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1. 发明申请

US20130041238A1 ELECTROCHEMICAL DISINFECTION OF IMPLANTED CATHETERS 有权
标题翻译：植入式电针的电化学消毒
公开(公告)号：US20130041238A1
公开(公告)日：2013-02-14
申请号：US13528788
申请日：2012-06-20
申请人： Jose P. Joseph , Pablo E. Garcia , Karen F. Shakespear , Sarah Young , Janus A.J. Haagensen , Sanjeev Dutta
发明人： Jose P. Joseph , Pablo E. Garcia , Karen F. Shakespear , Sarah Young , Janus A.J. Haagensen , Sanjeev Dutta
IPC分类号： A61M37/00 , A61B5/1455
CPC分类号： A61L29/06 , A61L2/03 , A61L29/02 , A61L29/04 , A61L29/041 , A61L29/126 , A61L29/14 , A61L2202/11 , A61L2202/24 , A61L2400/18 , A61M25/0017 , A61M25/0045 , A61M2025/0019 , A61M2025/0056 , A61N1/205
摘要： An implantable catheter is provided that may be disinfected without removal from the body of a patient, using an electrochemical method to generate an electric field on the catheter surface and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter and a voltage source that is operably connected to electrodes on or embedded in the exterior and optionally the interior catheter surface. Methods are also provided for disinfecting the implantable catheter in vivo and for detecting or confirming the presence of a pathogenic biofilm thereon.
摘要翻译：提供可植入导管，其可以在不从患者身体移除的情况下使用电化学方法进行消毒，以在导管表面上产生电场，从而破坏存在或形成的生物膜中的微生物。导管系统包括可植入导管和电压源，电压源可操作地连接到电极上或嵌入外部和可选地内导管表面。还提供了用于在体内消毒可植入导管并用于检测或确认其上存在致病性生物膜的方法。

2. 发明授权

US09320832B2 Electrochemical disinfection of implanted catheters 有权
标题翻译：植入导管的电化学消毒
公开(公告)号：US09320832B2
公开(公告)日：2016-04-26
申请号：US13528788
申请日：2012-06-20
申请人： Jose P. Joseph , Pablo E. Garcia , Karen F. Shakespear , Sarah Young , Janus A. J. Haagensen , Sanjeev Dutta
发明人： Jose P. Joseph , Pablo E. Garcia , Karen F. Shakespear , Sarah Young , Janus A. J. Haagensen , Sanjeev Dutta
IPC分类号： A61M25/00 , A61L29/04 , A61L29/14 , A61N1/20 , A61L2/03
CPC分类号： A61L29/06 , A61L2/03 , A61L29/02 , A61L29/04 , A61L29/041 , A61L29/126 , A61L29/14 , A61L2202/11 , A61L2202/24 , A61L2400/18 , A61M25/0017 , A61M25/0045 , A61M2025/0019 , A61M2025/0056 , A61N1/205
摘要： An implantable catheter is provided that may be disinfected without removal from the body of a patient, using an electrochemical method to generate an electric field on the catheter surface and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter and a voltage source that is operably connected to electrodes on or embedded in the exterior and optionally the interior catheter surface. Methods are also provided for disinfecting the implantable catheter in vivo and for detecting or confirming the presence of a pathogenic biofilm thereon.
摘要翻译：提供可植入导管，其可以在不从患者身体移除的情况下使用电化学方法进行消毒，以在导管表面上产生电场，从而破坏存在或形成的生物膜中的微生物。导管系统包括可植入导管和电压源，电压源可操作地连接到电极上或嵌入外部和可选地内导管表面。还提供了用于在体内消毒可植入导管并用于检测或确认其上存在致病性生物膜的方法。

3. 发明授权

US5183549A Multi-analyte sensing electrolytic cell 失效
标题翻译：多分辨率感应电解槽
公开(公告)号：US5183549A
公开(公告)日：1993-02-02
申请号：US470954
申请日：1990-01-26
申请人： Jose P. Joseph , Marc J. Madou
发明人： Jose P. Joseph , Marc J. Madou
IPC分类号： G01N27/416
CPC分类号： G01N27/4162
摘要： An electrolytic sensor is set forth for measuring the amounts of an ionic and of a vaporous species in a liquid. The system has an electrode sensitive to an ionic species and another electrode sensitive to a vaporous species. A unitary membrane covers the electrodes and the requisite electrolyte with the membrane being permeable to the vaporous species, impermeable to the liquid and having dispersed in it an ionophore which senses the ionic species via selective transfer into the membrane of a quantity of the ionic species determined by the concentration of the ionic species in the liquid. Such quantities as hydrogen ion concentration, carbon dioxide concentration and oxygen concentration can be determined by a single electrolytic cell structure.
摘要翻译：介绍了一种用于测量液体中离子和气态物质的量的电解传感器。该系统具有对离子物质敏感的电极和对气态物质敏感的另一电极。单一膜覆盖电极和所需的电解质，其中膜对于气态物质是可透过的，对液体是不可渗透的，并且在其中分散有离子载体，其通过选择性转移到一定量的离子物质中来检测离子物质通过离子物质在液体中的浓度。这样的氢离子浓度，二氧化碳浓度和氧气浓度可以通过单个电解池结构来确定。

4. 发明授权

US08508109B2 Electroactive polymer manufacturing 有权
公开(公告)号：US08508109B2
公开(公告)日：2013-08-13
申请号：US13042863
申请日：2011-03-08
申请人： Ronald E. Pelrine , Roy D. Kornbluh , Oibing Pei , Seajin Oh , Jose P. Joseph
发明人： Ronald E. Pelrine , Roy D. Kornbluh , Oibing Pei , Seajin Oh , Jose P. Joseph
IPC分类号： H01L41/04 , H01L41/193 , H01L41/047
CPC分类号： H01L41/047 , F02G1/043 , F02G2243/52 , F04B35/00 , F04B35/045 , F04B43/043 , F05C2225/08 , F25B9/14 , H01G5/16 , H01L41/0478 , H01L41/094 , H01L41/0986 , H01L41/113 , H01L41/1138 , H01L41/193 , H01L41/45 , H02N2/023 , H04R19/02 , H04R23/00 , Y10S310/80 , Y10T29/49826
摘要： Described herein are transducers and their fabrication. The transducers convert between mechanical and electrical energy. Some transducers of the present invention include a pre-strained polymer. The pre-strain improves the conversion between electrical and mechanical energy. The present invention provides methods for fabricating electromechanical devices including one or more electroactive polymers.

5. 发明授权

US07923064B2 Electroactive polymer manufacturing 有权
标题翻译：电聚合物制造
公开(公告)号：US07923064B2
公开(公告)日：2011-04-12
申请号：US11775021
申请日：2007-07-09
申请人： Ronald E. Pelrine , Roy D. Kornbluh , Qibing Pei , Seajin Oh , Jose P. Joseph
发明人： Ronald E. Pelrine , Roy D. Kornbluh , Qibing Pei , Seajin Oh , Jose P. Joseph
IPC分类号： B05D5/12 , B05D3/12
CPC分类号： H01L41/047 , F02G1/043 , F02G2243/52 , F04B35/00 , F04B35/045 , F04B43/043 , F05C2225/08 , F25B9/14 , H01G5/16 , H01L41/0478 , H01L41/094 , H01L41/0986 , H01L41/113 , H01L41/1138 , H01L41/193 , H01L41/45 , H02N2/023 , H04R19/02 , H04R23/00 , Y10S310/80 , Y10T29/49826
摘要： Described herein are transducers and their fabrication. The transducers convert between mechanical and electrical energy. Some transducers of the present invention include a pre-strained polymer. The pre-strain improves the conversion between electrical and mechanical energy. The present invention provides methods for fabricating electromechanical devices including one or more electroactive polymers.
摘要翻译：这里描述的是换能器及其制造。换能器在机械和电能之间转换。本发明的一些换能器包括预应变聚合物。预应变改善了电和机械能之间的转换。本发明提供了制造包括一种或多种电活性聚合物的机电装置的方法。

6. 发明授权

US06858184B2 Microlaboratory devices and methods 失效
标题翻译：微实验装置和方法
公开(公告)号：US06858184B2
公开(公告)日：2005-02-22
申请号：US09810919
申请日：2001-03-16
申请人： Ronald E. Pelrine , Subramanian Venkat Shastri , Jose P. Joseph
发明人： Ronald E. Pelrine , Subramanian Venkat Shastri , Jose P. Joseph
IPC分类号： B81B7/02 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , C12M1/00 , C40B40/06 , C40B40/10 , G01N35/00 , G01N33/48 , B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12
CPC分类号： B01L3/50273 , B01J19/0046 , B01J19/0093 , B01J2219/00497 , B01J2219/005 , B01J2219/00549 , B01J2219/00563 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00871 , B01L3/0293 , B01L3/502738 , B01L3/502761 , B01L2200/0647 , B01L2200/0657 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2300/087 , B01L2300/088 , B01L2400/043 , B01L2400/0475 , B01L2400/0484 , B01L2400/0633 , C40B40/06 , C40B40/10 , G01N35/0098 , G01N2035/00237
摘要： Disclosed herein are apparatuses and devices, and methods for using and making the same, for use in performing desired activities in an automated, microscale format. Microparticles are ushered about within a microscale apparatus, to selectively move between various stations in a selected order and manner. Some embodiments include reaction, micro-weighing, micro-analysis, reagent acquisition and deposition, and incubation stations. Microparticles can individually move, or move as trains. Samples, including particulate and solid tissue samples may be manipulated and analyzed within the device. Some embodiments may engage in micro-fabrication activities or micro-deconstruction activities. Systems for controlling such apparatuses are included as well as methods of operation.
摘要翻译：本文公开了用于使用和制造它们的装置和装置以及用于以自动化的微型格式执行所需活动的方法。在微型设备中引入微粒，以选择的顺序和方式选择性地在各个站之间移动。一些实施方案包括反应，微量称重，微量分析，试剂获取和沉积以及孵化站。微粒可以单独移动或作为火车移动。可以在装置内操纵和分析样品，包括颗粒和固体组织样品。一些实施例可以参与微制造活动或微解构活动。包括用于控制这些装置的系统以及操作方法。

7. 发明授权

US5169599A Method and apparatus for optically detecting presence of immunological components 失效
标题翻译：用于光学检测免疫组分存在的方法和装置
公开(公告)号：US5169599A
公开(公告)日：1992-12-08
申请号：US576359
申请日：1990-08-30
申请人： Jose P. Joseph , Kiminori Itoh
发明人： Jose P. Joseph , Kiminori Itoh
IPC分类号： G01N33/543 , G01N33/553
CPC分类号： G01N33/553 , G01N33/54373 , G01N33/54393 , Y10S436/808 , Y10S436/81
摘要： An optical immunosensing device for detecting the presence of an analyte in a liquid sample is fabricated by coating iron phosphate onto a silicon substrate and then etching the iron phosphate layer to obtain steps of varying thickness. Then, a first mip, capable of immunological reaction with the analyte, is immobilized on the iron phosphate steps. In the preferred embodiment, the first mip is chemically bound to the iron phosphate step surface. The presence of the analyte in the liquid sample is detected by visually observing color changes in the steps after contact of the detection zone with the liquid sample. A change in step color is related to increased thickness which can only result from the binding of the analyte to the first mip immobilized on the iron phosphate step. Aluminum phosphate can also be added to the iron phosphate.
摘要翻译：通过将磷酸铁涂覆到硅衬底上，然后蚀刻磷酸铁层以获得改变厚度的步骤来制造用于检测液体样品中分析物的存在的光学免疫感测装置。然后，能够与分析物进行免疫反应的第一个mip被固定在磷酸铁步骤上。在优选的实施方案中，第一絮凝剂化学键合到磷酸铁步骤表面。通过目视观察检测区域与液体样品接触后的步骤中的颜色变化来检测液体样品中分析物的存在。步骤颜色的改变与增加的厚度有关，这只能由分析物与固定在磷酸铁步骤上的第一个胶片结合而产生。磷酸铝也可以添加到磷酸铁中。

8. 发明申请

US20120169184A1 ELECTROACTIVE POLYMER MANUFACTURING 审中-公开
标题翻译：电动聚合物制造
公开(公告)号：US20120169184A1
公开(公告)日：2012-07-05
申请号：US13363692
申请日：2012-02-01
申请人： Ronald E. Pelrine , Roy D. Kornbluth , Qibing Pei , Seajin Oh , Jose P. Joseph
发明人： Ronald E. Pelrine , Roy D. Kornbluth , Qibing Pei , Seajin Oh , Jose P. Joseph
IPC分类号： H01L41/047
CPC分类号： H01L41/45 , H01L41/0986 , Y10S310/80
摘要： Described herein are transducers and their fabrication. The transducers convert between mechanical and electrical energy. Some transducers of the present invention include a pre-strained polymer. The pre-strain improves the conversion between electrical and mechanical energy. The present invention provides methods for fabricating electromechanical devices including one or more electroactive polymers.
摘要翻译：这里描述的是换能器及其制造。换能器在机械和电能之间转换。本发明的一些换能器包括预应变聚合物。预应变改善了电和机械能之间的转换。本发明提供了制造包括一种或多种电活性聚合物的机电装置的方法。

9. 发明授权

US06879162B2 System and method of micro-fluidic handling and dispensing using micro-nozzle structures 有权
标题翻译：使用微喷嘴结构的微流体处理和分配的系统和方法
公开(公告)号：US06879162B2
公开(公告)日：2005-04-12
申请号：US10285396
申请日：2002-10-31
申请人： Victor M. Aguero , Elizabeth J. Brackmann , Jose P. Joseph , Christopher E. Holland , Charles A. Spindt , Paul R. Schwoebel , Eric M. Pearson
发明人： Victor M. Aguero , Elizabeth J. Brackmann , Jose P. Joseph , Christopher E. Holland , Charles A. Spindt , Paul R. Schwoebel , Eric M. Pearson
IPC分类号： B01L3/02 , B41J2/06 , G01R29/24 , G01R31/00 , G01N27/60 , H01J49/00
CPC分类号： B01L3/0268 , B01L2300/0819 , B01L2400/027 , B01L2400/0415 , B41J2/06
摘要： Described are a method and system for dispensing a fluid. A fluid-dispensing device includes a substrate and a plurality of nozzles formed in the substrate. Each nozzle has an open-ended tip and a fluid-conducting channel between the tip and a source of fluid. A non-conducting spacer is on the substrate and electrically isolates a gate electrode from the substrate. The gate electrode is located adjacent to the tip of at least one of the nozzles to effect dispensing of the fluid in that nozzle in response to a voltage applied between the gate electrode and the nozzle or fluid in the nozzle. In one embodiment, the gate electrode includes a plurality of individually addressable gate electrodes used for selectively actuating nozzles.
摘要翻译：描述了用于分配流体的方法和系统。流体分配装置包括基板和形成在基板中的多个喷嘴。每个喷嘴具有开口端部和在尖端和流体源之间的流体传导通道。非导电间隔物在衬底上，并将栅电极与衬底电隔离。栅电极位于与至少一个喷嘴的尖端相邻的位置，以响应施加在喷嘴之间的电极和喷嘴之间的电压而在该喷嘴中分配流体。在一个实施例中，栅电极包括用于选择性地致动喷嘴的多个单独寻址的栅电极。

10. 发明授权

US5161532A Integral interstitial fluid sensor 失效
标题翻译：整体式间接流体传感器
公开(公告)号：US5161532A
公开(公告)日：1992-11-10
申请号：US511329
申请日：1990-04-19
申请人： Jose P. Joseph
发明人： Jose P. Joseph
IPC分类号： A61B5/145 , A61B5/00 , A61B5/103 , A61B5/1477 , A61B10/00 , G01N27/327 , G01N27/416 , G01N27/49
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/441 , A61B2010/008
摘要： An integral interstitial fluid sensor for application to the skin of a person or an animal for the detection of chemical components of tissue fluid is disclosed. The fluid sensor comprises a substrate of a porous material for the passage of the interstitial fluid therethrough. At least two electrodes are provided. One of the electrodes has two sides, with one side mounted on the substrate. The electrode is also of a porous material and permits the passage of the interstitial fluid from one side through to the second side which is generally opposite the one side. A layer of chemical is on the second side. The layer of chemical comprises a chemical for reaction with one component of the fluid, mixed in a mediating agent. The electrodes generate an electrical signal upon the detection of the reaction of the one component of the fluid with the chemical. The electrical signal is received by a detector and a display is generated, indicating the amount of the one component detected. Finally, a pump for sucking the fluid from the skin into the sensor is disclosed.

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