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1. 发明申请

US20110129468A1 PURIFIED IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF THEIR PURIFICATION 审中-公开
标题翻译：纯化的免疫球蛋白融合蛋白及其纯化方法
公开(公告)号：US20110129468A1
公开(公告)日：2011-06-02
申请号：US12919869
申请日：2009-02-27
申请人： Justin Mccue , Jonathan Romero , Werner Meier , Stephen Notarnicola , David Evans , Richard Macniven
发明人： Justin Mccue , Jonathan Romero , Werner Meier , Stephen Notarnicola , David Evans , Richard Macniven
IPC分类号： A61K39/395 , C07K16/00 , A61P37/06
CPC分类号： C07K14/7151 , A61K47/6811 , A61K47/6835 , C07K2319/30 , C07K2319/32
摘要： The invention provides methods and compositions for separating impurities during the manufacture of immunoglobulin (Ig) fusion proteins. Examples of impurities which may be removed in accordance with the methods of the invention include inactive forms of the Ig fusion protein and/or aggregates.
摘要翻译：本发明提供了在制造免疫球蛋白（Ig）融合蛋白期间分离杂质的方法和组合物。根据本发明的方法可以除去的杂质的实例包括Ig融合蛋白和/或聚集体的无活性形式。

2. 发明授权

US08992617B2 Adjustable intervertebral implant 有权
标题翻译：可调椎间植入物
公开(公告)号：US08992617B2
公开(公告)日：2015-03-31
申请号：US12527055
申请日：2008-03-13
申请人： William Woodburn , David Evans
发明人： William Woodburn , David Evans
IPC分类号： A61F2/44 , A61F2/28 , A61F2/30
CPC分类号： A61F2/44 , A61F2/4465 , A61F2002/2835 , A61F2002/30004 , A61F2002/30133 , A61F2002/302 , A61F2002/30235 , A61F2002/30369 , A61F2002/30405 , A61F2002/30495 , A61F2002/305 , A61F2002/30507 , A61F2002/30517 , A61F2002/30522 , A61F2002/3055 , A61F2002/30565 , A61F2002/30571 , A61F2002/30574 , A61F2002/30601 , A61F2002/30604 , A61F2002/30785 , A61F2002/30843 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033 , A61F2230/0015 , A61F2230/0065 , A61F2230/0069 , A61F2250/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179
摘要： An expandable intervertebral implant (10) includes a first member (20), a second member (40), and a collar operatively associated with the first and second members, wherein the collar includes a threaded mechanism so that rotation of the collar causes the second member to axially move with respect to the first member. The implant includes a ratchet mechanism (50, 80) so that when at least a predetermined amount of force is applied, the second member moves with respect to the first member in an axial, ratchet-type manner. The collar preferably includes a drive ring (60) rotatably attached to the first member and a ratchet ring (80) operatively associated with the drive ring. The ratchet ring includes an inner bore having at least one corresponding ratchet thread tooth form formed thereon for engaging a ratchet thread tooth form formed on the second member.
摘要翻译：可扩展的椎间植入物（10）包括第一构件（20），第二构件（40）和与第一和第二构件可操作地相关联的套环，其中，套环包括螺纹机构，使得套环的旋转使第二构件构件相对于第一构件轴向移动。植入物包括棘轮机构（50,80），使得当施加至少预定量的力时，第二构件相对于第一构件以轴向棘轮式移动。套环优选地包括可旋转地附接到第一构件的驱动环（60）和与驱动环可操作地相关联的棘轮环（80）。棘轮环包括内孔，其具有形成在其上的至少一个对应的棘齿螺纹齿，用于接合形成在第二构件上的棘轮螺纹齿形。

3. 发明申请

US20140236676A1 SYSTEM FOR PROVIDING CONSUMER RATINGS 审中-公开
标题翻译：提供消费者评级的系统
公开(公告)号：US20140236676A1
公开(公告)日：2014-08-21
申请号：US14180340
申请日：2014-02-13
申请人： Marie B. V. Olesen , Dana Fox , David Evans , April K. Linden , Eva K. Sheie , Aimee Ellingsen
发明人： Marie B. V. Olesen , Dana Fox , David Evans , April K. Linden , Eva K. Sheie , Aimee Ellingsen
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0282 , G06Q30/0203
摘要： A technique of providing consumer ratings relates to the requesting from providers, consumer contact information for consumers receiving goods and/or services from the providers by an independent third-party rating service. In response to receiving the consumer contact information, sending of survey questionnaires to the consumers may then be accomplished. The independent third-party rating service may then cause the compiling of the survey results, and then may display on its third-party website the consumer ratings for the actual consumers who have received the goods and/or services. The third-party rating service may supply to the provider computers the ratings or reviews from the surveyed consumers. Sub-categories may also be searched.
摘要翻译：提供消费者评级的技术涉及从供应商那里请求消费者的联系信息，以便消费者通过独立的第三方评级服务从供应商接收商品和/或服务。响应于收到消费者联系信息，可以向消费者发送调查问卷。独立的第三方评级服务可能导致调查结果的编制，然后可以在其第三方网站上显示已接收货物和/或服务的实际消费者的消费者评级。第三方评级服务可能会向提供商计算机提供受访消费者的评级或评价。也可以搜索子类别。

4. 发明申请

US20140037961A1 System For Purifying, Producing And Storing Biomolecules 审中-公开
标题翻译：净化，生产和储存生物分子系统
公开(公告)号：US20140037961A1
公开(公告)日：2014-02-06
申请号：US14111305
申请日：2012-04-12
申请人： David Evans
发明人： David Evans
IPC分类号： C07C319/28 , C07K17/02 , C07C323/58 , C07K1/22 , C07C59/347
CPC分类号： C07C319/28 , A61K47/6817 , A61K47/6855 , B01J20/287 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3274 , C07C59/347 , C07C323/58 , C07K1/22 , C07K17/02 , Y10T428/2982
摘要： The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
摘要翻译：本发明涉及一种应用于生物分子如抗体的锁定释放方法，以改善生物分子的纯化，生产，稳定性和储存。生物分子与包含二酮基团的聚合物载体共价结合，使得生物分子可以在从载体释放之前被纯化，产生和/或储存。聚合物载体的二酮基团是1,3-酮酯，1,3-酮硫代酯或1,3-酮酰胺是式（1）的基团：R 1是任选取代的烃基，全卤代烃基或杂环基; Y是氢，任选取代的烃基或杂环基; X是-O，-NR 2或-S，其中-O，-NR 2或-S的游离基任选地经由连接基与支持基结合; 和R 2是氢，任选取代的烃基或杂环基。本发明还涉及包含二酮基团的聚合物载体。

5. 发明申请

US20130257378A1 Transition Metal Hexacyanoferrate Battery Cathode with Single Plateau Charge/Discharge Curve 有权
标题翻译：过渡金属Hexacyanoferrate电池阴极与单一高原充电/放电曲线
公开(公告)号：US20130257378A1
公开(公告)日：2013-10-03
申请号：US13752930
申请日：2013-01-29
申请人： Yuhao Lu , Hidayat Kisdarjono , Jong-Jan Lee , David Evans
发明人： Yuhao Lu , Hidayat Kisdarjono , Jong-Jan Lee , David Evans
IPC分类号： H01M4/136 , H02J7/00
CPC分类号： H01M4/5825 , H01M4/136 , H01M4/58 , H01M4/625 , H01M10/054 , H01M10/0568 , H01M10/446 , H01M2004/028 , H02J7/0063 , H02J7/0068 , Y02E60/122
摘要： A transition metal hexacyanoferrate (TMH) cathode battery is provided. The battery has a AxMn[Fe(CN)6]y.zH2O cathode, where the A cations are either alkali or alkaline-earth cations, such as sodium or potassium, where x is in the range of 1 to 2, where y is in the range of 0.5 to 1, and where z is in the range of 0 to 3.5. The AxMn[Fe(CN)6]y.zH2O has a rhombohedral crystal structure with Mn2+/3+ and Fe2+3+ having the same reduction/oxidation potential. The battery also has an electrolyte, and anode made of an A metal, an A composite, or a material that can host A atoms. The battery has a single plateau charging curve, where a single plateau charging curve is defined as a constant charging voltage slope between 15% and 85% battery charge capacity. Fabrication methods are also provided.
摘要翻译：提供了一种过渡金属六氰基铁酸盐（TMH）阴极电池。电池具有AxMn [Fe（CN）6] y.zH 2 O阴极，其中A阳离子是碱金属或碱土金属阳离子，如钠或钾，其中x在1至2的范围内，其中y为在0.5至1的范围内，其中z在0至3.5的范围内。 AxMn [Fe（CN）6] y.zH2O具有具有相同还原/氧化电位的Mn2 + / 3 +和Fe2 + 3 +的菱方晶体结构。电池还具有电解质和由A金属，A复合材料或能够承载A原子的材料制成的阳极。电池具有单个平台充电曲线，其中单个平台充电曲线被定义为电池充电容量的15％至85％之间的恒定充电电压斜率。还提供制造方法。

6. 发明申请

US20130005470A1 METHOD OF OBTAINING A USER SELECTION 审中-公开
标题翻译：获取用户选择的方法
公开(公告)号：US20130005470A1
公开(公告)日：2013-01-03
申请号：US13382000
申请日：2010-07-05
申请人： David Evans , Doug Hardy
发明人： David Evans , Doug Hardy
IPC分类号： A63F9/24
CPC分类号： A63F13/424 , A63F13/215 , A63F13/814 , A63F2300/6072 , G06F3/0482 , G10H1/0016 , G10H1/18 , G10H3/188 , G10H2220/135
摘要： The present invention provides a method of obtaining a user selection in a software system, from a user with a musical instrument. One or more musical sounds are associated with each of a plurality of selectable objects (e.g. icons, menu items), which are provided to a user on a display. Musical audio is then received from the user, by playing on the musical instrument (e.g. guitar). The audio input may be received via a microphone or other audio input device. Then, the audio signal is analysed to determine whether the user played the one or more musical sounds associated with a selectable object. If so, that object is selected.
摘要翻译：本发明提供一种从具有乐器的用户获得软件系统中的用户选择的方法。一个或多个音乐声音与提供给显示器上的用户的多个可选择对象（例如图标，菜单项）中的每一个相关联。然后通过在乐器（例如吉他）上播放从用户接收音乐。可以经由麦克风或其他音频输入设备接收音频输入。然后，分析音频信号以确定用户是否播放与可选对象相关联的一个或多个音乐声音。如果是，则选择该对象。

7. 发明申请

US20120310219A1 Medical Device with Elastomeric Bulb 有权
标题翻译：带弹性球的医疗器械
公开(公告)号：US20120310219A1
公开(公告)日：2012-12-06
申请号：US13571795
申请日：2012-08-10
申请人： Roger Howard Meek , David Evans
发明人： Roger Howard Meek , David Evans
IPC分类号： A61M27/00 , B21D51/16
CPC分类号： A61M25/10183 , A61M25/0017 , A61M25/002 , A61M25/10 , A61M2039/222 , Y10T29/494
摘要： A drainage catheter including a body, a drainage lumen extending between the body proximal end and the body distal end, the drainage lumen including a distal fluid inflow port and a proximal fluid drain coupling, and an inflation lumen extending between the body proximal end and the body distal end, conveying inflating fluid from a proximal fluid supply element to a distal fluid acceptor balloon, the proximal fluid supply element adjacent the proximal fluid drain coupling. A sleeve may be secured about the proximal fluid supply element and the proximal fluid drain coupling to provide a fluid impervious coating.
摘要翻译：排水导管，其包括主体，在身体近端和身体远端之间延伸的排水腔，所述排液腔包括远端流体流入口和近端流体排出联接器，以及在身体近端和输送充气流体从近端流体供应元件到远端流体受体气囊，近端流体供应元件邻近近端流体排出联接器。套筒可以围绕近端流体供应元件和近端流体排放联接器固定以提供不透液体的涂层。

8. 发明授权

US08160979B1 Method and apparatus for providing a virtual service agent that receives queries, compares questions to a set of queries, and allows a user to confirm a closest match 有权
标题翻译：用于提供接收查询的虚拟服务代理的方法和装置，将问题与一组查询进行比较，并允许用户确认最接近的匹配
公开(公告)号：US08160979B1
公开(公告)日：2012-04-17
申请号：US11613830
申请日：2006-12-20
申请人： David Evans , Drew Thomas Burns , Edward Thaddeus Michael Miller , Paul Hewitt
发明人： David Evans , Drew Thomas Burns , Edward Thaddeus Michael Miller , Paul Hewitt
IPC分类号： G06F17/00
CPC分类号： G06F17/30675
摘要： A virtual agent is disclosed. The virtual agent may receive a question from a user, and compare the question against a list of queries contained in a database. The virtual agent may then assign a point value to the question, determine which of a set of ranges the point value matches, and perform an action responsive to which of the ranges the point value matches. The virtual agent is self-learning in that when a question is unanswerable, the virtual agent may seek out answers and store answers for future reference. Multiple virtual agents may be networked, creating a self-scaling pool of knowledge.
摘要翻译：公开了虚拟代理。虚拟代理可以从用户接收问题，并将问题与包含在数据库中的查询列表进行比较。然后，虚拟代理可以向该问题分配点值，确定点值匹配的一组范围中的哪一个，并且响应点值匹配的哪个范围来执行动作。虚拟代理是自学习的，因为一个问题是不可回答的，虚拟代理可以寻找答案并存储答案以备将来参考。可以联网多个虚拟代理，创建一个自扩展的知识库。

9. 发明申请

US20110143399A1 DNA JOINING METHOD 审中-公开
标题翻译： DNA接合方法
公开(公告)号：US20110143399A1
公开(公告)日：2011-06-16
申请号：US12503699
申请日：2009-07-15
申请人： David Evans , David O. Willer , Xiao-Dan Yao
发明人： David Evans , David O. Willer , Xiao-Dan Yao
IPC分类号： C12P19/34 , C12N9/10 , C07H21/04
CPC分类号： C12N15/66
摘要： The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving specific exonucleases alone. It has been determined that specific DNA polymerases are able to efficiently join one or more linear DNA molecules sharing ends with appropriate complementation.
摘要翻译：本发明提供了将任何线性模板DNA分子定向克隆到任何线性化载体中的方法。载体末端可以由任何限制酶切割产生。该方法不需要连接步骤，也不需要使用严格控制的条件，如同单独使用特定的核酸内切酶的方法一样。已经确定特定的DNA聚合酶能够有效地加入一个或多个具有适当互补共价末端的线性DNA分子。

10. 发明申请

US20110117800A1 Marine Heat Exchanger 审中-公开
标题翻译：海洋换热器
公开(公告)号：US20110117800A1
公开(公告)日：2011-05-19
申请号：US12946165
申请日：2010-11-15
申请人： Julian Gareth Crossley , David Evans
发明人： Julian Gareth Crossley , David Evans
IPC分类号： F01P3/20
CPC分类号： F28D7/16 , F28F21/08 , F28F2255/02 , F28F2265/26 , F28F2275/04
摘要： A marine heat exchanger comprising a housing assembly and a heat exchange core assembly. The housing assembly comprises a process fluid inlet, a process fluid outlet, a coolant inlet and a coolant outlet. The housing assembly defines a process fluid passageway between the process fluid inlet and the process fluid outlet. The heat exchange core assembly comprises a plurality of coolant tubes and a plurality of heat exchange fins. The coolant tubes comprise copper alloy and the heat exchange fins comprise copper. The coolant tubes are joined to the heat exchange fins by cuprobraze joints. The coolant tubes are provides between the coolant inlet and the coolant outlet and define a coolant passageway. At least part of the coolant tubes and at least part of the heat exchange fins extend through the process fluid passageway.
摘要翻译：一种船用热交换器，包括壳体组件和热交换芯组件。壳体组件包括过程流体入口，过程流体出口，冷却剂入口和冷却剂出口。壳体组件限定了过程流体入口和过程流体出口之间的过程流体通道。热交换芯组件包括多个冷却剂管和多个热交换翅片。冷却剂管包括铜合金，热交换翅片包括铜。冷却剂管通过杯形接头连接到热交换翅片。冷却剂管提供在冷却剂入口和冷却剂出口之间并且限定冷却剂通道。冷却剂管的至少一部分和至少一部分热交换翅片延伸穿过过程流体通道。

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