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1. 发明申请

US20060094967A1 Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous system 有权
标题翻译：提供受试者自主神经系统调节的诊断指标和治疗的方法和装置
公开(公告)号：US20060094967A1
公开(公告)日：2006-05-04
申请号：US10977073
申请日：2004-10-29
申请人： Tommy Bennett , Edwin Duffin , Robert Taepke , Barbro Kjellstrom
发明人： Tommy Bennett , Edwin Duffin , Robert Taepke , Barbro Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/4035 , A61B5/7239 , A61N1/36535 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/3702
摘要： A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.
摘要翻译：提供了一种用于确定用于患者监测或治疗递送控制的自主神经系统（ANS）或交感神经系统（SNS）活动指数的系统和方法。 ANS或SNS指数被计算为与自主神经或交感神经紧张度变化密切相关的多个被监测的生理变量的函数。这些受ANS影响的变量来自选定的血流动力学和/或电信号，并且可以包括与以下任何相关的变量：压力上升的最大速率（dP / dt最大值），最大压力下降速率（dP / dt分钟），脉压（PP），预喷射时间间隔（PEI）和/或收缩时间间隔（STI），心率（HR），心率变异性（HRV），以及压力反射增益。可以使用ANS或SNS指数的变化来自动调整设备传递的治疗。

2. 发明申请

US20070299477A1 Secure and Efficacious Therapy Delivery for a Pacing Engine 审中-公开
标题翻译：安全和有效的治疗发送起搏发动机
公开(公告)号：US20070299477A1
公开(公告)日：2007-12-27
申请号：US11765260
申请日：2007-06-19
申请人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
发明人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译：据信上述方法和装置对患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

3. 发明申请

US20050038479A1 Electrically efficient neurally-excitable stimulation technical field 失效
标题翻译：电动高效神经兴奋刺激技术领域
公开(公告)号：US20050038479A1
公开(公告)日：2005-02-17
申请号：US10638855
申请日：2003-08-11
申请人： D. Deno , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel
发明人： D. Deno , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564 , A61N1/368
摘要： A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.
摘要翻译：医疗装置，例如可植入的医疗装置，在组织难治的时期期间，向心肌组织递送一个或多个神经可兴奋的刺激脉冲。脉冲的宽度小于或等于大约一个半毫秒。在一些实施例中，脉冲的电流幅度小于或等于大约二十毫安。在示例性实施例中，医疗设备递送彼此间隔大于或等于大约十毫秒的六个或更少个脉冲的脉冲串。在一些实施例中，医疗装置根据存储在存储器中的计划或者作为患者的被监测的生理参数（例如心脏内压力）递送脉冲。在一些实施方案中，基于心脏缺血的检测，医疗装置暂停或禁止神经可兴奋的递送。

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