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1. 发明申请

US20070299477A1 Secure and Efficacious Therapy Delivery for a Pacing Engine 审中-公开
标题翻译：安全和有效的治疗发送起搏发动机
公开(公告)号：US20070299477A1
公开(公告)日：2007-12-27
申请号：US11765260
申请日：2007-06-19
申请人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
发明人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译：据信上述方法和装置对患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

2. 发明申请

US20050101998A1 Secure and efficacious therapy delivery for an extra-systolic stimulation pacing engine 有权
标题翻译：安全有效的治疗输精管收缩期刺激起搏引擎
公开(公告)号：US20050101998A1
公开(公告)日：2005-05-12
申请号：US10703956
申请日：2003-11-07
申请人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett
发明人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett
IPC分类号： A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。本发明涉及治疗递送指导和改善ESS治疗递送的选择。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

3. 发明申请

US20050090872A1 Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权
标题翻译：心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法
公开(公告)号：US20050090872A1
公开(公告)日：2005-04-28
申请号：US10692990
申请日：2003-10-24
申请人： D. Deno , Vincent Splett , Jeffrey Gillberg , Glenn Zillmer , Ruth Klepfer , Karen Kleckner
发明人： D. Deno , Vincent Splett , Jeffrey Gillberg , Glenn Zillmer , Ruth Klepfer , Karen Kleckner
IPC分类号： A61N20060101 , A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

4. 发明申请

US20060247698A1 Multi-site PESP with fusion pacing 审中-公开
标题翻译：多站点PESP与融合起搏
公开(公告)号：US20060247698A1
公开(公告)日：2006-11-02
申请号：US11116877
申请日：2005-04-28
申请人： John Burnes , Glenn Zillmer , D. Deno
发明人： John Burnes , Glenn Zillmer , D. Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： In some embodiments, a method of operating an implantable cardiac pacing device to provide coupled ventricular pacing may include one or more of the following steps: (a) sensing ventricular events at a first ventricular site and generating a ventricular sense event signal in response thereto, (b) providing coupled pacing pulses simultaneously at the first ventricular site and at a second ventricular site at a ventricular extra stimulus interval (VESI) timed from immediately preceding ventricular sense event signals sufficient to effect post-extra-systolic potentiation (PESP) of the ventricular sites, and (c) providing pacing pulse at the second ventricular site after sensing ventricular events at the first ventricular site.
摘要翻译：在一些实施例中，操作可植入心脏起搏装置以提供联合心室起搏的方法可以包括以下步骤中的一个或多个：（a）感测第一心室位点处的心室事件并响应于此产生心室感测事件信号，（b）在心室额外刺激间隔（VESI）的第一心室部位和第二心室部位处同时提供耦合的起搏脉冲，其从紧接在前的心室感测事件信号定时，足以影响术后收缩期增强（PESP）心室部位，以及（c）在感测第一心室部位的心室事件后在第二心室部位提供起搏脉冲。

5. 发明申请

US20050075673A1 Method and apparatus for controlling extra-systolic stimulation (ESS) therapy using ischemia detection 审中-公开
标题翻译：使用缺血检测来控制收缩期刺激（ESS）治疗的方法和装置
公开(公告)号：US20050075673A1
公开(公告)日：2005-04-07
申请号：US10680462
申请日：2003-10-07
申请人： Dwight Warkentin , Robert Stadler , Glenn Zillmer , D. Deno
发明人： Dwight Warkentin , Robert Stadler , Glenn Zillmer , D. Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： An implantable cardiac stimulation device capable of delivering ESS, monitoring for myocardial ischemia and responding to the detection of myocardial ischemia by modifying the delivery of ESS. Modification of ESS delivery may include disabling ESS, initiating ESS, and/or modifying ESS control parameters.
摘要翻译：一种植入式心脏刺激装置，能够传递ESS，监测心肌缺血，并通过修改ESS的传递来应对心肌缺血的检测。 ESS传送的修改可能包括禁用ESS，启动ESS和/或修改ESS控制参数。

6. 发明申请

US20050075674A1 Extra-systolic stimulation therapy delivery and sensing via different electrode sets 审中-公开
标题翻译：超声心动图刺激治疗通过不同电极组传递和感测
公开(公告)号：US20050075674A1
公开(公告)日：2005-04-07
申请号：US10680493
申请日：2003-10-07
申请人： Glenn Zillmer , D. Deno , Nirav Sheth
发明人： Glenn Zillmer , D. Deno , Nirav Sheth
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： Techniques for delivering ESS to a heart of a patient are disclosed. An implantable medical device delivers ESS stimulation, and in some embodiments pacing stimulation, to a chamber of the heart via a first electrode set. The implantable medical device senses electrical activity within the chamber via a second set of electrodes. In some embodiments, the implantable medical device is able to apply a shorter blanking interval than is typical in the pacing art to a sense amplifier coupled to the second set of electrodes, allowing the implantable medical device to better detect arrhythmias and evoked responses. A variety of electrodes may be used in conjunction with the present invention; including without limitation, tip, ring, coil, can-based, endocardial, epicardial, pericardial, cardiac vein-based, subcutaneous, and/or surface electrodes.
摘要翻译：公开了将ESS递送到患者心脏的技术。可植入医疗装置通过第一电极组将ESS刺激，并且在一些实施例中将起搏刺激提供给心脏室。可植入医疗装置经由第二组电极感测室内的电活动。在一些实施例中，可植入医疗装置能够将比起搏技术中典型的更短的消隐间隔应用于耦合到第二组电极的感测放大器，从而允许可植入医疗装置更好地检测心律失常和诱发反应。可以结合本发明使用各种电极; 包括但不限于尖端，环形，线圈，罐基，心内膜，心外膜，心包，心静脉，皮下和/或表面电极。

7. 发明申请

US20070179581A1 Intravascular medical device 失效
标题翻译：血管内医疗器械
公开(公告)号：US20070179581A1
公开(公告)日：2007-08-02
申请号：US11342734
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

8. 发明申请

US20070179552A1 Intravascular medical device 失效
公开(公告)号：US20070179552A1
公开(公告)日：2007-08-02
申请号：US11342735
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

9. 发明申请

US20070179550A1 Intravascular medical device 失效
公开(公告)号：US20070179550A1
公开(公告)日：2007-08-02
申请号：US11342948
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/372 , A61N1/025 , A61N1/362 , A61N1/37205 , A61N1/37229 , A61N1/375 , A61N1/3968
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

10. 发明申请

US20070265666A1 IMPLANTABLE SENSORS HAVING HIGH IMPEDANCE COUPLINGS PROVIDING CURRENT PATHWAYS FOR IMPROVED FAULT TOLERANCE 审中-公开
标题翻译：具有提供电流路径的高阻抗耦合的可插入传感器，用于改善故障容限
公开(公告)号：US20070265666A1
公开(公告)日：2007-11-15
申请号：US11380529
申请日：2006-04-27
申请人： Jonathan Roberts , W. Wold , Glenn Zillmer
发明人： Jonathan Roberts , W. Wold , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/36564 , A61N1/37 , A61N1/3962 , A61N2001/083
摘要： One aspect of the invention involves a possible fault scenario due to a breach of an inner layer of insulation of an elongated medical electrical lead which couples an active electrical circuit for an active implantable medical device (AIMD)—typically within a conductive AIMD housing—to a sensor disposed within a sensor capsule. In one form, the AIMD provides physiological sensing of a patient parameter, such as endocardial pressure via a chronically implanted absolute pressure sensor. In such a physiological monitor, a high impedance connection is established between the active electrical circuit and the conductive AIMD housing. In a therapy delivering AIMD, a high impedance connection is established between therapy electrodes and the active electrical circuit. As a result, any errant electrical current(s) will be shunted directly to the reference-ground of the sensor-bearing lead in lieu of traveling through a patient's tissue or conductive body fluid.
摘要翻译：本发明的一个方面涉及可能的故障情况，这是由于细长的医疗电线的绝缘层的内部破裂，其将用于有源可植入医疗装置（AIMD）的有源电路（典型地在导电AIMD外壳内）耦合到设置在传感器胶囊内的传感器。在一种形式中，AIMD通过长期植入的绝对压力传感器提供患者参数的生理感测，例如心内膜压。在这样的生理监视器中，在有源电路和导电AIMD外壳之间建立高阻抗连接。在提供AIMD的治疗中，在治疗电极和有源电路之间建立了高阻抗连接。结果，任何错误的电流将被直接分流到传感器承载引线的参考地，以代替穿过病人的组织或导电体液。

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