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1. 发明授权

US07200434B2 Control of arbitrary waveforms for constant delivered energy 有权
标题翻译：控制任意波形的恒定传送能量
公开(公告)号：US07200434B2
公开(公告)日：2007-04-03
申请号：US11089798
申请日：2005-03-25
申请人： William J. Havel , Paul J. Degroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. Degroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrarywaveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.
摘要翻译：本发明概述了通过自动补偿由可植入式心律转复除颤器（ICD）检测的负载阻抗来向患者传送可控量的能量的结构和方法。本发明采用高速，开关电源转换器技术，有效地生成高能量，任意波形。与线性放大器不同，开关电源转换器提供高能量波形，效率与所需波形的大小和幅度无关。使用开关功率转换器将期望的能量递送到患者的ICD存储要在存储电容器中传递的能量。然后，转换器通过以高速率切换存储电容器输入和输出输出电路，将该能量转换成任意形状的输出电压控制或电流控制波形。优选地，波形包括斜坡型波形。

2. 发明申请

US20070265666A1 IMPLANTABLE SENSORS HAVING HIGH IMPEDANCE COUPLINGS PROVIDING CURRENT PATHWAYS FOR IMPROVED FAULT TOLERANCE 审中-公开
标题翻译：具有提供电流路径的高阻抗耦合的可插入传感器，用于改善故障容限
公开(公告)号：US20070265666A1
公开(公告)日：2007-11-15
申请号：US11380529
申请日：2006-04-27
申请人： Jonathan Roberts , W. Wold , Glenn Zillmer
发明人： Jonathan Roberts , W. Wold , Glenn Zillmer
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/36564 , A61N1/37 , A61N1/3962 , A61N2001/083
摘要： One aspect of the invention involves a possible fault scenario due to a breach of an inner layer of insulation of an elongated medical electrical lead which couples an active electrical circuit for an active implantable medical device (AIMD)—typically within a conductive AIMD housing—to a sensor disposed within a sensor capsule. In one form, the AIMD provides physiological sensing of a patient parameter, such as endocardial pressure via a chronically implanted absolute pressure sensor. In such a physiological monitor, a high impedance connection is established between the active electrical circuit and the conductive AIMD housing. In a therapy delivering AIMD, a high impedance connection is established between therapy electrodes and the active electrical circuit. As a result, any errant electrical current(s) will be shunted directly to the reference-ground of the sensor-bearing lead in lieu of traveling through a patient's tissue or conductive body fluid.
摘要翻译：本发明的一个方面涉及可能的故障情况，这是由于细长的医疗电线的绝缘层的内部破裂，其将用于有源可植入医疗装置（AIMD）的有源电路（典型地在导电AIMD外壳内）耦合到设置在传感器胶囊内的传感器。在一种形式中，AIMD通过长期植入的绝对压力传感器提供患者参数的生理感测，例如心内膜压。在这样的生理监视器中，在有源电路和导电AIMD外壳之间建立高阻抗连接。在提供AIMD的治疗中，在治疗电极和有源电路之间建立了高阻抗连接。结果，任何错误的电流将被直接分流到传感器承载引线的参考地，以代替穿过病人的组织或导电体液。

3. 发明申请

US20070265671A1 SELECTABLE SWITCHING OF IMPLANTABLE SENSORS TO PROVIDE FAULT TOLEANCE FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可选择的可切换传感器切换以提供可植入医疗设备的故障检测
公开(公告)号：US20070265671A1
公开(公告)日：2007-11-15
申请号：US11380521
申请日：2006-04-27
申请人： Jonathan Roberts , W. Wold , Glenn Zillmer
发明人： Jonathan Roberts , W. Wold , Glenn Zillmer
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/042 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/11 , A61B5/14539 , A61B5/14542 , A61B2560/0257 , A61B2562/222 , A61N1/3605 , A61N1/36514 , A61N1/36557 , A61N2001/083
摘要： The present disclosure provides one or more structures, techniques, components and/or methods for avoiding or positively resolving failure modes for an implanted medical device coupled to one or more sensors. A common fault scenario involves unintended stimulation during therapy delivery. A pacing stimulus can couple to exposed conductive portion(s) of a medical electrical lead (e.g., a tip portion) that includes a sensor to cause the stimulation. Stimulation also occurs due to insulation breaches of a lead. Stimulation can also result from a breach in insulation surrounding a conductive set screw that couples the lead to active circuitry. Stimulation also results when high energy therapy energy shunts to sensor circuitry (e.g., sensor bus) via insulation breach of the sensor lead and/or the circuitry. Such unintended stimulation is avoided by disconnecting the pressure sensing lead and sensor: during therapy delivery, when impedance measurement or current measurement to the sensor indicate unintended stimulation.
摘要翻译：本公开提供了用于避免或积极地分解与一个或多个传感器耦合的植入医疗设备的故障模式的一个或多个结构，技术，部件和/或方法。常见的故障情况包括治疗期间的意外刺激。起搏刺激可以耦合到包括用于引起刺激的传感器的医疗电引线（例如，尖端部分）的暴露的导电部分。由于引线的绝缘破坏也会引起刺激。刺激也可能是由导线连接到有源电路的导电固定螺钉周围的绝缘体的破坏引起的。当高能量治疗能量通过传感器引线和/或电路的绝缘破坏分流到传感器电路（例如，传感器总线）时，也会产生刺激。通过断开压力感测引线和传感器来避免这种无意的刺激：在治疗传递期间，当传感器的阻抗测量或电流测量指示意外刺激时。

4. 发明授权

US07151963B2 Control of arbitrary waveforms for constant delivered energy 有权
公开(公告)号：US07151963B2
公开(公告)日：2006-12-19
申请号：US10308832
申请日：2002-12-03
申请人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.

5. 发明授权

US6094597A Implantable medical device incorporating distributed core, step-up transformer 有权
标题翻译：可植入医疗器械，包括分布式核心，升压变压器
公开(公告)号：US6094597A
公开(公告)日：2000-07-25
申请号：US245947
申请日：1999-02-05
申请人： Warren W. Wold
发明人： Warren W. Wold
IPC分类号： A61N1/375 , A61N1/378 , A61N1/36
CPC分类号： A61N1/3758 , A61N1/378
摘要： An implantable medical device (IMD) includes a distributed core, step-up transformer that is arranged within a hermetically sealed housing in space that would otherwise not be occupied and in a way that minimizes the size and weight of the IMD. The IMD preferably comprises an implantable cardioverter-defibrillator (ICD) of the type having a battery power source, a capacitor bank for storing a charge from the battery, and electronic circuitry coupled to the battery power supply and the capacitor bank for charging the capacitor bank through a step-up transformer and for discharging the capacitor bank into or around a patient's heart. The step up transformer comprises a plurality of distributed core step-up transformer modules which are miniaturized sufficiently to fit within small spaces of the housing cavity. The plurality of distributed core, step-up transformer modules are amenable to being arranged to fit into spaces within the cavity of the IMD housing that are not otherwise occupied. The space otherwise occupied by the bulky, prior art step-up transformer can than be occupied by other components or can result in making the housing itself smaller and possibly thinner in profile than it would otherwise be.
摘要翻译：可植入医疗装置（IMD）包括分布式核心升压变压器，其布置在空间中的密封壳体中，否则将不被占用并且以使IMD的尺寸和重量最小化的方式。 IMD优选地包括具有电池电源的类型的可植入心律转复除颤器（ICD），用于存储来自电池的电荷的电容器组，以及耦合到电池电源和电容器组的电子电路，用于对电容器组充电通过升压变压器并将电容器组放电到患者心脏内或周围。升压变压器包括多个分布式升压变压器模块，其小型化以足够装配在壳体空腔的小空间内。多个分布式核心升压变压器模块适于被布置成装配在未被占用的IMD外壳的空腔内的空间中。由庞大的现有技术的升压变压器占据的空间可以被其他部件占据，或者可能导致壳体本身的外形比其它情况更小，并且可能更薄。

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