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1. 发明授权

US5783399A Chemiluminescent assay methods and devices for detecting target analytes 失效
标题翻译：用于检测目标分析物的化学发光测定方法和装置
公开(公告)号：US5783399A
公开(公告)日：1998-07-21
申请号：US560094
申请日：1995-11-17
申请人： Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
发明人： Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
IPC分类号： C12Q1/66 , G01N21/76 , G01N33/543 , G01N33/53 , C12Q1/00 , C12Q1/02 , G01N33/554
CPC分类号： C12Q1/66 , G01N21/76 , G01N33/54366 , Y10S435/968
摘要： A method which utilize chemiluminescence for analyte detection and the detection of bacteria on surfaces. The method uses a device comprising a sampling portion made of a first adsorbent material, a container, and a second adsorbent material located within the container. The sampling portion collects analytes from a test sample which includes a surface or volume of a liquid. The second adsorbent material holds one or more chemiluminescent components including luciferase enzyme and cofactors in a dry state. In a preferred embodiment, the sampling portion is swabbed over a suspected contaminated surface. A bacteriolytic solution is then added to the adsorbent and releases ATP from any bacteria present. The ATP diffuses into the second adsorbent and mixes with the reagents therein to produce detectable light.
摘要翻译：利用化学发光进行分析物检测和表面细菌检测的方法。该方法使用包括由位于容器内的第一吸附剂材料，容器和第二吸附材料制成的取样部分的装置。采样部分从包括液体的表面或体积的测试样品中收集分析物。第二吸附材料在干燥状态下保持一种或多种化学发光成分，包括荧光素酶和辅因子。在优选实施例中，采样部分被擦拭在可疑的污染表面上。然后将溶菌溶液加入到吸附剂中并从存在的任何细菌释放ATP。 ATP扩散到第二吸附剂中并与其中的试剂混合以产生可检测的光。

2. 发明授权

US5641229A Sample rotator with manually energized spring motor 失效
标题翻译：带手动激励弹簧电机的样品转子
公开(公告)号：US5641229A
公开(公告)日：1997-06-24
申请号：US577621
申请日：1995-12-22
申请人： Joseph A. McClintock , Gregory K. Shipman
发明人： Joseph A. McClintock , Gregory K. Shipman
IPC分类号： B01F11/00 , B01F15/00 , F03G1/06
CPC分类号： F03G1/06 , B01F11/0005 , B01F11/0022 , B01F15/00435 , B01F2215/0037
摘要： A manual sample rotator and method provides a mechanical orbital motion, which is useful in medical industries. The rotator has a substantially rectangular orbiting member with four guiding wells, complementary to four guiding posts provided on a fixed member, such as a housing. Each guiding post is inserted into one of the guiding wells. The guiding wells are larger than the counterpart guiding posts so that when the guiding posts are seated into the wells, the clearance therebetween allows the orbiting member to move in the horizontal plane in all directions within the bounds of the guiding wells. The guiding post and well arrangement thus restrains the orbiting member from rotating about the orbital axis, but permits the member to orbit thereabout. The orbiting member is orbited around a main orbital axis using an offset crank (output shaft end), which rotates about the main orbital axis and is rotatable about an axis offset from the main axis relative to the orbiting member. A manually operated spring motor rotates the orbiting member. The spring motor also has a time indicator, a level indicator, and a level adjuster.
摘要翻译：手动样品旋转器和方法提供机械轨道运动，其在医疗行业中是有用的。旋转器具有大致矩形的轨道构件，其具有四个引导孔，与设置在诸如壳体的固定构件上的四个引导柱互补。每个引导柱插入到一个导向孔中。引导井比对应的引导柱大，使得当引导柱位于井中时，其间的间隙允许轨道构件在引导井的范围内的所有方向上在水平面中移动。因此，引导柱和井的布置限制了轨道构件围绕轨道轴线旋转，但是允许构件在其周围轨道运行。轨道构件围绕主轨道绕轨道运动，该偏移曲柄（输出轴端）围绕主轨道轴线旋转并且可绕相对于轨道构件偏离主轴线的轴线旋转。手动操作的弹簧马达旋转轨道构件。弹簧电机还具有时间指示器，电平指示器和电平调节器。

3. 发明授权

US5833923A Sampling-assay interface system 失效
标题翻译：取样分析界面系统
公开(公告)号：US5833923A
公开(公告)日：1998-11-10
申请号：US577107
申请日：1995-12-22
申请人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
发明人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
IPC分类号： G01N21/03 , G01N21/76
CPC分类号： G01N21/76 , G01N21/03
摘要： A system and method for performing an assay for target analytes includes a sampling-device holder interface and a quantifier. The sampling device has a sampling portion and a reading portion containing a chemiluminescent reagent. The interface has a sampling-device holder and a light detector. The holder has a housing having an enclosure with a channel and a base plate with an opening. The base plate and the enclosure houses a slidable tray. The tray has a compartment adapted to seat the sampling device and an opening extending through the compartment. The reading portion is aligned with the tray opening. When the tray is closed, the tray opening is also aligned with the base plate opening, exposing the reading portion. Once the sampling portion is exposed to a sample suspected of containing the target analyte, at least one carrier liquid is introduced, if needed, to the sampling portion to transport any target analyte to the reading portion by dispersion. To measure the emitted light, the sampling device is seated into the tray. The tray is then inserted into housing. The light detector, which is connected in close proximity to the reading portion, outputs a signal. This signal is then converted to quantifiable data indicative of the target analyte quantity, using for instance, an ammeter.
摘要翻译：用于对目标分析物进行测定的系统和方法包括采样设备保持器接口和定量器。采样装置具有采样部分和含有化学发光试剂的读取部分。该接口具有取样装置支架和光检测器。保持器具有壳体，其具有带通道的外壳和具有开口的基板。基板和外壳容纳可滑动的托盘。托盘具有适于安置取样装置的隔室和延伸穿过隔间的开口。阅读部分与托盘开口对齐。当托盘关闭时，托盘开口也与基板开口对准，露出读取部分。一旦采样部分暴露于怀疑含有目标分析物的样品，如果需要，将至少一种载体液体引入采样部分，以通过分散体将任何目标分析物输送到读取部分。为了测量发出的光线，采样装置就位于托盘中。然后将托盘插入外壳。连接在阅读部分附近的光检测器输出信号。然后，使用例如电流表将该信号转换成指示目标分析物量的可量化数据。

4. 发明授权

US5766962A Device for collecting and testing samples 失效
标题翻译：收集和测试样品的设备
公开(公告)号：US5766962A
公开(公告)日：1998-06-16
申请号：US577128
申请日：1995-12-22
申请人： Mary Ann Childs , Mohammed A. Chowdhury , David Bernstein , Gregory K. Shipman , Erick Gray
发明人： Mary Ann Childs , Mohammed A. Chowdhury , David Bernstein , Gregory K. Shipman , Erick Gray
IPC分类号： A61B10/00 , B01L3/00 , B01L9/00 , G01N33/543 , G01N33/569 , G01N21/00 , G01N31/22 , G01N33/53
CPC分类号： G01N33/56911 , A61B10/0038 , A61B10/0045 , B01L3/5023 , G01N33/54366 , B01L2300/0816 , B01L2300/0825 , B01L2400/0406 , B01L2400/0633 , B01L2400/0683 , B01L3/5029 , B01L9/52 , Y10S435/81 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： Improved devices for collecting and analyzing samples of aqueous solutions, body fluids, sewage or fecal matter to be used in detecting microbes and microbial byproducts. A device in accordance with the invention comprises a body including an internal channel having an entryway, a solute chamber connected to the entryway, a solute-adding mechanism operatively connected to the solute chamber, a window in the body that allows viewing of a portion of the channel, and an aperture in the body that opens to the channel; a bendable tang connected to the body; and a sample collection unit attached to the tang.
摘要翻译：用于收集和分析用于检测微生物和微生物副产物的水溶液，体液，污水或粪便物质样品的改进装置。根据本发明的装置包括主体，其包括具有入口通道的内部通道，连接到入口的溶质室，可操作地连接到溶质室的溶质添加机构，身体中允许观察部分通道和在通道中开口的体内的孔; 可弯曲的脚连接到身体; 和一个附在脚上的样本收集单元。

5. 发明授权

US5980828A Combined sampling-assay device and holder 失效
标题翻译：组合采样分析装置和支架
公开(公告)号：US5980828A
公开(公告)日：1999-11-09
申请号：US864377
申请日：1997-05-28
申请人： Joseph A. McClintock , Afzal Chowdhury , Mary Ann Childs , Gregory K. Shipman , David Bernstein , Uri Reichman , Craig A. Chung
发明人： Joseph A. McClintock , Afzal Chowdhury , Mary Ann Childs , Gregory K. Shipman , David Bernstein , Uri Reichman , Craig A. Chung
IPC分类号： B01L3/00 , C12Q1/66 , G01N21/03 , G01N33/48
CPC分类号： G01N21/03 , B01L3/5023 , C12Q1/66 , B01L2200/027 , B01L2300/043 , B01L2300/047 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633
摘要： A combined sample-assay device allows sampling and detection within an integrated device. The device is a flat plate-like body with a collection arm. The collection arm optionally folds to enter a recess that flatly supports and seats the arm. The arm may be friction held in this recess and completely enters the recess. Within the recess is a second recess that contains a reading portion and transport portion. Chemiluminescent or other light emitting chemical reagent is placed within the device and light is detected in response to the presence of a sample analyte in a fluid sample.
摘要翻译：组合的样品分析装置允许在集成装置内进行采样和检测。该装置是具有收集臂的平板状体。收集臂可选地折叠以进入平坦地支撑并且支撑臂的凹部。臂可以摩擦保持在该凹部中并且完全进入凹部。在凹部内是包含阅读部分和传送部分的第二凹部。将化学发光或其它发光化学试剂置于装置内，并响应于样品分析物在流体样品中的存在而检测光。

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