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    • 1. 发明授权
    • Method and apparatus for reducing motion artifacts and noise in video image processing
    • 用于减少视频图像处理中的运动伪像和噪声的方法和装置
    • US06788823B2
    • 2004-09-07
    • US09999697
    • 2001-10-26
    • Joseph AllredR. Larry AndertonSteven E. CurtisBarry K. Hanover
    • Joseph AllredR. Larry AndertonSteven E. CurtisBarry K. Hanover
    • G06K900
    • H04N5/21
    • A method and apparatus for reducing noise and motion artifacts in pixels of a processed or displayed video image by filtering pixel values of the video image based on a first frame having currently stored (filtered) pixel values and a second frame having recently captured but not yet filtered pixel values. The apparatus includes a spatial filter for computing a motion value of a pixel of interest by averaging difference values of selected pixels surrounding the pixel of interest. Also included is a filter function means for producing an output difference value of the pixel of interest based on the motion value and an adder for adding the output difference value to the first frame filtered pixel value of the pixel of interest. Thus, each pixel of the video image is filtered according to the amount of motion in the video image.
    • 一种通过基于具有当前存储的(滤波的)像素值的第一帧和最近被捕获但尚未到达的第二帧来滤除视频图像的像素值来减少处理或显示的视频图像的像素中的噪声和运动伪像的方法和装置 滤波像素值。 该装置包括空间滤波器,用于通过平均感兴趣像素周围的所选像素的差值来计算感兴趣像素的运动值。 还包括用于基于运动值产生感兴趣像素的输出差值的滤波器功能装置和用于将输出差分值与感兴趣像素的第一帧滤波像素值相加的加法器。 因此,根据视频图像中的运动量来对视频图像的每个像素进行滤波。
    • 3. 发明授权
    • Method and apparatus for reducing motion artifacts and noise in video image processing
    • 用于减少视频图像处理中的运动伪像和噪声的方法和装置
    • US06310982B1
    • 2001-10-30
    • US09191855
    • 1998-11-12
    • Joseph AllredLarry AndertonBarry K. HanoverSteven Curtis
    • Joseph AllredLarry AndertonBarry K. HanoverSteven Curtis
    • H04N750
    • H04N5/21
    • A method and apparatus for reducing noise and motion artifacts in pixels of a processed or displayed video image by filtering pixel values of the video image based on a first frame having currently stored (filtered) pixel values and a second frame having recently captured but not yet filtered pixel values. The apparatus includes a spatial filter for computing a motion value of a pixel of interest by averaging difference values of selected pixels surrounding the pixel of interest. Also included is a filter function means for producing an output difference value of the pixel of interest based on the motion value and an adder for adding the output difference value to the first frame filtered pixel value of the pixel of interest. Thus, each pixel of the video image is filtered according to the amount of motion in the video image.
    • 一种通过基于具有当前存储的(滤波的)像素值的第一帧和最近被捕获但尚未到达的第二帧来滤除视频图像的像素值来减少处理或显示的视频图像的像素中的噪声和运动伪像的方法和装置 滤波像素值。 该装置包括空间滤波器,用于通过平均感兴趣像素周围的所选像素的差值来计算感兴趣像素的运动值。 还包括用于基于运动值产生感兴趣像素的输出差值的滤波器功能装置和用于将输出差分值与感兴趣像素的第一帧滤波像素值相加的加法器。 因此,根据视频图像中的运动量来对视频图像的每个像素进行滤波。
    • 6. 发明授权
    • Implantable drug delivery system with piston acutation
    • 具有活塞功能的可植入药物递送系统
    • US5196002A
    • 1993-03-23
    • US716926
    • 1991-06-18
    • Barry K. HanoverStephen C. JacobsenEric M. SimonTomasz PetelenzMichael G. Mladejovsky
    • Barry K. HanoverStephen C. JacobsenEric M. SimonTomasz PetelenzMichael G. Mladejovsky
    • A61K9/00A61K9/22A61M31/00
    • A61K9/0024A61M31/002
    • An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
    • 可植入药物输送系统包括具有基端和排出端的壳体,用于在排出端保持药物溶液,设置在排出端处的阀,以允许药物溶液从壳体内部流过阀门并出口 的壳体,其中所述壳体被施加到所述阀上;活塞,其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动,以迫使溶液朝向排出端并排出所述阀;以及弹簧,设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞,另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端,直到接收释放信号,此时它释放系绳。 定时电路设置在基座的外壳中,以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号,以便当释放系绳时,允许活塞向排放端移动 从而将药物溶液从壳体排出或推出,直到下一个最短的未释放的系链停止活塞的进一步移动。
    • 7. 发明授权
    • Apparatus and methods for minimizing cellular adhesion on peritoneal
injection catheters
    • 用于最小化腹膜注射导管上的细胞粘附的装置和方法
    • US4557724A
    • 1985-12-10
    • US522914
    • 1983-08-12
    • Donald E. GregonisRobert L. StephenDennis L. ColemanStephen K. HunterBarry K. HanoverJeffrey J. Harrow
    • Donald E. GregonisRobert L. StephenDennis L. ColemanStephen K. HunterBarry K. HanoverJeffrey J. Harrow
    • A61M39/02A61M25/00
    • A61M39/0208
    • The present invention is directed to a subcutaneous peritoneal injection catheter apparatus and methods which minimizes catheter obstruction during use. The apparatus includes a receiving chamber or reservoir having a relatively small internal volume while employing a penetrable membrane and relatively enlarged target surface area. The reservoir is interconnected with the peritoneal cavity by a hollow stem. The penetrable membrane accommodates a hollow needle being inserted into the receiving reservoir and is configurated with a dome-like profile so that the membrane may also be depressed to expel insulin from the receiving reservoir into the peritoneal cavity in a direction generally toward the mesenteric peritoneal membrane.The portion of the apparatus which is in the peritoneal cavity is preferably constructed of, or coated with, a material which is capable of minimizing the adhesion of cells and the growth of bacteria on that portion of the apparatus. In a presently preferred embodiment of the subcutaneous peritoneal injection catheter, the portion of the catheter to be within the peritoneal cavity is constructed of a polyurethane material, and this polyurethane material is then coated with a solution of polyurethane and poly(ethylene glycol) in a suitable solvent.
    • 本发明涉及皮下腹膜内注射导管装置和使用过程中导尿管阻塞最小化的方法。 该装置包括具有相对小的内部体积的接收室或容器,同时使用可穿透的膜和相对扩大的目标表面积。 储存器通过中空茎与腹膜腔相互连接。 可穿透的膜容纳插入接收容器中的中空针,并且被配置成具有圆顶状轮廓,使得膜也可以被压下,以将胰岛素从接收储器排出到通常朝向肠系膜腹膜的方向进入腹膜腔 。 位于腹膜腔中的装置的部分优选由能够最小化细胞粘附和细菌生长在该装置的该部分上的材料构成或涂覆。 在皮下腹膜注射导管的当前优选实施例中,导管内部位于腹膜腔内的部分由聚氨酯材料构成,然后将该聚氨酯材料用聚氨酯和聚(乙二醇)溶液涂覆在 合适的溶剂。
    • 8. 发明授权
    • Iontophoretic electrode structure
    • 离子电渗电极结构
    • US4477971A
    • 1984-10-23
    • US536304
    • 1983-09-27
    • Stephen C. JacobsenRichard D. LuntzBarry K. Hanover
    • Stephen C. JacobsenRichard D. LuntzBarry K. Hanover
    • A61N1/04A61N1/30H01R43/02
    • A61N1/044A61N1/0472Y10T29/4921
    • An iontophoretic bioelectrode includes an enclosure having a bottom wall formed of a membrane through which ions may migrate when subjected to an electric field, and an upper wall joined to the bottom wall to define an interior compartment for holding an ion-containing solution. An electrode in the form of the male portion of a conventional clothing snap is mounted to the enclosure to communicate electrically with solution contained in the interior compartment. A needle receiving element is mounted in the upper wall of the enclosure. This element is in the form of a section of conduit having a receiving end, which is directed upwardly, and a blocking end which includes a platform for preventing a needle inserted into the receiving end from passing all the way through the conduit. A resilient plug is disposed in the receiving end of the conduit to prevent solution from escaping from the interior compartment. The plug is formed of a material through which a needle may be inserted but which, when the needle is retracted, closes about the opening made by the needle to prevent the escape of solution.
    • 离子电渗生物电极包括具有由膜形成的底壁的外壳,当经受电场时,离子可以通过该膜离子迁移,以及连接到底壁以限定用于保持含离子溶液的内部隔间的上壁。 传统衣服弹簧的阳部形式的电极安装到外壳上,以与包含在内部隔室中的溶液电气通信。 针接收元件安装在外壳的上壁中。 该元件是导管部分的形式,其具有向上指向的接收端,以及阻塞端,其包括用于防止插入接收端的针穿过导管的平台。 弹性塞子设置在导管的接收端中,以防止溶液从内部隔间逸出。 塞子由可以插入针的材料形成,但是当针缩回时,围绕由针形成的开口封闭以防止溶液逸出。