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1. 发明授权

US5635574A Microsphere and method for production thereof 失效
标题翻译：微球及其生产方法
公开(公告)号：US5635574A
公开(公告)日：1997-06-03
申请号：US617979
申请日：1996-03-15
申请人： Juuro Aoyagi , Toyoaki Suzuki , Reiko Kato , Masanori Nagata
发明人： Juuro Aoyagi , Toyoaki Suzuki , Reiko Kato , Masanori Nagata
IPC分类号： C08F2/06 , C08F2/04 , C08F220/54 , C08F226/02 , C08F222/38
CPC分类号： C08F220/54
摘要： A method for the production of a microsphere without use of a dispersion stabilizer is disclosed which permits the microsphere to be produced in the form of discrete particles readily treatable for purification. The method which produces this microsphere comprises the steps of dissolving in an organic solvent such as an alcohol a monomer mixture including an ethylenically unsaturated amide and 10 to 70% by weight, based on 100% by weight of said monomer mixture, of a cross-linking agent thereby preparing a mixed solution, keeping said mixed solution at a temperature in the range of from 30.degree. to 95.degree. C., and adding thereto at least one initiator selected from the group consisting of peroxide type initiators and azo type initiators in an amount such as to be contained therein at a final concentration in the range of from 1.times.10.sup.-5 to 8.times.10.sup.-2 mol/liter thereby inducing polymerization of said monomer mixture. The microsphere consequently obtained can be used as one kind of a substrate most suitable for the preparation of an affinity adsorbent serving ideally as a filler for use in affinity chromatography.
摘要翻译：公开了一种不使用分散稳定剂制备微球体的方法，该方法允许以容易处理以进行纯化的离散颗粒的形式制备微球体。制备该微球的方法包括以下步骤：将基于100重量％的所述单体混合物溶解在有机溶剂如醇中，所述单体混合物包含烯属不饱和酰胺和10至70重量％的单体混合物，连接剂，从而制备混合溶液，将所述混合溶液保持在30℃至95℃的温度范围内，并向其中加入至少一种选自过氧化物型引发剂和偶氮型引发剂的引发剂，其含量为1×10 -5至8×10 -2 mol /升范围内的最终浓度，从而引起所述单体混合物的聚合。由此获得的微球可以用作最适合于制备用作亲和色谱法的填料的亲和吸附剂的一种底物。

2. 发明授权

US4453940A Autoclavable medicinal-containing bag from ethylene-vinyl acetate copolymer 失效
标题翻译：乙烯 - 乙酸乙烯酯共聚物的可高压灭菌药用袋
公开(公告)号：US4453940A
公开(公告)日：1984-06-12
申请号：US276501
申请日：1981-06-23
申请人： Juuro Aoyagi , Toshizi Ichikawa
发明人： Juuro Aoyagi , Toshizi Ichikawa
IPC分类号： A61L29/00 , A61J1/00 , A61J1/05 , A61L29/04 , A61L31/00 , A61M1/00 , A61M25/16 , C08J7/10 , C08F210/00 , C08F214/00
CPC分类号： A61J1/10 , A61L29/041 , Y10S128/24 , Y10S206/828
摘要： A medical utensil having a portion to contact body fluid or liquid medicine is provided in which at least the contact portion is formed of a copolymer cross-linked by electron beam irradiation and/or .gamma.-ray irradiation.
摘要翻译：提供具有接触体液或液体药物的部分的医用器具，其中至少所述接触部分由通过电子束照射和/或γ射线照射交联的共聚物形成。

3. 发明授权

US5075003A Blood cleaning hollow fiber membrane method for cleaning blood, and apparatus therefor 失效
标题翻译：血清清洁中空纤维膜清洗方法及其设备
公开(公告)号：US5075003A
公开(公告)日：1991-12-24
申请号：US521141
申请日：1990-05-28
申请人： Juuro Aoyagi
发明人： Juuro Aoyagi
IPC分类号： A61M1/16 , B01D61/24 , B01D65/02 , B01D67/00 , B01D69/08
CPC分类号： B01D67/0093 , A61M1/16 , B01D61/243 , B01D65/022 , B01D69/08 , B01D2321/16 , B01D2321/346 , B01D2323/385
摘要： The present invention discloses a blood cleaning hollow fiber membrane characterized by comprising a hydrophobic porous hollow fiber membrane and having a hydrophilic thin layer formed at least on the inner surface of said hollow fiber membrane by the grafting of a hydrophilic compound through the agency of a gamma ray, a method for the cleaning blood and an apparatus therefor using the same.

4. 发明授权

US4940541A Blood cleaning hollow fiber membrane, method for cleaning blood, and apparatus therefor 失效
标题翻译：血液净化中空纤维膜，血液清洗方法及其装置
公开(公告)号：US4940541A
公开(公告)日：1990-07-10
申请号：US265822
申请日：1988-11-01
申请人： Juuro Aoyagi
发明人： Juuro Aoyagi
IPC分类号： A61M1/16 , B01D61/24 , B01D65/02 , B01D67/00 , B01D69/08 , B01D63/02 , B01D63/04
CPC分类号： B01D67/0093 , A61M1/16 , B01D61/243 , B01D65/022 , B01D69/08 , B01D2321/16 , B01D2321/346 , B01D2323/385
摘要： The present invention discloses a blood cleaning hollow fiber membrane characterized by comprising a hydrophobic porous hollow fiber membrane and having a hydrophilic thin layer formed at least on the inner surface of said hollow fiber membrane by the grafting of a hydrophilic compound through the agency of a gamma ray, a method for the cleaning blood and an apparatus therefor using the same.

5. 发明授权

US4609464A Hollow fibers for use in dialysis and artificial kidney 失效
标题翻译：中空纤维用于透析和人造肾
公开(公告)号：US4609464A
公开(公告)日：1986-09-02
申请号：US667478
申请日：1984-10-09
申请人： Juuro Aoyagi , Kazuaki Takahara , Yukio Seita
发明人： Juuro Aoyagi , Kazuaki Takahara , Yukio Seita
IPC分类号： A61M1/18 , A61M1/16 , B01D61/16 , B01D61/18 , B01D61/24 , B01D69/02 , B01D71/06 , B01D71/10 , D01D5/24 , D01F2/04 , B32B
CPC分类号： B01D71/10 , B01D69/02 , B01D69/081 , D01D5/24 , B01D2325/022
摘要： A dialytic hollow fiber having an improved dialytic effect is disclosed which is characterized by having a wall thickness of 5 to 35 .mu.m and a truly circular cross section 50 to 500 .mu.m in outside diameter throughout the entire length and the entire circumference thereof, having a skin layer of not more than 300 .ANG. in thickness in the outer surface thereof, and containing substantially no voids in the inner surface thereof. This dialytic hollow fiber shows a permeation ratio of 20 to 40% to cytochrome C having an average molecular weight of 12,400 and a maximum fractional molecular weight of about 40,000 at an inhibition ratio of 95%, and an artificial kidney using said dialytic hollow fiber.
摘要翻译： PCT No.PCT / JP84 / 00050 Sec。 371日期1984年10月9日第 102（e）日期1984年10月9日PCT提交1984年2月17日PCT公布。出版物WO84 / 0322800 日本1984年8月30日。公开了一种具有改善的透析效果的透析中空纤维，其特征在于在整个长度上具有5至35μm的壁厚和真空的圆形横截面为50至500μm的外径和其整个周边，其外表面具有厚度不超过300的表皮层，并且在其内表面基本上不含空隙。这种透析中空纤维的抑制率为95％，平均分子量为12400，最大分子量约为40,000的细胞色素C的渗透比为20〜40％，使用了所述透析中空纤维的人造肾。

6. 发明授权

US4444716A Method for manufacture of hollow fiber 失效
标题翻译：中空纤维的制造方法
公开(公告)号：US4444716A
公开(公告)日：1984-04-24
申请号：US381857
申请日：1982-05-25
申请人： Juuro Aoyagi , Kazuaki Takahara , Yukio Seita
发明人： Juuro Aoyagi , Kazuaki Takahara , Yukio Seita
IPC分类号： D01F2/00 , B01D67/00 , B01D69/08 , B01D71/06 , B01D71/10 , D01D5/24 , D01D5/247 , D01F1/08 , D01F2/04 , B29D27/00
CPC分类号： B01D71/10 , B01D69/08 , B01D69/087 , D01D5/24 , D01F2/04 , B01D2323/42
摘要： A method for the manufacture of a hollow fiber which comprises extruding a cellulosic spinning dope through an annular spinning nozzle directly into a non-coagulative liquid layer in a bath filled in the upper layer with a coagulative liquid relative to said spinning dope and in the lower layer with a non-coagulative liquid of a halogenated hydrocarbon and, at the same time, introducing a non-coagulative liquid relative to said spinning dope into the inner center of the tubularly extruded thread of spinning dope, and subsequently passing the resultant tubular fiber of spinning dope through said coagulative liquid thereby coagulating and regenerating the fiber.
摘要翻译：一种制造中空纤维的方法，其包括将纤维素纺丝原液通过环形纺丝喷嘴直接挤入位于上层中的浴中的非凝固性液体层中，所述溶液相对于所述纺丝原液凝固液体和下层层，同时将相对于所述纺丝原液的非凝固液体引入纺丝原液的管状挤出线的内部中心，然后将得到的管状纤维通过所述凝固液纺丝，从而凝结和再生纤维。

7. 发明授权

US4444663A Membrane and method for manufacture thereof 失效
标题翻译：膜及其制造方法
公开(公告)号：US4444663A
公开(公告)日：1984-04-24
申请号：US302214
申请日：1981-09-14
申请人： Juuro Aoyagi , Kazuhiko Suzuki , Kazuaki Takahara
发明人： Juuro Aoyagi , Kazuhiko Suzuki , Kazuaki Takahara
IPC分类号： B01D67/00 , B01D71/10 , D01D5/24 , B01D39/00
CPC分类号： B01D67/003 , B01D71/10 , D01D5/24 , Y10T428/2975
摘要： A liquid composition for the manufacture of a membrane, comprising a reaction product a cuprammonium cellulose with an ammonium or alkali metal salt of a polymer containing 10 to 70 equivalent percent of a carboxyl group and having a number-averaged molecular weight in the range of from 500 to 200,000, and a membrane is obtained by molding the composition in the form of a film, immersing the shaped article thus obtained in a dilute sulfuric acid solution thereby coagulating and regenerating it, subsequently immersing the shaped article in an strong alkali solution thereby expelling said ammonium or alkali metal salt of the polymer therefrom and forming therein fine pores substantially corresponding to the molecular weight of said salt.
摘要翻译：一种用于制造膜的液体组合物，其包含铜铵纤维素与含有10至70当量羧基的聚合物的铵或碱金属盐的反应产物，其数均分子量范围为 500至200,000，并且通过将该组合物成型为膜形成膜，将由此获得的成形制品浸入稀硫酸溶液中而使其凝结和再生，从而将成形制品浸入强碱溶液中，从而排出膜所述聚合物的铵或碱金属盐形成其中基本对应于所述盐的分子量的细孔。

8. 发明申请

US20060222714A1 Agent for preventing and ameliorating constipation 审中-公开
标题翻译：防止和改善便秘的药剂
公开(公告)号：US20060222714A1
公开(公告)日：2006-10-05
申请号：US10553880
申请日：2004-04-22
申请人： Juuro Aoyagi
发明人： Juuro Aoyagi
IPC分类号： A61K9/14 , A61K31/729 , A61K31/737
CPC分类号： A61K45/06 , A61K9/1652 , A61K31/734 , A61K33/00 , A61K2300/00
摘要： A novel agent for preventing and healing constipation which heals the symptom of constipation very effectively and entails absolutely no side effect is provided. This agent for preventing and healing constipation is formed by containing a hydrogen of a polyvalent metal salt of alginic acid possessing a spherical or ovaloid shape having a short diameter in the range of 1-10 mm and an aspect ratio (long diemter/short diameter) in the range of 1-25. The hydrogel of a polyvalent metal salt of alginic acid is obtained by dropping an aqueous solution of sodium alginate into an aqueous solution of a polyvlant metal salt. It is optionally stored in water and/or a hydrogen compound of a natural compound possessing a free acid group capable of reacting and sequestering a basic compound.
摘要翻译：提供了一种预防和治疗便秘治疗便秘症状的新型药剂，非常有效，并且绝对没有副作用。这种用于预防和治疗便秘的药剂通过含有具有1-10mm范围内的短直径和长宽比（长二体/短直径）的具有球形或椭圆形的海藻酸的多价金属盐的氢形成，在1-25的范围内。海藻酸多价金属盐的水凝胶是通过将藻酸钠水溶液滴加到聚氨酯金属盐的水溶液中而获得的。任选地存储在具有能够使碱性化合物反应和螯合的游离酸基团的天然化合物的水和/或氢化合物中。

9. 发明申请

US20050101482A1 Novel adsorbent 审中-公开
标题翻译：新型吸附剂
公开(公告)号：US20050101482A1
公开(公告)日：2005-05-12
申请号：US11018838
申请日：2004-12-20
申请人： Juuro Aoyagi , Ryuichi Endo
发明人： Juuro Aoyagi , Ryuichi Endo
IPC分类号： A23L5/20 , B01J20/02 , B01J20/20 , B01J20/22 , B01J20/32
CPC分类号： B01J20/20 , A23L5/273 , B01J20/3078 , B01J20/3204 , B01J20/3242 , B01J20/3268 , B01J20/3274 , B01J2220/58
摘要： An adsorbent is disclosed which is formed either by coating an adsorption mass such as active carbon with a gel-like substance such as the dibasic metallic salt of a macromolecular polycarboxylic acid, soybean curd, jelly, konjak, agar, perilla, gelidium jelly, or chitosanoxalic acid salt gel and subsequently subjecting the coated basis to a freezing treatment or by effecting the coating with the gel-like substance already made to contain a frost damage preventing substance such as glycerin and subsequently depriving the coated basis of the frost damage preventing substance. This adsorbent, on being brought into direct contact with foodstuffs or ingested directly into the digestive system, effects highly efficient removal by adsorption of such food additive, feed additive, agricultural pesticide, food poisoning substance, allergen, heavy metal or highly poisonous organic compound as are suffered to adhere to or exist in the foodstuffs, such surplus nutrients as persist in the digestive system, such oligomers and additives as are contained in liquors, such metabolites of alcohol as are formed in the digestive system after assimilation of alcohol, such harmful substances as hydroperoxides of unsaturated fatty acids as are suffered to exist in oils and fats, and such components of offensive odor as emanate from fish.
摘要翻译：公开了一种吸附剂，其通过用诸如大分子多元羧酸的二元金属盐，大豆凝乳，果冻，魔芋，琼脂，紫苏，凝胶状果胶等凝胶状物质涂覆活性炭等吸附物质形成。并且随后对涂覆的基础进行冷冻处理，或者通过使已经制成的凝胶状物质涂覆含有诸如甘油之类的防冻害物质，随后剥去防冻物质的涂覆基础。该吸附剂与食品直接接触或直接摄取到消化系统中，通过吸附这种食品添加剂，饲料添加剂，农药，食物中毒物质，过敏原，重金属或高毒性有机化合物，可以高效除去在食品中遭受粘附或存在，如消化系统中残留的剩余营养物质，如在酒类中所含的这种低聚物和添加剂，在消化系统中形成的醇的这种代谢物同化酒精后，这种有害物质作为在油和脂肪中存在的不饱和脂肪酸的氢过氧化物，以及由鱼产生的令人反感的气味的成分。

10. 发明授权

US06299867B1 Adsorbent 失效
标题翻译：吸附剂
公开(公告)号：US06299867B1
公开(公告)日：2001-10-09
申请号：US09230387
申请日：1999-01-22
申请人： Juuro Aoyagi , Ryuichi Endo
发明人： Juuro Aoyagi , Ryuichi Endo
IPC分类号： A61L900
CPC分类号： A23C7/043 , A21D2/02 , A23D9/06 , A23K20/10 , A23K20/184 , A23K20/20 , A23L5/273 , A23L33/29 , A23V2002/00 , A61K31/047 , A61L9/01 , B01J20/20 , B01J20/28047 , B01J20/30 , B01J20/3204 , B01J20/3236 , B01J20/327 , B01J20/3274 , B01J20/3276 , C12H1/04 , A23V2250/5066 , A23V2250/1576 , A23V2250/5026
摘要： An adsorbent is disclosed which is formed either by coating an adsorption mass such as active carbon with a gel-like substance such as the dibasic metallic salt of a macromolecular polycarboxylic acid, soybean curd, jelly, konjak, agar, perilla, gelidium jelly, or chitosanoxalic acid salt gel and subsequently subjecting the coated basis to a freezing treatment or by effecting the coating with the gel-like substance already made to contain a frost damage preventing substance such as glycerin and subsequently depriving the coated basis of the frost damage preventing substance. This adsorbent, on being brought into direct contact with foodstuffs or ingested directly into the digestive system, effects highly efficient removal by adsorption of such food additive, feed additive, agricultural pesticide, food poisoning substance, allergen, heavy metal or highly poisonous organic compound as are suffered to adhere to or exist in the foodstuffs, such surplus nutrients as persist in the digestive system, such oligomers and additives as are contained in liquors, such metabolites of alcohol as are formed in the digestive system after assimilation of alcohol, such harmful substances as hydroperoxides of unsaturated fatty acids as are suffered to exist in oils and fats, and such components of offensive odor as emanate from fish.
摘要翻译：公开了一种吸附剂，其通过用诸如大分子多元羧酸的二元金属盐，大豆凝乳，果冻，魔芋，琼脂，紫苏，凝胶状果胶等凝胶状物质涂覆活性炭等吸附物质形成。并且随后对涂覆的基础进行冷冻处理，或者通过使已经制成的凝胶状物质涂覆含有诸如甘油之类的防冻害物质，随后剥去防冻物质的涂覆基础。该吸附剂与食品直接接触或直接摄取到消化系统中，通过吸附这种食品添加剂，饲料添加剂，农药，食物中毒物质，过敏原，重金属或高毒性有机化合物，可以高效除去在食品中遭受粘附或存在，如消化系统中残留的剩余营养物质，如在酒类中所含的这种低聚物和添加剂，在消化系统中形成的醇的这种代谢物同化酒精后，这种有害物质作为在油和脂肪中存在的不饱和脂肪酸的氢过氧化物，以及由鱼产生的令人反感的气味的成分。

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