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1. 发明授权

US5833923A Sampling-assay interface system 失效
标题翻译：取样分析界面系统
公开(公告)号：US5833923A
公开(公告)日：1998-11-10
申请号：US577107
申请日：1995-12-22
申请人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
发明人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
IPC分类号： G01N21/03 , G01N21/76
CPC分类号： G01N21/76 , G01N21/03
摘要： A system and method for performing an assay for target analytes includes a sampling-device holder interface and a quantifier. The sampling device has a sampling portion and a reading portion containing a chemiluminescent reagent. The interface has a sampling-device holder and a light detector. The holder has a housing having an enclosure with a channel and a base plate with an opening. The base plate and the enclosure houses a slidable tray. The tray has a compartment adapted to seat the sampling device and an opening extending through the compartment. The reading portion is aligned with the tray opening. When the tray is closed, the tray opening is also aligned with the base plate opening, exposing the reading portion. Once the sampling portion is exposed to a sample suspected of containing the target analyte, at least one carrier liquid is introduced, if needed, to the sampling portion to transport any target analyte to the reading portion by dispersion. To measure the emitted light, the sampling device is seated into the tray. The tray is then inserted into housing. The light detector, which is connected in close proximity to the reading portion, outputs a signal. This signal is then converted to quantifiable data indicative of the target analyte quantity, using for instance, an ammeter.
摘要翻译：用于对目标分析物进行测定的系统和方法包括采样设备保持器接口和定量器。采样装置具有采样部分和含有化学发光试剂的读取部分。该接口具有取样装置支架和光检测器。保持器具有壳体，其具有带通道的外壳和具有开口的基板。基板和外壳容纳可滑动的托盘。托盘具有适于安置取样装置的隔室和延伸穿过隔间的开口。阅读部分与托盘开口对齐。当托盘关闭时，托盘开口也与基板开口对准，露出读取部分。一旦采样部分暴露于怀疑含有目标分析物的样品，如果需要，将至少一种载体液体引入采样部分，以通过分散体将任何目标分析物输送到读取部分。为了测量发出的光线，采样装置就位于托盘中。然后将托盘插入外壳。连接在阅读部分附近的光检测器输出信号。然后，使用例如电流表将该信号转换成指示目标分析物量的可量化数据。

2. 发明授权

US5980828A Combined sampling-assay device and holder 失效
标题翻译：组合采样分析装置和支架
公开(公告)号：US5980828A
公开(公告)日：1999-11-09
申请号：US864377
申请日：1997-05-28
申请人： Joseph A. McClintock , Afzal Chowdhury , Mary Ann Childs , Gregory K. Shipman , David Bernstein , Uri Reichman , Craig A. Chung
发明人： Joseph A. McClintock , Afzal Chowdhury , Mary Ann Childs , Gregory K. Shipman , David Bernstein , Uri Reichman , Craig A. Chung
IPC分类号： B01L3/00 , C12Q1/66 , G01N21/03 , G01N33/48
CPC分类号： G01N21/03 , B01L3/5023 , C12Q1/66 , B01L2200/027 , B01L2300/043 , B01L2300/047 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633
摘要： A combined sample-assay device allows sampling and detection within an integrated device. The device is a flat plate-like body with a collection arm. The collection arm optionally folds to enter a recess that flatly supports and seats the arm. The arm may be friction held in this recess and completely enters the recess. Within the recess is a second recess that contains a reading portion and transport portion. Chemiluminescent or other light emitting chemical reagent is placed within the device and light is detected in response to the presence of a sample analyte in a fluid sample.
摘要翻译：组合的样品分析装置允许在集成装置内进行采样和检测。该装置是具有收集臂的平板状体。收集臂可选地折叠以进入平坦地支撑并且支撑臂的凹部。臂可以摩擦保持在该凹部中并且完全进入凹部。在凹部内是包含阅读部分和传送部分的第二凹部。将化学发光或其它发光化学试剂置于装置内，并响应于样品分析物在流体样品中的存在而检测光。

4. 外观设计

USD407825S Octagonal diagnostic test device 失效
公开(公告)号：USD407825S
公开(公告)日：1999-04-06
申请号：US61172
申请日：1996-10-17
申请人： Mary Ann Childs , Thomas He , Greg K. Shipman , William Trainor , Erick Gray , Mohammud Afzal Chowdhury , Joseph A. McClintock , David Bernstein
设计人： Mary Ann Childs , Thomas He , Greg K. Shipman , William Trainor , Erick Gray , Mohammud Afzal Chowdhury , Joseph A. McClintock , David Bernstein

5. 发明授权

US5641229A Sample rotator with manually energized spring motor 失效
标题翻译：带手动激励弹簧电机的样品转子
公开(公告)号：US5641229A
公开(公告)日：1997-06-24
申请号：US577621
申请日：1995-12-22
申请人： Joseph A. McClintock , Gregory K. Shipman
发明人： Joseph A. McClintock , Gregory K. Shipman
IPC分类号： B01F11/00 , B01F15/00 , F03G1/06
CPC分类号： F03G1/06 , B01F11/0005 , B01F11/0022 , B01F15/00435 , B01F2215/0037
摘要： A manual sample rotator and method provides a mechanical orbital motion, which is useful in medical industries. The rotator has a substantially rectangular orbiting member with four guiding wells, complementary to four guiding posts provided on a fixed member, such as a housing. Each guiding post is inserted into one of the guiding wells. The guiding wells are larger than the counterpart guiding posts so that when the guiding posts are seated into the wells, the clearance therebetween allows the orbiting member to move in the horizontal plane in all directions within the bounds of the guiding wells. The guiding post and well arrangement thus restrains the orbiting member from rotating about the orbital axis, but permits the member to orbit thereabout. The orbiting member is orbited around a main orbital axis using an offset crank (output shaft end), which rotates about the main orbital axis and is rotatable about an axis offset from the main axis relative to the orbiting member. A manually operated spring motor rotates the orbiting member. The spring motor also has a time indicator, a level indicator, and a level adjuster.
摘要翻译：手动样品旋转器和方法提供机械轨道运动，其在医疗行业中是有用的。旋转器具有大致矩形的轨道构件，其具有四个引导孔，与设置在诸如壳体的固定构件上的四个引导柱互补。每个引导柱插入到一个导向孔中。引导井比对应的引导柱大，使得当引导柱位于井中时，其间的间隙允许轨道构件在引导井的范围内的所有方向上在水平面中移动。因此，引导柱和井的布置限制了轨道构件围绕轨道轴线旋转，但是允许构件在其周围轨道运行。轨道构件围绕主轨道绕轨道运动，该偏移曲柄（输出轴端）围绕主轨道轴线旋转并且可绕相对于轨道构件偏离主轴线的轴线旋转。手动操作的弹簧马达旋转轨道构件。弹簧电机还具有时间指示器，电平指示器和电平调节器。

6. 外观设计

USD401369S Hand-held luminometer 失效
公开(公告)号：USD401369S
公开(公告)日：1998-11-17
申请号：US69562
申请日：1997-04-28
申请人： Joseph A. McClintock , David Bernstein , William Trainor
设计人： Joseph A. McClintock , David Bernstein , William Trainor

7. 发明授权

US5477323A Fiber optic strain sensor and read-out system 失效
标题翻译：光纤应变传感器和读出系统
公开(公告)号：US5477323A
公开(公告)日：1995-12-19
申请号：US194960
申请日：1994-02-14
申请人： Jeffrey P. Andrews , Joseph A. McClintock , Carl F. Guerci, Jr.
发明人： Jeffrey P. Andrews , Joseph A. McClintock , Carl F. Guerci, Jr.
IPC分类号： G01D5/26 , G01B9/02
CPC分类号： G01D5/266
摘要： An optical sensor is described comprising a first optical fiber and a first reflective member. The first optical fiber has a first predetermined length of graded-index multimode optical fiber attached to its end. The first reflective member and the first optical fiber are arranged such that a gap is formed between the unattached end of the graded-index multimode optical fiber and the first reflective member. Also described is a rugged sensor design incorporating the first optical fiber and first reflective sensor as well as a method for providing the predetermined length of graded-index multimode fiber at the end of the first optical fiber. Finally, a readout system for an optical sensor is also described which comprises two optical paths differing in length by an amount equal to an optical path distance in the optical sensor. The readout system also comprises an optical source having a wavelength differing from that of the optical sensor, a modulator and a controller. The readout system provides a linear output signal that is independent of temperature and vibration effects associated with the read-out system.
摘要翻译：描述了包括第一光纤和第一反射构件的光学传感器。第一光纤具有附接到其端部的第一预定长度的渐变折射率多模光纤。第一反射构件和第一光纤布置成使得在渐变折射率多模光纤的未附着端与第一反射构件之间形成间隙。还描述了结合第一光纤和第一反射传感器的坚固的传感器设计以及在第一光纤端部处提供预定长度的渐变折射率多模光纤的方法。最后，还描述了一种用于光学传感器的读出系统，其包括长度不等于光学传感器中的光程距离的量的两个光路。读出系统还包括具有与光学传感器不同的波长的光源，调制器和控制器。读出系统提供与读出系统相关的温度和振动效应无关的线性输出信号。

8. 发明授权

US5276501A Fabry-Perot readout technique using wavelength tuning 失效
标题翻译：法布里 - 珀罗读出技术使用波长调谐
公开(公告)号：US5276501A
公开(公告)日：1994-01-04
申请号：US972397
申请日：1992-11-06
申请人： Joseph A. McClintock , Jeffrey P. Andrews
发明人： Joseph A. McClintock , Jeffrey P. Andrews
IPC分类号： G01B9/02 , G01D5/26 , G02B6/24 , G02B6/34
CPC分类号： G02B6/4215 , G01B9/02005 , G01D5/266 , G01D5/268 , G02B6/243 , G02B6/29337 , G02B6/29395 , G01B2290/25 , G02B6/29358
摘要： A method for sensing an environmental parameter includes the step of sensing the environmental parameter with an interferometer sensor that has a light source emitting a tunable wavelength of light and a gap that changes in length in response to the environmental parameter. The interferometer has a sinusoidal output curve that oscillates in intensity in response to changes in gap length. The wavelength of light emitted by the light source is tuned to a first wavelength to provide a first output value. Similarly, the wavelength of light emitted by the light source is next tuned to a second wavelength to provide a second output value. The first and second output values correspond to points on the sinusoidal output curve that differ by at least half a cycle. The gap length is then calculated from the values of the first wavelength and the difference between the first and second wavelengths. Finally, the value of the environmental parameter is determined from the value of the gap length.
摘要翻译：用于感测环境参数的方法包括用干涉仪传感器感测环境参数的步骤，所述干涉仪传感器具有发射可调谐波长的光的光源和响应于环境参数而改变长度的间隙。干涉仪具有响应于间隙长度变化而强度振荡的正弦输出曲线。由光源发射的光的波长被调谐到第一波长以提供第一输出值。类似地，由光源发射的光的波长接下来被调谐到第二波长以提供第二输出值。第一和第二输出值对应于正弦输出曲线上至少半个周期不同的点。然后从第一波长的值和第一和第二波长之间的差计算间隙长度。最后，根据间隙长度的值确定环境参数的值。

9. 发明授权

US07518710B2 Optical devices for biological and chemical detection 有权
标题翻译：用于生物和化学检测的光学装置
公开(公告)号：US07518710B2
公开(公告)日：2009-04-14
申请号：US11486619
申请日：2006-07-14
申请人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
发明人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N15/1463 , G01N2015/0261 , G01N2015/1488 , Y10T436/11 , Y10T436/115831
摘要： A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data. The processor determines whether the sample area includes predetermined biological or chemical particulates of interest based upon an analysis of the interrogation data and triggers an event such as an alarm or message if the predetermined biological or chemical particulates of interest are identified.
摘要翻译：提供了一种生物和化学检测系统，用于检测和识别感兴趣的生物和/或化学颗粒物。生物和化学检测系统包括收集器，第一光学装置，第二光学装置和处理器。收集器被配置为将从流体流中吸取的微粒沉积到样品基底上以限定样品区域。第一光学装置相对于样本区域的至少一部分导出第一数据，其被分析以确定至少一个视场和/或特定目标位置。然后，第二光学装置在每个确定的目标位置询问样品区域，例如使用拉曼光谱法，产生询问数据。处理器基于询问数据的分析来确定样本区域是否包括预期的生物或化学颗粒物，并且如果识别出预定的感兴趣的生物或化学颗粒物，则触发诸如报警或消息的事件。

10. 发明申请

US20090066934A1 OPTICAL DEVICES FOR BIOLOGICAL AND CHEMICAL DETECTION 有权
标题翻译：用于生物和化学检测的光学装置
公开(公告)号：US20090066934A1
公开(公告)日：2009-03-12
申请号：US11486619
申请日：2006-07-14
申请人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
发明人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N15/1463 , G01N2015/0261 , G01N2015/1488 , Y10T436/11 , Y10T436/115831
摘要： A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data. The processor determines whether the sample area includes predetermined biological or chemical particulates of interest based upon an analysis of the interrogation data and triggers an event such as an alarm or message if the predetermined biological or chemical particulates of interest are identified.
摘要翻译：提供了一种生物和化学检测系统，用于检测和识别感兴趣的生物和/或化学颗粒物。生物和化学检测系统包括收集器，第一光学装置，第二光学装置和处理器。收集器被配置为将从流体流中吸取的微粒沉积到样品基底上以限定样品区域。第一光学装置相对于样本区域的至少一部分导出第一数据，其被分析以确定至少一个视场和/或特定目标位置。然后，第二光学装置在每个确定的目标位置询问样品区域，例如使用拉曼光谱法，产生询问数据。处理器基于询问数据的分析来确定样品区域是否包括预期的生物或化学颗粒物，并且如果识别出预定的感兴趣的生物或化学颗粒物，则触发诸如报警或消息的事件。

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