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1. 发明授权

US4557724A Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters 失效
标题翻译：用于最小化腹膜注射导管上的细胞粘附的装置和方法
公开(公告)号：US4557724A
公开(公告)日：1985-12-10
申请号：US522914
申请日：1983-08-12
申请人： Donald E. Gregonis , Robert L. Stephen , Dennis L. Coleman , Stephen K. Hunter , Barry K. Hanover , Jeffrey J. Harrow
发明人： Donald E. Gregonis , Robert L. Stephen , Dennis L. Coleman , Stephen K. Hunter , Barry K. Hanover , Jeffrey J. Harrow
IPC分类号： A61M39/02 , A61M25/00
CPC分类号： A61M39/0208
摘要： The present invention is directed to a subcutaneous peritoneal injection catheter apparatus and methods which minimizes catheter obstruction during use. The apparatus includes a receiving chamber or reservoir having a relatively small internal volume while employing a penetrable membrane and relatively enlarged target surface area. The reservoir is interconnected with the peritoneal cavity by a hollow stem. The penetrable membrane accommodates a hollow needle being inserted into the receiving reservoir and is configurated with a dome-like profile so that the membrane may also be depressed to expel insulin from the receiving reservoir into the peritoneal cavity in a direction generally toward the mesenteric peritoneal membrane.The portion of the apparatus which is in the peritoneal cavity is preferably constructed of, or coated with, a material which is capable of minimizing the adhesion of cells and the growth of bacteria on that portion of the apparatus. In a presently preferred embodiment of the subcutaneous peritoneal injection catheter, the portion of the catheter to be within the peritoneal cavity is constructed of a polyurethane material, and this polyurethane material is then coated with a solution of polyurethane and poly(ethylene glycol) in a suitable solvent.
摘要翻译：本发明涉及皮下腹膜内注射导管装置和使用过程中导尿管阻塞最小化的方法。该装置包括具有相对小的内部体积的接收室或容器，同时使用可穿透的膜和相对扩大的目标表面积。储存器通过中空茎与腹膜腔相互连接。可穿透的膜容纳插入接收容器中的中空针，并且被配置成具有圆顶状轮廓，使得膜也可以被压下，以将胰岛素从接收储器排出到通常朝向肠系膜腹膜的方向进入腹膜腔。位于腹膜腔中的装置的部分优选由能够最小化细胞粘附和细菌生长在该装置的该部分上的材料构成或涂覆。在皮下腹膜注射导管的当前优选实施例中，导管内部位于腹膜腔内的部分由聚氨酯材料构成，然后将该聚氨酯材料用聚氨酯和聚（乙二醇）溶液涂覆在合适的溶剂。

2. 发明授权

US4784486A Multi-channel molecular gas analysis by laser-activated Raman light scattering 失效
标题翻译：通过激光激发拉曼光散射的多通道分子气体分析
公开(公告)号：US4784486A
公开(公告)日：1988-11-15
申请号：US106791
申请日：1987-10-06
申请人： Richard A. Van Wagenen , Jeffrey D. Geisler , Donald E. Gregonis , Dennis L. Coleman
发明人： Richard A. Van Wagenen , Jeffrey D. Geisler , Donald E. Gregonis , Dennis L. Coleman
IPC分类号： G01J3/44 , G01N21/03 , G01N21/39 , G01N21/65
CPC分类号： G01J3/44 , G01J3/4412 , G01N21/65 , G01N2021/391 , G01N2021/651 , G01N21/031
摘要： The concentration of multiple polyatomic gases are determined simultaneously by Raman light scattering. The gas sample is placed in a sampling cell and a polarized laser beam is passed through the cell, along a longitudinal axis. A portion of the light scattered by the gas sample is captured and detected by means of multiple collection optics-filter-detector channels. The scattered light exits the gas cell via windows located in the sides of the gas cell and enters the collection channels which are aligned with the cell windows. The cell windows are along the longitudinal axis of the laser beam and gas cell. Light scattered by the gas sample provides signals of both inelastic Raman scattered light and elastic laser scattered light which are directed to the collection channels. The optics of each channel transports the scattered light signals onto a laser line rejection filter where the elastic scattered laser signals are attenuated. The remaining inelastic Raman scattered signals are caused to be incident upon an interference filter which is specific to the transmission of one or more specific Raman lines. The interference filter in each collection channel is selected to a specific wavelength which is characteristic of Raman scattering from a particular polyatomic gas. The optical signals representative of these specific Raman lines passing through the interference filters are sensed by optical detectors, and amplified and converted into digital electrical pulses which are processed into simultaneous visual readouts indicative of the identity and concentration of each of the polyatomic gas molecules present in the sample of gas being analyzed.
摘要翻译：通过拉曼光散射同时测定多种多原子气体的浓度。将气体样品放置在采样单元中，并且偏振激光束沿着纵向轴线通过单元。通过多个收集光学器件 - 滤波器 - 检测器通道捕获并检测由气体样品散射的一部分光。散射光通过位于气室的侧面的窗口离开气室，并进入与电池窗对齐的收集通道。电池窗口沿着激光束和气室的纵向轴线。通过气体样品散射的光提供了两个非弹性拉曼散射光和弹性激光散射光的信号，这些信号指向收集通道。每个通道的光学器件将散射光信号传输到激光线路抑制滤波器上，其中弹性散射激光信号被衰减。使残留的非弹性拉曼散射信号入射到特定于一个或多个特定拉曼线的透射的干涉滤光片上。每个收集通道中的干涉滤光片被选择为特定波长，这是特定的多原子气体的拉曼散射特性。代表通过干涉滤光片的这些特定拉曼线的光信号由光学检测器检测，并被放大并转换为数字电脉冲，其被处理成同时的视觉读数，指示存在于每个多原子气体分子的同一性和浓度正在分析的气体样本。

3. 发明授权

US5233996A Patient interfacing system and method to prevent water contamination 失效
标题翻译：患者接口系统和防止水污染的方法
公开(公告)号：US5233996A
公开(公告)日：1993-08-10
申请号：US647170
申请日：1991-01-24
申请人： Dennis L. Coleman , Charles V. Owen , Noel de Nevers
发明人： Dennis L. Coleman , Charles V. Owen , Noel de Nevers
IPC分类号： A61B5/083
CPC分类号： A61B5/083
摘要： Described herein is a patient interfacing system for sampling the inspired and expired gases of a patient and removing moisture from the sample. In one embodiment of the present invention, a patient link receives the gases from the patient's airway circuit and a vaporization section vaporizes condensed moisture in the sample. A separator section allows the vaporized moisture component of the sample to exit the patient interfacing system before the gas sample reaches the monitoring instrument. A filter may also be utilized to prevent condensed moisture, particulates and liquids from entering the monitoring instrument. Thus, the patient interfacing system of the present invention provides a reliable, cost effective and efficient means for delivering gas samples to a monitoring instrument which reduces or prevents water condensation inside the gas analysis portion of the monitoring instrument.
摘要翻译：本文描述的是用于对患者的启发和呼气的气体进行取样并从样品中除去水分的患者接口系统。在本发明的一个实施例中，患者链路接收来自患者气道回路的气体，蒸发部分蒸发样品中的冷凝水分。在气体样品到达监测仪器之前，分离器部分允许样品的汽化水分组分离开患者接口系统。也可以使用过滤器来防止冷凝的水分，微粒和液体进入监测仪器。因此，本发明的患者接口系统提供了将气体样本输送到监测仪器的可靠，成本有效和有效的方法，其减少或防止监测仪器的气体分析部分内的水冷凝。

4. 发明授权

US07371705B2 Phospha-adamantane(s) catalytic system 有权
标题翻译：磷 - 金刚烷催化体系
公开(公告)号：US07371705B2
公开(公告)日：2008-05-13
申请号：US10524023
申请日：2003-08-06
申请人： Graham R. Eastham , Paul A. Cameron , Robert P. Tooze , Kingsley J. Cavell , Peter G. Edwards , Dennis L. Coleman
发明人： Graham R. Eastham , Paul A. Cameron , Robert P. Tooze , Kingsley J. Cavell , Peter G. Edwards , Dennis L. Coleman
IPC分类号： B01J31/00
CPC分类号： B01J31/1895 , B01J31/2457 , B01J35/0013 , B01J2231/321 , B01J2531/0258 , B01J2531/60 , B01J2531/80 , B01J2531/824 , C07C67/38 , C07C2603/74 , C07F9/5018 , C07F9/5027 , C07F9/5045 , C07F9/52 , C07C69/24 , C07C69/67
摘要： A catalyst system capable of catalysing the carbonylation of an olefinally unsaturated compound is described. The 5 catalyst system is obtainable by combining: (a) a metal of Group VIB or Group VIII B or a compound thereof; and (b) a bidentate phosphine of general formula (I) Ad)s(CR4R5R6)TQ2-A-(K,D)Ar(E,Z)-B-Q1(Ad)u(CR1R2R3)v. Ad represents an optionally substituted adamantyl radical bonded to the phosphorous atom via any one of its tertiary carbon atoms. A method of production of the catalyst is also illustrated.
摘要翻译：描述了能够催化烯属不饱和化合物羰基化的催化剂体系。 5催化剂体系可通过以下方法获得：（a）VIB族或VIIIB族金属或其化合物; 和（b）通式（I）的二齿膦Ad）（CR 4）5 R 5 D 6 （K，D）Ar（E，Z）-BQ 1（Ad）u u u u u u u u u u u u u u u u u u u u u u （CR 1）第2个和第3个或更多个。 Ad表示任意取代的金刚烷基，其通过其叔碳原子中的任一个与磷原子键合。还示出了催化剂的生产方法。

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