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1. 发明授权

US08679333B2 Closed loop flow control of a HPLC constant flow pump to enable low-flow operation 有权
标题翻译： HPLC恒流泵的闭环流量控制，以实现低流量运行
公开(公告)号：US08679333B2
公开(公告)日：2014-03-25
申请号：US12692795
申请日：2010-01-25
申请人： Geoff C. Gerhardt , Joseph A. Luongo
发明人： Geoff C. Gerhardt , Joseph A. Luongo
IPC分类号： B01D15/08
CPC分类号： B01D15/163 , B01L3/50273 , B01L2200/143 , B01L2400/086 , F04B13/02 , F04B23/04 , F04B2205/09 , G01N30/32 , G01N2030/324
摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (
摘要翻译：用于监测和控制HPLC系统的操作流路中的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常在HPLC中使用的溶剂组成梯度。该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使毛细管（<0.1mL / min）和纳米级（< 1μL/ min）HPLC流速。

2. 发明授权

US08176932B2 Defined leak path for high pressure seal 有权
标题翻译：定义高压密封泄漏路径
公开(公告)号：US08176932B2
公开(公告)日：2012-05-15
申请号：US12652271
申请日：2010-01-05
申请人： John Angelosanto , Joseph A. Luongo , Frank Rubino
发明人： John Angelosanto , Joseph A. Luongo , Frank Rubino
IPC分类号： F16L35/00
CPC分类号： F16J15/004 , F04B53/04 , F04B53/164 , Y10T137/0452 , Y10T137/5762 , Y10T137/9247
摘要： Embodiments of the present invention are directed to methods and devices for conveying or containing fluids under pressure in which seals are provided with a defined path to vent fluid in the event of a seal failure.
摘要翻译：本发明的实施例涉及用于在压力下输送或容纳流体的方法和装置，其中在密封件发生故障的情况下，密封件具有限定的排放流体路径。

3. 发明授权

US07955059B2 Fluid control device for a high pressure analytical instrument 有权
标题翻译：用于高压分析仪器的流体控制装置
公开(公告)号：US07955059B2
公开(公告)日：2011-06-07
申请号：US10598031
申请日：2005-03-02
申请人： Theodore D. Ciolkosz , Peter Kirby , Mark W. Moeller , Russell Keene , Daniel J. McCormick , Charles Murphy , Joseph A. Luongo , David R. Friswell , Theodore Dourdeville
发明人： Theodore D. Ciolkosz , Peter Kirby , Mark W. Moeller , Russell Keene , Daniel J. McCormick , Charles Murphy , Joseph A. Luongo , David R. Friswell , Theodore Dourdeville
IPC分类号： F04B39/04 , F16K15/04
CPC分类号： F16K15/04 , F04B53/1002 , G01N2030/326 , Y10T137/791 , Y10T137/7911 , Y10T137/7912
摘要： In various embodiments a fluid control device suitable for high pressure analytical instruments includes a housing having an interior surface with an end wall. The interior surface defines a chamber. A valve assembly disposed in the chamber controls the flow of fluid through the chamber. An end cap is disposed in the housing opposite the end wall to enclose the chamber. The end wall and end cap each have an opening to pass a fluid to the chamber or to remove a fluid from the chamber. The housing and end cap each has an abutment surface to receive the other abutment surface. At least one of the abutment surfaces has a plastic seal coating. A means of compression, such as a compression housing and compression sleeve, is included to engage the end cap to deform the plastic seal coating between the abutment surfaces and thereby seal the chamber.
摘要翻译：在各种实施例中，适用于高压分析仪器的流体控制装置包括具有带有端壁的内表面的壳体。内表面限定了一个室。设置在腔室中的阀组件控制通过腔室的流体流动。端盖设置在壳体中与端壁相对以封闭室。端壁和端盖各自具有用于将流体传递到室的开口或从腔室去除流体。壳体和端盖各自具有邻接表面以接收另一个邻接表面。至少一个邻接表面具有塑料密封涂层。包括诸如压缩壳体和压缩套筒的压缩装置以接合端盖，以使邻接表面之间的塑料密封涂层变形，从而密封腔室。

4. 发明申请

US20100116745A1 Closed Loop Flow Control Of A HPLC Constant Flow Pump To Enable Low-Flow Operation 有权
标题翻译：一种HPLC恒流泵的闭环流量控制，以实现低流量运行
公开(公告)号：US20100116745A1
公开(公告)日：2010-05-13
申请号：US12692795
申请日：2010-01-25
申请人： Geoff C. Gerhardt , Joseph A. Luongo
发明人： Geoff C. Gerhardt , Joseph A. Luongo
IPC分类号： B01D15/18
CPC分类号： B01D15/163 , B01L3/50273 , B01L2200/143 , B01L2400/086 , F04B13/02 , F04B23/04 , F04B2205/09 , G01N30/32 , G01N2030/324
摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (
摘要翻译：用于监测和控制HPLC系统的操作流路中的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常在HPLC中使用的溶剂组成梯度。该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使毛细管（<0.1mL / min）和纳米级（< 1μL/ min）HPLC流速。

5. 发明申请

US20080260558A1 Device and Methods of Measuring Pressure 有权
标题翻译：测量压力的装置和方法
公开(公告)号：US20080260558A1
公开(公告)日：2008-10-23
申请号：US10598310
申请日：2005-03-04
申请人： Joseph A. Luongo , John Angelosanto , Frank Rubino , Stanley P. Pensak Jr. , David J. First , Jean-Pierre Pugnaire , Richard R. Venable
发明人： Joseph A. Luongo , John Angelosanto , Frank Rubino , Stanley P. Pensak Jr. , David J. First , Jean-Pierre Pugnaire , Richard R. Venable
IPC分类号： F04B39/00 , G01L9/04
CPC分类号： F04B53/162 , F04B53/16 , F04B2205/03 , G01N2030/326
摘要： Embodiments of the present invention are directed to method and devices for measuring the pressure of a pump chamber in which no internal opening or connections are needed. One embodiment of the present invention is directed to an apparatus for pumping fluid. The apparatus comprises at least one housing having a transducer surface. The transducer surface has a thickness exhibiting measurable deformation upon the chamber holding a fluid under pressure such that the transducer surface has a first position at which the chamber is at one pressure and a second position at which the chamber is at a second pressure. A strain sensor is affixed to the transducer surface producing; at least one signal upon the transducer surface assuming the first position and at least one signal upon the transducer surface assuming the second position to function as an integrated pressure transducer.
摘要翻译：本发明的实施例涉及用于测量不需要内部开口或连接的泵室的压力的方法和装置。本发明的一个实施例涉及一种用于泵送流体的装置。该装置包括具有换能器表面的至少一个壳体。换能器表面具有在腔室上保持流体的压力下呈现可测量变形的厚度，使得换能器表面具有腔室处于一个压力的第一位置和腔室处于第二压力的第二位置。应变传感器固定在传感器表面上; 在换能器表面上的至少一个信号假设第一位置，并且在换能器表面上的至少一个信号假设第二位置用作集成的压力换能器。

6. 发明授权

US07186336B2 Flow sensing apparatus 有权
标题翻译：流量检测装置
公开(公告)号：US07186336B2
公开(公告)日：2007-03-06
申请号：US10851497
申请日：2004-05-21
申请人： Geoff C. Gerhardt , Joseph A. Luongo
发明人： Geoff C. Gerhardt , Joseph A. Luongo
IPC分类号： B01D15/08
CPC分类号： G01F1/68 , G01F1/363 , G01N30/10 , G01N30/30 , G01N30/32 , G01N2030/324 , G01N2030/326 , G05D11/132
摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system. A first flow sensor is disposed in a first flow path between a first flow-divider and a fluidic tee. A second flow sensor is disposed in a second flow path between a second flow-divider and the fluidic tee. A first recycle flow restrictor is disposed in the first recycle flow path in fluid communication with the first flow-divider. A second recycle flow restrictor is disposed in the second The permeability of each recycle flow restrictor can be selected to produce a desired flow rate with each respective flow path. The output signals of the first and second flow sensors to control output of a pump within each flow path.
摘要翻译：一种用于监测和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。第一流量传感器设置在第一分流器和流体三通之间的第一流动路径中。第二流量传感器设置在第二分流器和流体三通之间的第二流动路径中。第一再循环流量限制器设置在与第一分流器流体连通的第一再循环流动路径中。第二再循环流量限制器设置在第二循环流量限制器中。可以选择每个循环流量限制器的渗透率，以产生每个相应流动路径的期望流量。第一和第二流量传感器的输出信号以控制每个流动路径内的泵的输出。

7. 发明授权

US07674375B2 Closed loop flow control of a HPLC constant flow pump to enable low-flow operation 有权
标题翻译： HPLC恒流泵的闭环流量控制，以实现低流量运行
公开(公告)号：US07674375B2
公开(公告)日：2010-03-09
申请号：US11569301
申请日：2005-05-20
申请人： Geoff C. Gerhardt , Joseph A. Luongo
发明人： Geoff C. Gerhardt , Joseph A. Luongo
IPC分类号： B01D15/08
CPC分类号： B01D15/163 , B01L3/50273 , B01L2200/143 , B01L2400/086 , F04B13/02 , F04B23/04 , F04B2205/09 , G01N30/32 , G01N2030/324
摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (
摘要翻译：用于在HPLC系统的操作流程中监测和控制流体的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常用于HPLC的溶剂组成梯度。该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使得在毛细管（<0.1mL / min）和纳米级（< μL/ min）HPLC流速。

8. 发明申请

US20100012192A1 ACTIVE VALVE AND METHODS OF OPERATION THEREOF 有权
标题翻译：主动阀及其操作方法
公开(公告)号：US20100012192A1
公开(公告)日：2010-01-21
申请号：US12296461
申请日：2007-04-11
申请人： Theodore Dourdeville , Frank A. Rubino , Kurt D. Joudrey , Joseph A. Luongo , John Angelosanto
发明人： Theodore Dourdeville , Frank A. Rubino , Kurt D. Joudrey , Joseph A. Luongo , John Angelosanto
IPC分类号： F15D1/00 , F16K31/06
CPC分类号： F16K15/183 , F04B7/0076 , F16K31/047 , F16K37/0041 , Y10T137/0318
摘要： A valve including a linear positioning component operatively connected to a valve body and an actuating element.
摘要翻译：一种阀，包括可操作地连接到阀体和致动元件的线性定位部件。

9. 发明申请

US20080245136A1 Closed Loop Flow Control of a Hplc Constant Flow Pump To Enable Low-Flow Operation 有权
标题翻译： Hplc恒流泵的闭环流量控制，以实现低流量运行
公开(公告)号：US20080245136A1
公开(公告)日：2008-10-09
申请号：US11569301
申请日：2005-05-20
申请人： Geoff C. Gerhardt , Joseph A. Luongo
发明人： Geoff C. Gerhardt , Joseph A. Luongo
IPC分类号： G01N30/10 , B01D15/14 , G01N30/22 , G01F1/38 , G01F1/68
CPC分类号： B01D15/163 , B01L3/50273 , B01L2200/143 , B01L2400/086 , F04B13/02 , F04B23/04 , F04B2205/09 , G01N30/32 , G01N2030/324
摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (
摘要翻译：用于在HPLC系统的操作流程中监测和控制流体的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常用于HPLC的溶剂组成梯度。该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使得在毛细管（<0.1mL / min）和纳米级（< muL / min）HPLC流速。

10. 发明授权

US5788465A Tool-less pump head configuration 失效
标题翻译：无工具泵头配置
公开(公告)号：US5788465A
公开(公告)日：1998-08-04
申请号：US606149
申请日：1996-02-23
申请人： Joseph A. Luongo , Jeffrey Howard Stokes , Robert E. Reynolds , Wade P. Leveille , Robert J. Dumas
发明人： Joseph A. Luongo , Jeffrey Howard Stokes , Robert E. Reynolds , Wade P. Leveille , Robert J. Dumas
IPC分类号： F04B53/14 , F04B53/22 , F04B17/00
CPC分类号： F04B53/14 , F04B53/147 , F04B53/22 , F05C2201/0478 , F05C2203/0873
摘要： A pump configured so that tools are not required to remove the pump head and disassemble the plunger. A single large hand operated knob or head nut facilitates tool-less pump head removal. The pump head is guided into position in a manifold and held in place by the hand knob. The manifold is designed to receive all the external fluidic connections made to the pump head. Fluid paths to the pump head have been replaced with miniature face seals which facilitate high pressure sealing between the pump head and manifold. Low pressure tubing seals reside in a seal wash chamber or housing and are not attached to the head, eliminating the need for tooling to disconnect them during pump head removal. A tool-less plunger mechanism includes a nutcap assembly having a plunger socket receiving a plunger assembly including a sapphire plunger fixed to a plunger holder ball accommodated by the socket. The plunger assembly is captured within the socket by a plurality of cams. The cams are spring loaded to rotate and collapse onto the plunger holder ball, pulling the plunger assembly tightly into the socket. A restricting cone is actuated to rotate the cams away from the plunger holder ball for release and removal of the plunger assembly.
摘要翻译：泵被配置为使得不需要工具来移除泵头并拆卸柱塞。单个大型手动旋钮或头螺母便于无需泵头拆卸。泵头被引导到歧管中的位置，并通过手柄保持在适当的位置。歧管设计用于接收与泵头形成的所有外部流体连接。泵头的流体路径已被替换为便于在泵头和歧管之间进行高压密封的微型面密封件。低压油管密封件位于密封清洗室或外壳中，并且不连接到喷头上，因此无需在泵头拆卸过程中切割工具。一种无需工具的柱塞机构包括一个具有活塞插座的螺母盖组件，所述活塞插座接收柱塞组件，所述活塞组件包括固定到由所述插座容纳的柱塞座球的蓝宝石柱塞。柱塞组件通过多个凸轮捕获在插座内。凸轮被弹簧加载以旋转并塌陷到柱塞保持器球上，将柱塞组件紧紧地拉入插座中。致动限制锥以将凸轮转动离开活塞保持器球以释放和移除柱塞组件。

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