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1. 发明授权

US09546986B2 Column manager with a multi-zone thermal system for use in liquid chromatography 有权
标题翻译：具有用于液相色谱的多区域热系统的专栏经理
公开(公告)号：US09546986B2
公开(公告)日：2017-01-17
申请号：US14232681
申请日：2012-08-16
申请人： Joshua A. Shreve , John Maillet , Maria Maillet
发明人： Joshua A. Shreve , John Maillet
IPC分类号： G01N30/30 , G01N30/54 , G01N30/60 , G01N30/46 , G01N30/02 , G01N30/88
CPC分类号： G01N30/30 , G01N30/466 , G01N30/54 , G01N30/6047 , G01N2030/027 , G01N2030/303 , G01N2030/8881
摘要： A thermal system for use in a column manager of a liquid chromatography system comprises a plurality of spatially separated individually controlled thermoelectric chips. A column module houses a plurality of thermally conductive troughs. Each trough resides in a separate thermal zone to be thermally conditioned individually by one of the individually controlled thermoelectric chips. Each trough is adapted to hold one or more liquid chromatography columns therein. A plurality of spatially separated thermal bridges includes a first thermal bridge thermally coupling one of the thermoelectric chips to a first one of the plurality of troughs and a second thermal bridge of the plurality of thermal bridges thermally coupling another of the thermoelectric chips to a second one of the plurality of troughs.
摘要翻译：用于液相色谱系统的柱管理器的热系统包括多个空间分离的独立控制的热电芯片。列模块容纳多个导热槽。每个槽位于单独的热区中，由单独控制的热电芯片之一分别进行热调节。每个槽适于在其中容纳一个或多个液相色谱柱。多个空间分离的热桥包括将热电芯片中的一个热耦合到多个槽中的第一个槽的第一热桥和多个热桥中的另一个热桥将热耦合到第二热桥的第二热桥的多个槽。

2. 发明申请

US20180111062A1 GAS LIQUID SEPARATOR AND ASSOCIATED METHODS 审中-公开
公开(公告)号：US20180111062A1
公开(公告)日：2018-04-26
申请号：US15792418
申请日：2017-10-24
申请人： Joshua A. Shreve
发明人： Joshua A. Shreve
IPC分类号： B01D19/00 , B01D15/40 , B01D15/24
摘要： Exemplary embodiments are directed to a gas liquid separator that includes a chamber for receiving a fluid mixture, a fluid mixture inlet, a solvent outlet, and a gas outlet. The gas liquid separator can include a sensor disposed around or within the chamber for sensing at least one of a solvent level or a gas level. The gas liquid separator can include a regulator connected to at least one of the solvent outlet or the gas outlet for regulating at least one of the solvent level or the gas level within the chamber. Exemplary methods of regulating at least one of the solvent level or the gas level within a gas liquid separator of a CO2-based chromatography flow system are also provided.

3. 发明授权

US09377011B2 High pressure pump with reduced seal wear 有权
标题翻译：高压泵，减少密封磨损
公开(公告)号：US09377011B2
公开(公告)日：2016-06-28
申请号：US14007392
申请日：2012-04-17
申请人： Joshua A. Shreve , Neal B. Almeida , John Angelosanto , Joseph A. Luongo
发明人： Joshua A. Shreve , Neal B. Almeida , John Angelosanto , Joseph A. Luongo
IPC分类号： F04B7/00 , F04B15/00 , F04B53/00 , F04B53/02 , F04B53/16
CPC分类号： F04B7/0088 , F04B15/00 , F04B53/007 , F04B53/02 , F04B53/164
摘要： Described are embodiments of a pump that can be used, for example, in liquid chromatography applications. The pump includes a seal wash housing, pump head and seal assembly. A wear-resistant coating applied to a sealing surface or gland of the pump head or seal wash housing improves the hardness and chemical compatibility of the sealing surface. Oxidation of the sealing surface is reduced so that the sealing surface is less abrasive to the seal assembly and the lifetime of the seal assembly is increased.
摘要翻译：描述了可以用于例如液相色谱应用中的泵的实施方案。该泵包括一个密封清洗外壳，泵头和密封组件。施加到泵头或密封清洗壳体的密封表面或密封套上的耐磨涂层改善了密封表面的硬度和化学相容性。减小密封表面的氧化，使得密封表面对密封组件的磨损较小，并且密封组件的寿命增加。

4. 发明授权

US08961783B2 Apparatus and methods for preparative liquid chromatography 有权
标题翻译：制备液相色谱仪的设备和方法
公开(公告)号：US08961783B2
公开(公告)日：2015-02-24
申请号：US12555032
申请日：2009-09-08
申请人： Joshua A. Shreve , Michael R. Jackson
发明人： Joshua A. Shreve , Michael R. Jackson
IPC分类号： G01N30/34 , B01D15/16
CPC分类号： B01D15/18 , B01D15/166 , G01N30/34
摘要： A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography.
摘要翻译：液相色谱法包括提供一个或多个溶剂储存器，提供溶剂泵，响应于促进溶剂除气的压降，将一种或多种溶剂吸入泵中，以及将脱气气泡分散成较小的气泡，溶解气体。液相色谱装置包括至少两个溶剂储存器，泵，至少一个气泡分散单元，其从泵接收加压的成比例溶剂流，以及控制单元。控制单元包括处理器和存储指令的存储器; 控制单元控制溶剂的比例以获得预选的溶剂组合物，并以流速泵送以支持制备规模或过程规模的液相色谱。

5. 发明申请

US20130019695A1 APPARATUS FOR REDUCING VARIATION IN SAMPLE TEMPERATURES IN A LIQUID CHROMATOGRAPHY SYSTEM 有权
标题翻译：用于降低液相色谱系统中样品温度变化的设备
公开(公告)号：US20130019695A1
公开(公告)日：2013-01-24
申请号：US13520189
申请日：2011-01-11
申请人： Joshua A. Shreve , James E. Usowicz , Miguel Soares
发明人： Joshua A. Shreve , James E. Usowicz , Miguel Soares
IPC分类号： G01N1/10
CPC分类号： B01L7/02 , B01L2300/0829 , B01L2300/1838 , G01N30/7233 , G01N35/028 , G01N2035/00356 , G01N2035/00386
摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.
摘要翻译：描述了一种用于降低液相色谱样品的温度变化的装置。使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。

6. 发明申请

US20130004388A1 SELF-SEALING SAMPLE COMPARTMENT FOR A LIQUID CHROMATOGRAPHY SYSTEM 有权
标题翻译：用于液相色谱系统的自密封样品瓶
公开(公告)号：US20130004388A1
公开(公告)日：2013-01-03
申请号：US13519706
申请日：2011-01-11
申请人： Daniel J. Gagne , Joshua A. Shreve , James E. Usowicz
发明人： Daniel J. Gagne , Joshua A. Shreve , James E. Usowicz
IPC分类号： B01L9/00
CPC分类号： G01N30/04 , G01N30/54 , G01N2030/3084
摘要： Described is a self-sealing thermal enclosure. In various embodiments, the self-sealing thermal enclosure includes an enclosure having a wall with an opening. The enclosure is configured to surround a temperature-controlled environment. The self-sealing thermal enclosure also includes a porous seal disposed adjacent to the wall at the opening. The porous seal is compressible and is fabricated from an open cell foam material. When the porous seal has absorbed a fluid such as a condensate, the temperature-controlled environment is sealed from an ambient environment such that the flow of air into or out of the enclosure is substantially reduced or eliminated.
摘要翻译：描述了一种自密封热封装。在各种实施例中，自密封热封套包括具有开口的壁的外壳。外壳配置为围绕温度控制的环境。自密封热封壳还包括邻近开口处的壁布置的多孔密封件。多孔密封是可压缩的，并由开孔泡沫材料制成。当多孔密封件已经吸收了诸如冷凝物的流体时，温度受控的环境与环境环境密封，使得进入或离开外壳的空气流大幅减少或消除。

7. 发明申请

US20110261642A1 Valve Switch Modulation For Reducing Errors Due Oscillations Of The Inlet Fluid Of A Pump System 有权
标题翻译：用于减少泵系统入口流体的错误的阀门开关调制
公开(公告)号：US20110261642A1
公开(公告)日：2011-10-27
申请号：US13063382
申请日：2009-09-10
申请人： Joshua A. Shreve , Steven J. Ciavarini
发明人： Joshua A. Shreve , Steven J. Ciavarini
IPC分类号： G05D11/02
CPC分类号： B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
摘要： Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
摘要翻译：描述了在低压混合泵系统中减少液体组成误差的方法。表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。对于每个分组，调制与分组中的至少一个分量相关联的切换时间。调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。

8. 发明申请

US20130323103A1 SEAL ASSEMBLIES FOR RECIPROCATING AND ROTARY APPLICATIONS 审中-公开
标题翻译：密封组件用于复制和旋转应用
公开(公告)号：US20130323103A1
公开(公告)日：2013-12-05
申请号：US13985957
申请日：2012-03-09
申请人： Joshua A. Shreve , Neal Almeida
发明人： Joshua A. Shreve , Neal Almeida
IPC分类号： F16J15/32 , F04B53/00
CPC分类号： F15B15/1461 , F04B1/0448 , F04B53/00 , F04B53/143 , F16J15/3208 , G01N30/32 , G01N2030/326
摘要： Low-pressure and high-pressure reciprocating and rotary applications use seal assemblies to prevent leakage. One embodiment of a seal assembly includes a major annular body having opposing spaced-apart annular lips extending from a heel portion with a bore extending through the heel portion. A first spring is disposed between the lips, biasing the lips apart. A minor annular body extends from one of the lips of the major annular body. The minor annular body has opposing spaced-apart walls that extend from a base region and form a pocket. A second spring is disposed in the pocket between the spaced-apart walls, biasing the walls apart. During actuator operation, pressurized fluid urges one wall of the minor annular body against a pump head surface to produce a face seal and one of the lips of the major annular body against a rod surface to produce a radial seal.
摘要翻译：低压和高压往复和旋转应用使用密封组件来防止泄漏。密封组件的一个实施例包括主要环形体，其具有相对间隔开的环形唇缘，其从具有延伸穿过跟部部分的孔的跟部部分延伸。第一弹簧设置在嘴唇之间，使嘴唇分开。小环形体从主环形体的一个唇部延伸。小环形体具有从基部区域延伸并形成袋的相对的间隔开的壁。第二弹簧设置在间隔开的壁之间的袋中，使壁分开。在致动器操作期间，加压流体促使次环形体的一个壁抵靠泵头表面，以产生面密封件和主环形体的唇部中的一个抵靠杆表面以产生径向密封。

9. 发明授权

US08517597B2 Valve switch modulation for reducing errors due oscillations of the inlet fluid of a pump system 有权
标题翻译：阀门开关调节，用于减少泵系统入口流体振荡造成的误差
公开(公告)号：US08517597B2
公开(公告)日：2013-08-27
申请号：US13063382
申请日：2009-09-10
申请人： Joshua A. Shreve , Steven J. Ciavarini
发明人： Joshua A. Shreve , Steven J. Ciavarini
IPC分类号： B01F15/04 , B01F13/00
CPC分类号： B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
摘要： Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
摘要翻译：描述了在低压混合泵系统中减少液体组成误差的方法。表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。对于每个分组，调制与分组中的至少一个分量相关联的切换时间。调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。

10. 发明申请

US20120285872A1 THERMAL CONTROL OF THERMAL CHAMBER IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEMS 有权
标题翻译：高性能液相色谱系统中热室的热控制
公开(公告)号：US20120285872A1
公开(公告)日：2012-11-15
申请号：US13519776
申请日：2011-01-11
申请人： Joshua A. Shreve , Steven J. Ciavarini
发明人： Joshua A. Shreve , Steven J. Ciavarini
IPC分类号： F25B21/02 , B01D15/10
CPC分类号： F25B21/02 , F25B2321/0212 , F25B2321/0251 , F25B2700/2103 , F25D2700/02 , F25D2700/12 , F25D2700/123 , G01N30/24 , G01N30/30 , G01N2030/303
摘要： A sample manager of a liquid chromatography system implements a thermal system that uses a dual-loop feedback control system to control temperature within a thermal chamber. The sample manager includes an external heatsink disposed externally to the thermal chamber, an internal heatsink disposed within the thermal chamber, and one or more thermoelectric devices thermally coupled to the external and internal heatsinks to transfer heat therebetween in response to a pulse-width modulated power signal. A first temperature sensor disposed within the thermal chamber continuously measures a chamber temperature. A second temperature sensor coupled to the internal heatsink within the thermal chamber continuously measures temperature at the internal heatsink. A feedback control system controls a duty cycle of the pulse-width modulated power signal in response to a target chamber temperature and real-time temperature measurements produced by the first and second temperature sensors.
摘要翻译：液相色谱系统的样品管理器实现了使用双回路控制系统来控制热室内的温度的热系统。样品管理器包括设置在热室的外部的外部散热器，设置在热室内的内部散热器，以及一个或多个热耦合到外部和内部散热器的热电装置，以响应于脉冲宽度调制功率信号。设置在热室内的第一温度传感器连续测量腔室温度。耦合到热室内的内部散热器的第二温度传感器连续测量内部散热器的温度。反馈控制系统响应于目标腔室温度和由第一和第二温度传感器产生的实时温度测量值来控制脉冲宽度调制功率信号的占空比。

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