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1. 发明授权

US06398962B1 Use of monolithic sorbents for preparative chromatographic separation 有权
标题翻译：使用整体吸附剂进行制备色谱分离
公开(公告)号：US06398962B1
公开(公告)日：2002-06-04
申请号：US09445585
申请日：2000-05-19
申请人： Karin Cabrera , Dieter Lubda , Michael Schulte , Andreas Meudt , Olivier Ludemann-Hombourger , Gerhard Wieland , Kristina Czerny , Axel Delp , Edith Dicks , Alexander Kraus
发明人： Karin Cabrera , Dieter Lubda , Michael Schulte , Andreas Meudt , Olivier Ludemann-Hombourger , Gerhard Wieland , Kristina Czerny , Axel Delp , Edith Dicks , Alexander Kraus
IPC分类号： B01D1508
CPC分类号： B01J20/283 , B01D15/1821 , B01D2215/023 , B01J20/103 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/28016 , B01J20/28042 , B01J20/28083 , B01J20/28085 , B01J20/28092 , B01J20/286 , B01J20/29 , B01J20/3078 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3227 , B01J20/3246 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3257 , B01J20/3261 , B01J20/3263 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J2220/52 , B01J2220/54 , B01J2220/56 , B01J2220/58 , B01J2220/82 , G01N2030/324 , G01N2030/528
摘要： The invention relates to use of monolithic sorbents for preparative separation processes, specially for processes according to the simulated moving bed (SMB) principle.
摘要翻译：本发明涉及用于制备分离方法的整体吸附剂，特别适用于根据模拟移动床（SMB）原理的方法。

2. 发明申请

US20100108546A1 CONTAINER FOR A PLURALITY OF TEST STRIPS 有权
标题翻译：集装箱大量的测试条
公开(公告)号：US20100108546A1
公开(公告)日：2010-05-06
申请号：US12593445
申请日：2008-02-29
申请人： Peter Mueller , Horst Langkau , Berthold WAGNER , Gerhard Wieland , Norbert Stork , Stefan Bernhard
发明人： Peter Mueller , Horst Langkau , Berthold WAGNER , Gerhard Wieland , Norbert Stork , Stefan Bernhard
IPC分类号： B65D85/38
CPC分类号： G01N33/48778 , B65D47/0852 , B65D83/0847
摘要： A container (1) for a plurality of test strips, in particular for strip-shaped indicator sticks, has a housing lower part (2) and a housing upper part (3), which can be brought into engagement with the housing lower part (2) in a positive manner, where the housing upper part (3) has an opening with a sealing flap (14) mounted in a pivotable manner, where the housing lower part (2) has a plurality of projecting snap-in elements (7), which can be brought into engagement with matched recesses (10) of the housing upper part (3), and where the sealing flap (14) is connected along its periphery to the housing upper part (3) by means of at least one connecting strip which can be torn off. The snap-in elements (7) project by more than one wall thickness of the housing upper part (3) in the region around the recesses (10). The sealing flap (14) preferably has a tear-off connecting strip on each of two opposite sides. The sealing flap (14) is preferably mounted in a pivotable manner on the housing lid (15) of the housing upper part (3) and forms a corner (13) of the housing upper part (3). The length of the sealing flap (14) along the housing lid (15) is preferably less than the length of the sealing flap (14) along the side wall (24) of the housing upper part (3).
摘要翻译：用于多个测试条的容器（1），特别是带状指示棒，具有壳体下部（2）和壳体上部（3），其可以与壳体下部（ 2）以积极的方式，其中壳体上部（3）具有带有以可枢转方式安装的密封翼片（14）的开口，其中壳体下部（2）具有多个突出的卡入元件（7）），其可以与壳体上部（3）的匹配的凹部（10）接合，并且其中密封翼片（14）沿其周边通过至少一个连接到壳体上部（3）而连接到壳体上部可拆卸的连接条。卡扣元件（7）在凹部（10）周围的区域中由壳体上部（3）的多于一个壁厚突出。密封翼片（14）优选地在两个相对侧的每一侧上具有撕开连接条。密封翼（14）优选地以可枢转的方式安装在壳体上部（3）的壳体盖（15）上并且形成壳体上部（3）的角部（13）。沿着壳体盖（15）的密封翼片（14）的长度优选小于沿着壳体上部（3）的侧壁（24）的密封翼片（14）的长度。

3. 发明授权

US07997435B2 Container for a plurality of test strips 有权
标题翻译：用于多个测试条的容器
公开(公告)号：US07997435B2
公开(公告)日：2011-08-16
申请号：US12593445
申请日：2008-02-29
申请人： Peter Mueller , Horst Langkau , Berthold Wagner , Gerhard Wieland , Norbert Stork , Stefan Bernhard
发明人： Peter Mueller , Horst Langkau , Berthold Wagner , Gerhard Wieland , Norbert Stork , Stefan Bernhard
IPC分类号： B65D41/32
CPC分类号： G01N33/48778 , B65D47/0852 , B65D83/0847
摘要： A container (1) for a plurality of test strips, in particular for strip-shaped indicator sticks, has a housing lower part (2) and a housing upper part (3), which can be brought into engagement with the housing lower part (2) in a positive manner, where the housing upper part (3) has an opening with a sealing flap (14) mounted in a pivotable manner, where the housing lower part (2) has a plurality of projecting snap-in elements (7), which can be brought into engagement with matched recesses (10) of the housing upper part (3), and where the sealing flap (14) is connected along its periphery to the housing upper part (3) by means of at least one connecting strip which can be torn off. The snap-in elements (7) project by more than one wall thickness of the housing upper part (3) in the region around the recesses (10). The sealing flap (14) preferably has a tear-off connecting strip on each of two opposite sides. The sealing flap (14) is preferably mounted in a pivotable manner on the housing lid (15) of the housing upper part (3) and forms a corner (13) of the housing upper part (3). The length of the sealing flap (14) along the housing lid (15) is preferably less than the length of the sealing flap (14) along the side wall (24) of the housing upper part (3).
摘要翻译：用于多个测试条的容器（1），特别是带状指示棒，具有壳体下部（2）和壳体上部（3），其可以与壳体下部（ 2）以积极的方式，其中壳体上部（3）具有带有以可枢转方式安装的密封翼片（14）的开口，其中壳体下部（2）具有多个突出的卡入元件（7）），其可以与壳体上部（3）的匹配的凹部（10）接合，并且其中密封翼片（14）沿其周边通过至少一个连接到壳体上部（3）而连接到壳体上部可拆卸的连接条。卡扣元件（7）在凹部（10）周围的区域中由壳体上部（3）的多于一个壁厚突出。密封翼片（14）优选地在两个相对侧的每一侧上具有撕开连接条。密封翼（14）优选地以可枢转的方式安装在壳体上部（3）的壳体盖（15）上并且形成壳体上部（3）的角部（13）。沿着壳体盖（15）的密封翼片（14）的长度优选小于沿着壳体上部（3）的侧壁（24）的密封翼片（14）的长度。

4. 发明申请

US20110178580A1 ENHANCED ANTI-MICROBIAL PDT 有权
标题翻译：增强抗微生物PDT
公开(公告)号：US20110178580A1
公开(公告)日：2011-07-21
申请号：US13006274
申请日：2011-01-13
申请人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
发明人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity includes the steps of administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensitizer. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580 nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：本发明提供增强的方法和改进的装置，以消除，减少，破坏和/或抑制不期望的体液物质，例如病原体微生物和复杂环境如血液，血清和其它体液中的恶化或恶性细胞。在优选的实施方案中，本发明提供了在复合体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的抗微生物PDT治疗。增强抗菌PDT活性的方法包括以下步骤：在细菌污染的流体与光敏剂通过通道引导细菌污染的流体停留时间之后，向细菌污染的流体施用光敏剂，优选以间歇的方式发射辐射，并将经处理的体液恢复到对应的身体地区。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。优选的装置实施例包括分开或依次布置的引导通道和至少一个电磁辐射源。优选地，激光装置或LED面板用于递送电磁辐射以激活光敏剂。当与基于Safranin O的优选光敏剂组合物一起使用时，优选的激光辐射波长在500-580nm的范围内。此外，本发明通过中和病原微生物片段的生物活性来减少不良宿主的炎症反应，还原和/或除去负责其的病原微生物片段。

5. 发明授权

US5102804A Karl-Fischer reagent, kit, and a process for the determination of water with the aid of this reagent 失效
标题翻译： KARL-FISCHER试剂，工具包，以及用该试剂援助确定水的方法
公开(公告)号：US5102804A
公开(公告)日：1992-04-07
申请号：US633848
申请日：1990-12-26
申请人： Wolfgang Fischer , Gerhard Wieland , Karl-Dieter Krenn
发明人： Wolfgang Fischer , Gerhard Wieland , Karl-Dieter Krenn
IPC分类号： G01N31/00 , G01N31/16 , G01N31/22
CPC分类号： G01N31/168
摘要： The invention relates to a Karl-Fischer reagent, kit and a process for the determination of water with the aid of this reagent, which contains, instead of iodine, an approximately equimolar amount of iodine halides and salts of aromatic nitrogen-containing heterocyclic compounds.
摘要翻译：本发明涉及卡尔费休试剂，试剂盒和借助于该试剂测定水的方法，该试剂包含代替碘的近似等摩尔量的碘卤化物和芳族含氮杂环化合物的盐。

6. 发明授权

US4964521A Ampuls and apparatus thereon for opening same 失效
标题翻译：安瓿及其上用于打开它的装置
公开(公告)号：US4964521A
公开(公告)日：1990-10-23
申请号：US322385
申请日：1989-03-13
申请人： Gerhard Wieland , Klaus Steckenreuter , Wolfgang Gernand , Helmut Simgen
发明人： Gerhard Wieland , Klaus Steckenreuter , Wolfgang Gernand , Helmut Simgen
IPC分类号： B65D51/20 , A61J1/06 , A61M5/315 , B01L3/00 , B65D51/22
CPC分类号： B65D51/228 , B01L3/569 , B65D2251/0015 , B65D2251/0096 , Y10S215/902
摘要： The invention relates to opening aids for an ampul which is closed by upper and lower plastic membranes. The opening aids are funnel-shaped sleeves, one of which contains a membrane welded to one of the plastic membranes closing the ampul, and the other of which includes a plastic punch for rupturing the upper membrane.
摘要翻译：本发明涉及一种用于上下塑料膜封闭的安瓿的开启助剂。开口助剂是漏斗形套管，其中一个套管包含一个与封闭安瓿的塑料膜之一焊接的膜，另一个包括用于破裂上膜的塑料冲头。

7. 发明授权

US08505434B2 Fire guidance device for a hand fire weapon 有权
标题翻译：手火消防武器消防导弹装置
公开(公告)号：US08505434B2
公开(公告)日：2013-08-13
申请号：US12838312
申请日：2010-07-16
申请人： Gerhard Wieland
发明人： Gerhard Wieland
IPC分类号： F41G3/08
CPC分类号： F41G1/473 , F41G1/48 , F41G3/06 , F41G3/16
摘要： A fire guidance device for a hand fired weapon is suitable for day and night deployment for large caliber and slow flying ammunition or missiles, such as, for example, 40 mm grenade throwers and anti tank weapons. The fire guidance device also serves to determine and automatically adjust a set-up angle for adjustment of ballistics, and a lateral angle for spin correction. The fire guidance device is attached to the weapon so it can be tilted automatically or manually and twisting is thereby dependent upon a required set-up angle of the weapon so that direct view, by the operator, to the target is preserved. For spin correction, a defined angle in horizontal orientation is adjusted between axes of the fire guidance device and the weapon. Alternatively, the fire guidance device is mounted vertically and a required cant (tilt) is then indicated in a display, followed by tilt adjustment.
摘要翻译：用于手持式武器的消防导弹装置适用于大口径和慢速弹药或导弹的白天和黑夜部署，例如40毫米榴弹炮和反坦克武器。消防引导装置还用于确定并自动调整用于调整弹道的设置角度和自旋校正的横向角度。消防引导装置附接到武器，使其可以自动或手动地倾斜，从而扭转武器的所需设置角度，从而保持操作者直接观察目标。对于旋转校正，水平方向的限定角度在火灾引导装置和武器的轴线之间进行调整。或者，火灾引导装置垂直安装，然后在显示器中指示所需的倾斜（倾斜），然后进行倾斜调整。

8. 发明申请

US20120101427A1 NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的新型光敏剂配方
公开(公告)号：US20120101427A1
公开(公告)日：2012-04-26
申请号：US13266056
申请日：2009-04-28
申请人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
发明人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61K31/498 , C07D487/22 , C07D241/46 , A61K9/127 , A61K38/02 , A61K31/7056 , A61K31/706 , A61K31/79 , A61P35/00 , A61P17/00 , A61P9/00 , A61P19/02 , A61P31/04 , A61P33/02 , A61P31/12 , A61P31/00 , A61K31/409 , B82Y5/00
CPC分类号： A61K31/122 , A61K31/40 , A61K31/498 , A61K41/0071
摘要： The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic, antiviral, antiprionic and PDT treatments for diagnostic and therapeutic purposes. In a preferred embodiment the oral drug formulation comprises a photosensitizer and suitable excipients and may be administered in multiple doses over an extended period of time with exposure to activating radiation occurring generally between individual doses or in a light-independent manner. In another preferred embodiment PDT methods for treating hyperplasia and neoplasia, for localizing hyperplasic and neoplasic tissues and pathogen bacteria by fluorescence, for treating infections caused by pathogen bacteria in complex body fluids and for fat reduction, skin disorders and vascular diseases are provided.
摘要翻译：本发明提供用于口服给药以用于各种医学应用的新型药物制剂，包括用于诊断和治疗目的的抗癌，抗转移，抗细菌，抗真菌，抗原生动脉，抗病毒，抗细胞和PDT治疗。在优选的实施方案中，口服药物制剂包含光敏剂和合适的赋形剂，并且可以在延长的时间段内以多个剂量施用，暴露于通常在单独剂量之间或以轻轻独立的方式发生的活化辐射。在另一个优选实施方案中，提供了用于治疗增生和瘤形成的PDT方法，用于通过荧光定位超基质和新生组织和病原体细菌，用于治疗复杂体液中由病原体引起的感染和用于减脂，皮肤病和血管疾病。

9. 发明授权

US09409037B2 Enhanced anti-microbial PDT 有权
标题翻译：增强抗微生物PDT
公开(公告)号：US09409037B2
公开(公告)日：2016-08-09
申请号：US13006274
申请日：2011-01-13
申请人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
发明人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61M1/36 , A61L2/00
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Methods and devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids are provided. In preferred embodiments, an antimicrobial photodynamic therapy (PDT) treatment is given that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity include administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Additionally, the method/device diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：提供了用于消除，减少，破坏和/或抑制诸如病原体微生物和诸如血液，血清和其他体液的复杂环境中的恶化或恶性细胞的不期望的体液物质的方法和装置。在优选的实施方案中，给出了在复合体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的抗微生物光动力疗法（PDT）治疗。增强抗微生物PDT活性的方法包括在通过通道引导细菌污染的流体与光敏剂停留时间之后，向细菌污染的流体施用光敏剂，优选以间歇方式发射辐射，并将经处理的体液恢复到相应的身体区域。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。此外，该方法/装置通过中和致病微生物片段的生物活性并减少和/或除去负责其的病原微生物片段来减少不良宿主的炎症反应。

10. 发明授权

US08815931B2 Oral formulations for tetrapyrrole derivatives 有权
标题翻译：四吡咯衍生物的口服制剂
公开(公告)号：US08815931B2
公开(公告)日：2014-08-26
申请号：US12768244
申请日：2010-04-27
申请人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
发明人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
IPC分类号： A61K31/40 , A61K9/127 , A61K31/498 , A61K9/00 , A61K31/409
CPC分类号： A61K31/409 , A61K9/0065 , A61K9/127 , A61K9/1271 , A61K31/498
摘要： Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.
摘要翻译：提出了在光动力治疗（PDT）和抗微生物光动力疗法（APDT）治疗中配制口服光敏剂的口服制剂和方法。口服配制的光敏剂显示增加的溶解度和渗透性，从而提高光敏剂在治疗部位的生物利用度。口服给药的光敏剂适于配制用于通过胃肠粘膜进行粘膜粘附和吸收。本文提供的口服制剂通过口服途径使用脂质和已知蛋白质作为光敏剂的载体。用于封装预选光敏剂的载体包括常规脂质体，聚乙二醇化脂质体，纳米乳剂，纳米胶体，纳米颗粒，脂肪乳剂，脂质制剂，水溶胶，SMEDDS，α-铁蛋白（AFP）和牛血清白蛋白（BSA），脂肪乳剂，热熔融挤出物和纳米颗粒。在本发明的疏水性光敏剂的情况下，使用合适的表面活性剂/增溶剂稳定口服制剂，从而防止药物在胃中的聚集，直到其被吸收到十二指肠和小肠中。口服制剂可以以液体，胶囊，片剂，粉末，糊剂或凝胶的形式施用。配制药物可以在给予PDT之前以一次剂量或多次剂量口服给药。在一个实施方案中，Temoporfin（m-THPC）用作口服制剂中的光敏剂。类似于许多疏水性光敏剂的Temoporfin特别适合于口服给药，因为哺乳动物体内没有已知的可以代谢Temoporfin或类似光敏剂的酶系统。 Temoporfin可以在胃肠道吸收制剂后达到血液系统不变和充分活性。

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