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1. 发明申请

US20070179581A1 Intravascular medical device 失效
标题翻译：血管内医疗器械
公开(公告)号：US20070179581A1
公开(公告)日：2007-08-02
申请号：US11342734
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

2. 发明申请

US20070179552A1 Intravascular medical device 失效
公开(公告)号：US20070179552A1
公开(公告)日：2007-08-02
申请号：US11342735
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

3. 发明申请

US20070179550A1 Intravascular medical device 失效
公开(公告)号：US20070179550A1
公开(公告)日：2007-08-02
申请号：US11342948
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/372 , A61N1/025 , A61N1/362 , A61N1/37205 , A61N1/37229 , A61N1/375 , A61N1/3968
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

4. 发明申请

US20060078623A1 Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent 审中-公开
标题翻译：含有递送剂的微粒或纳米颗粒的药物制剂
公开(公告)号：US20060078623A1
公开(公告)日：2006-04-13
申请号：US11204778
申请日：2005-08-15
申请人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
发明人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
IPC分类号： A61K9/50 , A61K9/16 , A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

5. 发明授权

US06730077B2 Catheter system 失效
公开(公告)号：US06730077B2
公开(公告)日：2004-05-04
申请号：US10237376
申请日：2002-09-09
申请人： Sean Carroll , George Klein , Marwan Abboud , Steven G. Arless , Fredric L. Milder , Dan Wittenberger
发明人： Sean Carroll , George Klein , Marwan Abboud , Steven G. Arless , Fredric L. Milder , Dan Wittenberger
IPC分类号： A61B1802
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/00026 , A61B2017/00084 , A61B2018/0212 , A61B2018/0262 , A61B2090/065
摘要： A cryocatheter for treatment of tissue has a tip adapted to provide a signal indicative of the quality and/or orientation of the tip contact with surrounding tissue. In one embodiment, a signal conductor extends through the catheter to the tip and connects to a thermally and electrically conductive shell or cap that applies an RF current to the region of tissue contacted by the tip. The tissue impedance path between the signal lead and a surface electrode mounted on the patient's skin is monitored to develop a quantitative measure of tissue contact at the distal tip, which is preferably displayed on the screen of a catheter monitoring console. In yet a further embodiment, the catheter is provided with a split tip having temperature monitoring sensors, such as thermistors, mounted on opposed halves of the tip so as to sense temperature on two sides of the catheter axis. The thermistor signals are processed to determine and display differential temperature between the two sides of the tip, thus revealing which side lies in contact. In yet a further aspect of the first embodiment, two separate and distinct high frequency electrical signals are applied to the two halves of a split metal shell or cap at the tip. Signals received at the surface electrode are filtered into first and second frequency components, and these are processed to determine the relative magnitude of the signal or the impedance of the path for each of the injected signals to determine and display the tissue contact orientation of the catheter. The catheter preferably has two separate cooling chambers within the cooling tip, positioned with one chamber on each side of the axis, and a separate cooling inlet to each chamber is switched on by a valve which directs the flow of coolant to the contact side during active cryotreatment. In another embodiment, the cap provides an RF electrode that may be opposed to the cooling side so that either the cryogenic or the RF ablation side may be rotated into contact to selectively heat or cool, or in representative protocol treat, then thaw, the same tissue site.

6. 发明授权

US08475440B2 Wide area ablation of myocardial tissue 有权
标题翻译：广泛消融心肌组织
公开(公告)号：US08475440B2
公开(公告)日：2013-07-02
申请号：US11953189
申请日：2007-12-10
申请人： Marwan Abboud , Fredric L. Milder , George Klein
发明人： Marwan Abboud , Fredric L. Milder , George Klein
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分心脏组织的形貌。消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

7. 发明申请

US20140200577A1 ABLATION GRASPER 审中-公开
标题翻译：排水砂浆
公开(公告)号：US20140200577A1
公开(公告)日：2014-07-17
申请号：US14115595
申请日：2012-05-03
申请人： George Klein , Harold Wodlinger , Steve Wayne Berhow , Douglas Scott Wahnschaffe
发明人： George Klein , Harold Wodlinger , Steve Wayne Berhow , Douglas Scott Wahnschaffe
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00196 , A61B2018/00273 , A61B2018/00351 , A61B2018/00482 , A61B2018/00505 , A61B2018/00541 , A61B2218/002
摘要： The present invention provides improved catheters for ablative procedures for biological tissue, e.g., in the heart. The catheters allow active fixation to the tissue using a pair of jaws, and a sheath actuates the jaws, simplifying actuation. In particular embodiments, the pair of jaws provides additional stability in attachment to difficult ablation sites, e.g., along the ridges of cardiac structures.
摘要翻译：本发明提供了用于例如在心脏中的用于生物组织的烧蚀程序的改进的导管。导管允许使用一对钳口主动固定到组织，并且护套致动钳口，从而简化致动。在特定实施例中，该对钳口在附着到难消化部位（例如沿着心脏结构的脊）提供额外的稳定性。

8. 发明申请

US20120046666A1 ANCHORING CATHETER SHEATH 审中-公开
标题翻译：锚固导管
公开(公告)号：US20120046666A1
公开(公告)日：2012-02-23
申请号：US13202854
申请日：2010-02-24
申请人： George Klein
发明人： George Klein
IPC分类号： A61B17/00
CPC分类号： A61M25/0662 , A61B18/1492 , A61B2018/00214 , A61B2018/00285 , A61B2018/00898 , A61M25/0068 , A61M25/0082 , A61M25/01 , A61M25/04 , A61M25/10 , A61M2025/0681
摘要： In general, the invention provides improved sheaths for enhanced control over the relative position of the sheath or inserted catheter relative to a biological tissue. The invention also provides improved sheaths for controlling the longitudinal and axial movement of inserted catheters relative to the sheath. The sheaths include an active anchor at the distal end capable of reversibly adhering the sheath to a tissue. Exemplary active anchors include a reversibly inflatable balloon, a deflectable tip, a suction cup, a screw, and a barb.
摘要翻译：通常，本发明提供改进的护套，用于增强对鞘或插入的导管相对于生物组织的相对位置的控制。本发明还提供了改进的护套，用于控制插入的导管相对于护套的纵向和轴向运动。护套包括能够将护套可逆地粘附到组织的远端处的活性锚固件。示例性的活动锚固件包括可逆膨胀的气囊，可偏转的尖端，吸盘，螺钉和倒钩。

9. 发明授权

US07085601B1 External atrial defibrillator and method for personal termination of atrial fibrillation 失效
标题翻译：外用心房除颤器和个人终止房颤的方法
公开(公告)号：US07085601B1
公开(公告)日：2006-08-01
申请号：US09441936
申请日：1999-11-17
申请人： Gust H. Bardy , George Klein
发明人： Gust H. Bardy , George Klein
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/395 , A61N1/3956 , A61N1/3987
摘要： An atrial defibrillator includes a portable, non-implantable housing, a pair of defibrillator pads, a shock generator, and an analyzer. The pads are applied to the outside of a patient's body, and the shock generator delivers a shock to the patient via the pads. The analyzer receives a cardiac signal from the patient, determines from the signal whether the patient is experiencing atrial fibrillation, and enables the shock generator if the patient is experiencing atrial fibrillation. Unlike conventional external atrial defibrillators, such an atrial defibrillator can be used by a layperson in the comfort of a patient's own home. Furthermore, such a defibrillator does not cause the surgery-related problems associated with implantable atrial defibrillators. Moreover, because the patient can choose when to receive a shock, such a defibrillator is less likely to surprise and embarrass the patient than automatic implantable defibrillators are.
摘要翻译：心房除颤器包括便携式非植入式外壳，一对除颤器垫，冲击发生器和分析器。垫被施加到患者身体的外部，并且冲击发生器通过垫片向患者传递冲击。分析仪从患者接收心脏信号，根据信号确定患者是否正在经历心房颤动，并且如果患者正在经历心房纤维性颤动，则能够进行休克发生器。与传统的外部心房除颤器不同，这种心房除颤器可以由外行人在患者自己的家中舒适地使用。此外，这种除颤器不会引起与可植入心房除颤器相关的手术相关问题。此外，由于患者可以选择何时接受休克，因此与自动植入性除颤器相比，这种除颤器不太可能令人惊奇，并且使患者感到尴尬。

10. 发明申请

US20060069410A1 Method and system for terminating an atrial arrhythmia 有权
公开(公告)号：US20060069410A1
公开(公告)日：2006-03-30
申请号：US11244764
申请日：2005-10-06
申请人： Rahul Mehra , George Klein , Michael Ujhelyi
发明人： Rahul Mehra , George Klein , Michael Ujhelyi
IPC分类号： A61N1/365
CPC分类号： A61M5/14244 , A61B2017/00044 , A61M5/1723 , A61M2230/04 , A61N1/3621
摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

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