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1. 发明授权

US08668971B2 Multiple compartment container 有权
标题翻译：多隔间容器
公开(公告)号：US08668971B2
公开(公告)日：2014-03-11
申请号：US10548622
申请日：2004-03-11
申请人： Toyoaki Suzuki , Koichi Miura
发明人： Toyoaki Suzuki , Koichi Miura
IPC分类号： B32B27/32
CPC分类号： A61J1/2093 , A61J1/2024 , B32B7/04 , B32B7/06 , B32B7/10 , B32B7/12 , B32B7/14 , B32B27/08 , B32B27/325 , B32B2270/00 , B32B2307/30 , B32B2307/31 , B32B2307/748 , B32B2439/40 , B32B2439/46 , B32B2439/80 , B65D81/3266 , Y10T428/13 , Y10T428/1352 , Y10T428/1359
摘要： A package with multiple chambers, wherein the inside of the package is partitioned into multiple chambers by a weak seal part(s) formed by sealing one sheet having a heat seal layer in at least one surface thereof and the other sheet having a heat seal layer in at least one surface thereof with the heat seal layers facing each other and sealing the peripheral edge parts thereof, and heat-pressing, from the outside of the package, a part of the inner surfaces of the walls of the package with the heat seal layers. The package is characterized in that both of two heat seal layers forming the inner surfaces of the walls include only a cyclic polyolefin resin as a resin ingredient.
摘要翻译：一种具有多个室的包装，其中通过在其至少一个表面中密封具有热密封层的一个片材而形成的弱密封部分将包装的内部分隔成多个室，而另一个片材具有热封层在其至少一个表面中，热封层彼此面对并且密封其周边部分，并且从包装的外部将包装的壁的内表面的一部分用热封层。该封装的特征在于，形成壁的内表面的两个热封层都仅包含作为树脂成分的环状聚烯烃树脂。

2. 发明申请

US20080044606A1 Medical Container and Medical Duplex Container 有权
标题翻译：医疗集装箱和医疗复式集装箱
公开(公告)号：US20080044606A1
公开(公告)日：2008-02-21
申请号：US11663886
申请日：2005-09-26
申请人： Kenji Omori , Takeshi Nizuka , Dai Sudo , Manabu Fujimoto , Koichi Miura , Toyoaki Suzuki , Kaori Ikeda , Hideji Kashiwagi , Hidetoshi Myojyo , Masashi Moteki
发明人： Kenji Omori , Takeshi Nizuka , Dai Sudo , Manabu Fujimoto , Koichi Miura , Toyoaki Suzuki , Kaori Ikeda , Hideji Kashiwagi , Hidetoshi Myojyo , Masashi Moteki
IPC分类号： A61J1/00 , B32B27/32
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , A61M2207/00 , B32B3/02 , B32B15/08 , B32B15/20 , B32B27/08 , B32B27/32 , B32B27/325 , B32B27/36 , B32B2255/10 , B32B2255/205 , B32B2307/7242 , B32B2307/7246 , B32B2307/75 , B32B2439/46 , B32B2439/80 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139
摘要： A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.
摘要翻译：一种医疗容器，包括用于容纳药物的主体，所述医疗容器的主体由多层膜形成，所述多层膜包括（i）由线性聚烯烃形成的层和（ii）由邻近所述层的环状聚烯烃形成的层 i）和由线性聚烯烃形成的满足以下条件（a）和/或（b）的层（i））：条件（a）：索格利特有机溶剂萃取后留下的液体组分的量溶剂的蒸发为0.2重量％以下，条件（b）：在索氏提取后，用正己烷蒸发后残留的成分的分支度为每1000个碳原子数为50以下原子

3. 发明申请

US20050031812A1 Packaging bag and method for production thereof 审中-公开
标题翻译：包装袋及其生产方法
公开(公告)号：US20050031812A1
公开(公告)日：2005-02-10
申请号：US10496077
申请日：2002-11-21
申请人： Toyoaki Suzuki
发明人： Toyoaki Suzuki
IPC分类号： B29C45/14 , B29C47/06 , B29C65/02 , B29C65/08 , B29C65/48 , B29C65/50 , B29C65/52 , B29C65/70 , B31B19/64 , B31B19/84 , B65D30/02 , B65D75/28 , B65D75/58 , B65D1/00
CPC分类号： B65D75/5883 , B29C45/14336 , B29C45/14467 , B29C48/08 , B29C48/18 , B29C65/02 , B29C65/08 , B29C65/4815 , B29C65/5057 , B29C65/525 , B29C65/70 , B29C66/1122 , B29C66/24 , B29C66/43 , B29C66/4326 , B29C66/53262 , B29C66/71 , B29C66/723 , B29C66/72321 , B29C66/72341 , B29C66/8322 , B29K2023/0625 , B29K2023/086 , B29K2027/08 , B29K2027/18 , B29K2033/20 , B29K2067/00 , B29K2069/00 , B29K2077/00 , B29K2995/0067 , B29L2009/00 , B29L2009/003 , B29L2009/008 , B29L2031/7128 , B29L2031/7148 , B31B70/64 , B31B70/844 , B65D75/28 , Y10T428/1334 , Y10T428/1352 , B29K2067/003 , B29K2027/12 , B29K2023/38 , B29K2023/12 , B29K2023/06
摘要： A packaging bag, characterized in that it comprises 2 sheets of resin film (2,2) having innermost layers (2a, 2a) made from one or more resins selected from the group consisting of a polyester, a polyamide, a polyacrylonitrile, a polycarbonate, a cyclic polyolefin and a polyfluoroethylene, the 2 sheets of resin film are arranged so that the innermost layers (2a, 2a) face each other in the inner sides thereof, and peripheral edge portions of the two resin films (2,2) are bound to each other via a peripheral edge adhesion section (3) comprising a thermoplastic resin capable of melting and adhering to the resin films (2, 2).
摘要翻译：一种包装袋，其特征在于，它包括2片由一种或多种选自聚酯，聚酰胺，聚丙烯腈，聚碳酸酯的树脂制成的最内层（2a，2a）的树脂膜（2,2），环状聚烯烃和聚氟乙烯，所述2片树脂膜的内侧配置有最内层（2a，2a）彼此面对，并且两个树脂膜（2,2）的周缘部分为通过包括能够熔融粘合到树脂膜（2,2）上的热塑性树脂的周边边缘粘合部分（3）彼此结合。

4. 发明授权

US06582603B1 Method for purifying thrombin substrate and/or inhibitors or method for eliminating the same 失效
标题翻译：凝血酶底物和/或抑制剂的纯化方法或其除去方法
公开(公告)号：US06582603B1
公开(公告)日：2003-06-24
申请号：US09529963
申请日：2000-07-21
申请人： Toyoaki Suzuki , Kazuya Hosokawa , Masanori Nagata
发明人： Toyoaki Suzuki , Kazuya Hosokawa , Masanori Nagata
IPC分类号： B01D1508
CPC分类号： C12N9/1044 , C07K14/755 , C12N9/6429 , C12N9/6443 , C12N11/00 , C12Y304/21005 , C12Y304/21027
摘要： A method for the refinement of a thrombin substrate, characterized by comprising therein a step of affinity chromatography formed by using an affinity adsorbent having as a ligand a thrombin or thrombin analogue deprived of nucleophilicity (activity) without causing stereostructure to the linkage with a substrate is disclosed.
摘要翻译：一种精制凝血酶底物的方法，其特征在于在其中包含通过使用没有引起立体结构与底物连接的凝血酶或没有亲核性（活性）的凝血酶或凝血酶类似物作为配体的亲和吸附剂形成的亲和层析步骤，披露

5. 发明申请

US20110266184A1 POURING PORT, METHOD FOR PRODUCING SAME AND CONTAINER FOR LIQUID PROVIDED WITH THE POURING PORT 有权
标题翻译：浇口，用于生产它们的方法和用于在POURING PORT提供的液体的容器
公开(公告)号：US20110266184A1
公开(公告)日：2011-11-03
申请号：US13143330
申请日：2009-12-24
申请人： Toyoaki Suzuki , Koichi Miura
发明人： Toyoaki Suzuki , Koichi Miura
IPC分类号： B65D85/00 , B32B37/06
CPC分类号： A61J1/1475 , A61J1/10 , B29C65/08 , B29C66/712 , B32B7/12 , B32B27/08 , B32B27/304 , B32B27/306 , B32B27/32 , B32B27/34 , B32B27/36 , B32B2307/306 , B32B2307/31 , B32B2307/412 , B32B2307/50 , B32B2307/518 , B32B2307/546 , B32B2307/7244 , B32B2307/7246 , B32B2439/46 , B32B2439/80
摘要： A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an antioxidant in an amount of 0.1% by mass or more and not more than 1.0% by mass.
摘要翻译：一种用于液体的容器的倾倒口嵌入一个允许注射针穿过的橡胶塞，其中：所述倾倒口是通过焊接端口部分形成的，至少其最内层形成排出其通道包括含有COP基树脂作为主要成分的树脂，具有塞体部分，其通过包含各COP的树脂层保持橡胶塞并包含含有COP基树脂作为主要成分的树脂基树脂为主要成分; 并且至少构成塞体部的树脂含有不超过30质量％的橡胶组分，或者在主链中具有由通式（1）表示的分子结构[其中R表示氢原子或碳原子数为1〜20的有机基团; n表示1以上的整数]，含有30质量％以下的PE系树脂，和/或含有0.1质量％以上且不大于 1.0质量％。

6. 发明授权

US5939304A Method for synthesis of anhydrothrombin 失效
标题翻译：合成脱水凝血酶的方法
公开(公告)号：US5939304A
公开(公告)日：1999-08-17
申请号：US88244
申请日：1998-06-01
申请人： Toyoaki Suzuki , Kazuya Hosokawa , Masanori Nagata
发明人： Toyoaki Suzuki , Kazuya Hosokawa , Masanori Nagata
IPC分类号： A61P7/02 , C07K1/113 , C07K14/745 , C12N9/74 , A61K38/48
CPC分类号： C12N9/6429 , C12Y304/21005
摘要： A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields.The method comprises(A) a step of causing an active serine residue site of thrombin to react with an inhibitor,(B) a step of performing an alkali treatment at a pH of not less than 11, and(C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.
摘要翻译：提供了一种合成脱水凝血酶的方法，其具有短程序，易操作和高产率。该方法包括（A）使凝血酶的活性丝氨酸残基部位与抑制剂反应的步骤，（B）在pH不低于11的情况下进行碱处理的工序，（C）回收操作，按顺序依次进行，其特征在于至少在至少一种选自多元醇和多元醇的化合物的存在下至少进行回收操作的步骤，糖类，以及盐或两性电解质。

7. 发明授权

US08309189B2 Multilayered liquid container 有权
标题翻译：多层液体容器
公开(公告)号：US08309189B2
公开(公告)日：2012-11-13
申请号：US13057439
申请日：2009-07-27
申请人： Toyoaki Suzuki , Koichi Miura , Atsushi Mio
发明人： Toyoaki Suzuki , Koichi Miura , Atsushi Mio
IPC分类号： B29D22/00
CPC分类号： B65D75/5883 , A61J1/10 , A61J1/1475 , B32B27/32 , Y10T428/1352
摘要： A multilayered liquid container having a discharge port welded under specified conditions to a sealant, which is constituted of a resin comprising a cycloolefin resin as a main component. The discharge port is composed of: an innermost layer constituted of a resin comprising a cycloolefin as a main component; and a surface layer whose main part is constituted of a resin comprising a specific type of polyethylene as a main component. According to the present invention, there can be provided a multilayered liquid container, which can prevent an effective component of a content fluid from being adsorbed onto or penetrating through not only the container body, but also the resin constituting the discharge port, and enables high temperature sterilization treatment, coupled with the discharge port having high welded strength and drop strength.
摘要翻译：一种多层液体容器，其具有在特定条件下焊接到由包含环烯烃树脂作为主要成分的树脂构成的密封剂的排出口。排出口由以下物质构成：由以环烯为主要成分的树脂构成的最内层; 以及其主要部分由包含特定类型的聚乙烯作为主要成分的树脂构成的表面层。根据本发明，可以提供一种多层液体容器，其能够防止含量流体的有效成分不仅吸附到或穿过容器主体，也可以渗透到构成排出口的树脂上，并且能够高与排出口相结合，焊接强度高，落下强度高。

8. 发明授权

US08029878B2 Medical container and medical duplex container 有权
标题翻译：医用容器和医用双相容器
公开(公告)号：US08029878B2
公开(公告)日：2011-10-04
申请号：US11663886
申请日：2005-09-26
申请人： Kenji Omori , Takeshi Nizuka , Dai Sudo , Manabu Fujimoto , Masashi Moteki , Toyoaki Suzuki , Koichi Miura , Kaori Ikeda , Hideji Kashiwagi , Hidetoshi Myojyo
发明人： Kenji Omori , Takeshi Nizuka , Dai Sudo , Manabu Fujimoto , Masashi Moteki , Toyoaki Suzuki , Koichi Miura , Kaori Ikeda , Hideji Kashiwagi , Hidetoshi Myojyo
IPC分类号： B32B1/02 , B32B1/08
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , A61M2207/00 , B32B3/02 , B32B15/08 , B32B15/20 , B32B27/08 , B32B27/32 , B32B27/325 , B32B27/36 , B32B2255/10 , B32B2255/205 , B32B2307/7242 , B32B2307/7246 , B32B2307/75 , B32B2439/46 , B32B2439/80 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139
摘要： A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.
摘要翻译：一种医疗容器，包括用于容纳药物的主体，所述医疗容器的主体由多层膜形成，所述多层膜包括（i）由线性聚烯烃形成的层和（ii）由邻近所述层的环状聚烯烃形成的层 i）和由线性聚烯烃形成的满足以下条件（a）和/或（b）的层（i））：条件（a）：索格利特有机溶剂萃取后留下的液体组分的量溶剂的蒸发为0.2重量％以下，条件（b）：在索氏提取后，用正己烷蒸发后残留的成分的分支度为每1000个碳原子数为50以下原子

9. 发明授权

US07976917B2 Multi-chamber container 有权
标题翻译：多室容器
公开(公告)号：US07976917B2
公开(公告)日：2011-07-12
申请号：US10582100
申请日：2004-12-10
申请人： Toyoaki Suzuki , Koichi Miura , Kenjiro Takayanagi
发明人： Toyoaki Suzuki , Koichi Miura , Kenjiro Takayanagi
IPC分类号： B29D22/00
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , A61M2207/00 , B32B27/08 , B32B27/32 , B32B2250/242 , B32B2307/31 , B32B2307/5825 , B32B2439/40 , B65D75/5883 , B65D81/3266 , Y10T428/1334 , Y10T428/1352
摘要： Multi-chamber container (1) having its interior partitioned by weak seal portions (3) provided through detachable heat sealing so that multiple contents are accommodated separately from each other, wherein use is made of heat seal layers consisting of a composition comprising two types of propylene copolymers components (component A and component B) from propylene and ethylene and/or a C4-C8 α-olefin which have the following elution properties. Thus, a region wherein a change of seal strength by a change of heat seal temperature is small has a wide temperature range to thereby facilitate controlling of the seal strength at the weak seal portions. The proportion (mass %) of, to total solution, elution according to the TREF method (temperature: 0 to 140° C. and solvent: ODCB) is as follows. With respect to component A: 15 to 50 at 0° C., and 5 to less than 15 at 60 to 90° C. With respect to component B: 0 to 25 at 0° C., and 15 to 70 at 60 to 90° C.
摘要翻译：多室容器（1）具有通过可拆卸热封提供的弱密封部分（3）的内部分隔，使得多个内容物彼此分开容纳，其中使用的热封层由包含两种来自丙烯和乙烯的丙烯共聚物组分（组分A和组分B）和/或具有以下洗脱性质的C 4 -C 8α-烯烃。因此，通过热封温度的变化，密封强度的变化小的区域具有宽的温度范围，从而有助于控制弱密封部分处的密封强度。相对于总溶液，根据TREF方法（温度：0〜140℃，溶剂：ODCB）的洗脱比例（质量％）如下。相对于组分A，在0℃为15〜50℃，在60〜90℃为5〜15℃。相对于组分B，0℃为0〜25℃，在60〜 90°C

10. 发明申请

US20100163446A1 LIQUID CONTAINER 审中-公开
标题翻译：液体容器
公开(公告)号：US20100163446A1
公开(公告)日：2010-07-01
申请号：US12303759
申请日：2007-06-26
申请人： Toyoaki Suzuki , Koichi Miura , Akemi Kishimoto , Kunihiko Kimura , Yoshikazu Kato , Yukie Ito
发明人： Toyoaki Suzuki , Koichi Miura , Akemi Kishimoto , Kunihiko Kimura , Yoshikazu Kato , Yukie Ito
IPC分类号： A61J1/10 , B32B27/00 , B65D30/02
CPC分类号： B65D31/02 , A61J1/10 , B32B27/32 , B32B27/325 , B32B2439/00 , Y10T428/1341
摘要： To provide a liquid container, which exhibits excellent storage stability and impact resistance and which can be used for producing a soft bag pharmaceutical product of an injection liquid containing nitroglycerin, a protein, hyaluronic acid, a vitamin, a trace element, a radical scavenger, and the like.The liquid container of the invention formed of a multilayer film and/or multilayer sheet, characterized in that the multilayer film and/or multilayer sheet has a barrier layer containing, as a predominant component, a polycycloolefin-based resin having a glass transition temperature higher by 5° C. or more than the temperature at which the container is subjected to thermal treatment or high-pressure steam sterilization, and a seal layer containing, as a predominant component, a polyethylene-based resin or a polypropylene-based resin, and the barrier layer being provided adjacent to the seal layer.
摘要翻译：本发明提供一种储存稳定性和耐冲击性优异的液体容器，其能够用于生产含有硝酸甘油，蛋白质，透明质酸，维生素，微量元素，自由基清除剂的注射液的软袋药物，等等。本发明的液体容器由多层薄膜和/或多层薄片形成，其特征在于，多层薄膜和/或多层薄片具有阻挡层，该阻挡层含有玻璃化转变温度较高的聚环烯烃系树脂作为主要成分比容器进行热处理或高压蒸汽灭菌的温度高5℃或以上，以及包含聚乙烯类树脂或聚丙烯类树脂作为主要成分的密封层，以及所述阻挡层邻近所述密封层设置。

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