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1. 发明授权

US07006232B2 Phase-referenced doppler optical coherence tomography 有权
公开(公告)号：US07006232B2
公开(公告)日：2006-02-28
申请号：US10408745
申请日：2003-04-07
申请人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
发明人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
IPC分类号： G01B9/02
CPC分类号： G01B9/02045 , G01B9/02007 , G01B9/02076 , G01B9/02083 , G01B9/02091 , G01B2290/45
摘要： A phase-referenced Doppler optical coherence tomography (OCT) system includes a low-coherence optical radiation source and a reference source co-propagated to a sample arm and a reference arm. The low-coherence and reference optical radiation reflected from the reference and arms is detected by a pair of detectors, yielding OCT and reference interferometric data output signals. The reference interferometric data output signal can be used to correct the OCT interferometric to yield velocity-indicating images that are free from defects due to sample motion and/or interferometer jitter.

2. 发明授权

US07061622B2 Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography 有权
公开(公告)号：US07061622B2
公开(公告)日：2006-06-13
申请号：US10213326
申请日：2002-08-05
申请人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Siavash Yazdanfar
发明人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Siavash Yazdanfar
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , G01B11/2441
摘要： An optical coherence tomography (OCT) system including an interferometer provides illuminating light along a first optical path to a sample and an optical delay line and collects light from the sample along a second optical path remitted at several scattering angles to a detector. In one embodiment, illuminating light is directed along a number of incident light paths through a focusing lens to a sample. The light paths and focusing lens are related to the sample and to both the incident light source and the detector. In another embodiment, a focusing system directs light to a location in the sample. A transmission grating or acousto-optic modulator directs light from the sample at an angle representative of the wavelength of the incident light on the transmission grating or acousto-optic modulator.

3. 发明授权

US07075658B2 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US07075658B2
公开(公告)日：2006-07-11
申请号：US10765010
申请日：2004-01-26
申请人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
发明人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

4. 发明授权

US07072047B2 Method and system for quantitative image correction for optical coherence tomography 有权
标题翻译：光学相干断层扫描定量图像校正方法与系统
公开(公告)号：US07072047B2
公开(公告)日：2006-07-04
申请号：US10619574
申请日：2003-07-14
申请人： Volker Westphal , Andrew M. Rollins , Joseph A. Izatt
发明人： Volker Westphal , Andrew M. Rollins , Joseph A. Izatt
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/02083
摘要： A method of correcting optical coherence tomography (OCT) image data obtained from a layered media sample includes identifying at least one interface from the obtained OCT data and correcting the OCT data for distortion at the at least one interface. The OCT image data can be corrected for extrinsic distortions, such as those caused by scan geometry, as well as, intrinsic distortions, such as those caused by refraction at each interface.
摘要翻译：校正从分层介质样本获得的光学相干断层摄影（OCT）图像数据的方法包括从所获得的OCT数据识别至少一个接口，并且在所述至少一个界面处校正OCT数据以进行失真。 OCT图像数据可以被校正为外部失真，例如由扫描几何引起的失真，以及固有失真，例如由每个界面处的折射造成的。

5. 发明授权

US07362444B2 Interferometers for optical coherence domain reflectometry 有权
标题翻译：用于光学相干畴反射测量的干涉仪
公开(公告)号：US07362444B2
公开(公告)日：2008-04-22
申请号：US11470079
申请日：2006-09-05
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学探测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

6. 发明授权

US06775007B2 Frequency-encoded parallel OCT and associated systems and methods 有权
标题翻译：频率编码的并行OCT和相关系统和方法
公开(公告)号：US06775007B2
公开(公告)日：2004-08-10
申请号：US10059723
申请日：2002-01-29
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B902
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02007 , G01B9/0201 , G01B9/02028 , G01B9/02091 , G01B2290/35 , G01B2290/40 , G01N21/4795
摘要： Rapid scan optical delay techniques are used in parallel implementation of OCT using a detector and signal processing can be carried out using algorithms. Frequency encoded parallel OCT and multi-path, frequency encoded reference delay networks are used. A large number of frequency-correlated depth channels are used to acquire multiple depth scans of a sample. A different frequency shift (Doppler shift) on each different path length, or delay, is used to obtain simultaneous respective signals and, thus, information about the sample, from different depths in the sample. Reference delay line functions are obtained using bulk optics, integrated optics and fiber optics.
摘要翻译：快速扫描光延迟技术用于使用检测器并行执行OCT，并且可以使用算法执行信号处理。使用频率编码的并行OCT和多路径，频率编码的参考延迟网络。使用大量频率相关深度通道来采集样本的多个深度扫描。使用每个不同路径长度或延迟上的不同频移（多普勒频移）来从样本中的不同深度获得相应的信号，从而获得关于样本的信息。参考延迟线功能使用体光学，集成光学和光纤获得。

7. 发明授权

US07826059B2 Method and apparatus for polarization-sensitive optical coherence tomography 有权
标题翻译：用于偏振敏感光学相干断层扫描的方法和装置
公开(公告)号：US07826059B2
公开(公告)日：2010-11-02
申请号：US10055282
申请日：2002-01-22
申请人： Jonathan E. Roth , Joseph A. Izatt , Andrew M. Rollins
发明人： Jonathan E. Roth , Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02011 , G01B9/02072 , G01B9/02091 , G01B9/04 , G01B2290/70 , G01N21/4795 , Y10T29/49716
摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation 2.2°) over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°.
摘要翻译：一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。该方法测量净延迟，净快轴和反射率。通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。该方法可以使用非偏振维持光纤和单个检测器来实现。这种PS-OCT方法报道了快轴测量。在系统的校准测试中，在0°至180°的延迟范围内测量平均误差为7.5°（标准偏差2.2°）的净延迟，平均误差为4.8°的快轴在0°至 180°。

8. 发明授权

US07102756B2 Interferometers for optical coherence tomography and reflectometry 有权
标题翻译：用于光学相干断层扫描和反射测量的干涉仪
公开(公告)号：US07102756B2
公开(公告)日：2006-09-05
申请号：US10646202
申请日：2003-08-22
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学探测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

9. 发明授权

US06657727B1 Interferometers for optical coherence domain reflectometry and optical coherence tomography using nonreciprocal optical elements 有权
标题翻译：用于光学相干畴反射测量和使用非互易光学元件的光学相干断层扫描的干涉仪
公开(公告)号：US06657727B1
公开(公告)日：2003-12-02
申请号：US09393761
申请日：1999-09-10
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B902
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学探测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

10. 发明授权

US09788712B2 Device and method for determining the presence of middle ear fluid 有权
公开(公告)号：US09788712B2
公开(公告)日：2017-10-17
申请号：US13882236
申请日：2011-11-04
申请人： Rahul Seth , Matthew R. Ford , Andrew M. Rollins , Paul K. Krakovitz
发明人： Rahul Seth , Matthew R. Ford , Andrew M. Rollins , Paul K. Krakovitz
IPC分类号： A61B1/227 , A61B1/06 , A61B5/00 , A61B5/12
CPC分类号： A61B1/227 , A61B1/063 , A61B1/0638 , A61B1/0684 , A61B5/0075 , A61B5/0084 , A61B5/12 , A61B5/6817
摘要： A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.

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