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1. 发明授权

US08005529B2 Systems and methods for internal tissue penetration 有权
标题翻译：内部组织穿透的系统和方法
公开(公告)号：US08005529B2
公开(公告)日：2011-08-23
申请号：US12749234
申请日：2010-03-29
申请人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
发明人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
IPC分类号： A61B5/05
CPC分类号： A61B1/00087 , A61B1/00082 , A61B1/00135 , A61B1/3132 , A61B5/0066 , A61B5/0084 , A61B8/12 , A61B8/445 , A61B17/32002 , A61B17/3478 , A61B2017/00247 , A61B2017/22075 , A61B2017/22077 , A61B2017/22078 , A61B2017/320004 , A61B2018/00392 , A61B2090/378 , A61B2090/3782
摘要： A medical system includes an inner core and an imager located at the distal end of the inner core, wherein the imager is extendable from within an elongated tubular member and configured to penetrate a body tissue within a living body. The elongated tubular member is configured to slideably receive the inner core. The inner core is configured to rotate radially around a longitudinal axis of the elongated member, and the imager can be configured to image a body tissue and output an image signal to an imaging system communicatively coupled with the imager. The imaging system is configured to generate an image of the body tissue from the image signal of the imager when the imager is rotated and placed into contact with the body tissue.
摘要翻译：医疗系统包括内芯和位于内芯的远端的成像器，其中成像器可从细长的管状构件中延伸并构造成穿透活体内的身体组织。细长管状构件构造成可滑动地容纳内芯。内芯构造成围绕细长构件的纵向轴线径向旋转，并且成像器可以被配置为对身体组织成像并将图像信号输出到与成像器通信地耦合的成像系统。成像系统被配置为当成像器旋转并与身体组织接触时从成像器的图像信号生成身体组织的图像。

2. 发明授权

US07715896B2 Systems and methods for internal tissue penetration 有权
标题翻译：内部组织穿透的系统和方法
公开(公告)号：US07715896B2
公开(公告)日：2010-05-11
申请号：US10394079
申请日：2003-03-21
申请人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
发明人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
IPC分类号： A61B5/05
CPC分类号： A61B1/00087 , A61B1/00082 , A61B1/00135 , A61B1/3132 , A61B5/0066 , A61B5/0084 , A61B8/12 , A61B8/445 , A61B17/32002 , A61B17/3478 , A61B2017/00247 , A61B2017/22075 , A61B2017/22077 , A61B2017/22078 , A61B2017/320004 , A61B2018/00392 , A61B2090/378 , A61B2090/3782
摘要： A medical system is a medical device, such as a catheter, that includes an inner core and an imager that is extendable from within an elongated tubular member and configured to penetrate a body tissue within a living body. The elongated tubular member has a distal end and is configured to slideably receive the inner core. The distal end is further configured to allow the inner core to advance outside the elongated member. The inner core has a distal end and is configured to rotate radially around a longitudinal axis of the elongated member. The device can further include an imager located at the distal end of the inner core, and the imager can be configured to image a body tissue and output an image signal to an imaging system communicatively coupled with the imager. The imaging system is configured to generate an image of the body tissue from the image signal of the imager when the imager is rotated and placed into contact with the body tissue such that the imager penetrates the body tissue.
摘要翻译：医疗系统是诸如导管的医疗装置，其包括内芯和成像器，该内芯和成像器可从细长的管状构件中延伸并且构造成穿透生物体内的身体组织。细长管状构件具有远端并且构造成可滑动地容纳内芯。远端进一步构造成允许内芯在细长构件的外部前进。内芯具有远端并且构造成围绕细长构件的纵向轴线径向旋转。该装置还可以包括位于内芯的远端处的成像器，并且成像器可以被配置成对身体组织成像并将图像信号输出到与成像器通信地耦合的成像系统。成像系统被配置为当成像器旋转并且与身体组织接触以使得成像器穿透身体组织时，从成像器的图像信号生成身体组织的图像。

3. 发明申请

US20100185054A1 Systems and Methods for Internal Tissue Penetration 有权
标题翻译：内部组织穿透的系统和方法
公开(公告)号：US20100185054A1
公开(公告)日：2010-07-22
申请号：US12749234
申请日：2010-03-29
申请人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
发明人： Kamal Ramzipoor , James D. Koger , Gopal Chopra
IPC分类号： A61B1/01
CPC分类号： A61B1/00087 , A61B1/00082 , A61B1/00135 , A61B1/3132 , A61B5/0066 , A61B5/0084 , A61B8/12 , A61B8/445 , A61B17/32002 , A61B17/3478 , A61B2017/00247 , A61B2017/22075 , A61B2017/22077 , A61B2017/22078 , A61B2017/320004 , A61B2018/00392 , A61B2090/378 , A61B2090/3782
摘要： A medical system is a medical device, such as a catheter, that includes an inner core and an imager that is extendable from within an elongated tubular member and configured to penetrate a body tissue within a living body. The elongated tubular member has a distal end and is configured to slideably receive the inner core. The distal end is further configured to allow the inner core to advance outside the elongated member. The inner core has a distal end and is configured to rotate radially around a longitudinal axis of the elongated member. The device can further include an imager located at the distal end of the inner core, and the imager can be configured to image a body tissue and output an image signal to an imaging system communicatively coupled with the imager. The imaging system is configured to generate an image of the body tissue from the image signal of the imager when the imager is rotated and placed into contact with the body tissue such that the imager penetrates the body tissue.
摘要翻译：医疗系统是诸如导管的医疗装置，其包括内芯和成像器，该内芯和成像器可从细长的管状构件中延伸并且构造成穿透生物体内的身体组织。细长管状构件具有远端并且构造成可滑动地容纳内芯。远端进一步构造成允许内芯在细长构件的外部前进。内芯具有远端并且构造成围绕细长构件的纵向轴线径向旋转。该装置还可以包括位于内芯的远端处的成像器，并且成像器可以被配置成对身体组织成像并将图像信号输出到与成像器通信地耦合的成像系统。成像系统被配置为当成像器旋转并且与身体组织接触以使得成像器穿透身体组织时，从成像器的图像信号生成身体组织的图像。

4. 发明授权

US06529760B2 Intravascular imaging guidewire 有权
标题翻译：血管内成像导丝
公开(公告)号：US06529760B2
公开(公告)日：2003-03-04
申请号：US09876717
申请日：2001-06-06
申请人： Anthony J. Pantages , William Martin Belef , Lawrence D. Wasicek , Donald S. Mamayek , James D. Koger , Steven Nelson Roe
发明人： Anthony J. Pantages , William Martin Belef , Lawrence D. Wasicek , Donald S. Mamayek , James D. Koger , Steven Nelson Roe
IPC分类号： A61B500
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/4488 , A61M25/09
摘要： An intravascular imaging guidewire which can accomplish longitudinal translation of an imaging plane allowing imaging, by acoustic other high quality imaging energy, of an axial length of a region of interest without moving the guidewire. The imaging guidewire comprises a body in the form of a flexible elongate tubular member. An elongate flexible imaging core is slidably received within the body. The imaging core includes a shaft having an imaging device mounted on its distal end. The body and the imaging core are cooperatively constructed to enable axial translation of the imaging core and imaging device relative to the body. The body has a transparent distal portion extending an axial length over which axially translatable imaging may be performed. The imaging guidewire has a maximum diameter over its entire length sized to be received within a guidewire lumen of an intravascular catheter.
摘要翻译：可以实现成像平面的纵向平移的血管内成像导丝，允许感兴趣区域的轴向长度的声学其他高质量成像能量，而不移动导丝。成像导丝包括柔性细长管状构件形式的主体。细长的柔性成像芯可滑动地容纳在体内。成像芯包括具有安装在其远端上的成像装置的轴。协同构造身体和成像芯，以使得成像芯和成像装置相对于身体能够轴向平移。主体具有延伸轴向长度的透明远端部分，可在其上执行可轴向平移的成像。成像导丝在其整个长度上具有最大直径，其尺寸被设计成容纳在血管内导管的导丝管腔内。

5. 发明授权

US08187194B2 Method of mounting a transducer to a driveshaft 有权
标题翻译：将传感器安装到驱动轴上的方法
公开(公告)号：US08187194B2
公开(公告)日：2012-05-29
申请号：US12793115
申请日：2010-06-03
申请人： Manuel Serrano , James D. Koger
发明人： Manuel Serrano , James D. Koger
IPC分类号： A61B8/00
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
摘要翻译：一种将换能器安装到驱动轴上的方法，其消除了对换能器壳体的需要，该改进的方法直接将换能器附接到作为导管组件的可旋转成像芯的一部分的驱动轴的刚性远端。该方法考虑热处理驱动轴的远端以使其刚性，加工远侧末端以确定尺寸以保持换能器，并且通过夹紧，压接或粘合剂将换能器附接到远侧末端。

6. 发明授权

US06261246B1 Intravascular imaging guidewire 有权
标题翻译：血管内成像导丝
公开(公告)号：US06261246B1
公开(公告)日：2001-07-17
申请号：US09162090
申请日：1998-09-28
申请人： Anthony J. Pantages , William Martin Belef , Lawrence D. Wasicek , Donald S. Mamayek , James D. Koger , Steven Nelson Roe
发明人： Anthony J. Pantages , William Martin Belef , Lawrence D. Wasicek , Donald S. Mamayek , James D. Koger , Steven Nelson Roe
IPC分类号： A61B812
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/4488 , A61M25/09
摘要： An intravascular imaging guidewire which can accomplish longitudinal translation of an imaging plane allowing imaging of an axial length of a region of interest without moving the guidewire. The imaging guidewire comprises a body in the form of a flexible elongate tubular member. An elongate flexible imaging core is slidably received within the body. The imaging core includes a shaft having an imaging device mounted on its distal end. The body and the imaging core are cooperatively constructed to enable axial translation of the imaging core and imaging device relative to the body. The body has a transparent distal portion extending an axial length over which axially translatable imaging may be performed. The imaging guidewire has a maximum diameter over its entire length sized to be received within a guidewire lumen of an intravascular catheter.
摘要翻译：血管内成像导丝，其可以实现成像平面的纵向平移，允许在不移动导丝的情况下成像感兴趣区域的轴向长度。成像导丝包括柔性细长管状构件形式的主体。细长的柔性成像芯可滑动地容纳在体内。成像芯包括具有安装在其远端上的成像装置的轴。协同构造身体和成像芯，以使得成像芯和成像装置相对于身体能够轴向平移。主体具有延伸轴向长度的透明远端部分，可在其上执行可轴向平移的成像。成像导丝在其整个长度上具有最大直径，其尺寸被设计成容纳在血管内导管的导丝管腔内。

7. 发明授权

US06371915B1 One-twelfth wavelength impedence matching transformer 失效
标题翻译：第十二波长阻抗匹配变压器
公开(公告)号：US06371915B1
公开(公告)日：2002-04-16
申请号：US09432914
申请日：1999-11-02
申请人： James D. Koger , Robert W. Crowley
发明人： James D. Koger , Robert W. Crowley
IPC分类号： A61B800
CPC分类号： G10K11/02 , Y10T29/42
摘要： An ultrasound transducer including a one-twelfth wavelength impedance matching transformer and methods of manufacturing and using the same. The transducer comprises a transducer element for transmitting and receiving ultrasound waves, a first impedance matching layer, and a second impedance matching layer. The transducer element has a transmitting/receiving surface, an impedance, and a thickness of substantially one-half wavelength of an ultrasound wave generated thereby. The first impedance matching layer is formed on the transmitting/receiving surface of the transducer element and has a thickness of substantially one-twelfth wavelength of the ultrasound wave travelling therein. The second impedance matching layer is formed on a selected surface of the first impedance matching layer and has a thickness of substantially one-twelfth wavelength of the ultrasound passing therethrough. An impedance of the first impedance matching layer is substantially equal to an impedance of an operating medium; whereas, an impedance of the second impedance matching layer is substantially equal to the impedance of the transducer element.
摘要翻译：包括第十二波长阻抗匹配变压器的超声波换能器及其制造和使用方法。换能器包括用于发射和接收超声波的换能器元件，第一阻抗匹配层和第二阻抗匹配层。换能器元件具有由其产生的超声波的发射/接收表面，阻抗和基本上为二分之一波长的厚度。第一阻抗匹配层形成在换能器元件的发送/接收表面上，并且具有在其中传播的超声波的基本上十二分之一波长的厚度。第二阻抗匹配层形成在第一阻抗匹配层的选定表面上，并且具有通过其的超声波的基本上第十二分之一波长的厚度。第一阻抗匹配层的阻抗基本上等于操作介质的阻抗; 而第二阻抗匹配层的阻抗基本上等于换能器元件的阻抗。

8. 发明授权

US6106474A Aerogel backed ultrasound transducer 失效
公开(公告)号：US6106474A
公开(公告)日：2000-08-22
申请号：US972962
申请日：1997-11-19
申请人： James D. Koger , Isaac Ostrovsky
发明人： James D. Koger , Isaac Ostrovsky
IPC分类号： B06B1/06 , A61B8/14
CPC分类号： B06B1/0674
摘要： An ultrasound transducer having an acoustic backing layer made of an aerogel material is disclosed. The ultrasound transducer comprises an acoustic element for transmitting and receiving ultrasound waves. An aerogel acoustic backing layer is bonded to the back side of the acoustic element. A matching layer may be attached to the front side of the acoustic element. The ultrasound transducer may be electrically connected using electrodes directly connected to the acoustic element. Alternatively, the aerogel acoustic backing may be coated with a metalized layer or doped so that it is electrically conductive. Then, the electrodes may be connected directly to the aerogel acoustic backing.

9. 发明授权

US5437282A Drive shaft for acoustic imaging catheters and flexible catheters 失效
标题翻译：用于声学成像导管和柔性导管的驱动轴
公开(公告)号：US5437282A
公开(公告)日：1995-08-01
申请号：US144725
申请日：1993-10-29
申请人： James D. Koger , Andrew Kapravy , Kevin R. Heath , Robert J. Crowley
发明人： James D. Koger , Andrew Kapravy , Kevin R. Heath , Robert J. Crowley
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61M25/00 , G10K11/00 , G10K11/35
CPC分类号： A61B8/12 , A61B8/4461 , A61M25/0045 , G10K11/004 , G10K11/355 , A61B2017/00526 , A61B2017/22078 , Y10T29/4987 , Y10T29/49872
摘要： A shaft is shown having inner and outer members in interfering contact along their length, at least one of which comprises a wire, at least a portion of which is superelastic, to achieve substantial mechanical fidelity and resistance to damage. An ultrasound imaging catheter has a hollow catheter shaft, an ultrasound transducer in the shaft, and a drive shaft that rotates the transducer. The shaft comprises at least one metal coil having characteristic elastic deformation under stress in the range of about 3% to 9%, while a restraint means prevents torsional deflection of the coil. A drive shaft having a coil surrounded by a tube, a coil bonded to an inner coaxial cable, and an inner and outer coil that interfere with one another are shown. A superelastic coil is formed by continuously winding a wire about a mandrel, heating a region of the wire to render it superelastic, and after cooling, removing it from the mandrel.
摘要翻译：轴被示出为具有沿其长度干涉接触的内部和外部构件，其中至少一个包括线，其至少一部分是超弹性的，以实现显着的机械保真度和抗损坏性。超声成像导管具有中空导管轴，轴中的超声换能器以及旋转换能器的驱动轴。轴包括至少一个金属线圈，其在应力下具有在约3％至9％的范围内的特征弹性变形，而约束装置防止线圈的扭转偏转。示出了具有被管围绕的线圈的驱动轴，与内部同轴电缆接合的线圈以及彼此干涉的内部和外部线圈。超弹性线圈通过围绕心轴连续缠绕线而形成，加热线的区域以使其超弹性，并且在冷却之后，将其从心轴移除。

10. 发明申请

US20100274140A1 METHOD OF MOUNTING A TRANSDUCER TO A DRIVESHAFT 有权
标题翻译：将传感器安装到驱动器的方法
公开(公告)号：US20100274140A1
公开(公告)日：2010-10-28
申请号：US12793115
申请日：2010-06-03
申请人： Manuel Serrano , James D. Koger
发明人： Manuel Serrano , James D. Koger
IPC分类号： A61B8/00
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
摘要翻译：一种将换能器安装到驱动轴上的方法，其消除了对换能器壳体的需要，该改进的方法直接将换能器附接到作为导管组件的可旋转成像芯的一部分的驱动轴的刚性远端。该方法考虑热处理驱动轴的远端以使其刚性，加工远侧末端以确定尺寸以保持换能器，并且通过夹紧，压接或粘合剂将换能器附接到远侧末端。

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