有更好的动态范围和灵敏度的蛋白质混合物的定量质谱分析的一般方法。

10. 发明授权

US5688678A DNA encoding and methods for producing BMP-8 proteins 失效
标题翻译： DNA编码和产生BMP-8蛋白的方法
公开(公告)号：US5688678A
公开(公告)日：1997-11-18
申请号：US800364
申请日：1991-11-26
申请人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
发明人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
IPC分类号： A61K38/00 , C07K14/51 , C12N1/21 , C12N15/16
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的软骨和/或骨诱导蛋白及其制备方法。蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。

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