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1. 发明申请

US20070032640A1 Cytokine receptor 审中-公开
标题翻译：细胞因子受体
公开(公告)号：US20070032640A1
公开(公告)日：2007-02-08
申请号：US10489705
申请日：2002-09-16
申请人： Joseph Varghese , Richard Simpson , Robert Moritz , Meizhen Lou , Hong Ji , Kim Branson , Brian Smith
发明人： Joseph Varghese , Richard Simpson , Robert Moritz , Meizhen Lou , Hong Ji , Kim Branson , Brian Smith
IPC分类号： C07K14/54 , G06F19/00 , G01N33/48 , G01N33/50 , A61K38/20
CPC分类号： A61K31/00 , A61K31/325 , A61K31/472 , C07K14/7155 , C07K2299/00 , G01N2500/04 , G16B15/00 , G16C20/50
摘要： A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided arc methods of modulating an IL-6 receptor comprising contacting the IL-6 receptor with a compound identified by the screening method of the invention.
摘要翻译：提供了包含IL-6受体I链的晶体的结晶组合物。还提供了使用晶体和相关结构信息来筛选和设计与IL-6R相互作用的化合物或其变体的方法。还提供调节IL-6受体的电弧法，包括使IL-6受体与通过本发明的筛选方法鉴定的化合物接触。

2. 发明申请

US20120145767A1 Surgical Apparatus Including Surgical Buttress 有权
标题翻译：手术器械包括手术支架
公开(公告)号：US20120145767A1
公开(公告)日：2012-06-14
申请号：US12964916
申请日：2010-12-10
申请人： Sachin Shah , Richard Simpson
发明人： Sachin Shah , Richard Simpson
IPC分类号： A61B17/068 , A61B17/32
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00477 , A61B2017/00951 , A61B2017/07214
摘要： A surgical buttress for use with a surgical stapling apparatus having a first jaw in the form of an anvil assembly and a second jaw configured to selectively receive a staple cartridge assembly. The surgical buttress includes a first body portion and a second body portion. The first body portion substantially overlies a portion of a plurality of fastener slots of the staple cartridge assembly. The staple cartridge assembly is removably operably couplable to the second jaw of the surgical stapling apparatus. The second body portion extends from the first body portion and is configured and dimensioned to be removably positioned to substantially overlie a portion of a plurality of fastener pockets of the anvil assembly of the surgical stapling apparatus when the staple cartridge assembly is operably coupled to the second jaw of the surgical stapling apparatus.
摘要翻译：一种与外科缝合装置一起使用的手术支撑件，其具有砧座组件形式的第一钳口和被配置为选择性地容纳钉仓组件的第二钳口。手术支撑体包括第一主体部分和第二主体部分。第一主体部分基本上覆盖在钉仓组件的多个紧固件槽的一部分上。钉仓组件可移除地可操作地联接到外科缝合装置的第二钳口。第二主体部分从第一主体部分延伸并且被构造和尺寸设计成可拆卸地定位成基本覆盖在外科缝合装置的砧座组件的多个紧固件凹部的一部分上，当钉仓组件可操作地联接到第二主体部分手术吻合装置的颚。

3. 发明授权

US07742520B2 Equalization circuit 有权
标题翻译：均衡电路
公开(公告)号：US07742520B2
公开(公告)日：2010-06-22
申请号：US11367660
申请日：2006-03-03
申请人： Richard Simpson , Ruediger Kuhn
发明人： Richard Simpson , Ruediger Kuhn
IPC分类号： H03H7/30
CPC分类号： H04L7/033 , H04B3/06 , H04L25/03031 , H04L25/03885 , H04L2025/03681
摘要： An equalization circuit that allows particularly for lowpass filtering by transmission lines comprises a compensating equalizer controlled according to whether the edges between bits in the data waveform are early or late. Adjusting the equalization causes edges to appear in the same place, whereas if the adjustment is incorrect certain edges will be late and certain edges will be early depending on the history of “1”s and “0”s in the data stream. This is an effect of so-called intersymbol interference. The control mechanism includes circuits for recognizing patterns of “1”s and “0”s in the recent history of the data waveform whose occurrence is used to trigger the adjustment of the equalizer.
摘要翻译：特别是允许传输线进行低通滤波的均衡电路包括根据数据波形中的位之间的边缘是早还是晚的控制的补偿均衡器。调整均衡会使边缘出现在相同的位置，而如果调整不正确，则某些边缘将迟到，某些边缘将提前取决于数据流中“1”和“0”的历史记录。这是所谓的码间干扰的影响。控制机构包括用于识别出现用于触发均衡器的调整的数据波形的最近历史中的“1”和“0”的模式的电路。

4. 发明授权

US07236552B2 Data transmission 有权
标题翻译：数据传输
公开(公告)号：US07236552B2
公开(公告)日：2007-06-26
申请号：US10624262
申请日：2003-07-22
申请人： Iain Robertson , Richard Simpson , Michael Harwood
发明人： Iain Robertson , Richard Simpson , Michael Harwood
IPC分类号： H04L7/00
CPC分类号： H04L7/0337 , H04L7/0025 , H04L25/14
摘要： A circuit for receiving multiple serial datastreams in parallel is disclosed. A bit clock is recovered from each data stream, there being one data bit for ach transition of the clock signal both positive and negative going. The phases of the bit clocks are compared and are adjusted by 180 degrees so that the positive going edges of all occur close to each other. The bits of each stream are assembled into words under the control of a word clock. In one embodiment a common word clock is derived form the set of bit clocks as a whole. In another embodiment each stream is provided with its own word clock which is aligned to positive edges of the respective bit clocks that are close to each other.
摘要翻译：公开了并行接收多个串行数据流的电路。从每个数据流恢复一个位时钟，有一个数据位用于时钟信号的正向和负向的ach转换。比较时钟的相位并将其调整180度，使得所有位的正向沿都彼此接近。每个流的位在字时钟的控制下组装成单词。在一个实施例中，作为整体的位时钟集合导出公共字时钟。在另一个实施例中，每个流被提供有其自己的字时钟，其对准彼此接近的相应位时钟的正边沿。

5. 发明申请

US20060242718A1 SOCS-box containing peptides 审中-公开
标题翻译：含有SOCS盒的肽
公开(公告)号：US20060242718A1
公开(公告)日：2006-10-26
申请号：US11400964
申请日：2006-04-10
申请人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
发明人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
IPC分类号： A01K67/00 , A61K38/22
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associate therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signaling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.
摘要翻译：本发明一般涉及可从SOCS蛋白获得并且能够与细胞内分子相互作用的氨基酸序列。本发明还涉及编码所述氨基酸序列的核酸分子。编码本发明的氨基酸序列和核酸分子可用于调节蛋白质分子的降解，例如但不限于与其缔合的SOCS蛋白和蛋白质分子。本发明提供了通过调节活化的信号转导分子或其负调节物（即SOCS蛋白）的降解来调节细胞因子或细胞因子样分子信号传导的机制。

6. 发明申请

US20060072271A1 Electrical power distribution system 有权
标题翻译：配电系统
公开(公告)号：US20060072271A1
公开(公告)日：2006-04-06
申请号：US11242878
申请日：2005-10-05
申请人： Nicolas Jones , Steve Montgomery , Richard Simpson , Gregory Baker
发明人： Nicolas Jones , Steve Montgomery , Richard Simpson , Gregory Baker
IPC分类号： H02H3/08
CPC分类号： G06K19/07758 , H01H2300/03 , H01R13/7039 , H01R13/7135 , H02H1/0015 , H02H3/006 , H02H3/08 , Y02B70/3241 , Y02B90/224 , Y04S20/14 , Y04S20/227
摘要： An electrical power distribution system for connecting an electrical device to a source of electrical power and disconnecting the electrical device therefrom. The system includes a PCD tag associated with the electrical device, and a PCD reader associated with a receptacle electrically connectable to the source of electrical power. The PCD tag has a PCD tag memory in which data related to the electrical device is stored in a format readable by the PCD reader, the data including an electrical device load rating. The system also has a switch device for connecting and disconnecting the receptacle to the power source. In addition, the system has a measuring device for measuring actual load and a control circuit for comparing actual load to the electrical device load rating. The control circuit provides a disconnect signal to the switch device upon the actual load exceeding the electrical device load rating.
摘要翻译：一种用于将电气设备连接到电力源并从其断开电气设备的电力分配系统。该系统包括与电气设备相关联的PCD标签，以及与可电连接到电源的插座相关联的PCD读取器。 PCD标签具有PCD标签存储器，其中与电气设备相关的数据以PCD读取器可读取的格式存储，该数据包括电气设备负载额定值。该系统还具有用于将插座连接和断开到电源的开关装置。此外，该系统具有用于测量实际负载的测量装置和用于将实际负载与电气装置额定负载进行比较的控制电路。当实际负载超过电气设备负载额定值时，控制电路向开关装置提供断开信号。

7. 发明授权

US06994960B1 Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage 失效
标题翻译：基于质谱或质量分离和碱基特异性切割的核酸诊断
公开(公告)号：US06994960B1
公开(公告)日：2006-02-07
申请号：US09424629
申请日：1998-05-28
申请人： Simon Foote , Colleen Elso , Richard Simpson , Gavin Reid
发明人： Simon Foote , Colleen Elso , Richard Simpson , Gavin Reid
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/63 , C12N1/20 , C07H21/04
CPC分类号： C12Q1/683 , C12Q2565/627
摘要： A method of detecting a mutation or a difference of one or more nucleotides between a nucleic acid molecule to be tested and a reference nucleic acid molecule, said method comprising subjecting the test nucleic acid molecule to base specific cleavage to generate oligonucleotide fragments, separating the resulting oligonucleotide fragments based on mass by MALDI-ATOF MS and/or other equivalent procedure to produce a fingerprint of then oligonucleotide fragments comprising one or more peaks wherein a peak represents the mass of each fragment and identifying an altered peak relative to a reference nucleic acid molecule subjected to the same procedure wherein the presence of an altered peak is indicative of a difference of one or more nucleotides in said tested nucleic acid molecule.
摘要翻译：一种检测待测核酸分子与参考核酸分子之间的一个或多个核苷酸的突变或差异的方法，所述方法包括使测试核酸分子对特异性切割进行碱基产生寡核苷酸片段，分离所得的基于质量的基于质粒的寡核苷酸片段通过MALDI-ATOF MS和/或其他等同方法产生包含一个或多个峰的寡核苷酸片段的指纹，其中峰表示每个片段的质量，并鉴定相对于参照核酸分子的改变的峰进行相同的程序，其中改变的峰的存在指示所述测试的核酸分子中一个或多个核苷酸的差异。

8. 发明授权

US5630160A Floating point exponent compare using repeated two bit compare cell 失效
标题翻译：使用重复的两位比较单元进行浮点指数比较
公开(公告)号：US5630160A
公开(公告)日：1997-05-13
申请号：US400709
申请日：1995-03-08
申请人： Richard Simpson , Erick Oakland
发明人： Richard Simpson , Erick Oakland
IPC分类号： G06F7/02 , G06F7/00
CPC分类号： G06F7/026 , G06F7/483
摘要： A magnitude comparator employs plural layers of repeated circuits which are scalable to any size. The magnitude comparator indicates whether two multibit inputs are equal, and if not equal indicates if a first multibit input is greater than a second multibit input. A single bit comparator circuit receives a corresponding bit of the two multibit inputs. Each single bit comparator generates an A=B output equal to the exclusive NOR of the two inputs and an A>B output equal to the first input. The magnitude comparator includes at least one two bit comparator circuit disposed in at least one layer. Each two bit comparator circuit includes an A[0]=B[0] input, an A[0]>B[0] input, an A[1]=B[1] input and an A[1]>B[1] input. Each two bit comparator circuit generates an A=B output of an AND of signals received at the A[0]=B[0] and A[1]=B[1] inputs. Each two bit comparator circuit generates an A>B output equal to the A[1]>B[1] input if the A[0]=B[0] input is "1" and equal to the A[0]>B[0] input if the A[0]=B[0] input is "0".
摘要翻译：幅度比较器采用可以任意尺寸缩放的多层重复电路。幅度比较器指示两个多位输入是否相等，如果不相等则指示第一个多位输入是否大于第二个多位输入。单位比较器电路接收两个多位输入的相应位。每个单比特比较器产生等于两个输入的异或的A = B输出和等于第一个输入的A> B输出。幅度比较器包括设置在至少一层中的至少一个二位比较器电路。每个比特比较电路包括A [0] = B [0]输入，A [0]> B [0]输入，A [1] = B [1]输入和A [1]> B [ 1]输入。每个2比特比较电路产生A [B]输入，A = B输出在A [0] = B [0]和A [1] = B [1]输入端接收的信号。如果A [0] = B [0]输入为“1”，并且等于A [0]> B，则每两位比较电路产生等于A [1]> B [1]输入的A> B输出如果A [0] = B [0]输入为“0”，则输入[0]。

9. 发明授权

US08366016B2 Adjustable water jet device 有权
标题翻译：可调式喷水装置
公开(公告)号：US08366016B2
公开(公告)日：2013-02-05
申请号：US12909992
申请日：2010-10-22
申请人： Richard Simpson
发明人： Richard Simpson
IPC分类号： B05B17/08
CPC分类号： B05B1/14 , B05B1/3026
摘要： An adjustable water jet device so as to continuously regulate the velocity of water exiting the device without interrupting the water flow, the water jet device including a nozzle body, rotatable nozzle seat, a flow control plate, an inlet, and a nozzle eyeball configured to direct the water supply, and a water supply system including the adjustable water jet device, a plate for accommodating the water jet device in a pool deck or pool wall, and a cover that is mounted flush with the pool deck or pool wall.
摘要翻译：一种可调节的喷水装置，以便连续地调节离开装置的水的速度而不中断水流，该喷水装置包括喷嘴体，可旋转的喷嘴座，流量控制板，入口和喷嘴眼球，其配置成引导供水，以及包括可调节水喷射装置的供水系统，用于在水池甲板或池壁中容纳喷水装置的板以及与池甲板或池壁齐平地安装的盖。

10. 发明授权

US08365972B2 Surgical stapling apparatus 有权
标题翻译：手术吻合装置
公开(公告)号：US08365972B2
公开(公告)日：2013-02-05
申请号：US13097194
申请日：2011-04-29
申请人： Ernie Aranyi , Patrick Mozdzierz , Lee Olson , Sachin Shah , Kevin Golebieski , Richard Simpson , Anthony Gaddy
发明人： Ernie Aranyi , Patrick Mozdzierz , Lee Olson , Sachin Shah , Kevin Golebieski , Richard Simpson , Anthony Gaddy
IPC分类号： A61B17/068
CPC分类号： A61B17/068
摘要： A loading unit for use with a surgical stapling apparatus is provided and includes: a tool assembly having a cartridge assembly and an anvil assembly that are movable in relation to one another; a surgical buttress releasably secured to a tissue contacting surface of the anvil assembly and/or the cartridge assembly, wherein the surgical buttress secured to the anvil assembly is secured by at least one anchor; and a drive assembly slidably translatable through the tool assembly between proximal and distal positions. The anvil assembly has pairs of side recesses, at least one of which is a keyhole-shaped, or has an enlarged head portion.
摘要翻译：提供了一种与外科缝合装置一起使用的装载单元，包括：具有相对于彼此可移动的盒组件和砧座组件的工具组件; 可释放地固定到砧座组件和/或盒组件的组织接触表面的手术支撑件，其中固定到砧座组件的手术支撑件由至少一个锚固件固定; 以及驱动组件，其可在近端和远端位置之间通过所述工具组件可滑动地平移。砧组件具有成对的侧凹部，其至少一个是锁眼形的或具有扩大的头部。

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