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    • 4. 发明授权
    • Implantable drug delivery system with piston acutation
    • 具有活塞功能的可植入药物递送系统
    • US5196002A
    • 1993-03-23
    • US716926
    • 1991-06-18
    • Barry K. HanoverStephen C. JacobsenEric M. SimonTomasz PetelenzMichael G. Mladejovsky
    • Barry K. HanoverStephen C. JacobsenEric M. SimonTomasz PetelenzMichael G. Mladejovsky
    • A61K9/00A61K9/22A61M31/00
    • A61K9/0024A61M31/002
    • An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
    • 可植入药物输送系统包括具有基端和排出端的壳体,用于在排出端保持药物溶液,设置在排出端处的阀,以允许药物溶液从壳体内部流过阀门并出口 的壳体,其中所述壳体被施加到所述阀上;活塞,其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动,以迫使溶液朝向排出端并排出所述阀;以及弹簧,设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞,另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端,直到接收释放信号,此时它释放系绳。 定时电路设置在基座的外壳中,以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号,以便当释放系绳时,允许活塞向排放端移动 从而将药物溶液从壳体排出或推出,直到下一个最短的未释放的系链停止活塞的进一步移动。
    • 6. 发明申请
    • CELL CULTURE APPARATUS AND ASSOCIATED METHODS
    • 细胞培养装置及相关方法
    • US20100055790A1
    • 2010-03-04
    • US12514798
    • 2007-11-14
    • Eric M. Simon
    • Eric M. Simon
    • C12N5/02B01L3/00C12M1/24C12M1/18B28B23/00
    • C12M23/20C12M23/08C12M23/12C12M23/24
    • A cell culture apparatus consists of a vessel or array of vessels, each comprising a substantially flat bottom and substantially vertical sides, and composed of a substantially gas permeable material. The inner bottom surface of the vessel is commonly textured to provide the cells with adequate features for attachment and spreading. The vessel may include an integral annular flange which can be used to suspend the vessel from a suspensory element of a rack structure. To promote cell attachment and growth, the inner surfaces of the vessel bottom and sides may be coated with commonly available bio-active materials. Cells cultured in the system commonly grow in three dimensions for extended periods of time, and often produce significantly higher quantities of cellular products than cells grown in conventional labware.
    • 细胞培养装置由容器或容器阵列组成,每个容器包括基本上平坦的底部和基本上垂直的侧面,并且由基本上透气的材料构成。 容器的内底表面通常是纹理化的,为细胞提供足够的附着和扩散特征。 容器可以包括整体的环形凸缘,其可以用于将容器悬挂在齿条结构的悬挂元件上。 为了促进细胞附着和生长,容器底部和侧面的内表面可以涂覆有常用的生物活性材料。 在系统中培养的细胞通常在三维中长时间生长,并且通常比常规实验器皿中生长的细胞产生显着更高量的细胞产物。
    • 8. 再颁专利
    • Lens and associatable flow cell
    • 透镜和可关联的流动池
    • USRE39772E1
    • 2007-08-14
    • US10225687
    • 1997-03-19
    • James N. HerronDouglas A. ChristensenVictor A. PollackRichard D. McEachernEric M. Simon
    • James N. HerronDouglas A. ChristensenVictor A. PollackRichard D. McEachernEric M. Simon
    • G02B6/26G02B6/10G01N21/00G01N33/552G01N33/72
    • G01N21/0303G01N2021/058
    • Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 134, 136) of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket (162), the gasket is associated with the members and waveguide in such a way (e.g. by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g. plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.
    • 公开了具有用于分析生物液体的储存器或孔的类型的生物传感器的改进。 生物传感器(190)包括布置在诸如板(100,186)之间的多个构件之间的波导(164),所述构件(100)中的至少一个被形成以限定所述壁(132,134,136) 生物分析液体的储层。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈(162),但是垫圈以这样的方式(例如通过将垫圈凹入形成金属板的通道)与构件和波导相关联,使得垫圈不形成任何重要的部分 水库墙。 不同组成的波导(例如塑料,石英或玻璃)可以与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口,用于在反应槽中输入,排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导,以将光从波导耦合以用作质量控制措施,从而确保生物传感器被正确放置并且光正在工作。
    • 9. 发明授权
    • Lens and associatable flow cell
    • 透镜和可关联的流动池
    • US06356676B1
    • 2002-03-12
    • US09608714
    • 2000-06-30
    • James N. HerronDouglas A. ChristensenVictor A. PollakRichard D. McEachernEric M. Simon
    • James N. HerronDouglas A. ChristensenVictor A. PollakRichard D. McEachernEric M. Simon
    • G02B626
    • G01N21/0303G01N21/05G01N2021/0346
    • Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor includes a waveguide placed between a plurality of members such as plates at least one of the members being formed to define the walls of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket, the gasket is associated with the members and waveguide in such a way (e.g., by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g., plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.
    • 公开了具有用于分析生物液体的储存器或孔的类型的生物传感器的改进。 生物传感器包括放置在诸如板之间的多个构件之间的波导,所述构件中的至少一个形成为限定储存器的壁,其中液体被生物分析。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈,但是垫圈以这样的方式(例如通过将垫圈凹入形成金属板的通道)与构件和波导相关联,使得垫圈不形成储存器的任何重要部分 壁。 不同组成的波导(例如,塑料,石英或玻璃)可以与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口,用于在反应槽中输入,排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导,以将光从波导耦合以用作质量控制措施,从而确保生物传感器被正确放置并且光正在工作。