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    • 4. 发明申请
    • System For Purifying, Producing And Storing Biomolecules
    • 净化,生产和储存生物分子系统
    • US20140037961A1
    • 2014-02-06
    • US14111305
    • 2012-04-12
    • David Evans
    • David Evans
    • C07C319/28C07K17/02C07C323/58C07K1/22C07C59/347
    • C07C319/28A61K47/6817A61K47/6855B01J20/287B01J20/3212B01J20/3219B01J20/3248B01J20/3251B01J20/3274C07C59/347C07C323/58C07K1/22C07K17/02Y10T428/2982
    • The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
    • 本发明涉及一种应用于生物分子如抗体的锁定释放方法,以改善生物分子的纯化,生产,稳定性和储存。 生物分子与包含二酮基团的聚合物载体共价结合,使得生物分子可以在从载体释放之前被纯化,产生和/或储存。 聚合物载体的二酮基团是1,3-酮酯,1,3-酮硫代酯或1,3-酮酰胺是式(1)的基团:R 1是任选取代的烃基,全卤代烃基或杂环基; Y是氢,任选取代的烃基或杂环基; X是-O,-NR 2或-S,其中-O,-NR 2或-S的游离基任选地经由连接基与支持基结合; 和R 2是氢,任选取代的烃基或杂环基。 本发明还涉及包含二酮基团的聚合物载体。
    • 10. 发明申请
    • Marine Heat Exchanger
    • 海洋换热器
    • US20110117800A1
    • 2011-05-19
    • US12946165
    • 2010-11-15
    • Julian Gareth CrossleyDavid Evans
    • Julian Gareth CrossleyDavid Evans
    • F01P3/20
    • F28D7/16F28F21/08F28F2255/02F28F2265/26F28F2275/04
    • A marine heat exchanger comprising a housing assembly and a heat exchange core assembly. The housing assembly comprises a process fluid inlet, a process fluid outlet, a coolant inlet and a coolant outlet. The housing assembly defines a process fluid passageway between the process fluid inlet and the process fluid outlet. The heat exchange core assembly comprises a plurality of coolant tubes and a plurality of heat exchange fins. The coolant tubes comprise copper alloy and the heat exchange fins comprise copper. The coolant tubes are joined to the heat exchange fins by cuprobraze joints. The coolant tubes are provides between the coolant inlet and the coolant outlet and define a coolant passageway. At least part of the coolant tubes and at least part of the heat exchange fins extend through the process fluid passageway.
    • 一种船用热交换器,包括壳体组件和热交换芯组件。 壳体组件包括过程流体入口,过程流体出口,冷却剂入口和冷却剂出口。 壳体组件限定了过程流体入口和过程流体出口之间的过程流体通道。 热交换芯组件包括多个冷却剂管和多个热交换翅片。 冷却剂管包括铜合金,热交换翅片包括铜。 冷却剂管通过杯形接头连接到热交换翅片。 冷却剂管提供在冷却剂入口和冷却剂出口之间并且限定冷却剂通道。 冷却剂管的至少一部分和至少一部分热交换翅片延伸穿过过程流体通道。